LOCUS       NM_020529               1559 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens NFKB inhibitor alpha (NFKBIA), mRNA.
ACCESSION   NM_020529
VERSION     NM_020529.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1559)
  AUTHORS   Vazquez-Coto,D., Perez-Oliveira,S., Menendez-Gonzalez,M., Coto,E.
            and Alvarez,V.
  TITLE     Assessing the association between common functional Nuclear Factor
            Kappa-b gene polymorphisms (NFKB1, NFKBIZ, NFKBIA) and Alzheimer s
            disease
  JOURNAL   Behav Brain Res 476, 115264 (2025)
   PUBMED   39322062
  REMARK    GeneRIF: Assessing the association between common functional
            Nuclear Factor Kappa-b gene polymorphisms (NFKB1, NFKBIZ, NFKBIA)
            and Alzheimer s disease.
REFERENCE   2  (bases 1 to 1559)
  AUTHORS   Simoneau,C.R., Chen,P.Y., Xing,G.K., Hayashi,J.M., Chen,I.P.,
            Khalid,M.M., Meyers,N.L., Taha,T.Y., Leon,K.E., Suryawanshi,R.K.,
            McCavitt-Malvido,M., Ashuach,T., Fontaine,K.A., Rodriguez,L.,
            Joehnk,B., Walcott,K., Vasudevan,S., Fang,X., Maishan,M.,
            Schultz,S., Roose,J.P., Matthay,M.A., Sil,A., Arjomandi,M.,
            Yosef,N. and Ott,M.
  TITLE     NF-kappaB inhibitor alpha controls SARS-CoV-2 infection in
            ACE2-overexpressing human airway organoids
  JOURNAL   Sci Rep 14 (1), 15351 (2024)
   PUBMED   38961189
  REMARK    GeneRIF: NF-kappaB inhibitor alpha controls SARS-CoV-2 infection in
            ACE2-overexpressing human airway organoids.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1559)
  AUTHORS   Niu,Z., Qu,S.T., Zhang,L., Dai,J.H., Wang,K., Liu,Y., Chen,L.,
            Song,Y., Sun,R., Xu,Z.H. and Zhang,H.L.
  TITLE     Trim14-IkappaBalpha Signaling Regulates Chronic Inflammatory Pain
            in Rats and Osteoarthritis Patients
  JOURNAL   Neuroscience 548, 39-49 (2024)
   PUBMED   38697463
  REMARK    GeneRIF: Trim14-IkappaBalpha Signaling Regulates Chronic
            Inflammatory Pain in Rats and Osteoarthritis Patients.
REFERENCE   4  (bases 1 to 1559)
  AUTHORS   He,Y., Shi,Q., Ling,Y., Guo,H., Fei,Y., Wu,R., Tang,C., Zhang,X.
            and Yao,L.
  TITLE     ABLIM1, a novel ubiquitin E3 ligase, promotes growth and metastasis
            of colorectal cancer through targeting IkBalpha ubiquitination and
            activating NF-kB signaling
  JOURNAL   Cell Death Differ 31 (2), 203-216 (2024)
   PUBMED   38228802
  REMARK    GeneRIF: ABLIM1, a novel ubiquitin E3 ligase, promotes growth and
            metastasis of colorectal cancer through targeting IkBalpha
            ubiquitination and activating NF-kB signaling.
REFERENCE   5  (bases 1 to 1559)
  AUTHORS   Wu,J. and Yan,Y.
  TITLE     SIAH1 Promotes the Pyroptosis of Cardiomyocytes in Diabetic
            Cardiomyopathy via Regulating IkappaB-alpha/NF-kappacapital VE,
            Cyrillic Signaling
  JOURNAL   Crit Rev Eukaryot Gene Expr 34 (5), 45-57 (2024)
   PUBMED   38842203
  REMARK    GeneRIF: SIAH1 Promotes the Pyroptosis of Cardiomyocytes in
            Diabetic Cardiomyopathy via Regulating
            IkappaB-alpha/NF-kappacapital VE, Cyrillic Signaling.
REFERENCE   6  (bases 1 to 1559)
  AUTHORS   Scherer,D.C., Brockman,J.A., Chen,Z., Maniatis,T. and Ballard,D.W.
  TITLE     Signal-induced degradation of I kappa B alpha requires
            site-specific ubiquitination
  JOURNAL   Proc Natl Acad Sci U S A 92 (24), 11259-11263 (1995)
   PUBMED   7479976
REFERENCE   7  (bases 1 to 1559)
  AUTHORS   Ganchi,P.A., Sun,S.C., Greene,W.C. and Ballard,D.W.
  TITLE     I kappa B/MAD-3 masks the nuclear localization signal of NF-kappa B
            p65 and requires the transactivation domain to inhibit NF-kappa B
            p65 DNA binding
  JOURNAL   Mol Biol Cell 3 (12), 1339-1352 (1992)
   PUBMED   1493333
REFERENCE   8  (bases 1 to 1559)
  AUTHORS   Le Beau,M.M., Ito,C., Cogswell,P., Espinosa,R. 3rd, Fernald,A.A.
            and Baldwin,A.S. Jr.
  TITLE     Chromosomal localization of the genes encoding the p50/p105
            subunits of NF-kappa B (NFKB2) and the I kappa B/MAD-3 (NFKBI)
            inhibitor of NF-kappa B to 4q24 and 14q13, respectively
  JOURNAL   Genomics 14 (2), 529-531 (1992)
   PUBMED   1427874
REFERENCE   9  (bases 1 to 1559)
  AUTHORS   Haskill,S., Beg,A.A., Tompkins,S.M., Morris,J.S., Yurochko,A.D.,
            Sampson-Johannes,A., Mondal,K., Ralph,P. and Baldwin,A.S. Jr.
  TITLE     Characterization of an immediate-early gene induced in adherent
            monocytes that encodes I kappa B-like activity
  JOURNAL   Cell 65 (7), 1281-1289 (1991)
   PUBMED   1829648
REFERENCE   10 (bases 1 to 1559)
  AUTHORS   Baeuerle,P.A. and Baltimore,D.
  TITLE     I kappa B: a specific inhibitor of the NF-kappa B transcription
            factor
  JOURNAL   Science 242 (4878), 540-546 (1988)
   PUBMED   3140380
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL133163.3 and BC004983.1.
            
            On Dec 4, 2019 this sequence version replaced NM_020529.2.
            
            Summary: This gene encodes a member of the NF-kappa-B inhibitor
            family, which contain multiple ankrin repeat domains. The encoded
            protein interacts with REL dimers to inhibit NF-kappa-B/REL
            complexes which are involved in inflammatory responses. The encoded
            protein moves between the cytoplasm and the nucleus via a nuclear
            localization signal and CRM1-mediated nuclear export. Mutations in
            this gene have been found in ectodermal dysplasia anhidrotic with
            T-cell immunodeficiency autosomal dominant disease. [provided by
            RefSeq, Aug 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC004983.1, SRR11853565.8745.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000216797.10/ ENSP00000216797.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AL133163.3         104527-104538       c
            13-410              BC004983.1         1-398
            411-411             AL133163.3         103509-103509       c
            412-1559            BC004983.1         400-1547
FEATURES             Location/Qualifiers
     source          1..1559
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q13.2"
     gene            1..1559
                     /gene="NFKBIA"
                     /gene_synonym="EDAID2; IKBA; MAD-3; NFKBI"
                     /note="NFKB inhibitor alpha"
                     /db_xref="GeneID:4792"
                     /db_xref="HGNC:HGNC:7797"
                     /db_xref="MIM:164008"
     exon            1..332
                     /gene="NFKBIA"
                     /gene_synonym="EDAID2; IKBA; MAD-3; NFKBI"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..1059
                     /gene="NFKBIA"
                     /gene_synonym="EDAID2; IKBA; MAD-3; NFKBI"
                     /note="nuclear factor of kappa light chain gene enhancer
                     in B-cells; IkappaBalpha; major histocompatibility complex
                     enhancer-binding protein MAD3; ikB-alpha; I-kappa-B-alpha;
                     nuclear factor of kappa light polypeptide gene enhancer in
                     B-cells inhibitor, alpha"
                     /codon_start=1
                     /product="NF-kappa-B inhibitor alpha"
                     /protein_id="NP_065390.1"
                     /db_xref="CCDS:CCDS9656.1"
                     /db_xref="GeneID:4792"
                     /db_xref="HGNC:HGNC:7797"
                     /db_xref="MIM:164008"
                     /translation="MFQAAERPQEWAMEGPRDGLKKERLLDDRHDSGLDSMKDEEYEQ
                     MVKELQEIRLEPQEVPRGSEPWKQQLTEDGDSFLHLAIIHEEKALTMEVIRQVKGDLA
                     FLNFQNNLQQTPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASV
                     GVLTQSCTTPHLHSILKATNYNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGR
                     TALHLAVDLQNPDLVSLLLKCGADVNRVTYQGYSPYQLTWGRPSTRIQQQLGQLTLEN
                     LQMLPESEDEESYDTESEFTEFTEDELPYDDCVFGGQRLTL"
     exon            333..441
                     /gene="NFKBIA"
                     /gene_synonym="EDAID2; IKBA; MAD-3; NFKBI"
                     /inference="alignment:Splign:2.1.0"
     exon            442..652
                     /gene="NFKBIA"
                     /gene_synonym="EDAID2; IKBA; MAD-3; NFKBI"
                     /inference="alignment:Splign:2.1.0"
     exon            653..741
                     /gene="NFKBIA"
                     /gene_synonym="EDAID2; IKBA; MAD-3; NFKBI"
                     /inference="alignment:Splign:2.1.0"
     exon            742..1011
                     /gene="NFKBIA"
                     /gene_synonym="EDAID2; IKBA; MAD-3; NFKBI"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1559
                     /gene="NFKBIA"
                     /gene_synonym="EDAID2; IKBA; MAD-3; NFKBI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1540..1545
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NFKBIA"
                     /gene_synonym="EDAID2; IKBA; MAD-3; NFKBI"
                     /note="hexamer: ATTAAA"
     polyA_site      1559
                     /gene="NFKBIA"
                     /gene_synonym="EDAID2; IKBA; MAD-3; NFKBI"
                     /note="major polyA site"
ORIGIN      
        1 acagcagtcc gtgccgccgt cccgcccgcc agcgccccag cgaggaagca gcgcgcagcc
       61 cgcggcccag cgcacccgca gcagcgcccg cagctcgtcc gcgccatgtt ccaggcggcc
      121 gagcgccccc aggagtgggc catggagggc ccccgcgacg ggctgaagaa ggagcggcta
      181 ctggacgacc gccacgacag cggcctggac tccatgaaag acgaggagta cgagcagatg
      241 gtcaaggagc tgcaggagat ccgcctcgag ccgcaggagg tgccgcgcgg ctcggagccc
      301 tggaagcagc agctcaccga ggacggggac tcgttcctgc acttggccat catccatgaa
      361 gaaaaggcac tgaccatgga agtgatccgc caggtgaagg gagacctggc cttcctcaac
      421 ttccagaaca acctgcagca gactccactc cacttggctg tgatcaccaa ccagccagaa
      481 attgctgagg cacttctggg agctggctgt gatcctgagc tccgagactt tcgaggaaat
      541 acccccctac accttgcctg tgagcagggc tgcctggcca gcgtgggagt cctgactcag
      601 tcctgcacca ccccgcacct ccactccatc ctgaaggcta ccaactacaa tggccacacg
      661 tgtctacact tagcctctat ccatggctac ctgggcatcg tggagctttt ggtgtccttg
      721 ggtgctgatg tcaatgctca ggagccctgt aatggccgga ctgcccttca cctcgcagtg
      781 gacctgcaaa atcctgacct ggtgtcactc ctgttgaagt gtggggctga tgtcaacaga
      841 gttacctacc agggctattc tccctaccag ctcacctggg gccgcccaag cacccggata
      901 cagcagcagc tgggccagct gacactagaa aaccttcaga tgctgccaga gagtgaggat
      961 gaggagagct atgacacaga gtcagagttc acggagttca cagaggacga gctgccctat
     1021 gatgactgtg tgtttggagg ccagcgtctg acgttatgag cgcaaagggg ctgaaagaac
     1081 atggacttgt atatttgtac aaaaaaaaag ttttattttt ctaaaaaaag aaaaaagaag
     1141 aaaaaattta aagggtgtac ttatatccac actgcacact gcctggccca aaacgtctta
     1201 ttgtggtagg atcagccctc attttgttgc ttttgtgaac tttttgtagg ggacgagaaa
     1261 gatcattgaa attctgagaa aacttctttt aaacctcacc tttgtggggt ttttggagaa
     1321 ggttatcaaa aatttcatgg aaggaccaca ttttatattt attgtgcttc gagtgactga
     1381 ccccagtggt atcctgtgac atgtaacagc caggagtgtt aagcgttcag tgatgtgggg
     1441 tgaaaagtta ctacctgtca aggtttgtgt taccctcctg taaatggtgt acataatgta
     1501 ttgttggtaa ttattttggt acttttatga tgtatattta ttaaacagat ttttacaaa
//
