LOCUS       NM_001143835            5173 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens nuclear factor related to kappaB binding protein
            (NFRKB), transcript variant 1, mRNA.
ACCESSION   NM_001143835
VERSION     NM_001143835.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5173)
  AUTHORS   Fusaro,M., Coustal,C., Barnabei,L., Riller,Q., Heller,M., Ho
            Nhat,D., Fourrage,C., Riviere,S., Rieux-Laucat,F., Maria,A.T.J. and
            Picard,C.
  TITLE     A large deletion in a non-coding regulatory region leads to NFKB1
            haploinsufficiency in two adult siblings
  JOURNAL   Clin Immunol 261, 110165 (2024)
   PUBMED   38423196
  REMARK    GeneRIF: A large deletion in a non-coding regulatory region leads
            to NFKB1 haploinsufficiency in two adult siblings.
REFERENCE   2  (bases 1 to 5173)
  AUTHORS   Peng,Q., Wan,D., Zhou,R., Luo,H., Wang,J., Ren,L., Zeng,Y., Yu,C.,
            Zhang,S., Huang,X. and Peng,Y.
  TITLE     The biological function of metazoan-specific subunit nuclear factor
            related to kappaB binding protein of INO80 complex
  JOURNAL   Int J Biol Macromol 203, 176-183 (2022)
   PUBMED   35093437
  REMARK    GeneRIF: The biological function of metazoan-specific subunit
            nuclear factor related to kappaB binding protein of INO80 complex.
            Review article
REFERENCE   3  (bases 1 to 5173)
  AUTHORS   Peng,Q., Zhou,M., Zuo,S., Liu,Y., Li,X., Yang,Y., He,Q., Yu,X.,
            Zhou,J., He,Z. and He,Q.
  TITLE     Nuclear Factor Related to KappaB Binding Protein (NFRKB) Is a
            Telomere-Associated Protein and Involved in Liver Cancer
            Development
  JOURNAL   DNA Cell Biol 40 (10), 1298-1307 (2021)
   PUBMED   34591601
  REMARK    GeneRIF: Nuclear Factor Related to KappaB Binding Protein (NFRKB)
            Is a Telomere-Associated Protein and Involved in Liver Cancer
            Development.
REFERENCE   4  (bases 1 to 5173)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 5173)
  AUTHORS   Zhang,Z., Hu,X., Kuang,J., Liao,J. and Yuan,Q.
  TITLE     LncRNA DRAIC inhibits proliferation and metastasis of gastric
            cancer cells through interfering with NFRKB deubiquitination
            mediated by UCHL5
  JOURNAL   Cell Mol Biol Lett 25, 29 (2020)
   PUBMED   32351584
  REMARK    GeneRIF: LncRNA DRAIC inhibits proliferation and metastasis of
            gastric cancer cells through interfering with NFRKB
            deubiquitination mediated by UCHL5.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5173)
  AUTHORS   Nousiainen,M., Sillje,H.H., Sauer,G., Nigg,E.A. and Korner,R.
  TITLE     Phosphoproteome analysis of the human mitotic spindle
  JOURNAL   Proc Natl Acad Sci U S A 103 (14), 5391-5396 (2006)
   PUBMED   16565220
REFERENCE   7  (bases 1 to 5173)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   8  (bases 1 to 5173)
  AUTHORS   Adams,B.S., Leung,K., Meltzer,P.S., Lewis,K.A.,
            Wagner-McPherson,C., Evans,G.A. and Nabel,G.J.
  TITLE     Localization of the gene encoding R kappa B (NFRKB), a
            tissue-specific DNA binding protein, to chromosome 11q24-q25
  JOURNAL   Genomics 14 (2), 270-274 (1992)
   PUBMED   1427843
REFERENCE   9  (bases 1 to 5173)
  AUTHORS   Adams,B.S., Leung,K.Y., Hanley,E.W. and Nabel,G.J.
  TITLE     Cloning of R kappa B, a novel DNA-binding protein that recognizes
            the interleukin-2 receptor alpha chain kappa B site
  JOURNAL   New Biol 3 (11), 1063-1073 (1991)
   PUBMED   1777480
REFERENCE   10 (bases 1 to 5173)
  AUTHORS   Urban,M.B., Schreck,R. and Baeuerle,P.A.
  TITLE     NF-kappa B contacts DNA by a heterodimer of the p50 and p65 subunit
  JOURNAL   EMBO J 10 (7), 1817-1825 (1991)
   PUBMED   2050119
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP003327.3.
            
            On Jun 2, 2019 this sequence version replaced NM_001143835.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript but encodes the shorter isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC063280.1, SRR14038194.694924.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000682444.1/ ENSP00000506850.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                AP003327.3         145180-145262       c
            84-163              AP003327.3         144043-144122       c
            164-319             AP003327.3         142399-142554       c
            320-521             AP003327.3         138278-138479       c
            522-649             AP003327.3         136001-136128       c
            650-824             AP003327.3         135119-135293       c
            825-926             AP003327.3         134429-134530       c
            927-1000            AP003327.3         133754-133827       c
            1001-1085           AP003327.3         132806-132890       c
            1086-1266           AP003327.3         132135-132315       c
            1267-1375           AP003327.3         131770-131878       c
            1376-1502           AP003327.3         131411-131537       c
            1503-1568           AP003327.3         131127-131192       c
            1569-1648           AP003327.3         128148-128227       c
            1649-1695           AP003327.3         127993-128039       c
            1696-1756           AP003327.3         127009-127069       c
            1757-1931           AP003327.3         126405-126579       c
            1932-2038           AP003327.3         125041-125147       c
            2039-2162           AP003327.3         124477-124600       c
            2163-2242           AP003327.3         124185-124264       c
            2243-2463           AP003327.3         123797-124017       c
            2464-2734           AP003327.3         123429-123699       c
            2735-2947           AP003327.3         122568-122780       c
            2948-3715           AP003327.3         119178-119945       c
            3716-3822           AP003327.3         115561-115667       c
            3823-3958           AP003327.3         114650-114785       c
            3959-5173           AP003327.3         113320-114534       c
FEATURES             Location/Qualifiers
     source          1..5173
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q24.3"
     gene            1..5173
                     /gene="NFRKB"
                     /gene_synonym="INO80G"
                     /note="nuclear factor related to kappaB binding protein"
                     /db_xref="GeneID:4798"
                     /db_xref="HGNC:HGNC:7802"
                     /db_xref="MIM:164013"
     exon            1..83
                     /gene="NFRKB"
                     /gene_synonym="INO80G"
                     /inference="alignment:Splign:2.1.0"
     exon            84..163
                     /gene="NFRKB"
                     /gene_synonym="INO80G"
                     /inference="alignment:Splign:2.1.0"
     exon            164..319
                     /gene="NFRKB"
                     /gene_synonym="INO80G"
                     /inference="alignment:Splign:2.1.0"
     CDS             185..4084
                     /gene="NFRKB"
                     /gene_synonym="INO80G"
                     /note="isoform 1 is encoded by transcript variant 1; INO80
                     complex subunit G; nuclear factor related to
                     kappa-B-binding protein; DNA-binding protein R kappa B"
                     /codon_start=1
                     /product="nuclear factor related to kappa-B-binding
                     protein isoform 1"
                     /protein_id="NP_001137307.1"
                     /db_xref="CCDS:CCDS44770.1"
                     /db_xref="GeneID:4798"
                     /db_xref="HGNC:HGNC:7802"
                     /db_xref="MIM:164013"
                     /translation="MDSLDHMLTDPLELGPCGDGHGTRIMEDCLLGGTRVSLPEDLLE
                     DPEIFFDVVSLSTWQEVLSDSQREHLQQFLPQFPEDSAEQQNELILALFSGENFRFGN
                     PLHIAQKLFRDGHFNPEVVKYRQLCFKSQYKRYLNSQQQYFHRLLKQILASRSDLLEM
                     ARRSGPALPFRQKRPSPSRTPEEREWRTQQRYLKVLREVKEECGDTALSSDEEDLSSW
                     LPSSPARSPSPAVPLRVVPTLSTTDMKTADKVELGDSDLKIMLKKHHEKRKHQPDHPD
                     LLTGDLTLNDIMTRVNAGRKGSLAALYDLAVLKKKVKEKEEKKKKKIKTIKSEAEDLA
                     EPLSSTEGVAPLSQAPSPLAIPAIKEEPLEDLKPCLGINEISSSFFSLLLEILLLESQ
                     ASLPMLEERVLDWQSSPASSLNSWFSAAPNWAELVLPALQYLAGESRAVPSSFSPFVE
                     FKEKTQQWKLLGQSQDNEKELAALFQLWLETKDQAFCKQENEDSSDATTPVPRVRTDY
                     VVRPSTGEEKRVFQEQERYRYSQPHKAFTFRMHGFESVVGPVKGVFDKETSLNKAREH
                     SLLRSDRPAYVTILSLVRDAAARLPNGEGTRAEICELLKDSQFLAPDVTSTQVNTVVS
                     GALDRLHYEKDPCVKYDIGRKLWIYLHRDRSEEEFERIHQAQAAAAKARKALQQKPKP
                     PSKVKSSSKESSIKVLSSGPSEQSQMSLSDSSMPPTPVTPVTPTTPALPAIPISPPPV
                     SAVNKSGPSTVSEPAKSSSGVLLVSSPTMPHLGTMLSPASSQTAPSSQAAARVVSHSG
                     SAGLSQVRVVAQPSLPAVPQQSGGPAQTLPQMPAGPQIRVPATATQTKVVPQTVMATV
                     PVKAQTTAATVQRPGPGQTGLTVTSLPATASPVSKPATSSPGTSAPSASTAAVIQNVT
                     GQNIIKQVAITGQLGVKPQTGNSIPLTATNFRIQGKDVLRLPPSSITTDAKGQTVLRI
                     TPDMMATLAKSQVTTVKLTQDLFGTGGNTTGKGISATLHVTSNPVHAADSPAKASSAS
                     APSSTPTGTTVVKVTPDLKPTEASSSAFRLMPALGVSVADQKGKSTVASSEAKPAATI
                     RIVQGLGVMPPKAGQTITVATHAKQGASVASGSGTVHTSAVSLPSMNAAVSKTVAVAS
                     GAASTPISISTGAPTVRQVPVSTTVVSTSQAGKLPTRITVPLSVISQPMKGKSVVTAP
                     IIKGNLGANLSGLGRNIILTTMPAGTKLIAGNKPVSFLTAQQLQQLQQQGQATQVRIQ
                     TVPASHLQQGTASGSSKAVSTVVVTTAPSPKQAPEQQ"
     exon            320..521
                     /gene="NFRKB"
                     /gene_synonym="INO80G"
                     /inference="alignment:Splign:2.1.0"
     exon            522..649
                     /gene="NFRKB"
                     /gene_synonym="INO80G"
                     /inference="alignment:Splign:2.1.0"
     exon            650..824
                     /gene="NFRKB"
                     /gene_synonym="INO80G"
                     /inference="alignment:Splign:2.1.0"
     exon            825..926
                     /gene="NFRKB"
                     /gene_synonym="INO80G"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1000
                     /gene="NFRKB"
                     /gene_synonym="INO80G"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1085
                     /gene="NFRKB"
                     /gene_synonym="INO80G"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1266
                     /gene="NFRKB"
                     /gene_synonym="INO80G"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1375
                     /gene="NFRKB"
                     /gene_synonym="INO80G"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1502
                     /gene="NFRKB"
                     /gene_synonym="INO80G"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1568
                     /gene="NFRKB"
                     /gene_synonym="INO80G"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1648
                     /gene="NFRKB"
                     /gene_synonym="INO80G"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..1695
                     /gene="NFRKB"
                     /gene_synonym="INO80G"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1756
                     /gene="NFRKB"
                     /gene_synonym="INO80G"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..1931
                     /gene="NFRKB"
                     /gene_synonym="INO80G"
                     /inference="alignment:Splign:2.1.0"
     exon            1932..2038
                     /gene="NFRKB"
                     /gene_synonym="INO80G"
                     /inference="alignment:Splign:2.1.0"
     exon            2039..2162
                     /gene="NFRKB"
                     /gene_synonym="INO80G"
                     /inference="alignment:Splign:2.1.0"
     exon            2163..2242
                     /gene="NFRKB"
                     /gene_synonym="INO80G"
                     /inference="alignment:Splign:2.1.0"
     exon            2243..2463
                     /gene="NFRKB"
                     /gene_synonym="INO80G"
                     /inference="alignment:Splign:2.1.0"
     exon            2464..2734
                     /gene="NFRKB"
                     /gene_synonym="INO80G"
                     /inference="alignment:Splign:2.1.0"
     exon            2735..2947
                     /gene="NFRKB"
                     /gene_synonym="INO80G"
                     /inference="alignment:Splign:2.1.0"
     exon            2948..3715
                     /gene="NFRKB"
                     /gene_synonym="INO80G"
                     /inference="alignment:Splign:2.1.0"
     exon            3716..3822
                     /gene="NFRKB"
                     /gene_synonym="INO80G"
                     /inference="alignment:Splign:2.1.0"
     exon            3823..3958
                     /gene="NFRKB"
                     /gene_synonym="INO80G"
                     /inference="alignment:Splign:2.1.0"
     exon            3959..5173
                     /gene="NFRKB"
                     /gene_synonym="INO80G"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5008..5013
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NFRKB"
                     /gene_synonym="INO80G"
                     /note="hexamer: AATAAA"
     polyA_site      5029
                     /gene="NFRKB"
                     /gene_synonym="INO80G"
                     /note="major polyA site"
     regulatory      5151..5156
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NFRKB"
                     /gene_synonym="INO80G"
                     /note="hexamer: AGTAAA"
     polyA_site      5173
                     /gene="NFRKB"
                     /gene_synonym="INO80G"
ORIGIN      
        1 agactccttg cgggagcgag tgcgtctggg agcccgcggc cggagaaggg ctgcgggtta
       61 gggggccggc gcccgcggtt caggattcca gaattggaaa taacgggagg gaggacctgg
      121 tccagcttcc cttcctcaaa taaggaaatt gacacctggc gtgagtacct gtggagaaga
      181 aacaatggat tccttagacc atatgctgac agatcctctg gaacttggtc cgtgtggaga
      241 tggccatggc acgcgcatca tggaggattg cctcctggga ggcaccagag ttagtctgcc
      301 cgaggacctt ctggaggatc ctgagatctt ctttgatgtt gtcagcctct caacatggca
      361 ggaagtgtta agtgattctc aacgtgaaca cctccagcag tttctgcccc agtttcctga
      421 agacagtgct gagcagcaga atgaactcat cttagccttg ttcagtgggg agaacttccg
      481 ctttggaaac cctctgcaca ttgcccagaa gcttttccga gacggacact ttaaccccga
      541 ggtggtcaag taccggcagt tatgcttcaa gtcacagtac aagcgctacc tcaactccca
      601 gcagcagtat ttccatcggc tgctgaagca aattcttgct tcccggagtg atctgctgga
      661 gatggcccgg cggagtggcc ccgcccttcc cttccggcag aaacgccctt caccatcccg
      721 cacacctgag gagcgggagt ggcggaccca gcagcgctac ttgaaggtct taagggaagt
      781 gaaagaggag tgtggtgaca cagccctgtc atctgatgaa gaggatctca gctcatggct
      841 tccgagctct ccagcacgtt ctcctagtcc tgcggtgccc ctgcgggtgg tgcccacact
      901 ttcaaccacg gatatgaaaa ctgcagataa agtagaactg ggggacagtg acctgaagat
      961 aatgttaaag aagcaccacg agaagcggaa acatcagcca gatcacccgg accttttgac
     1021 aggggacctg actctcaatg acatcatgac tcgagtaaat gctggcagga agggctctct
     1081 ggcagcctta tatgacttgg ctgtccttaa aaaaaaggtt aaggaaaaag aggaaaagaa
     1141 gaagaagaaa ataaaaacga tcaaatcaga ggcagaggac ctggccgagc cgctaagcag
     1201 tactgaaggg gtcgcacctc tctcacaggc cccctctccg ctggcaattc ctgctatcaa
     1261 ggaagagccc cttgaagacc tcaagccttg ccttggaatc aatgaaatat cttccagctt
     1321 cttctctctt ctattagaga tcttgctgct ggagagtcag gctagccttc ctatgctaga
     1381 ggagcgagtt ttggattggc agtcatcgcc agccagctcc ctcaacagct ggttctctgc
     1441 ggcccccaac tgggctgagt tggtactacc agccctgcag tatcttgctg gagaaagtcg
     1501 agctgttcct tccagtttct ctccatttgt tgaattcaaa gagaaaaccc agcagtggaa
     1561 gttgcttggc caatcccaag ataatgaaaa ggaattagct gccctcttcc agctatggct
     1621 agagaccaaa gatcaggcct tctgtaagca agaaaatgaa gacagctcag atgccacaac
     1681 acctgtccct cgggtaagaa ctgactatgt ggtgcgtccc agcacggggg aggagaaacg
     1741 ggtttttcag gagcaggagc gttacaggta tagccaaccc cataaggcgt tcacctttcg
     1801 catgcacggc tttgagtctg tggtggggcc agtgaagggc gtgtttgaca aggagacctc
     1861 gctcaacaag gctcgggagc actccctgct gcgctccgac cggcctgcct acgtcaccat
     1921 tctgtctctt gttcgggacg ctgcggctcg actgcctaat ggagaaggca cacgggcaga
     1981 gatctgtgaa ctgcttaagg actcccagtt tcttgcacca gatgtcacca gcactcaggt
     2041 aaatacagta gtgagtggtg cactggatcg gctacattac gaaaaagatc cctgtgtgaa
     2101 atacgacatt ggacgaaagc tgtggatcta cctgcatcgt gaccggagtg aagaagagtt
     2161 tgagcggatt caccaagcac aagcagctgc agctaaagcc agaaaagctc ttcagcaaaa
     2221 acccaagccc ccatccaagg tgaagtccag tagcaaggag agctccataa aggtccttag
     2281 cagtggccct tctgagcaga gccagatgag cctcagtgac tccagtatgc cacccacccc
     2341 agtcacacct gtaaccccca ccacaccagc attgcccgcc attcccatct cccctccacc
     2401 tgtatcggca gtgaacaaaa gcggcccttc cacagtctca gaaccagcta agtctagctc
     2461 gggtgttctt ctggtgtctt caccaacaat gccacatctg ggaacaatgc tttccccagc
     2521 ttccagccag actgcaccca gttctcaggc tgccgcccgg gtcgtgagcc actctggctc
     2581 tgctggactg tctcaggtgc gagtggtggc ccagcctagc cttcctgctg ttccccagca
     2641 gtcgggaggg ccggcacaga cattgccaca gatgccagca ggaccgcaga tccgggttcc
     2701 agccactgcc acacagacca aagtagtgcc ccagacagta atggccactg tgcccgtcaa
     2761 agcgcagact acggcagcca ctgtgcagcg gcctggaccc gggcagacag ggctcacggt
     2821 gacaagtctc cctgccacag ccagccctgt gagtaagcca gccacgagtt ctcctgggac
     2881 ctctgctccc agtgcctcca cggctgccgt cattcaaaat gtcacaggac agaacatcat
     2941 caagcaggtg gcaatcactg ggcagcttgg tgtgaagccc caaacaggca acagcattcc
     3001 actcacagcc actaacttcc gcatccaggg taaggatgta ttgcgtctgc cgccctcttc
     3061 catcaccaca gatgccaagg gccagacggt tctgcgaatc actccggaca tgatggccac
     3121 attggccaag tcccaggtta ccacagtcaa attgacccag gacctcttcg ggacaggagg
     3181 caacactaca ggcaaaggca tctctgccac cttacacgtc acttccaatc cagtacatgc
     3241 agctgatagc cctgccaagg ccagttcagc cagtgcccct tcatccactc caacaggtac
     3301 cactgtggtc aaagtgactc ctgacctcaa gccaacagaa gcctcaagtt cggcttttcg
     3361 cttgatgcca gctcttggcg tgagtgtggc tgaccagaag ggaaaaagca cagtggcctc
     3421 ttcagaagca aaaccagctg ccacgatccg catcgtgcag ggactgggag tgatgcctcc
     3481 caaagcaggc cagaccatca ccgttgcaac ccacgccaag caaggggcct cggtggccag
     3541 tgggtctgga actgtccata cttcagcggt gtccttaccc agtatgaatg ctgctgtgtc
     3601 caagactgta gctgtggctt ctggggctgc aagcaccccc atcagcatca gcacaggagc
     3661 ccccaccgtg cggcaggtcc ctgtcagcac cacggttgtg tccacgtccc aggctgggaa
     3721 gttgcctaca cggatcacag ttcccctctc tgtgatcagc cagccaatga agggcaagag
     3781 cgtggtcaca gcccccatca tcaaaggcaa ccttggagcc aacctcagtg ggttgggccg
     3841 caacatcatc ctcacaacta tgccagcagg cactaagctc attgctggca ataagcctgt
     3901 tagtttcctc actgctcagc agttgcagca gcttcagcag caaggtcagg ccacacaggt
     3961 gcgcatccag actgtccctg catcccatct ccaacaggga acagcttctg gctcctccaa
     4021 agcagtctcc actgttgttg tgactacagc tccgtctcct aaacaggcac ctgagcaaca
     4081 atgattatga gagaggatgg cttccgtgaa agaccatgcc tggtctgtcc tggctgagaa
     4141 gggaccaggg aggttgcatc attgttttaa gcttgcctgt tcaaggcagc caggcgaggg
     4201 gtgatggcaa cggtggcctg gattcgtggc ctggattctg ctgccacgtg ccatagtgga
     4261 gcaccctgag aaaggttcac tccagggttc caaggtctgc tctctaccaa tctaggagaa
     4321 tattctgttg aaattgcagg aattaccagt tacgtccaac aagccagagt tctgagagta
     4381 agacccccag ggaaggctta ccagttgcag agtgcacaca gcgaataggc tggttctcca
     4441 tgaggattgt attttttggc ttctggtctt ctccatgact agtggtctgg ataggagttt
     4501 tgtgtccaga aaattttatg taatttattt ttttaaagaa cctgttgtac atctttctca
     4561 aatacaaact tgggctttag ctgccccctc cactaaaccg atgacttact tttttgacta
     4621 gaatgagaaa atggcaagaa tcttagtaag gtggtagcca gcttggtaac tgcatagtaa
     4681 tcgagaggct gtaagatggg aattcatcgt aggcagcgag gtagagtggg tcccctgaaa
     4741 tgggattcgc ttggcactgc ctcttaaaga taggggtgtt gggatcttga ttgtggccgc
     4801 cccccccagc tttacctgcc cactttgtcc ttcttggcaa gcctgttcac atggacgtcc
     4861 agagccagtg gacagagagg aggggacgga cagcagaggt gctgcttttg cagcagaaac
     4921 tttgttgcag ttcagagtat accttctgct ctgctccaga gcaagagttg caaaccaggc
     4981 ccttggggct ggccatttgt ttttgtaaat aaagttttat tggaacacag cccagaccaa
     5041 tttgtgtttg tattatctgt ggctgctttc agattcgaag gcagaattga gtagttgaca
     5101 tagagactgg atggccctga agcctaaagt atttcctata tggcctttta agtaaaagcg
     5161 ttttttgttt gtt
//
