LOCUS       NM_001369700             916 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens NFKB inhibitor beta (NFKBIB), transcript variant 5,
            mRNA.
ACCESSION   NM_001369700
VERSION     NM_001369700.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 916)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 916)
  AUTHORS   Goos,H., Kinnunen,M., Salokas,K., Tan,Z., Liu,X., Yadav,L.,
            Zhang,Q., Wei,G.H. and Varjosalo,M.
  TITLE     Human transcription factor protein interaction networks
  JOURNAL   Nat Commun 13 (1), 766 (2022)
   PUBMED   35140242
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 916)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 916)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 916)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 916)
  AUTHORS   Suyang,H., Phillips,R., Douglas,I. and Ghosh,S.
  TITLE     Role of unphosphorylated, newly synthesized I kappa B beta in
            persistent activation of NF-kappa B
  JOURNAL   Mol Cell Biol 16 (10), 5444-5449 (1996)
   PUBMED   8816457
REFERENCE   7  (bases 1 to 916)
  AUTHORS   Beauparlant,P., Kwon,H., Clarke,M., Lin,R., Sonenberg,N.,
            Wainberg,M. and Hiscott,J.
  TITLE     Transdominant mutants of I kappa B alpha block Tat-tumor necrosis
            factor synergistic activation of human immunodeficiency virus type
            1 gene expression and virus multiplication
  JOURNAL   J Virol 70 (9), 5777-5785 (1996)
   PUBMED   8709193
REFERENCE   8  (bases 1 to 916)
  AUTHORS   DiDonato,J., Mercurio,F., Rosette,C., Wu-Li,J., Suyang,H., Ghosh,S.
            and Karin,M.
  TITLE     Mapping of the inducible IkappaB phosphorylation sites that signal
            its ubiquitination and degradation
  JOURNAL   Mol Cell Biol 16 (4), 1295-1304 (1996)
   PUBMED   8657102
REFERENCE   9  (bases 1 to 916)
  AUTHORS   Harhaj,E., Blaney,J., Millhouse,S. and Sun,S.C.
  TITLE     Differential effects of I kappa B molecules on Tat-mediated
            transactivation of HIV-1 LTR
  JOURNAL   Virology 216 (1), 284-287 (1996)
   PUBMED   8615004
REFERENCE   10 (bases 1 to 916)
  AUTHORS   Lee,J.W., Choi,H.S., Gyuris,J., Brent,R. and Moore,D.D.
  TITLE     Two classes of proteins dependent on either the presence or absence
            of thyroid hormone for interaction with the thyroid hormone
            receptor
  JOURNAL   Mol Endocrinol 9 (2), 243-254 (1995)
   PUBMED   7776974
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC011455.6.
            
            Summary: The protein encoded by this gene belongs to the NF-kappa-B
            inhibitor family, which inhibit NF-kappa-B by complexing with, and
            trapping it in the cytoplasm. Phosphorylation of serine residues on
            these proteins by kinases marks them for destruction via the
            ubiquitination pathway, thereby allowing activation of the
            NF-kappa-B, which translocates to the nucleus to function as a
            transcription factor. Alternatively spliced transcript variants
            have been found for this gene.[provided by RefSeq, Jul 2011].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.328360.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145893, SAMEA2148874
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-243               AC011455.6         53128-53370
            244-349             AC011455.6         58174-58279
            350-407             AC011455.6         58637-58694
            408-496             AC011455.6         60380-60468
            497-757             AC011455.6         60558-60818
            758-916             AC011455.6         61890-62048
FEATURES             Location/Qualifiers
     source          1..916
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..916
                     /gene="NFKBIB"
                     /gene_synonym="IKBB; TRIP9"
                     /note="NFKB inhibitor beta"
                     /db_xref="GeneID:4793"
                     /db_xref="HGNC:HGNC:7798"
                     /db_xref="MIM:604495"
     exon            1..243
                     /gene="NFKBIB"
                     /gene_synonym="IKBB; TRIP9"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..859
                     /gene="NFKBIB"
                     /gene_synonym="IKBB; TRIP9"
                     /note="isoform 4 is encoded by transcript variant 5;
                     NF-kappa-B inhibitor beta; ikB-B; nuclear factor of kappa
                     light polypeptide gene enhancer in B-cells inhibitor,
                     beta; TRIP-9; ikB-beta; ikappaBbeta; NF-kappa-BIB;
                     I-kappa-B-beta; TR-interacting protein 9; thyroid
                     receptor-interacting protein 9"
                     /codon_start=1
                     /product="NF-kappa-B inhibitor beta isoform 4"
                     /protein_id="NP_001356629.1"
                     /db_xref="GeneID:4793"
                     /db_xref="HGNC:HGNC:7798"
                     /db_xref="MIM:604495"
                     /translation="MAGVACLGKAADADEWCDSGLGSLGPDAAAPGGPGLGAELGPGL
                     SWAPLVFGYVTEDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQEEEESEE
                     DWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQ
                     AADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGP
                     CSSSSDSDSGDEGDEYDDIVVHSSRSQTRLPPTPASKPLPDDPRPV"
     exon            244..349
                     /gene="NFKBIB"
                     /gene_synonym="IKBB; TRIP9"
                     /inference="alignment:Splign:2.1.0"
     exon            350..407
                     /gene="NFKBIB"
                     /gene_synonym="IKBB; TRIP9"
                     /inference="alignment:Splign:2.1.0"
     exon            408..496
                     /gene="NFKBIB"
                     /gene_synonym="IKBB; TRIP9"
                     /inference="alignment:Splign:2.1.0"
     exon            497..757
                     /gene="NFKBIB"
                     /gene_synonym="IKBB; TRIP9"
                     /inference="alignment:Splign:2.1.0"
     exon            758..916
                     /gene="NFKBIB"
                     /gene_synonym="IKBB; TRIP9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      895..900
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NFKBIB"
                     /gene_synonym="IKBB; TRIP9"
                     /note="hexamer: AACAAA"
     polyA_site      916
                     /gene="NFKBIB"
                     /gene_synonym="IKBB; TRIP9"
                     /note="major polyA site"
ORIGIN      
        1 gaactcccgg caaagcccag ctacaggcgg gcgactgcgg ggggcccctg aggcggcggg
       61 ggccatggct ggggtcgcgt gcttgggaaa agctgccgac gcagatgaat ggtgcgacag
      121 cggcctgggc tccctgggtc cggacgcagc ggcccccgga ggacctgggt tgggcgcgga
      181 gttgggcccg gggctgtcgt gggctcccct cgtcttcggc tacgtcactg aggatgggga
      241 cacggcactg cacttggctg tgattcatca gcatgaaccc ttcctggatt ttcttctagg
      301 cttctcggcc ggcactgagt acatggacct gcagaatgac ctaggccagg aagaagagga
      361 gagtgaggag gactggaagc tgcagctgga ggctgaaaac tacgagggcc acaccccact
      421 ccacgtggcc gttatccaca aagatgtgga gatggtccgg ctgctccgag atgctggagc
      481 tgaccttgac aaaccggagc ccacgtgcgg ccggagcccc cttcatttgg cagtggaggc
      541 ccaggcagcc gatgtgctgg agcttctcct gagggcaggc gcgaaccctg ctgcccgcat
      601 gtacggtggc cgcaccccac tcggcagtgc catgctccgg cccaacccca tcctcgcccg
      661 cctcctccgt gcacacggag cccctgagcc cgagggcgag gacgagaaat ccggcccctg
      721 cagcagcagt agcgacagcg acagcggaga cgagggcgat gaatacgacg acattgtggt
      781 tcacagcagc cgcagccaaa cccggctgcc tcccacccca gcctcaaaac ctcttcctga
      841 cgacccccgc cccgtgtgat ttgtttcatt gttaatataa tttccagttt aataaacaaa
      901 accctagttc tgacaa
//
