LOCUS       NM_139239               2013 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens NFKB inhibitor delta (NFKBID), transcript variant 1,
            mRNA.
ACCESSION   NM_139239
VERSION     NM_139239.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2013)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2013)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2013)
  AUTHORS   Presa,M., Racine,J.J., Dwyer,J.R., Lamont,D.J., Ratiu,J.J.,
            Sarsani,V.K., Chen,Y.G., Geurts,A., Schmitz,I., Stearns,T.,
            Allocco,J., Chapman,H.D. and Serreze,D.V.
  TITLE     A Hypermorphic Nfkbid Allele Contributes to Impaired Thymic
            Deletion of Autoreactive Diabetogenic CD8+ T Cells in NOD Mice
  JOURNAL   J Immunol 201 (7), 1907-1917 (2018)
   PUBMED   30127089
REFERENCE   4  (bases 1 to 2013)
  AUTHORS   Tao,Z., Fusco,A., Huang,D.B., Gupta,K., Young Kim,D., Ware,C.F.,
            Van Duyne,G.D. and Ghosh,G.
  TITLE     p100/IkappaBdelta sequesters and inhibits NF-kappaB through
            kappaBsome formation
  JOURNAL   Proc Natl Acad Sci U S A 111 (45), 15946-15951 (2014)
   PUBMED   25349408
  REMARK    GeneRIF: The unique ability of p100/IkappaBdelta to stably interact
            with all NF-kappaB subunits by forming kappaBsomes demonstrates its
            importance in sequestering NF-kappaB subunits and releasing them as
            dictated by specific stimuli for developmental programs.
REFERENCE   5  (bases 1 to 2013)
  AUTHORS   Ivanov,I.P., Firth,A.E., Michel,A.M., Atkins,J.F. and Baranov,P.V.
  TITLE     Identification of evolutionarily conserved non-AUG-initiated
            N-terminal extensions in human coding sequences
  JOURNAL   Nucleic Acids Res 39 (10), 4220-4234 (2011)
   PUBMED   21266472
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AD000864.1.
            
            On Aug 24, 2023 this sequence version replaced NM_139239.4.
            
            Transcript Variant: This variant (1) encodes isoform 1 and uses a
            non-AUG (CUG) translation initiation codon.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074967.2158454.1, AF385434.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN04284274 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match       :: ENST00000641389.3/ ENSP00000493265.2
            non-AUG initiation codon :: inferred from conservation
            RefSeq Select criteria   :: based on manual assertion,
                                        conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-99                AD000864.1         35054-35152         c
            100-203             AD000864.1         33331-33434         c
            204-264             AD000864.1         33084-33144         c
            265-470             AD000864.1         32263-32468         c
            471-616             AD000864.1         31525-31670         c
            617-722             AD000864.1         31338-31443         c
            723-869             AD000864.1         31004-31150         c
            870-921             AD000864.1         30830-30881         c
            922-1070            AD000864.1         30592-30740         c
            1071-1187           AD000864.1         24986-25102         c
            1188-1352           AD000864.1         24502-24666         c
            1353-2013           AD000864.1         22564-23224         c
FEATURES             Location/Qualifiers
     source          1..2013
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.12"
     gene            1..2013
                     /gene="NFKBID"
                     /gene_synonym="IkappaBNS; IkBNS; TA-NFKBH"
                     /note="NFKB inhibitor delta"
                     /db_xref="GeneID:84807"
                     /db_xref="HGNC:HGNC:15671"
                     /db_xref="MIM:618887"
     exon            1..99
                     /gene="NFKBID"
                     /gene_synonym="IkappaBNS; IkBNS; TA-NFKBH"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..1406
                     /gene="NFKBID"
                     /gene_synonym="IkappaBNS; IkBNS; TA-NFKBH"
                     /note="isoform 1 is encoded by transcript variant 1;
                     non-AUG (CUG) translation initiation codon; NF-kappa-B
                     inhibitor delta; T-cell activation NFKB-like protein;
                     ikB-delta; ikappaBdelta; I-kappa-B-delta; nuclear factor
                     of kappa light polypeptide gene enhancer in B-cells
                     inhibitor, delta"
                     /codon_start=1
                     /product="NF-kappa-B inhibitor delta isoform 1"
                     /protein_id="NP_640332.2"
                     /db_xref="GeneID:84807"
                     /db_xref="HGNC:HGNC:15671"
                     /db_xref="MIM:618887"
                     /translation="MAQRRGRGPGGPQSTPRNPRVSRGERSHCPTQTVKKLLEEQRRR
                     QQQQPDAGGVQGQFLPPPEQPLTPSVNEAVTGHPPFPAHSETVGSGPSSLGFPDWDPN
                     THAAYTDSPYSCPASAAENFLPPDFYPPSDPGQPCPFPQGMEAGPWRVSAPPSGPPQF
                     PAVVPGPSLEVARAHMLALGPQQLLAQDEEGDTLLHLFAARGLRWAAYAAAEVLQVYR
                     RLDIREHKGKTPLLVAAAANQPLIVEDLLNLGAEPNAADHQGRSVLHVAATYGLPGVL
                     LAVLNSGVQVDLEARDFEGLTPLHTAILALNVAMRPSDLCPRVLSTQARDRLDCVHML
                     LQMGANHTSQEIKSNKTVLHLAVQAANPTLVQLLLELPRGDLRTFVNMKAHGNTALHM
                     AAALPPGPAQEAIVRHLLAAGADPTLRNLENEQPVHLLRPGPGPEGLRQLLKRSRVAP
                     PGLSS"
     exon            100..203
                     /gene="NFKBID"
                     /gene_synonym="IkappaBNS; IkBNS; TA-NFKBH"
                     /inference="alignment:Splign:2.1.0"
     exon            204..264
                     /gene="NFKBID"
                     /gene_synonym="IkappaBNS; IkBNS; TA-NFKBH"
                     /inference="alignment:Splign:2.1.0"
     exon            265..470
                     /gene="NFKBID"
                     /gene_synonym="IkappaBNS; IkBNS; TA-NFKBH"
                     /inference="alignment:Splign:2.1.0"
     exon            471..616
                     /gene="NFKBID"
                     /gene_synonym="IkappaBNS; IkBNS; TA-NFKBH"
                     /inference="alignment:Splign:2.1.0"
     exon            617..722
                     /gene="NFKBID"
                     /gene_synonym="IkappaBNS; IkBNS; TA-NFKBH"
                     /inference="alignment:Splign:2.1.0"
     exon            723..869
                     /gene="NFKBID"
                     /gene_synonym="IkappaBNS; IkBNS; TA-NFKBH"
                     /inference="alignment:Splign:2.1.0"
     exon            870..921
                     /gene="NFKBID"
                     /gene_synonym="IkappaBNS; IkBNS; TA-NFKBH"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1070
                     /gene="NFKBID"
                     /gene_synonym="IkappaBNS; IkBNS; TA-NFKBH"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1187
                     /gene="NFKBID"
                     /gene_synonym="IkappaBNS; IkBNS; TA-NFKBH"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1352
                     /gene="NFKBID"
                     /gene_synonym="IkappaBNS; IkBNS; TA-NFKBH"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..2013
                     /gene="NFKBID"
                     /gene_synonym="IkappaBNS; IkBNS; TA-NFKBH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1992..1997
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NFKBID"
                     /gene_synonym="IkappaBNS; IkBNS; TA-NFKBH"
                     /note="hexamer: ATTAAA"
     polyA_site      2013
                     /gene="NFKBID"
                     /gene_synonym="IkappaBNS; IkBNS; TA-NFKBH"
                     /note="major polyA site"
ORIGIN      
        1 ggggacccgg cggcggctcc gcgggggaaa cagcgaggct ggcgcagcgc cgaggccgcg
       61 gccctggggg cccgcaatcc acgccacgga atccccgagt gagcaggggt gagcgcagcc
      121 actgcccaac gcaaaccgtg aagaagcttc tggaagagca gaggcgccgc cagcagcagc
      181 agcccgacgc tggcggggtg cagggacaat ttctccctcc cccagagcag cccctgaccc
      241 catctgtgaa tgaggctgtg actggccacc ctcccttccc agcacactcg gagactgtgg
      301 gttctggacc tagcagcctg ggctttccag actgggaccc caacacgcat gctgcctaca
      361 ctgacagccc ctactcttgc cctgcttctg ctgccgaaaa tttcctgcct cctgacttct
      421 acccaccctc ggacccaggg cagccgtgcc catttcccca gggcatggag gctggaccct
      481 ggagagtttc tgcaccccct tcaggacccc cacagttccc cgctgtggtc cctggaccat
      541 cgctggaggt ggcccgagct cacatgctgg ctttggggcc acagcagctg ctggcccagg
      601 atgaggaggg ggacacgctc cttcacctgt ttgcggctcg ggggctgcgc tgggcggcat
      661 atgctgcggc tgaggtgctc caggtgtacc ggcgtcttga cattcgtgag cataagggca
      721 agacccctct cctggtggcg gctgctgcca accagcccct gattgtggag gatctgttga
      781 acctgggagc agagcccaat gccgctgacc atcagggacg ttcggtcttg cacgtggccg
      841 ctacctacgg gctcccagga gttctcttgg ctgtgcttaa ctctggggtc caggttgacc
      901 tggaagccag agacttcgag ggcctcaccc cgctccacac ggccatcctg gcccttaacg
      961 ttgctatgcg cccttccgac ctctgtcccc gggtgctgag cacacaggcc cgagacaggc
     1021 tggattgtgt ccacatgttg ctgcaaatgg gtgctaatca caccagccag gagatcaaga
     1081 gcaacaagac agttctgcac ttggccgtgc aggctgccaa ccccactctg gttcagctgc
     1141 tgctggagct gccccgggga gacctgcgga cctttgtcaa catgaaggcc cacgggaaca
     1201 cagccctcca catggcggct gccctgcccc ctgggccggc ccaggaggcc atcgtgcggc
     1261 acctgttggc agctggggcg gaccccacac tgcgcaacct ggagaatgag cagcccgttc
     1321 acctgctgcg gcccgggccg ggccctgagg ggctccggca gctgttgaag aggagccgtg
     1381 tggcgccgcc aggcctgtcc tcttaggact caaacccaga ccctggactg attttccagt
     1441 ccccaccgtc ctgcgggaca gccagcgtat gctaatgttg caaacccatg ataatgtatg
     1501 tggaatatcc tgccattggg gttttacatt aaaaccccag aatggctgca gaggggtgaa
     1561 caggccccaa tatttggggt gctgtgatac ccctcttcta cccacaagga gccctcttga
     1621 tgatttctgt gaaatcgagg ccccttgatt gtttctgtga aacaccctgc acccctagtc
     1681 ctttccccac tgagatcttt cgggttctct cccctaactc agctcttcgt tcccagaaac
     1741 ccagatgtaa tccccctacg tggtgcttgg ggcatcccga taccatctca gtaaatctcc
     1801 tacaatggcc tcctcaccct ccccgggacc cacacccttc aggtcctcac cctgagacag
     1861 gagggaccct ctgagatcag ggacccttag gtctcactgc tctctgattc agagctcagc
     1921 tgggccccca gttccagacc ccagcattcc cggtcactcc ctccctaatc tgagcatcac
     1981 tcaagctctt tattaaactc aatttgggcc aga
//
