LOCUS       NM_002503               1192 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens NFKB inhibitor beta (NFKBIB), transcript variant 1,
            mRNA.
ACCESSION   NM_002503
VERSION     NM_002503.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1192)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 1192)
  AUTHORS   Goos,H., Kinnunen,M., Salokas,K., Tan,Z., Liu,X., Yadav,L.,
            Zhang,Q., Wei,G.H. and Varjosalo,M.
  TITLE     Human transcription factor protein interaction networks
  JOURNAL   Nat Commun 13 (1), 766 (2022)
   PUBMED   35140242
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1192)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1192)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 1192)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1192)
  AUTHORS   Suyang,H., Phillips,R., Douglas,I. and Ghosh,S.
  TITLE     Role of unphosphorylated, newly synthesized I kappa B beta in
            persistent activation of NF-kappa B
  JOURNAL   Mol Cell Biol 16 (10), 5444-5449 (1996)
   PUBMED   8816457
REFERENCE   7  (bases 1 to 1192)
  AUTHORS   Beauparlant,P., Kwon,H., Clarke,M., Lin,R., Sonenberg,N.,
            Wainberg,M. and Hiscott,J.
  TITLE     Transdominant mutants of I kappa B alpha block Tat-tumor necrosis
            factor synergistic activation of human immunodeficiency virus type
            1 gene expression and virus multiplication
  JOURNAL   J Virol 70 (9), 5777-5785 (1996)
   PUBMED   8709193
REFERENCE   8  (bases 1 to 1192)
  AUTHORS   DiDonato,J., Mercurio,F., Rosette,C., Wu-Li,J., Suyang,H., Ghosh,S.
            and Karin,M.
  TITLE     Mapping of the inducible IkappaB phosphorylation sites that signal
            its ubiquitination and degradation
  JOURNAL   Mol Cell Biol 16 (4), 1295-1304 (1996)
   PUBMED   8657102
REFERENCE   9  (bases 1 to 1192)
  AUTHORS   Harhaj,E., Blaney,J., Millhouse,S. and Sun,S.C.
  TITLE     Differential effects of I kappa B molecules on Tat-mediated
            transactivation of HIV-1 LTR
  JOURNAL   Virology 216 (1), 284-287 (1996)
   PUBMED   8615004
REFERENCE   10 (bases 1 to 1192)
  AUTHORS   Lee,J.W., Choi,H.S., Gyuris,J., Brent,R. and Moore,D.D.
  TITLE     Two classes of proteins dependent on either the presence or absence
            of thyroid hormone for interaction with the thyroid hormone
            receptor
  JOURNAL   Mol Endocrinol 9 (2), 243-254 (1995)
   PUBMED   7776974
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA633677.1, BC015528.1 and
            AI684894.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_002503.4.
            
            Summary: The protein encoded by this gene belongs to the NF-kappa-B
            inhibitor family, which inhibit NF-kappa-B by complexing with, and
            trapping it in the cytoplasm. Phosphorylation of serine residues on
            these proteins by kinases marks them for destruction via the
            ubiquitination pathway, thereby allowing activation of the
            NF-kappa-B, which translocates to the nucleus to function as a
            transcription factor. Alternatively spliced transcript variants
            have been found for this gene.[provided by RefSeq, Jul 2011].
            
            Transcript Variant: This variant (1) represents the predominant
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.297667.1,
                                           SRR1163655.559868.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000313582.6/ ENSP00000312988.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                DA633677.1         62-91
            31-1189             BC015528.1         1-1159
            1190-1192           AI684894.1         13-15               c
FEATURES             Location/Qualifiers
     source          1..1192
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..1192
                     /gene="NFKBIB"
                     /gene_synonym="IKBB; TRIP9"
                     /note="NFKB inhibitor beta"
                     /db_xref="GeneID:4793"
                     /db_xref="HGNC:HGNC:7798"
                     /db_xref="MIM:604495"
     exon            1..243
                     /gene="NFKBIB"
                     /gene_synonym="IKBB; TRIP9"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..1135
                     /gene="NFKBIB"
                     /gene_synonym="IKBB; TRIP9"
                     /note="isoform 1 is encoded by transcript variant 1;
                     NF-kappa-B inhibitor beta; ikB-B; nuclear factor of kappa
                     light polypeptide gene enhancer in B-cells inhibitor,
                     beta; TRIP-9; ikB-beta; ikappaBbeta; NF-kappa-BIB;
                     I-kappa-B-beta; TR-interacting protein 9; thyroid
                     receptor-interacting protein 9"
                     /codon_start=1
                     /product="NF-kappa-B inhibitor beta isoform 1"
                     /protein_id="NP_002494.2"
                     /db_xref="CCDS:CCDS12524.1"
                     /db_xref="GeneID:4793"
                     /db_xref="HGNC:HGNC:7798"
                     /db_xref="MIM:604495"
                     /translation="MAGVACLGKAADADEWCDSGLGSLGPDAAAPGGPGLGAELGPGL
                     SWAPLVFGYVTEDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAA
                     ILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDT
                     YLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHK
                     DVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRT
                     PLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGPCSSSSDSDSGDEGDEYDDIVVHSS
                     RSQTRLPPTPASKPLPDDPRPV"
     exon            244..349
                     /gene="NFKBIB"
                     /gene_synonym="IKBB; TRIP9"
                     /inference="alignment:Splign:2.1.0"
     exon            350..683
                     /gene="NFKBIB"
                     /gene_synonym="IKBB; TRIP9"
                     /inference="alignment:Splign:2.1.0"
     exon            684..772
                     /gene="NFKBIB"
                     /gene_synonym="IKBB; TRIP9"
                     /inference="alignment:Splign:2.1.0"
     exon            773..1033
                     /gene="NFKBIB"
                     /gene_synonym="IKBB; TRIP9"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1192
                     /gene="NFKBIB"
                     /gene_synonym="IKBB; TRIP9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1171..1176
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NFKBIB"
                     /gene_synonym="IKBB; TRIP9"
                     /note="hexamer: AACAAA"
     polyA_site      1192
                     /gene="NFKBIB"
                     /gene_synonym="IKBB; TRIP9"
                     /note="major polyA site"
ORIGIN      
        1 gaactcccgg caaagcccag ctacaggcgg gcgactgcgg ggggcccctg aggcggcggg
       61 ggccatggct ggggtcgcgt gcttgggaaa agctgccgac gcagatgaat ggtgcgacag
      121 cggcctgggc tccctgggtc cggacgcagc ggcccccgga ggacctgggt tgggcgcgga
      181 gttgggcccg gggctgtcgt gggctcccct cgtcttcggc tacgtcactg aggatgggga
      241 cacggcactg cacttggctg tgattcatca gcatgaaccc ttcctggatt ttcttctagg
      301 cttctcggcc ggcactgagt acatggacct gcagaatgac ctaggccaga cagccctgca
      361 cctggcagcc atcctggggg agacatccac ggtggagaag ctgtacgcag caggcgccgg
      421 gctgtgtgtg gcggagcgta ggggccacac ggcgctgcac ctggcctgcc gtgtgggggc
      481 acacgcctgt gcccgtgccc tgcttcagcc ccgcccccgg cgccccaggg aagcccccga
      541 cacctacctc gctcagggcc ctgaccgtac tcccgacacc aaccataccc ctgtcgcctt
      601 gtaccccgat tccgacttgg agaaggaaga agaggagagt gaggaggact ggaagctgca
      661 gctggaggct gaaaactacg agggccacac cccactccac gtggccgtta tccacaaaga
      721 tgtggagatg gtccggctgc tccgagatgc tggagctgac cttgacaaac cggagcccac
      781 gtgcggccgg agcccccttc atttggcagt ggaggcccag gcagccgatg tgctggagct
      841 tctcctgagg gcaggcgcga accctgctgc ccgcatgtac ggtggccgca ccccactcgg
      901 cagtgccatg ctccggccca accccatcct cgcccgcctc ctccgtgcac acggagcccc
      961 tgagcccgag ggcgaggacg agaaatccgg cccctgcagc agcagtagcg acagcgacag
     1021 cggagacgag ggcgatgaat acgacgacat tgtggttcac agcagccgca gccaaacccg
     1081 gctgcctccc accccagcct caaaacctct tcctgacgac ccccgccccg tgtgatttgt
     1141 ttcattgtta atataatttc cagtttaata aacaaaaccc tagttctgac aa
//
