LOCUS       NM_001322934            3015 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens nuclear factor kappa B subunit 2 (NFKB2), transcript
            variant 5, mRNA.
ACCESSION   NM_001322934 XM_005269860
VERSION     NM_001322934.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3015)
  AUTHORS   De Paolis,V., Troisi,V., Bordin,A., Pagano,F., Caputo,V. and
            Parisi,C.
  TITLE     Unconventional p65/p52 NF-kappaB module regulates key tumor
            microenvironment-related genes in breast tumor-associated
            macrophages (TAMs)
  JOURNAL   Life Sci 357, 123059 (2024)
   PUBMED   39278618
  REMARK    GeneRIF: Unconventional p65/p52 NF-kappaB module regulates key
            tumor microenvironment-related genes in breast tumor-associated
            macrophages (TAMs).
REFERENCE   2  (bases 1 to 3015)
  AUTHORS   Yu,X., Zhao,P., Luo,Q., Wu,X., Wang,Y., Nan,Y., Liu,S., Gao,W.,
            Li,B., Liu,Z. and Cui,Z.
  TITLE     RUNX1-IT1 acts as a scaffold of STAT1 and NuRD complex to promote
            ROS-mediated NF-kappaB activation and ovarian cancer progression
  JOURNAL   Oncogene 43 (6), 420-433 (2024)
   PUBMED   38092960
  REMARK    GeneRIF: RUNX1-IT1 acts as a scaffold of STAT1 and NuRD complex to
            promote ROS-mediated NF-kappaB activation and ovarian cancer
            progression.
REFERENCE   3  (bases 1 to 3015)
  AUTHORS   Vallabhapurapu,S. and Karin,M.
  TITLE     Regulation and function of NF-kappaB transcription factors in the
            immune system
  JOURNAL   Annu Rev Immunol 27, 693-733 (2009)
   PUBMED   19302050
  REMARK    Review article
REFERENCE   4  (bases 1 to 3015)
  AUTHORS   Heusch,M., Lin,L., Geleziunas,R. and Greene,W.C.
  TITLE     The generation of nfkb2 p52: mechanism and efficiency
  JOURNAL   Oncogene 18 (46), 6201-6208 (1999)
   PUBMED   10597218
REFERENCE   5  (bases 1 to 3015)
  AUTHORS   Lombardi,L., Ciana,P., Cappellini,C., Trecca,D., Guerrini,L.,
            Migliazza,A., Maiolo,A.T. and Neri,A.
  TITLE     Structural and functional characterization of the promoter regions
            of the NFKB2 gene
  JOURNAL   Nucleic Acids Res 23 (12), 2328-2336 (1995)
   PUBMED   7541912
REFERENCE   6  (bases 1 to 3015)
  AUTHORS   Liptay,S., Schmid,R.M., Nabel,E.G. and Nabel,G.J.
  TITLE     Transcriptional regulation of NF-kappa B2: evidence for kappa
            B-mediated positive and negative autoregulation
  JOURNAL   Mol Cell Biol 14 (12), 7695-7703 (1994)
   PUBMED   7969113
REFERENCE   7  (bases 1 to 3015)
  AUTHORS   Potter,D.A., Larson,C.J., Eckes,P., Schmid,R.M., Nabel,G.J.,
            Verdine,G.L. and Sharp,P.A.
  TITLE     Purification of the major histocompatibility complex class I
            transcription factor H2TF1. The full-length product of the nfkb2
            gene
  JOURNAL   J Biol Chem 268 (25), 18882-18890 (1993)
   PUBMED   8360178
REFERENCE   8  (bases 1 to 3015)
  AUTHORS   Bours,V., Burd,P.R., Brown,K., Villalobos,J., Park,S., Ryseck,R.P.,
            Bravo,R., Kelly,K. and Siebenlist,U.
  TITLE     A novel mitogen-inducible gene product related to p50/p105-NF-kappa
            B participates in transactivation through a kappa B site
  JOURNAL   Mol Cell Biol 12 (2), 685-695 (1992)
   PUBMED   1531086
REFERENCE   9  (bases 1 to 3015)
  AUTHORS   Schreck,R., Albermann,K. and Baeuerle,P.A.
  TITLE     Nuclear factor kappa B: an oxidative stress-responsive
            transcription factor of eukaryotic cells (a review)
  JOURNAL   Free Radic Res Commun 17 (4), 221-237 (1992)
   PUBMED   1473734
  REMARK    Review article
REFERENCE   10 (bases 1 to 3015)
  AUTHORS   Schmid,R.M., Perkins,N.D., Duckett,C.S., Andrews,P.C. and
            Nabel,G.J.
  TITLE     Cloning of an NF-kappa B subunit which stimulates HIV transcription
            in synergy with p65
  JOURNAL   Nature 352 (6337), 733-736 (1991)
   PUBMED   1876189
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL121928.13, KT935449.1 and
            AK098415.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jan 11, 2019 this sequence version replaced NM_001322934.1.
            
            Summary: This gene encodes a subunit of the transcription factor
            complex nuclear factor-kappa-B (NFkB). The NFkB complex is
            expressed in numerous cell types and functions as a central
            activator of genes involved in inflammation and immune function.
            The protein encoded by this gene can function as both a
            transcriptional activator or repressor depending on its
            dimerization partner. The p100 full-length protein is
            co-translationally processed into a p52 active form. Chromosomal
            rearrangements and translocations of this locus have been observed
            in B cell lymphomas, some of which may result in the formation of
            fusion proteins. There is a pseudogene for this gene on chromosome
            18. Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Dec 2013].
            
            Transcript Variant: This variant (5) and variant 1 both encode the
            same isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1966682,
                              SAMEA1968189 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000661543.1/ ENSP00000499294.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-92                AL121928.13        41071-41162
            93-164              AL121928.13        41254-41325
            165-2726            KT935449.1         1-2562
            2727-3014           AK098415.1         1709-1996
            3015-3015           AL121928.13        47890-47890
FEATURES             Location/Qualifiers
     source          1..3015
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.32"
     gene            1..3015
                     /gene="NFKB2"
                     /gene_synonym="CVID10; H2TF1; LYT-10; LYT10; NF-kB2; p100;
                     p49/p100; p52"
                     /note="nuclear factor kappa B subunit 2"
                     /db_xref="GeneID:4791"
                     /db_xref="HGNC:HGNC:7795"
                     /db_xref="MIM:164012"
     exon            1..92
                     /gene="NFKB2"
                     /gene_synonym="CVID10; H2TF1; LYT-10; LYT10; NF-kB2; p100;
                     p49/p100; p52"
                     /inference="alignment:Splign:2.1.0"
     exon            93..185
                     /gene="NFKB2"
                     /gene_synonym="CVID10; H2TF1; LYT-10; LYT10; NF-kB2; p100;
                     p49/p100; p52"
                     /inference="alignment:Splign:2.1.0"
     CDS             165..2867
                     /gene="NFKB2"
                     /gene_synonym="CVID10; H2TF1; LYT-10; LYT10; NF-kB2; p100;
                     p49/p100; p52"
                     /note="isoform a is encoded by transcript variant 5;
                     nuclear factor NF-kappa-B p100 subunit; oncogene Lyt-10;
                     DNA-binding factor KBF2; lymphocyte translocation
                     chromosome 10 protein; transcription factor NFKB2; NFKB,
                     p52/p100 subunit; nuclear factor Kappa-B, subunit 2;
                     nuclear factor of kappa light polypeptide gene enhancer in
                     B-cells 2 (p49/p100); nuclear factor of Kappa light chain
                     gene enhancer in B cells 2; nuclear factor NF-kappa-B p52
                     subunit"
                     /codon_start=1
                     /product="nuclear factor NF-kappa-B p100 subunit isoform
                     a"
                     /protein_id="NP_001309863.1"
                     /db_xref="CCDS:CCDS41564.1"
                     /db_xref="GeneID:4791"
                     /db_xref="HGNC:HGNC:7795"
                     /db_xref="MIM:164012"
                     /translation="MESCYNPGLDGIIEYDDFKLNSSIVEPKEPAPETADGPYLVIVE
                     QPKQRGFRFRYGCEGPSHGGLPGASSEKGRKTYPTVKICNYEGPAKIEVDLVTHSDPP
                     RAHAHSLVGKQCSELGICAVSVGPKDMTAQFNNLGVLHVTKKNMMGTMIQKLQRQRLR
                     SRPQGLTEAEQRELEQEAKELKKVMDLSIVRLRFSAFLRASDGSFSLPLKPVISQPIH
                     DSKSPGASNLKISRMDKTAGSVRGGDEVYLLCDKVQKDDIEVRFYEDDENGWQAFGDF
                     SPTDVHKQYAIVFRTPPYHKMKIERPVTVFLQLKRKRGGDVSDSKQFTYYPLVEDKEE
                     VQRKRRKALPTFSQPFGGGSHMGGGSGGAAGGYGGAGGGGSLGFFPSSLAYSPYQSGA
                     GPMGCYPGGGGGAQMAATVPSRDSGEEAAEPSAPSRTPQCEPQAPEMLQRAREYNARL
                     FGLAQRSARALLDYGVTADARALLAGQRHLLTAQDENGDTPLHLAIIHGQTSVIEQIV
                     YVIHHAQDLGVVNLTNHLHQTPLHLAVITGQTSVVSFLLRVGADPALLDRHGDSAMHL
                     ALRAGAGAPELLRALLQSGAPAVPQLLHMPDFEGLYPVHLAVRARSPECLDLLVDSGA
                     EVEATERQGGRTALHLATEMEELGLVTHLVTKLRANVNARTFAGNTPLHLAAGLGYPT
                     LTRLLLKAGADIHAENEEPLCPLPSPPTSDSDSDSEGPEKDTRSSFRGHTPLDLTCST
                     KVKTLLLNAAQNTMEPPLTPPSPAGPGLSLGDTALQNLEQLLDGPEAQGSWAELAERL
                     GLRSLVDTYRQTTSPSGSLLRSYELAGGDLAGLLEALSDMGLEEGVRLLRGPETRDKL
                     PSTAEVKEDSAYGSQSVEQEAEKLGPPPEPPGGLCHGHPQPQVH"
     exon            186..267
                     /gene="NFKB2"
                     /gene_synonym="CVID10; H2TF1; LYT-10; LYT10; NF-kB2; p100;
                     p49/p100; p52"
                     /inference="alignment:Splign:2.1.0"
     exon            268..308
                     /gene="NFKB2"
                     /gene_synonym="CVID10; H2TF1; LYT-10; LYT10; NF-kB2; p100;
                     p49/p100; p52"
                     /inference="alignment:Splign:2.1.0"
     exon            309..407
                     /gene="NFKB2"
                     /gene_synonym="CVID10; H2TF1; LYT-10; LYT10; NF-kB2; p100;
                     p49/p100; p52"
                     /inference="alignment:Splign:2.1.0"
     exon            408..559
                     /gene="NFKB2"
                     /gene_synonym="CVID10; H2TF1; LYT-10; LYT10; NF-kB2; p100;
                     p49/p100; p52"
                     /inference="alignment:Splign:2.1.0"
     exon            560..666
                     /gene="NFKB2"
                     /gene_synonym="CVID10; H2TF1; LYT-10; LYT10; NF-kB2; p100;
                     p49/p100; p52"
                     /inference="alignment:Splign:2.1.0"
     exon            667..825
                     /gene="NFKB2"
                     /gene_synonym="CVID10; H2TF1; LYT-10; LYT10; NF-kB2; p100;
                     p49/p100; p52"
                     /inference="alignment:Splign:2.1.0"
     exon            826..930
                     /gene="NFKB2"
                     /gene_synonym="CVID10; H2TF1; LYT-10; LYT10; NF-kB2; p100;
                     p49/p100; p52"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1016
                     /gene="NFKB2"
                     /gene_synonym="CVID10; H2TF1; LYT-10; LYT10; NF-kB2; p100;
                     p49/p100; p52"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1155
                     /gene="NFKB2"
                     /gene_synonym="CVID10; H2TF1; LYT-10; LYT10; NF-kB2; p100;
                     p49/p100; p52"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1281
                     /gene="NFKB2"
                     /gene_synonym="CVID10; H2TF1; LYT-10; LYT10; NF-kB2; p100;
                     p49/p100; p52"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1491
                     /gene="NFKB2"
                     /gene_synonym="CVID10; H2TF1; LYT-10; LYT10; NF-kB2; p100;
                     p49/p100; p52"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1633
                     /gene="NFKB2"
                     /gene_synonym="CVID10; H2TF1; LYT-10; LYT10; NF-kB2; p100;
                     p49/p100; p52"
                     /inference="alignment:Splign:2.1.0"
     exon            1634..1748
                     /gene="NFKB2"
                     /gene_synonym="CVID10; H2TF1; LYT-10; LYT10; NF-kB2; p100;
                     p49/p100; p52"
                     /inference="alignment:Splign:2.1.0"
     exon            1749..1962
                     /gene="NFKB2"
                     /gene_synonym="CVID10; H2TF1; LYT-10; LYT10; NF-kB2; p100;
                     p49/p100; p52"
                     /inference="alignment:Splign:2.1.0"
     exon            1963..2132
                     /gene="NFKB2"
                     /gene_synonym="CVID10; H2TF1; LYT-10; LYT10; NF-kB2; p100;
                     p49/p100; p52"
                     /inference="alignment:Splign:2.1.0"
     exon            2133..2235
                     /gene="NFKB2"
                     /gene_synonym="CVID10; H2TF1; LYT-10; LYT10; NF-kB2; p100;
                     p49/p100; p52"
                     /inference="alignment:Splign:2.1.0"
     exon            2236..2387
                     /gene="NFKB2"
                     /gene_synonym="CVID10; H2TF1; LYT-10; LYT10; NF-kB2; p100;
                     p49/p100; p52"
                     /inference="alignment:Splign:2.1.0"
     exon            2388..2457
                     /gene="NFKB2"
                     /gene_synonym="CVID10; H2TF1; LYT-10; LYT10; NF-kB2; p100;
                     p49/p100; p52"
                     /inference="alignment:Splign:2.1.0"
     exon            2458..2630
                     /gene="NFKB2"
                     /gene_synonym="CVID10; H2TF1; LYT-10; LYT10; NF-kB2; p100;
                     p49/p100; p52"
                     /inference="alignment:Splign:2.1.0"
     exon            2631..2742
                     /gene="NFKB2"
                     /gene_synonym="CVID10; H2TF1; LYT-10; LYT10; NF-kB2; p100;
                     p49/p100; p52"
                     /inference="alignment:Splign:2.1.0"
     exon            2743..3015
                     /gene="NFKB2"
                     /gene_synonym="CVID10; H2TF1; LYT-10; LYT10; NF-kB2; p100;
                     p49/p100; p52"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2969..2974
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NFKB2"
                     /gene_synonym="CVID10; H2TF1; LYT-10; LYT10; NF-kB2; p100;
                     p49/p100; p52"
                     /note="hexamer: AATAAA"
     polyA_site      3015
                     /gene="NFKB2"
                     /gene_synonym="CVID10; H2TF1; LYT-10; LYT10; NF-kB2; p100;
                     p49/p100; p52"
                     /note="major polyA site"
ORIGIN      
        1 aactttcctg ccccttcccc ggccaagccc aactccggat ctcgctctcc accggatctc
       61 acccgccaca cccggacagg cggctggagg aggcgggcgt ctaaaattct gggaagcaga
      121 acctggccgg agccactaga cagagccggg cctagcccag agacatggag agttgctaca
      181 acccaggtct ggatggtatt attgaatatg atgatttcaa attgaactcc tccattgtgg
      241 aacccaagga gccagcccca gaaacagctg atggccccta cctggtgatc gtggaacagc
      301 ctaagcagag aggcttccga tttcgatatg gctgtgaagg cccctcccat ggaggactgc
      361 ccggtgcctc cagtgagaag ggccgaaaga cctatcccac tgtcaagatc tgtaactacg
      421 agggaccagc caagatcgag gtggacctgg taacacacag tgacccacct cgtgctcatg
      481 cccacagtct ggtgggcaag caatgctcgg agctggggat ctgcgccgtt tctgtggggc
      541 ccaaggacat gactgcccaa tttaacaacc tgggtgtcct gcatgtgact aagaagaaca
      601 tgatggggac tatgatacaa aaacttcaga ggcagcggct ccgctctagg ccccagggcc
      661 ttacggaggc cgagcagcgg gagctggagc aagaggccaa agaactgaag aaggtgatgg
      721 atctgagtat agtgcggctg cgcttctctg ccttccttag agccagtgat ggctccttct
      781 ccctgcccct gaagccagtc atctcccagc ccatccatga cagcaaatct ccgggggcat
      841 caaacctgaa gatttctcga atggacaaga cagcaggctc tgtgcggggt ggagatgaag
      901 tttatctgct ttgtgacaag gtgcagaaag atgacattga ggttcggttc tatgaggatg
      961 atgagaatgg atggcaggcc tttggggact tctctcccac agatgtgcat aaacagtatg
     1021 ccattgtgtt ccggacaccc ccctatcaca agatgaagat tgagcggcct gtaacagtgt
     1081 ttctgcaact gaaacgcaag cgaggagggg acgtgtctga ttccaaacag ttcacctatt
     1141 accctctggt ggaagacaag gaagaggtgc agcggaagcg gaggaaggcc ttgcccacct
     1201 tctcccagcc cttcgggggt ggctcccaca tgggtggagg ctctgggggt gcagccgggg
     1261 gctacggagg agctggagga ggtggcagcc tcggtttctt cccctcctcc ctggcctaca
     1321 gcccctacca gtccggcgcg ggccccatgg gctgctaccc gggaggcggg ggcggggcgc
     1381 agatggccgc cacggtgccc agcagggact ccggggagga agccgcggag ccaagcgccc
     1441 cctccaggac cccccagtgc gagccgcagg ccccggagat gctgcagcga gctcgagagt
     1501 acaacgcgcg cctgttcggc ctggcgcagc gcagcgcccg agccctactc gactacggcg
     1561 tcaccgcgga cgcgcgcgcg ctgctggcgg gacagcgcca cctgctgacg gcgcaggacg
     1621 agaacggaga cacaccactg cacctagcca tcatccacgg gcagaccagt gtcattgagc
     1681 agatagtcta tgtcatccac cacgcccagg acctcggcgt tgtcaacctc accaaccacc
     1741 tgcaccagac gcccctgcac ctggcggtga tcacggggca gacgagtgtg gtgagctttc
     1801 tgctgcgggt aggtgcagac ccagctctgc tggatcggca tggagactca gccatgcatc
     1861 tggcgctgcg ggcaggcgct ggtgctcctg agctgctgcg tgcactgctt cagagtggag
     1921 ctcctgctgt gccccagctg ttgcatatgc ctgactttga gggactgtat ccagtacacc
     1981 tggcagtccg agcccgaagc cctgagtgcc tggatctgct ggtggacagt ggggctgaag
     2041 tggaggccac agagcggcag gggggacgaa cagccttgca tctagccaca gagatggagg
     2101 agctggggtt ggtcacccat ctggtcacca agctccgggc caacgtgaac gctcgcacct
     2161 ttgcgggaaa cacacccctg cacctggcag ctggactggg gtacccgacc ctcacccgcc
     2221 tccttctgaa ggctggtgct gacatccatg ctgaaaacga ggagcccctg tgcccactgc
     2281 cttcaccccc tacctctgat agcgactcgg actctgaagg gcctgagaag gacacccgaa
     2341 gcagcttccg gggccacacg cctcttgacc tcacttgcag caccaaggtg aagaccttgc
     2401 tgctaaatgc tgctcagaac accatggagc cacccctgac cccgcccagc ccagcagggc
     2461 cgggactgtc acttggtgat acagctctgc agaacctgga gcagctgcta gacgggccag
     2521 aagcccaggg cagctgggca gagctggcag agcgtctggg gctgcgcagc ctggtagaca
     2581 cgtaccgaca gacaacctca cccagtggca gcctcctgcg cagctacgag ctggctggcg
     2641 gggacctggc aggtctactg gaggccctgt ctgacatggg cctagaggag ggagtgaggc
     2701 tgctgagggg tccagaaacc cgagacaagc tgcccagcac agcagaggtg aaggaagaca
     2761 gtgcgtacgg gagccagtca gtggagcagg aggcagagaa gctgggccca ccccctgagc
     2821 caccaggagg gctctgccac gggcaccccc agcctcaggt gcactgacct gctgcctgcc
     2881 cccagccccc ttcccggacc ccctgtacag cgtccccacc tatttcaaat cttatttaac
     2941 accccacacc cacccctcag ttgggacaaa taaaggattc tcatgggaag gggaggaccc
     3001 ctccttccca actta
//
