LOCUS       NM_031419               3923 bp    mRNA    linear   PRI 05-DEC-2024
DEFINITION  Homo sapiens NFKB inhibitor zeta (NFKBIZ), transcript variant 1,
            mRNA.
ACCESSION   NM_031419
VERSION     NM_031419.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3923)
  AUTHORS   Vazquez-Coto,D., Perez-Oliveira,S., Menendez-Gonzalez,M., Coto,E.
            and Alvarez,V.
  TITLE     Assessing the association between common functional Nuclear Factor
            Kappa-b gene polymorphisms (NFKB1, NFKBIZ, NFKBIA) and Alzheimer s
            disease
  JOURNAL   Behav Brain Res 476, 115264 (2025)
   PUBMED   39322062
  REMARK    GeneRIF: Assessing the association between common functional
            Nuclear Factor Kappa-b gene polymorphisms (NFKB1, NFKBIZ, NFKBIA)
            and Alzheimer s disease.
REFERENCE   2  (bases 1 to 3923)
  AUTHORS   Yamazaki,S.
  TITLE     The Nuclear NF-kappaB Regulator IkappaBzeta: Updates on Its
            Molecular Functions and Pathophysiological Roles
  JOURNAL   Cells 13 (17), 1467 (2024)
   PUBMED   39273036
  REMARK    GeneRIF: The Nuclear NF-kappaB Regulator IkappaBzeta: Updates on
            Its Molecular Functions and Pathophysiological Roles.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3923)
  AUTHORS   Zhu,N., Rogers,W.E., Heidary,D.K. and Huxford,T.
  TITLE     Structural and biochemical analyses of the nuclear IkappaBzeta
            protein in complex with the NF-kappaB p50 homodimer
  JOURNAL   Genes Dev 38 (11-12), 528-535 (2024)
   PUBMED   38960718
  REMARK    GeneRIF: Structural and biochemical analyses of the nuclear
            IkappaBzeta protein in complex with the NF-kappaB p50 homodimer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3923)
  AUTHORS   Guo,D., Zhang,M., Wei,T., Zhang,X., Shi,X., Tang,H., Ding,M.,
            Li,J., Zhang,S. and Guo,W.
  TITLE     NFKBIZ regulates NFkappaB signaling pathway to mediate
            tumorigenesis and metastasis of hepatocellular carcinoma by direct
            interaction with TRIM16
  JOURNAL   Cell Mol Life Sci 81 (1), 167 (2024)
   PUBMED   38581570
  REMARK    GeneRIF: NFKBIZ regulates NFkappaB signaling pathway to mediate
            tumorigenesis and metastasis of hepatocellular carcinoma by direct
            interaction with TRIM16.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3923)
  AUTHORS   Taylor,T.C., Coleman,B.M., Arunkumar,S.P., Dey,I., Dillon,J.T.,
            Ponde,N.O., Poholek,A.C., Schwartz,D.M., McGeachy,M.J., Conti,H.R.
            and Gaffen,S.L.
  TITLE     IkappaBzeta is an essential mediator of immunity to oropharyngeal
            candidiasis
  JOURNAL   Cell Host Microbe 31 (10), 1700-1713 (2023)
   PUBMED   37725983
  REMARK    GeneRIF: IkappaBzeta is an essential mediator of immunity to
            oropharyngeal candidiasis.
REFERENCE   6  (bases 1 to 3923)
  AUTHORS   Yamazaki,S., Muta,T., Matsuo,S. and Takeshige,K.
  TITLE     Stimulus-specific induction of a novel nuclear factor-kappaB
            regulator, IkappaB-zeta, via Toll/Interleukin-1 receptor is
            mediated by mRNA stabilization
  JOURNAL   J Biol Chem 280 (2), 1678-1687 (2005)
   PUBMED   15522867
REFERENCE   7  (bases 1 to 3923)
  AUTHORS   Yamamoto,M., Yamazaki,S., Uematsu,S., Sato,S., Hemmi,H.,
            Hoshino,K., Kaisho,T., Kuwata,H., Takeuchi,O., Takeshige,K.,
            Saitoh,T., Yamaoka,S., Yamamoto,N., Yamamoto,S., Muta,T., Takeda,K.
            and Akira,S.
  TITLE     Regulation of Toll/IL-1-receptor-mediated gene expression by the
            inducible nuclear protein IkappaBzeta
  JOURNAL   Nature 430 (6996), 218-222 (2004)
   PUBMED   15241416
REFERENCE   8  (bases 1 to 3923)
  AUTHORS   Eto,A., Muta,T., Yamazaki,S. and Takeshige,K.
  TITLE     Essential roles for NF-kappa B and a Toll/IL-1 receptor
            domain-specific signal(s) in the induction of I kappa B-zeta
  JOURNAL   Biochem Biophys Res Commun 301 (2), 495-501 (2003)
   PUBMED   12565889
  REMARK    GeneRIF: These results indicate the existence of another signal
            essential for I kappa B-zeta induction, which is specifically
            mediated by the Toll/interleukin-1 receptor (TIR) domain-mediated
            signaling pathway.
REFERENCE   9  (bases 1 to 3923)
  AUTHORS   Yamazaki,S., Muta,T. and Takeshige,K.
  TITLE     A novel IkappaB protein, IkappaB-zeta, induced by proinflammatory
            stimuli, negatively regulates nuclear factor-kappaB in the nuclei
  JOURNAL   J Biol Chem 276 (29), 27657-27662 (2001)
   PUBMED   11356851
REFERENCE   10 (bases 1 to 3923)
  AUTHORS   Haruta,H., Kato,A. and Todokoro,K.
  TITLE     Isolation of a novel interleukin-1-inducible nuclear protein
            bearing ankyrin-repeat motifs
  JOURNAL   J Biol Chem 276 (16), 12485-12488 (2001)
   PUBMED   11278262
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC060800.1 and BC014587.2.
            
            On Nov 23, 2018 this sequence version replaced NM_031419.3.
            
            Summary: This gene is a member of the ankyrin-repeat family and is
            induced by lipopolysaccharide (LPS). The C-terminal portion of the
            encoded product which contains the ankyrin repeats, shares high
            sequence similarity with the I kappa B family of proteins. The
            latter are known to play a role in inflammatory responses to LPS by
            their interaction with NF-B proteins through ankyrin-repeat
            domains. Studies in mouse indicate that this gene product is one of
            the nuclear I kappa B proteins and an activator of IL-6 production.
            Two transcript variants encoding different isoforms have been found
            for this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060800.1, SRR1660809.227881.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000326172.9/ ENSP00000325663.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2089              BC060800.1         1-2089
            2090-3699           BC014587.2         2006-3615
            3700-3714           BC060800.1         3700-3714
            3715-3916           BC014587.2         3631-3832
            3917-3923           BC060800.1         3916-3922
FEATURES             Location/Qualifiers
     source          1..3923
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q12.3"
     gene            1..3923
                     /gene="NFKBIZ"
                     /gene_synonym="I-kappa-B-zeta; IkappaB-zeta; ikappaBzeta;
                     ikB-zeta; IKBZ; INAP; MAIL"
                     /note="NFKB inhibitor zeta"
                     /db_xref="GeneID:64332"
                     /db_xref="HGNC:HGNC:29805"
                     /db_xref="MIM:608004"
     exon            1..404
                     /gene="NFKBIZ"
                     /gene_synonym="I-kappa-B-zeta; IkappaB-zeta; ikappaBzeta;
                     ikB-zeta; IKBZ; INAP; MAIL"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..2272
                     /gene="NFKBIZ"
                     /gene_synonym="I-kappa-B-zeta; IkappaB-zeta; ikappaBzeta;
                     ikB-zeta; IKBZ; INAP; MAIL"
                     /note="isoform a is encoded by transcript variant 1;
                     molecule possessing ankyrin repeats induced by
                     lipopolysaccharide; NF-kappa-B inhibitor zeta; nuclear
                     factor of kappa light polypeptide gene enhancer in B-cells
                     inhibitor, zeta; IL-1 inducible nuclear ankyrin-repeat
                     protein"
                     /codon_start=1
                     /product="NF-kappa-B inhibitor zeta isoform a"
                     /protein_id="NP_113607.1"
                     /db_xref="CCDS:CCDS2946.1"
                     /db_xref="GeneID:64332"
                     /db_xref="HGNC:HGNC:29805"
                     /db_xref="MIM:608004"
                     /translation="MIVDKLLDDSRGGEGLRDAAGGCGLMTSPLNLSYFYGASPPAAA
                     PGACDASCSVLGPSAPGSPGSDSSDFSSASSVSSCGAVESRSRGGARAERQPVEPHMG
                     VGRQQRGPFQGVRVKNSVKELLLHIRSHKQKASGQAVDDFKTQGVNIEQFRELKNTVS
                     YSGKRKGPDSLSDGPACKRPALLHSQFLTPPQTPTPGESMEDVHLNEPKQESSADLLQ
                     NIINIKNECSPVSLNTVQVSWLNPVVVPQSSPAEQCQDFHGGQVFSPPQKCQPFQVRG
                     SQQMIDQASLYQYSPQNQHVEQQPHYTHKPTLEYSPFPIPPQSPAYEPNLFDGPESQF
                     CPNQSLVSLLGDQRESENIANPMQTSSSVQQQNDAHLHSFSMMPSSACEAMVGHEMAS
                     DSSNTSLPFSNMGNPMNTTQLGKSLFQWQVEQEESKLANISQDQFLSKDADGDTFLHI
                     AVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNT
                     TDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIAHNAV
                     VHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEA
                     NLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTR
                     NLENEQPVHLVPDGPVGEQIRRILKGKSIQQRAPPY"
     exon            405..544
                     /gene="NFKBIZ"
                     /gene_synonym="I-kappa-B-zeta; IkappaB-zeta; ikappaBzeta;
                     ikB-zeta; IKBZ; INAP; MAIL"
                     /inference="alignment:Splign:2.1.0"
     exon            545..575
                     /gene="NFKBIZ"
                     /gene_synonym="I-kappa-B-zeta; IkappaB-zeta; ikappaBzeta;
                     ikB-zeta; IKBZ; INAP; MAIL"
                     /inference="alignment:Splign:2.1.0"
     exon            576..679
                     /gene="NFKBIZ"
                     /gene_synonym="I-kappa-B-zeta; IkappaB-zeta; ikappaBzeta;
                     ikB-zeta; IKBZ; INAP; MAIL"
                     /inference="alignment:Splign:2.1.0"
     exon            680..1452
                     /gene="NFKBIZ"
                     /gene_synonym="I-kappa-B-zeta; IkappaB-zeta; ikappaBzeta;
                     ikB-zeta; IKBZ; INAP; MAIL"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..1558
                     /gene="NFKBIZ"
                     /gene_synonym="I-kappa-B-zeta; IkappaB-zeta; ikappaBzeta;
                     ikB-zeta; IKBZ; INAP; MAIL"
                     /inference="alignment:Splign:2.1.0"
     exon            1559..1705
                     /gene="NFKBIZ"
                     /gene_synonym="I-kappa-B-zeta; IkappaB-zeta; ikappaBzeta;
                     ikB-zeta; IKBZ; INAP; MAIL"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..1769
                     /gene="NFKBIZ"
                     /gene_synonym="I-kappa-B-zeta; IkappaB-zeta; ikappaBzeta;
                     ikB-zeta; IKBZ; INAP; MAIL"
                     /inference="alignment:Splign:2.1.0"
     exon            1770..1939
                     /gene="NFKBIZ"
                     /gene_synonym="I-kappa-B-zeta; IkappaB-zeta; ikappaBzeta;
                     ikB-zeta; IKBZ; INAP; MAIL"
                     /inference="alignment:Splign:2.1.0"
     exon            1940..2050
                     /gene="NFKBIZ"
                     /gene_synonym="I-kappa-B-zeta; IkappaB-zeta; ikappaBzeta;
                     ikB-zeta; IKBZ; INAP; MAIL"
                     /inference="alignment:Splign:2.1.0"
     exon            2051..2218
                     /gene="NFKBIZ"
                     /gene_synonym="I-kappa-B-zeta; IkappaB-zeta; ikappaBzeta;
                     ikB-zeta; IKBZ; INAP; MAIL"
                     /inference="alignment:Splign:2.1.0"
     exon            2219..3923
                     /gene="NFKBIZ"
                     /gene_synonym="I-kappa-B-zeta; IkappaB-zeta; ikappaBzeta;
                     ikB-zeta; IKBZ; INAP; MAIL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3904..3909
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NFKBIZ"
                     /gene_synonym="I-kappa-B-zeta; IkappaB-zeta; ikappaBzeta;
                     ikB-zeta; IKBZ; INAP; MAIL"
                     /note="hexamer: AATAAA"
     polyA_site      3923
                     /gene="NFKBIZ"
                     /gene_synonym="I-kappa-B-zeta; IkappaB-zeta; ikappaBzeta;
                     ikB-zeta; IKBZ; INAP; MAIL"
                     /note="major polyA site"
ORIGIN      
        1 gtactggccc gcgccgtccg cccgccgaca gctccctgag ccagcccggg aggcagccgc
       61 gcgcagcgag ccggtggcgc aggtgtcggg gtcctcgagc gcccagcctg ggagcatgat
      121 tgtggacaag ctgctggacg acagccgcgg cggagagggg ctgcgggacg cggcgggcgg
      181 ctgcggcctc atgaccagcc cgctcaacct gagctacttc tacggcgcgt cgccgcccgc
      241 cgccgccccg ggcgcctgcg acgccagctg ctcggtcttg ggcccctcgg cgcccggctc
      301 gcccggctcc gactcctccg acttctcctc tgcctcgtcg gtgtcctcct gcggcgccgt
      361 ggagtcccgg tcgagaggcg gcgcccgcgc cgagcgccag ccagttgagc cccatatggg
      421 ggttggcagg cagcagagag gcccctttca aggtgttcgg gtaaagaact cagtgaagga
      481 actcctgttg cacatccgaa gtcataaaca gaaggcttct ggccaagctg tggatgattt
      541 taagacacaa ggtgtgaaca tagaacagtt cagagaattg aagaacacag tatcatacag
      601 tgggaaaagg aaagggcccg attcgttgtc tgatggacct gcttgcaaaa ggccagctct
      661 gttgcattcc caatttttga caccacctca aacaccaacg cccggggaga gcatggaaga
      721 tgttcatctc aatgaaccca aacaggagag cagtgctgat ctgcttcaga acattatcaa
      781 cattaagaat gaatgcagcc ccgtttccct gaacacagtt caagttagct ggctgaaccc
      841 cgtggtggtc cctcagagct cccccgcaga gcagtgtcag gacttccatg gagggcaggt
      901 cttttctcca cctcagaaat gccaaccatt ccaagtcagg ggctcccaac aaatgataga
      961 ccaggcttcc ctgtaccagt attctccaca gaaccagcat gtagagcagc agccacacta
     1021 cacccacaaa ccaactctgg aatacagtcc ttttcccata cctccccagt cccccgctta
     1081 tgaaccaaac ctctttgatg gtccagaatc acagttttgc ccaaaccaaa gcttagtttc
     1141 ccttcttggt gatcaaaggg aatctgagaa tattgctaat cccatgcaga cttcctccag
     1201 tgttcagcag caaaatgatg ctcacttgca cagcttcagc atgatgccca gcagcgcctg
     1261 tgaggccatg gtggggcacg agatggcctc tgactcttca aacacttcac tgccattctc
     1321 aaacatggga aatccaatga acaccacaca gttagggaaa tcactttttc agtggcaggt
     1381 ggagcaggaa gaaagcaaat tggcaaatat ttcccaagac cagtttcttt caaaggatgc
     1441 agatggtgac acgttccttc atattgctgt tgcccaaggg agaagggcac tttcctatgt
     1501 tcttgcaaga aagatgaatg cacttcacat gctggatatt aaagagcaca atggacagag
     1561 tgcctttcag gtggcagtgg ctgccaatca gcatctcatt gtgcaggatc tggtgaacat
     1621 cggggcacag gtgaacacca cagactgctg gggaagaaca cctctgcatg tgtgtgctga
     1681 gaagggccac tcccaggtgc ttcaggcgat tcagaaggga gcagtgggaa gtaatcagtt
     1741 tgtggatctt gaggcaacta actatgatgg cctgactccc cttcactgtg cagtcatagc
     1801 ccacaatgct gtggtccatg aactccagag aaatcaacag cctcattcac ctgaagttca
     1861 ggagctttta ctgaagaata agagtctggt tgataccatt aagtgcctaa ttcaaatggg
     1921 agcagcggtg gaagcgaagg atcgcaaaag tggccgcaca gccctgcatt tggcagctga
     1981 agaagcaaat ctggaactca ttcgcctctt tttggagctg cccagttgcc tgtcttttgt
     2041 gaatgcaaag gcttacaatg gcaacactgc cctccatgtt gctgccagct tgcagtatcg
     2101 gttgacacaa ttagatgctg tccgcctgtt gatgaggaag ggagcagacc caagtactcg
     2161 gaacttggag aacgaacagc cagtgcattt ggttcccgat ggccctgtgg gagaacagat
     2221 ccgacgtatc ctgaagggaa agtccattca gcagagagct ccaccgtatt agctccatta
     2281 gcttggagcc tggctagcaa cactcactgt cagttaggca gtcctgatgt atctgtacat
     2341 agaccatttg ccttatattg gcaaatgtaa gttgtttcta tgaaacaaac atatttagtt
     2401 cactattata tagtgggtta tattaaaaga aaagaagaaa aatatctaat ttctcttggc
     2461 agatttgcat atttcatacc caggtatctg ggatctagac atctgaattt gatctcaatg
     2521 gtaacattgc cttcaattaa cagtagcttt tgagtaggaa aggactttga tttgtggcac
     2581 aaaacattat taatatagct attgacagtt tcaaagcagg taaattgtaa atgtttcttt
     2641 aagaaaaagc atgtgaaagg aaaaaggtaa atacagcatt gaggcttcat ttggccttag
     2701 tccctgggag ttactggcgt tggacaggct tcagtcattg gactagatga aaggtgtcca
     2761 tggttagaat ttgatctttg caaactgtat ataattgtta tttttgtcct taaaaatatt
     2821 gtacatactt ggttgttaac atggtcatat ttgaaatgta taagtccata aaatagaaaa
     2881 gaacaagtga attgttgcta tttaaaaaaa ttttacaatt cttactaagg agtttttatt
     2941 gtgtaatcac taagtctttg tagataaagc agatggggag ttacggagtt gttcctttac
     3001 tggctgaaag atatattcga attgtaaaga tgctttttct catgcattga aattatacat
     3061 tatttgtagg gaattgcatg cttttttttt tttttctccc gagacagggt cttgctctgg
     3121 cgcccaggct ggagtacagt ggcatgatct tggctcactt cagccttgac ttgggctcaa
     3181 gtgatcctcc tacctgagcc ttctgagtaa ctggaactac aggtgtgcac tcctcgcctg
     3241 gctaattttt tattttttgt acaggcagga tcttgccacc ttgcccaggc tggtcttgaa
     3301 ctcctgagct catgccatct gcctgcctta gtctcccaaa atgctgggat tacaggagtg
     3361 agccaccatg cccggctggc agttgcatgg aagagaacac ctctttatgg cttaccctct
     3421 agaatttcta atttatgtgt tctgttgaaa tttttgtttt tttaccttta ttgaaacaac
     3481 aaaaagtcag tattgaaaca tatcttcctg ttttctgttg tcaaatgatg ataatgtgcc
     3541 atgatgtttt atatatatca ttcagaaaaa gttttatttt ttaataacat tctattaaca
     3601 ttattttgct tgccgctggc atgcctgagg aatgtatttg gctttgatta cacactaagt
     3661 ttttgtaata aatttgactc attaaaaacc tttttttttt aaaaaaaaaa aaaaagaaaa
     3721 tctcattagt gaacttatct ttgcagctga gtacttaaat tctttttaaa aagataccct
     3781 ttggattgat cacattgttt gacccagtat gtcttgtaga cacgttagtt ataatcacct
     3841 tgtatctcta aatatggtgt gatatgaacc agtccattca cattggaaaa actgatggtt
     3901 ttaaataaac taattcacta ata
//
