LOCUS       NM_001414528            3411 bp    mRNA    linear   PRI 10-APR-2024
DEFINITION  Homo sapiens nuclear transcription factor Y subunit beta (NFYB),
            transcript variant 12, mRNA.
ACCESSION   NM_001414528
VERSION     NM_001414528.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3411)
  AUTHORS   Liu,P., Xing,N., Xiahou,Z., Yan,J., Lin,Z. and Zhang,J.
  TITLE     Unraveling the intricacies of glioblastoma progression and
            recurrence: insights into the role of NFYB and oxidative
            phosphorylation at the single-cell level
  JOURNAL   Front Immunol 15, 1368685 (2024)
   PUBMED   38510250
  REMARK    GeneRIF: Unraveling the intricacies of glioblastoma progression and
            recurrence: insights into the role of NFYB and oxidative
            phosphorylation at the single-cell level.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3411)
  AUTHORS   Zhang,Y., Huang,H., Liu,P. and Xie,Y.
  TITLE     NFYB increases chemosensitivity in glioblastoma by promoting
            HDAC5-mediated transcriptional inhibition of SHMT2
  JOURNAL   J Neuropathol Exp Neurol 82 (11), 911-920 (2023)
   PUBMED   37742129
  REMARK    GeneRIF: NFYB increases chemosensitivity in glioblastoma by
            promoting HDAC5-mediated transcriptional inhibition of SHMT2.
REFERENCE   3  (bases 1 to 3411)
  AUTHORS   Feng,L., Yan,Q. and Xu,X.
  TITLE     Long Non-coding RNA H19 Recruits NFYB to Activate MBTD1 and
            Regulate Doxorubicin Resistance in Lymphoma Cells
  JOURNAL   Mol Biotechnol 65 (6), 997-1009 (2023)
   PUBMED   36434485
  REMARK    GeneRIF: Long Non-coding RNA H19 Recruits NFYB to Activate MBTD1
            and Regulate Doxorubicin Resistance in Lymphoma Cells.
REFERENCE   4  (bases 1 to 3411)
  AUTHORS   Lu,T., Li,C., Xiang,C., Gong,Y., Peng,W., Hou,F. and Chen,C.
  TITLE     Over-expression of NFYB affects stromal cells reprogramming and
            predicts worse survival in gastric cancer patients
  JOURNAL   Aging (Albany NY) 14 (19), 7851-7865 (2022)
   PUBMED   36152055
  REMARK    GeneRIF: Over-expression of NFYB affects stromal cells
            reprogramming and predicts worse survival in gastric cancer
            patients.
REFERENCE   5  (bases 1 to 3411)
  AUTHORS   Goos,H., Kinnunen,M., Salokas,K., Tan,Z., Liu,X., Yadav,L.,
            Zhang,Q., Wei,G.H. and Varjosalo,M.
  TITLE     Human transcription factor protein interaction networks
  JOURNAL   Nat Commun 13 (1), 766 (2022)
   PUBMED   35140242
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3411)
  AUTHORS   Lloberas,J., Maki,R.A. and Celada,A.
  TITLE     Repression of major histocompatibility complex I-A beta gene
            expression by dbpA and dbpB (mYB-1) proteins
  JOURNAL   Mol Cell Biol 15 (9), 5092-5099 (1995)
   PUBMED   7651426
REFERENCE   7  (bases 1 to 3411)
  AUTHORS   Chang,Z.F. and Liu,C.J.
  TITLE     Human thymidine kinase CCAAT-binding protein is NF-Y, whose A
            subunit expression is serum-dependent in human IMR-90 diploid
            fibroblasts
  JOURNAL   J Biol Chem 269 (27), 17893-17898 (1994)
   PUBMED   8027044
REFERENCE   8  (bases 1 to 3411)
  AUTHORS   Li,X.Y., Hooft van Huijsduijnen,R., Mantovani,R., Benoist,C. and
            Mathis,D.
  TITLE     Intron-exon organization of the NF-Y genes. Tissue-specific
            splicing modifies an activation domain
  JOURNAL   J Biol Chem 267 (13), 8984-8990 (1992)
   PUBMED   1577736
REFERENCE   9  (bases 1 to 3411)
  AUTHORS   Li,X.Y., Mantovani,R., Hooft van Huijsduijnen,R., Andre,I.,
            Benoist,C. and Mathis,D.
  TITLE     Evolutionary variation of the CCAAT-binding transcription factor
            NF-Y
  JOURNAL   Nucleic Acids Res 20 (5), 1087-1091 (1992)
   PUBMED   1549471
  REMARK    Erratum:[Nucleic Acids Res 1992 Apr 11;20(7):1841]
REFERENCE   10 (bases 1 to 3411)
  AUTHORS   Li,X.Y., Mattei,M.G., Zaleska-Rutczynska,Z., Hooft van
            Huijsduijnen,R., Figueroa,F., Nadeau,J., Benoist,C. and Mathis,D.
  TITLE     One subunit of the transcription factor NF-Y maps close to the
            major histocompatibility complex in murine and human chromosomes
  JOURNAL   Genomics 11 (3), 630-634 (1991)
   PUBMED   1774067
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC089983.23.
            
            Summary: The protein encoded by this gene is one subunit of a
            trimeric complex, forming a highly conserved transcription factor
            that binds with high specificity to CCAAT motifs in the promoter
            regions in a variety of genes. This gene product, subunit B, forms
            a tight dimer with the C subunit, a prerequisite for subunit A
            association. The resulting trimer binds to DNA with high
            specificity and affinity. Subunits B and C each contain a
            histone-like motif. Observation of the histone nature of these
            subunits is supported by two types of evidence; protein sequence
            alignments and experiments with mutants. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR4643865.17114.1,
                                           ERR4643830.1472220.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-70                AC089983.23        40926-40995         c
            71-155              AC089983.23        38233-38317         c
            156-249             AC089983.23        31209-31302         c
            250-367             AC089983.23        28899-29016         c
            368-565             AC089983.23        26011-26208         c
            566-647             AC089983.23        24025-24106         c
            648-727             AC089983.23        23185-23264         c
            728-3411            AC089983.23        19871-22554         c
FEATURES             Location/Qualifiers
     source          1..3411
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q23.3"
     gene            1..3411
                     /gene="NFYB"
                     /gene_synonym="CBF-A; CBF-B; HAP3; NF-YB"
                     /note="nuclear transcription factor Y subunit beta"
                     /db_xref="GeneID:4801"
                     /db_xref="HGNC:HGNC:7805"
                     /db_xref="MIM:189904"
     exon            1..70
                     /gene="NFYB"
                     /gene_synonym="CBF-A; CBF-B; HAP3; NF-YB"
                     /inference="alignment:Splign:2.1.0"
     exon            71..155
                     /gene="NFYB"
                     /gene_synonym="CBF-A; CBF-B; HAP3; NF-YB"
                     /inference="alignment:Splign:2.1.0"
     exon            156..249
                     /gene="NFYB"
                     /gene_synonym="CBF-A; CBF-B; HAP3; NF-YB"
                     /inference="alignment:Splign:2.1.0"
     exon            250..367
                     /gene="NFYB"
                     /gene_synonym="CBF-A; CBF-B; HAP3; NF-YB"
                     /inference="alignment:Splign:2.1.0"
     CDS             251..760
                     /gene="NFYB"
                     /gene_synonym="CBF-A; CBF-B; HAP3; NF-YB"
                     /note="isoform f is encoded by transcript variant 12;
                     CCAAT-binding transcription factor subunit A;
                     Transcription factor NF-Y, B subunit; CAAT box DNA-binding
                     protein subunit B; nuclear transcription factor Y subunit
                     B; nuclear transcription factor Y, beta"
                     /codon_start=1
                     /product="nuclear transcription factor Y subunit beta
                     isoform f"
                     /protein_id="NP_001401457.1"
                     /db_xref="GeneID:4801"
                     /db_xref="HGNC:HGNC:7805"
                     /db_xref="MIM:189904"
                     /translation="MNDHEDTNGSKESFREQDIYLPIANVARIMKNAIPQTGKIAKDA
                     KECVQECVSEFISFITSEASERCHQEKRKTINGEDILFAMSTLGFDSYVEPLKLYLQK
                     FREAMKGEKGIGGAVTATDGLSEELTEEAFTNQLPAGLITTDGQQQNVMVYTTSYQQI
                     SGVQQIQFS"
     exon            368..565
                     /gene="NFYB"
                     /gene_synonym="CBF-A; CBF-B; HAP3; NF-YB"
                     /inference="alignment:Splign:2.1.0"
     exon            566..647
                     /gene="NFYB"
                     /gene_synonym="CBF-A; CBF-B; HAP3; NF-YB"
                     /inference="alignment:Splign:2.1.0"
     exon            648..727
                     /gene="NFYB"
                     /gene_synonym="CBF-A; CBF-B; HAP3; NF-YB"
                     /inference="alignment:Splign:2.1.0"
     exon            728..3411
                     /gene="NFYB"
                     /gene_synonym="CBF-A; CBF-B; HAP3; NF-YB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1151..1156
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NFYB"
                     /gene_synonym="CBF-A; CBF-B; HAP3; NF-YB"
                     /note="hexamer: AATAAA"
     polyA_site      1174
                     /gene="NFYB"
                     /gene_synonym="CBF-A; CBF-B; HAP3; NF-YB"
                     /note="major polyA site"
     regulatory      2380..2385
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NFYB"
                     /gene_synonym="CBF-A; CBF-B; HAP3; NF-YB"
                     /note="hexamer: AATATA"
     polyA_site      2408
                     /gene="NFYB"
                     /gene_synonym="CBF-A; CBF-B; HAP3; NF-YB"
     regulatory      2519..2524
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NFYB"
                     /gene_synonym="CBF-A; CBF-B; HAP3; NF-YB"
                     /note="hexamer: TATAAA"
     polyA_site      2539
                     /gene="NFYB"
                     /gene_synonym="CBF-A; CBF-B; HAP3; NF-YB"
     regulatory      2687..2692
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NFYB"
                     /gene_synonym="CBF-A; CBF-B; HAP3; NF-YB"
                     /note="hexamer: GATAAA"
     polyA_site      2714
                     /gene="NFYB"
                     /gene_synonym="CBF-A; CBF-B; HAP3; NF-YB"
     regulatory      3392..3397
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NFYB"
                     /gene_synonym="CBF-A; CBF-B; HAP3; NF-YB"
                     /note="hexamer: CATAAA"
     polyA_site      3411
                     /gene="NFYB"
                     /gene_synonym="CBF-A; CBF-B; HAP3; NF-YB"
ORIGIN      
        1 ccttcgcagc cattttctgt ccaaccaaac agccgattgg agacgggagc caaccagggc
       61 tgcattggag gttgaaatca caaagattag acaccttttt agataggtgt tcttcagcac
      121 cactgacaac acggttctga cagtatttca tgacaatgga tggtgacagt tctacaacag
      181 atgcttctca actaggaatc tctgcagact atattggagg aagtcattat gttatacagc
      241 ctcatgatgc atgaatgatc atgaagacac aaatggttca aaagaaagtt tcagagaaca
      301 agatatatat cttccaatag caaacgtggc taggataatg aaaaatgcca tacctcaaac
      361 gggaaagatt gcaaaagatg ccaaagaatg tgttcaagaa tgtgtaagtg agttcatcag
      421 ttttataaca tctgaagcaa gtgaaaggtg ccatcaagag aaacggaaaa caatcaatgg
      481 agaagatatt ctctttgcta tgtctacttt aggctttgac agttatgtgg aacctctgaa
      541 attatacctt cagaaattca gagaggctat gaaaggagaa aagggaattg gtggagcagt
      601 cacagctaca gatggactaa gtgaagagct tacagaggag gcatttacta accagttacc
      661 agctggctta ataaccacag acggtcaaca acaaaatgtt atggtttaca caacatcata
      721 tcaacagatt tctggtgttc agcaaattca gttttcatga tctgaagaaa tgatggaatg
      781 gggagtgtag agaaatgaga gtctgtatga ttctggaaca gagacatcag aaggaaagac
      841 tggtgaaaag atgtatcttt gtatattaat agctgtaatg tagcttcctg atgcttgact
      901 aattgaggtg ttaattctga cttgagaatc tttttcatga atgattttaa agaaaaattt
      961 ggattttaaa ggtattaaaa tatttttgtt ttgtacgaga gtttgttgct ctgtatgact
     1021 cctgtatgca ttgtatattg caatttatta ctgtcagaga tttgtagaca gtttcttatt
     1081 ttcatattga atcatgttac ttttgtaatt caagtaagcg gctgggttaa ttcatgatgt
     1141 ttgccctttt aataaaatat aagggtagag ttcattttga atgcaagttg cctttattat
     1201 aaatttgagt ttgtcttggt tataccttgc atgataacct agctagattt ctagcatttg
     1261 ctgtatttat taaaattatt atttttttgg taaaacatta atagtttaag cagcatcatt
     1321 tttttaaaaa atgtaattga ataagtgtga atgcagaagc aaatattgtc tgccctgtta
     1381 aacttggtgc ccattaacag tgtttacact gttcatcgtg cctgttaatg tagttttagt
     1441 tactggagct tttttaagac tagatttggt tttgagttac atttttaaga atgtgggaat
     1501 atatttaagt ttaatgtagt cctagtgctc ttgaaatggt gcccctttca tttggtacat
     1561 gatttttttt caaatcatat cttcaagtac tatagtattc tcttacagaa gaggagtttt
     1621 atagtctgat ggtaaatgtc ttcattttac ctttttaatt gaaatgtcaa gtttcctgtt
     1681 acactatgga aaccaagaaa catcagacat cattgcgtgt acagaccttt tgcatgggtg
     1741 agtggatgaa atggagaaca gagtgagtgc tgtgaacggt gtgaaataga agccaacttc
     1801 tagtatgctg tcttcatctc tgcaataaac taaacgtaaa taatgtaact ttgtataatt
     1861 tagtagtatg tacttggatt gtttcttttt gaaaagtgag gatttgtatt ttctcatcta
     1921 ttctttttgg tgttaattaa cttgagggat ttctttttta agtttttaat atcaaaaatt
     1981 gctattgtat agtttgccta aaaggaagtt ggagtgaata tcatctttga aggacactca
     2041 aatttataag gtagaagcaa tttcccagat ataggctgaa cagaaacatt tactttgcca
     2101 gaaggagcct ttaggagtat atgtgggcta atcagaggtt aataatgtcc tcatctccta
     2161 ctctccattt aaaaaacaaa cttcattgta gtaaattcaa ataggaaaaa atgggggagt
     2221 agttaagcaa aatcaacagt catcctacta tgttgaaaga accaatgtta atattttgat
     2281 aaatatcatt tgtcctttta ctttgctaaa tatgtatatt tttataaaaa tgggctcata
     2341 ttgtgcatac cattttgtaa cctgcttttt tcacttaaca atatattggg aacatctttt
     2401 ccaggtcatg catagtcttc tgcatcattt ttattggttt attattctgc tgtatgactc
     2461 aatcataatt catttaatct tctattggat attttgacta tttacatctt ttcacagtta
     2521 taaacagcac ttcactgaat cccatgtaca tccatgactg ttttcttaaa ttctttgaat
     2581 tgctgggtta ccaaatatgc aaaattttaa ggcttttgat acttcgttat gagtgtattt
     2641 ttgagatatt ttccacttga tccaagcagt gtgtcactat ataactgata aaagcacttg
     2701 gtctttgatt atcagatact gtctctaaaa ttattttaaa gattaatatt tgttcaagta
     2761 gagaatgaag ataaaaaagg aatttgaggc caggtatggg gtgtctcatg cctataattc
     2821 cagcactttg ggaggccaag gcaggcagat cactttgagg tcaggagttt gagaccagcc
     2881 tggccaacat ggagaacccc ccgtctctac aaaaaataca aaattagcag ggtgtggtgg
     2941 tgcacacctg tagtccctta ctccctggtg gctgaggcat tatcccttga acctgggagg
     3001 cagagcctaa agtgagccga gatcgcgcca ctgcactcca gcctgggtga cacagcaaga
     3061 ctcttgtctc aaacaaacag gaatttgagt aaattttaaa ttagtatata ctacaacaaa
     3121 tttccaaact tcataatttg ctagtagtgc taactaaaat tttacaccag gtaaaatcag
     3181 gtcacctttt ttatgtattg acttcattgt tggacttcat actctgatgg gaaagaaaat
     3241 ggacattctg aatgtgtcag gtgcataata tcctaattta tgcttgtcag agctggggtc
     3301 tctgtcttcc ttggcccatg ttgcatttaa ctgaatgtca tgttttctcc tctggaactt
     3361 cttatgtatg caagctccca tgttaaccta tcataaaaat gttttttata a
//
