LOCUS       NM_002504               4599 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens nuclear transcription factor, X-box binding 1 (NFX1),
            transcript variant 1, mRNA.
ACCESSION   NM_002504
VERSION     NM_002504.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4599)
  AUTHORS   Chintala,S., Quist,K.M., Gonzalez-DeWhitt,P.A. and
            Katzenellenbogen,R.A.
  TITLE     High expression of NFX1-123 in HPV positive head and neck squamous
            cell carcinomas
  JOURNAL   Head Neck 44 (1), 177-188 (2022)
   PUBMED   34693597
  REMARK    GeneRIF: High expression of NFX1-123 in HPV positive head and neck
            squamous cell carcinomas.
REFERENCE   2  (bases 1 to 4599)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 4599)
  AUTHORS   Ben-Yishay,R., Mor,A., Shraga,A., Ashkenazy-Titelman,A., Kinor,N.,
            Schwed-Gross,A., Jacob,A., Kozer,N., Kumar,P., Garini,Y. and
            Shav-Tal,Y.
  TITLE     Imaging within single NPCs reveals NXF1's role in mRNA export on
            the cytoplasmic side of the pore
  JOURNAL   J Cell Biol 218 (9), 2962-2981 (2019)
   PUBMED   31375530
  REMARK    GeneRIF: initial mRNP binding to the NPC did not require NXF1 in
            the NPC, whereas release into the cytoplasm did. NXF1 localization
            in the NPC did not require RNA or RNA binding. Superresolution
            microscopy showed that NXF1 consistently occupied positions on the
            cytoplasmic side of the NPC.
REFERENCE   4  (bases 1 to 4599)
  AUTHORS   Chen,X., Lu,D., Gao,J., Zhu,H., Zhou,Y., Gao,D. and Zhou,H.
  TITLE     Identification of a USP9X Substrate NFX1-123 by SILAC-Based
            Quantitative Proteomics
  JOURNAL   J Proteome Res 18 (6), 2654-2665 (2019)
   PUBMED   31059266
  REMARK    GeneRIF: we found that NFX1-123 was a bona fide substrate of the
            deubiquitinase USP9X and that it could be degraded by the
            ubiquitin-proteasome system. The present study provided new insight
            into understanding the biological function of USP9X by targeting
            its substrate NFX1-123.
REFERENCE   5  (bases 1 to 4599)
  AUTHORS   Levan,J., Vliet-Gregg,P.A., Robinson,K.L., Matsumoto,L.R. and
            Katzenellenbogen,R.A.
  TITLE     HPV type 16 E6 and NFX1-123 augment JNK signaling to mediate
            keratinocyte differentiation and L1 expression
  JOURNAL   Virology 531, 171-182 (2019)
   PUBMED   30903928
  REMARK    GeneRIF: NFX1-123 in mediating epithelial differentiation through
            the JNK signaling pathway.
REFERENCE   6  (bases 1 to 4599)
  AUTHORS   Zhou,Z., Licklider,L.J., Gygi,S.P. and Reed,R.
  TITLE     Comprehensive proteomic analysis of the human spliceosome
  JOURNAL   Nature 419 (6903), 182-185 (2002)
   PUBMED   12226669
REFERENCE   7  (bases 1 to 4599)
  AUTHORS   Arlotta,P., Miyazaki,D., Copeland,N.G., Gilbert,D.J., Jenkins,N.A.
            and Ono,S.J.
  TITLE     Murine NFX.1: isolation and characterization of its messenger RNA,
            mapping of its chromosomal location and assessment of its
            developmental expression
  JOURNAL   Immunology 106 (2), 173-181 (2002)
   PUBMED   12047746
REFERENCE   8  (bases 1 to 4599)
  AUTHORS   Lorick,K.L., Jensen,J.P., Fang,S., Ong,A.M., Hatakeyama,S. and
            Weissman,A.M.
  TITLE     RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent
            ubiquitination
  JOURNAL   Proc Natl Acad Sci U S A 96 (20), 11364-11369 (1999)
   PUBMED   10500182
REFERENCE   9  (bases 1 to 4599)
  AUTHORS   Song,Z., Krishna,S., Thanos,D., Strominger,J.L. and Ono,S.J.
  TITLE     A novel cysteine-rich sequence-specific DNA-binding protein
            interacts with the conserved X-box motif of the human major
            histocompatibility complex class II genes via a repeated Cys-His
            domain and functions as a transcriptional repressor
  JOURNAL   J Exp Med 180 (5), 1763-1774 (1994)
   PUBMED   7964459
REFERENCE   10 (bases 1 to 4599)
  AUTHORS   Hume,C.R. and Lee,J.S.
  TITLE     Congenital immunodeficiencies associated with absence of HLA class
            II antigens on lymphocytes result from distinct mutations in
            trans-acting factors
  JOURNAL   Hum Immunol 26 (4), 288-309 (1989)
   PUBMED   2511169
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB076795.1, BP871782.1 and
            BC012151.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_002504.5.
            
            Summary: MHC class II gene expression is controlled primarily at
            the transcriptional level by transcription factors that bind to the
            X and Y boxes, two highly conserved elements in the proximal
            promoter of MHC class II genes. The protein encoded by this gene is
            a transcriptional repressor capable of binding to the conserved X
            box motif of HLA-DRA and other MHC class II genes in vitro. The
            protein may play a role in regulating the duration of an
            inflammatory response by limiting the period in which class II MHC
            molecules are induced by IFN-gamma. Three alternative splice
            variants, each of which encodes a different isoform, have been
            identified. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.172918.1,
                                           SRR1803613.51729.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379540.8/ ENSP00000368856.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                DB076795.1         100-117
            19-31               BP871782.1         60-72
            32-4599             BC012151.1         1-4568
FEATURES             Location/Qualifiers
     source          1..4599
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p13.3"
     gene            1..4599
                     /gene="NFX1"
                     /gene_synonym="NFX2; TEG-42; Tex42"
                     /note="nuclear transcription factor, X-box binding 1"
                     /db_xref="GeneID:4799"
                     /db_xref="HGNC:HGNC:7803"
                     /db_xref="MIM:603255"
     exon            1..82
                     /gene="NFX1"
                     /gene_synonym="NFX2; TEG-42; Tex42"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..3420
                     /gene="NFX1"
                     /gene_synonym="NFX2; TEG-42; Tex42"
                     /EC_number="6.3.2.-"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transcriptional repressor NF-X1; nuclear transcription
                     factor, X box-binding protein 1"
                     /codon_start=1
                     /product="transcriptional repressor NF-X1 isoform 1"
                     /protein_id="NP_002495.2"
                     /db_xref="CCDS:CCDS6538.1"
                     /db_xref="GeneID:4799"
                     /db_xref="HGNC:HGNC:7803"
                     /db_xref="MIM:603255"
                     /translation="MAEAPPVSGTFKFNTDAAEFIPQEKKNSGLNCGTQRRLDSNRIG
                     RRNYSSPPPCHLSRQVPYDEISAVHQHSYHPSGSKPKSQQTSFQSSPCNKSPKSHGLQ
                     NQPWQKLRNEKHHIRVKKAQSLAEQTSDTAGLESSTRSESGTDLREHSPSESEKEVVG
                     ADPRGAKPKKATQFVYSYGRGPKVKGKLKCEWSNRTTPKPEDAGPESTKPVGVFHPDS
                     SEASSRKGVLDGYGARRNEQRRYPQKRPPWEVEGARPRPGRNPPKQEGHRHTNAGHRN
                     NMGPIPKDDLNERPAKSTCDSENLAVINKSSRRVDQEKCTVRRQDPQVVSPFSRGKQN
                     HVLKNVETHTGSLIEQLTTEKYECMVCCELVRVTAPVWSCQSCYHVFHLNCIKKWARS
                     PASQADGQSGWRCPACQNVSAHVPNTYTCFCGKVKNPEWSRNEIPHSCGEVCRKKQPG
                     QDCPHSCNLLCHPGPCPPCPAFMTKTCECGRTRHTVRCGQAVSVHCSNPCENILNCGQ
                     HQCAELCHGGQCQPCQIILNQVCYCGSTSRDVLCGTDVGKSDGFGDFSCLKICGKDLK
                     CGNHTCSQVCHPQPCQQCPRLPQLVRCCPCGQTPLSQLLELGSSSRKTCMDPVPSCGK
                     VCGKPLPCGSLDFIHTCEKLCHEGDCGPCSRTSVISCRCSFRTKELPCTSLKSEDATF
                     MCDKRCNKKRLCGRHKCNEICCVDKEHKCPLICGRKLRCGLHRCEEPCHRGNCQTCWQ
                     ASFDELTCHCGASVIYPPVPCGTRPPECTQTCARVHECDHPVYHSCHSEEKCPPCTFL
                     TQKWCMGKHEFRSNIPCHLVDISCGLPCSATLPCGMHKCQRLCHKGECLVDEPCKQPC
                     TTPRADCGHPCMAPCHTSSPCPVTACKAKVELQCECGRRKEMVICSEASSTYQRIAAI
                     SMASKITDMQLGGSVEISKLITKKEVHQARLECDEECSALERKKRLAEAFHISEDSDP
                     FNIRSSGSKFSDSLKEDARKDLKFVSDVEKEMETLVEAVNKGKNSKKSHSFPPMNRDH
                     RRIIHDLAQVYGLESVSYDSEPKRNVVVTAIRGKSVCPPTTLTGVLEREMQARPPPPI
                     PHHRHQSDKNPGSSNLQKITKEPIIDYFDVQD"
     exon            83..1090
                     /gene="NFX1"
                     /gene_synonym="NFX2; TEG-42; Tex42"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1249
                     /gene="NFX1"
                     /gene_synonym="NFX2; TEG-42; Tex42"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1327
                     /gene="NFX1"
                     /gene_synonym="NFX2; TEG-42; Tex42"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1433
                     /gene="NFX1"
                     /gene_synonym="NFX2; TEG-42; Tex42"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1505
                     /gene="NFX1"
                     /gene_synonym="NFX2; TEG-42; Tex42"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1645
                     /gene="NFX1"
                     /gene_synonym="NFX2; TEG-42; Tex42"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..1745
                     /gene="NFX1"
                     /gene_synonym="NFX2; TEG-42; Tex42"
                     /inference="alignment:Splign:2.1.0"
     exon            1746..1963
                     /gene="NFX1"
                     /gene_synonym="NFX2; TEG-42; Tex42"
                     /inference="alignment:Splign:2.1.0"
     exon            1964..2061
                     /gene="NFX1"
                     /gene_synonym="NFX2; TEG-42; Tex42"
                     /inference="alignment:Splign:2.1.0"
     exon            2062..2092
                     /gene="NFX1"
                     /gene_synonym="NFX2; TEG-42; Tex42"
                     /inference="alignment:Splign:2.1.0"
     exon            2093..2172
                     /gene="NFX1"
                     /gene_synonym="NFX2; TEG-42; Tex42"
                     /inference="alignment:Splign:2.1.0"
     exon            2173..2281
                     /gene="NFX1"
                     /gene_synonym="NFX2; TEG-42; Tex42"
                     /inference="alignment:Splign:2.1.0"
     exon            2282..2401
                     /gene="NFX1"
                     /gene_synonym="NFX2; TEG-42; Tex42"
                     /inference="alignment:Splign:2.1.0"
     exon            2402..2481
                     /gene="NFX1"
                     /gene_synonym="NFX2; TEG-42; Tex42"
                     /inference="alignment:Splign:2.1.0"
     exon            2482..2712
                     /gene="NFX1"
                     /gene_synonym="NFX2; TEG-42; Tex42"
                     /inference="alignment:Splign:2.1.0"
     exon            2713..2786
                     /gene="NFX1"
                     /gene_synonym="NFX2; TEG-42; Tex42"
                     /inference="alignment:Splign:2.1.0"
     exon            2787..2888
                     /gene="NFX1"
                     /gene_synonym="NFX2; TEG-42; Tex42"
                     /inference="alignment:Splign:2.1.0"
     exon            2889..2930
                     /gene="NFX1"
                     /gene_synonym="NFX2; TEG-42; Tex42"
                     /inference="alignment:Splign:2.1.0"
     exon            2931..3029
                     /gene="NFX1"
                     /gene_synonym="NFX2; TEG-42; Tex42"
                     /inference="alignment:Splign:2.1.0"
     exon            3030..3096
                     /gene="NFX1"
                     /gene_synonym="NFX2; TEG-42; Tex42"
                     /inference="alignment:Splign:2.1.0"
     exon            3097..3242
                     /gene="NFX1"
                     /gene_synonym="NFX2; TEG-42; Tex42"
                     /inference="alignment:Splign:2.1.0"
     exon            3243..3347
                     /gene="NFX1"
                     /gene_synonym="NFX2; TEG-42; Tex42"
                     /inference="alignment:Splign:2.1.0"
     exon            3348..4599
                     /gene="NFX1"
                     /gene_synonym="NFX2; TEG-42; Tex42"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4576..4581
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NFX1"
                     /gene_synonym="NFX2; TEG-42; Tex42"
                     /note="hexamer: ATTAAA"
     polyA_site      4599
                     /gene="NFX1"
                     /gene_synonym="NFX2; TEG-42; Tex42"
                     /note="major polyA site"
ORIGIN      
        1 gacctggtga cagtgctgac ttggctgtac agctcgatct aggttctgcg gcacgggatg
       61 gcggaggcgc ctcctgtctc aggtactttt aaattcaata cagatgctgc tgaattcatt
      121 cctcaggaga aaaaaaattc tggtctaaat tgtgggactc aaaggagact agactctaat
      181 aggattggta gaagaaatta cagttcacca cctccctgtc acctttccag gcaggtccct
      241 tatgatgaaa tctctgctgt tcatcagcat agttatcatc cgtcaggaag caaacctaag
      301 agtcagcaga cgtctttcca gtcctctcct tgtaataaat cgcccaagag ccatggcctt
      361 cagaatcaac cttggcagaa attgaggaat gagaagcacc atatcagagt caagaaagca
      421 cagagtcttg ctgagcagac ctcagataca gctggattag agagctcgac cagatcagag
      481 agtgggacag acctcagaga gcatagtcct tctgagagtg agaaggaagt tgtgggtgca
      541 gatcccaggg gagcaaaacc caaaaaagca acacagtttg tatacagcta tggtagagga
      601 ccaaaagtca aggggaaact caaatgtgaa tggagtaacc gaacaactcc aaaaccggag
      661 gatgctggac ccgaaagtac caaacctgtg ggggttttcc accctgactc ttcagaggca
      721 tcctctagaa aaggagtatt ggatgggtat ggagccagac gaaatgagca gagaagatac
      781 ccacagaaaa ggcctccctg ggaagtggag ggggccaggc cacgaccagg cagaaatcca
      841 ccaaaacagg agggccaccg acatacaaac gcaggacaca gaaacaacat gggccccatt
      901 ccaaaggatg acctcaatga aagaccagca aaatctacct gtgacagtga gaacttggca
      961 gtcatcaaca agtcttccag gagggttgac caagagaaat gcactgtacg gaggcaggat
     1021 cctcaagtag tatctccttt ctcccgaggc aaacagaacc atgtgctaaa gaatgtggaa
     1081 acgcacacag gttctctaat tgaacaacta acaacagaaa aatacgagtg catggtgtgc
     1141 tgtgaattgg ttcgtgtcac ggccccagtg tggagttgtc agagctgtta ccatgtgttt
     1201 catttgaact gcataaagaa atgggcaagg tctccagcat ctcaagcaga tggccagagt
     1261 ggttggaggt gccctgcctg tcagaatgtt tctgcacatg ttcctaatac ctacacttgt
     1321 ttctgtggca aggtaaagaa tcctgagtgg agcagaaatg aaattccaca tagctgtggt
     1381 gaggtttgta gaaagaaaca gcctggccag gactgcccac attcctgtaa ccttctctgc
     1441 catccaggac cctgcccacc ctgccctgcc tttatgacaa aaacatgtga atgtggacga
     1501 accaggcaca cagttcgctg tggtcaggct gtctcagtcc actgttctaa cccatgtgag
     1561 aatattttga actgtggtca gcaccagtgt gctgagctgt gccatggggg tcagtgccag
     1621 ccttgccaga tcattttgaa ccaggtatgc tattgcggca gcacctcccg agatgtgtta
     1681 tgtggaaccg atgtaggaaa gtctgatgga tttggggatt tcagctgttt aaagatatgt
     1741 ggcaaggact tgaaatgcgg taaccataca tgttcgcaag tgtgccaccc tcagccctgc
     1801 cagcaatgcc cacggctccc ccagctggtg cgctgttgcc cctgtggcca aactcctctc
     1861 agccaattgc tagaacttgg aagtagtagt cggaaaacat gcatggaccc tgtgccttca
     1921 tgtggaaaag tgtgcggcaa gcctctgcct tgtggttcct tagatttcat tcatacctgt
     1981 gaaaagctct gccatgaagg agactgtgga ccatgctctc gcacatcagt tatttcctgc
     2041 agatgctctt tcagaacaaa ggagcttcca tgtaccagtc tcaaaagtga agatgctaca
     2101 tttatgtgtg acaagcggtg taacaagaaa cggttgtgtg gacggcataa atgtaatgag
     2161 atatgctgtg tggataagga gcacaagtgt cctttgattt gtgggaggaa actccgttgt
     2221 ggccttcata ggtgtgaaga accttgtcat cgtggaaact gccagacatg ctggcaagcc
     2281 agttttgatg aattaacctg ccattgtggt gcatcagtga tttaccctcc agttccctgt
     2341 ggtactaggc cccctgaatg tacccaaacc tgcgctagag tccatgagtg tgaccatcca
     2401 gtatatcatt cttgtcatag tgaggagaag tgtccccctt gcactttcct aactcagaag
     2461 tggtgcatgg gcaagcatga gtttcggagc aacatcccct gtcacctggt tgatatctct
     2521 tgcggattac cctgcagtgc cacgctacca tgtgggatgc acaaatgtca gagactctgt
     2581 cacaaagggg agtgtcttgt ggatgagccc tgcaagcagc cctgcaccac ccccagagct
     2641 gactgtggtc acccgtgtat ggcaccctgc cataccagct caccctgccc tgtgactgct
     2701 tgtaaagcta aggtagagct acagtgtgaa tgtggacgaa gaaaagagat ggtgatttgc
     2761 tctgaagcat ctagtactta tcaaagaata gctgcaatct ccatggcctc taagataaca
     2821 gacatgcagc ttggaggttc agtggagatc agcaagttaa ttaccaaaaa ggaagttcat
     2881 caagccaggc tggagtgtga tgaggagtgt tcagccttgg aaaggaaaaa gagattagca
     2941 gaggcatttc atatcagtga ggattctgat cctttcaata tacgttcttc agggtcaaaa
     3001 ttcagtgata gtttgaaaga agatgccagg aaggacttaa agtttgtcag tgacgttgag
     3061 aaggaaatgg aaaccctcgt ggaggccgtg aataagggaa agaatagtaa gaaaagccac
     3121 agcttccctc ccatgaacag agaccaccgc cggatcatcc atgacttggc ccaagtttat
     3181 ggcctggaga gcgtgagcta tgacagtgaa ccgaagcgca atgtggtggt cactgccatc
     3241 agggggaagt ccgtttgtcc tcctaccacg ctgacaggtg tgcttgaaag ggaaatgcag
     3301 gcacggcctc caccaccgat tcctcatcac agacatcagt cagacaagaa tcctgggagc
     3361 agtaatttac agaaaataac caaggagcca ataattgact attttgacgt ccaggactaa
     3421 gaagatcatg atgcacttag ataaaagaat gattaggtat agtggagact tatttgccag
     3481 cagataaatc atgcccgttc ccctctgcct ggcagaatca cagtctcaca tactgtcttg
     3541 tactgacaca tccaaagcat gagtgtgtca gaaatccctt gtctattcct gtctgtataa
     3601 agtgtttcat tatgaccaga tctctgattg tatggtcact aggtatgcaa tcacgcattc
     3661 aaagaggctc tttacaccat cactgtgatt gctctgagag ttgagggact attgggcttt
     3721 atttggacaa accaaacttt tagcctgaaa ccaactttat gccactaagt catagcctca
     3781 gttgtcccag ttatttgtcc tcctgaaaat gcctgaaaca tcagacagac attgcttgct
     3841 ttacccaaac tgatcaaaat ctttaggagc acaaatgaat tttttagtct gaaataccaa
     3901 ataatgaatt ggtataccat atccggaatc acacatgtta tcttaaaccc agccatcata
     3961 cctaagtctt ttgccaaaac ctctcatagg tatatctagc tgaacttatt ttggcatttt
     4021 caatgtgatc agttctagac ctagaagggg gtcaggctgc tttacagaat tctatttcct
     4081 taagtccctg gcacttctca taccacatca ctgaacctgt tcagtaacaa tcagtttggc
     4141 cgtcccccat gatggtagga aatatagaga gcaagttctt ctgccagggt cacactgtgg
     4201 tctctgaact gaccagtata tccctaactc ctctttgata gagaaagagt ctcaaatgga
     4261 caactgtcct gtgttgcttt ccctaggcct tcagcagcct attggctctc cctgcctctg
     4321 agctctggac tctgtttgaa tattccaagt agtatatgga cagtccaggg cttatgccca
     4381 gcagcccact ggaggcattc ttcaggctcc tttaaggcag gtgcattgat agttccatta
     4441 gtgtgaccct tgcattggca cccctccagc ctggaggcca ggcttccagc aacttccttc
     4501 tgccctagag caagccatga gccccagagc agtagcagga gacttgagaa gtagagtgac
     4561 aaaaacaagc acttaattaa attataaaat ttaacttta
//
