LOCUS       NM_004556               2344 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens NFKB inhibitor epsilon (NFKBIE), mRNA.
ACCESSION   NM_004556
VERSION     NM_004556.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2344)
  AUTHORS   Bonato,A., Chakraborty,S., Bomben,R., Canarutto,G., Felician,G.,
            Martines,C., Zucchetto,A., Pozzo,F., Vujovikj,M., Polesel,J.,
            Chiarenza,A., Del Principe,M.I., Del Poeta,G., D'Arena,G.,
            Marasca,R., Tafuri,A., Laurenti,L., Piazza,S., Dimovski,A.J.,
            Gattei,V. and Efremov,D.G.
  TITLE     NFKBIE mutations are selected by the tumor microenvironment and
            contribute to immune escape in chronic lymphocytic leukemia
  JOURNAL   Leukemia 38 (7), 1511-1521 (2024)
   PUBMED   38486128
  REMARK    GeneRIF: NFKBIE mutations are selected by the tumor
            microenvironment and contribute to immune escape in chronic
            lymphocytic leukemia.
REFERENCE   2  (bases 1 to 2344)
  AUTHORS   Bordini,J., Lenzi,C., Frenquelli,M., Morabito,A., Pseftogas,A.,
            Belloni,D., Mansouri,L., Tsiolas,G., Perotta,E., Ranghetti,P.,
            Gandini,F., Genova,F., Hagerstrand,D., Gavriilidis,G., Keisaris,S.,
            Pechlivanis,N., Davi,F., Kay,N.E., Langerak,A.W., Pospisilova,S.,
            Scarfo,L., Makris,A., Psomopoulos,F.E., Stamatopoulos,K.,
            Rosenquist,R., Campanella,A. and Ghia,P.
  TITLE     IkappaBepsilon deficiency accelerates disease development in
            chronic lymphocytic leukemia
  JOURNAL   Leukemia 38 (6), 1287-1298 (2024)
   PUBMED   38575671
  REMARK    GeneRIF: IkappaBepsilon deficiency accelerates disease development
            in chronic lymphocytic leukemia.
REFERENCE   3  (bases 1 to 2344)
  AUTHORS   Wang,D., Zheng,X., Chai,L., Zhao,J., Zhu,J., Li,Y., Yang,P., Mao,Q.
            and Xia,H.
  TITLE     FAM76B regulates NF-kappaB-mediated inflammatory pathway by
            influencing the translocation of hnRNPA2B1
  JOURNAL   Elife 12, e85659 (2023)
   PUBMED   37643469
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2344)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 2344)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 2344)
  AUTHORS   Li,Z. and Nabel,G.J.
  TITLE     A new member of the I kappaB protein family, I kappaB epsilon,
            inhibits RelA (p65)-mediated NF-kappaB transcription
  JOURNAL   Mol Cell Biol 17 (10), 6184-6190 (1997)
   PUBMED   9315679
REFERENCE   7  (bases 1 to 2344)
  AUTHORS   Curristin,S.M., Bird,K.J., Tubbs,R.J. and Ruddell,A.
  TITLE     VBP and RelA regulate avian leukosis virus long terminal
            repeat-enhanced transcription in B cells
  JOURNAL   J Virol 71 (8), 5972-5981 (1997)
   PUBMED   9223487
REFERENCE   8  (bases 1 to 2344)
  AUTHORS   Whiteside,S.T., Epinat,J.C., Rice,N.R. and Israel,A.
  TITLE     I kappa B epsilon, a novel member of the I kappa B family, controls
            RelA and cRel NF-kappa B activity
  JOURNAL   EMBO J 16 (6), 1413-1426 (1997)
   PUBMED   9135156
REFERENCE   9  (bases 1 to 2344)
  AUTHORS   Hansen,S.K., Baeuerle,P.A. and Blasi,F.
  TITLE     Purification, reconstitution, and I kappa B association of the
            c-Rel-p65 (RelA) complex, a strong activator of transcription
  JOURNAL   Mol Cell Biol 14 (4), 2593-2603 (1994)
   PUBMED   8139561
REFERENCE   10 (bases 1 to 2344)
  AUTHORS   Kumar,S. and Gelinas,C.
  TITLE     I kappa B alpha-mediated inhibition of v-Rel DNA binding requires
            direct interaction with the RXXRXRXXC Rel/kappa B DNA-binding motif
  JOURNAL   Proc Natl Acad Sci U S A 90 (19), 8962-8966 (1993)
   PUBMED   8415639
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U91616.1, BC063609.1 and
            AL139392.10.
            
            On Aug 31, 2019 this sequence version replaced NM_004556.2.
            
            Summary: The protein encoded by this gene binds to components of
            NF-kappa-B, trapping the complex in the cytoplasm and preventing it
            from activating genes in the nucleus. Phosphorylation of the
            encoded protein targets it for destruction by the ubiquitin
            pathway, which activates NF-kappa-B by making it available to
            translocate to the nucleus. [provided by RefSeq, Sep 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC063609.1, SRR11853563.28229.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000619360.6/ ENSP00000480216.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                U91616.1           246-262
            18-2269             BC063609.1         1-2252
            2270-2344           AL139392.10        42643-42717         c
FEATURES             Location/Qualifiers
     source          1..2344
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.1"
     gene            1..2344
                     /gene="NFKBIE"
                     /gene_synonym="IKBE"
                     /note="NFKB inhibitor epsilon"
                     /db_xref="GeneID:4794"
                     /db_xref="HGNC:HGNC:7799"
                     /db_xref="MIM:604548"
     exon            1..570
                     /gene="NFKBIE"
                     /gene_synonym="IKBE"
                     /inference="alignment:Splign:2.1.0"
     CDS             206..1291
                     /gene="NFKBIE"
                     /gene_synonym="IKBE"
                     /note="ikB-E; ikB-epsilon; NF-kappa-BIE; ikappaBepsilon;
                     I-kappa-B-epsilon; nuclear factor of kappa light
                     polypeptide gene enhancer in B-cells inhibitor, epsilon"
                     /codon_start=1
                     /product="NF-kappa-B inhibitor epsilon"
                     /protein_id="NP_004547.3"
                     /db_xref="CCDS:CCDS34463.2"
                     /db_xref="GeneID:4794"
                     /db_xref="HGNC:HGNC:7799"
                     /db_xref="MIM:604548"
                     /translation="MSEARKGPDEAEESQYDSGIESLRSLRSLPESTSAPASGPSDGS
                     PQPCTHPPGPVKEPQEKEDADGERADSTYGSSSLTYTLSLLGGPEAEDPAPRLPLPHV
                     GALSPQQLEALTYISEDGDTLVHLAVIHEAPAVLLCCLALLPQEVLDIQNNLYQTALH
                     LAVHLDQPGAVRALVLKGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGRGT
                     SHSLDLQLQNWQGLACLHIATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLAVETQ
                     ERGLVQFLLQAGAQVDARMLNGCTPLHLAAGRGLMGISSTLCKAGADSLLRNVEDETP
                     QDLTEESLVLLPFDDLKISGKLLLCTD"
     exon            571..673
                     /gene="NFKBIE"
                     /gene_synonym="IKBE"
                     /inference="alignment:Splign:2.1.0"
     exon            674..896
                     /gene="NFKBIE"
                     /gene_synonym="IKBE"
                     /inference="alignment:Splign:2.1.0"
     exon            897..985
                     /gene="NFKBIE"
                     /gene_synonym="IKBE"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1225
                     /gene="NFKBIE"
                     /gene_synonym="IKBE"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..2344
                     /gene="NFKBIE"
                     /gene_synonym="IKBE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1797..1802
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NFKBIE"
                     /gene_synonym="IKBE"
                     /note="hexamer: ACTAAA"
     polyA_site      1823
                     /gene="NFKBIE"
                     /gene_synonym="IKBE"
                     /note="major polyA site"
     regulatory      2323..2328
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NFKBIE"
                     /gene_synonym="IKBE"
                     /note="hexamer: AATAAA"
     polyA_site      2344
                     /gene="NFKBIE"
                     /gene_synonym="IKBE"
ORIGIN      
        1 agtaaccgct gggtggacct ggccagcgct ccgaaccttg tcctcgctgc gcgccggccc
       61 ctcggagccc cacagcccgg gaaggaggcc gccgcgggcc gggcgcccgc tctgccaagc
      121 ggacccgcaa cccggaaagg cggcgcggcg gagcctggag ccggatcctg ctcagaccgg
      181 gccccggccg gccagagccg cgggcatgtc ggaggcgcgg aaggggccgg acgaggcgga
      241 ggagagccag tacgactctg gcattgagtc tctgcgctct ctgcgctccc tacccgagtc
      301 cacctcggct ccagcctccg ggccctcgga cggcagcccc cagccctgca cccatcctcc
      361 gggacccgtc aaggaaccac aggagaagga agacgcggat ggggagcggg ctgattccac
      421 ctatggctcc tcctcgctca cctacaccct gtccttgctg gggggccccg aggctgagga
      481 cccggcccca cgcctgccac tcccccacgt gggggcgctg agccctcagc agctggaagc
      541 actcacttac atctccgagg acggagacac gctggtccac ctggcagtga ttcatgaggc
      601 cccagcggtg ctgctctgtt gcctggcttt gctgccccag gaggtcctgg acattcaaaa
      661 taacctttac cagacagcac tccatctggc tgtacatctg gaccaaccgg gcgcagttcg
      721 ggcactggtg ctgaaggggg ccagccgggc actacaggac cggcatggtg acacagccct
      781 tcatgtggcc tgccagcgcc agcacttggc ctgtgcccgc tgcctgctgg aagggcggcc
      841 agagccaggc agaggaacat ctcactctct ggacctccag ctgcaaaact ggcaaggtct
      901 ggcttgtctc cacattgcca cccttcagaa gaaccaacca ctcatggaat tgctgcttcg
      961 gaatggagct gacattgatg tgcaggaggg caccagtggt aagacagcgc tgcacctggc
     1021 tgtggaaacc caagagcggg gcctggtaca gttcctgctc caggctggtg cccaggtaga
     1081 tgcccgcatg ctgaacgggt gcacacccct gcacctggca gctggccggg gtctcatggg
     1141 catctcatcc actctgtgca aggcgggtgc tgactccctg ctgcggaatg tggaggatga
     1201 gacgccccag gacctgactg aggaatccct tgtccttttg ccctttgatg acctgaagat
     1261 ctcagggaaa ctgctgctgt gtaccgactg aagccaggca gggtctggga tcctcagggc
     1321 tccacctctc catctggaag ccggagccat aactgctgca gtttgggccc aggctatgtg
     1381 ctcttctggt gccctaggga ctgctgtggc cagagcctgg ggccagccag tacagtcctg
     1441 agccgaggag gagggactgc aagtggaaga gagccagtct ggaaggaaga gctttccagg
     1501 tggacagggc ttcttggaag acccccaaag ccccaggtat cctgggtgaa gcctgtttgc
     1561 ctctcttgaa aatggcaggt gctcttgttt tacccatgtt gggtcagcct gaaactgcca
     1621 accagtagga agcatggact ctcctgagtg agaagagact gaaataggag caagcagaac
     1681 cctgagaggt gtcccatctt attgctgttg aggaccctga aacaccgttg tttaaagact
     1741 tcacacagaa ggctctgaac tgagccactg gggaagggaa gtttcagtaa catgacacta
     1801 aaatggcaga gacgttaaaa aaagtttttc ccttctagag ctgttttgcg cgcatgcatg
     1861 tctgtgtgca ttggggcttt ttagacaggc ctgccctgtg actttgtggt agaggcagag
     1921 agaaggaaat tgtcccctga gcacggtagg gccttgctgg gtggggtcag aggccagtag
     1981 ttccaggcct ttctctgtgt ccagcacaga cccttgtcct tgctgtggaa atgatgaggg
     2041 atggagggac aagaggaaga atgagaggac acacgccctg gagccctcac cactgccctg
     2101 ggggttgcca tctggaggag cctggggata agggtaaccc agggaggctg ggcacgaggg
     2161 agctgactcc acgtttttcc ccccgttcct caccttcgag ggccctgcta ggtcacccct
     2221 atgctggcat gaagagcatg gggcaataaa ccagcacagt ctctgaccac ttggagcgtc
     2281 tcatccagtg agagagacag ccgttaaaag cataaacatc caaataaaga tgcctttcca
     2341 agtt
//
