LOCUS       NM_001382625            3934 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens nuclear factor kappa B subunit 1 (NFKB1), transcript
            variant 4, mRNA.
ACCESSION   NM_001382625
VERSION     NM_001382625.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3934)
  AUTHORS   Vazquez-Coto,D., Perez-Oliveira,S., Menendez-Gonzalez,M., Coto,E.
            and Alvarez,V.
  TITLE     Assessing the association between common functional Nuclear Factor
            Kappa-b gene polymorphisms (NFKB1, NFKBIZ, NFKBIA) and Alzheimer s
            disease
  JOURNAL   Behav Brain Res 476, 115264 (2025)
   PUBMED   39322062
  REMARK    GeneRIF: Assessing the association between common functional
            Nuclear Factor Kappa-b gene polymorphisms (NFKB1, NFKBIZ, NFKBIA)
            and Alzheimer s disease.
REFERENCE   2  (bases 1 to 3934)
  AUTHORS   Al-Salihy,S.R., Al-Shawk,R.S., Al-Waysi,S.A. and Rasheed,M.N.
  TITLE     Association of nuclear factor-kappa B1 (NF-kappaB1) Ins/Del gene
            polymorphism with Hepatitis C virus outcomes
  JOURNAL   J Pak Med Assoc 74 (10 (Supple-8)), S34-S38 (2024)
   PUBMED   39434268
  REMARK    GeneRIF: Association of nuclear factor-kappa B1 (NF-kappaB1)
            Ins/Del gene polymorphism with Hepatitis C virus outcomes.
REFERENCE   3  (bases 1 to 3934)
  AUTHORS   Lin,S., Shu,Y., Shen,R., Zhou,Y., Pan,H., He,L., Fang,F., Zhu,X.,
            Wang,X., Wang,Y., Xu,W. and Ding,J.
  TITLE     The regulation of NFKB1 on CD200R1 expression and their potential
            roles in Parkinson's disease
  JOURNAL   J Neuroinflammation 21 (1), 229 (2024)
   PUBMED   39294682
  REMARK    GeneRIF: The regulation of NFKB1 on CD200R1 expression and their
            potential roles in Parkinson's disease.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3934)
  AUTHORS   Eluard,B., Thieblemont,C. and Baud,V.
  TITLE     NF-kappaB in the New Era of Cancer Therapy
  JOURNAL   Trends Cancer 6 (8), 677-687 (2020)
   PUBMED   32409139
  REMARK    Review article
REFERENCE   5  (bases 1 to 3934)
  AUTHORS   Lin,L. and Ghosh,S.
  TITLE     A glycine-rich region in NF-kappaB p105 functions as a processing
            signal for the generation of the p50 subunit
  JOURNAL   Mol Cell Biol 16 (5), 2248-2254 (1996)
   PUBMED   8628291
REFERENCE   6  (bases 1 to 3934)
  AUTHORS   Muller,C.W., Rey,F.A., Sodeoka,M., Verdine,G.L. and Harrison,S.C.
  TITLE     Structure of the NF-kappa B p50 homodimer bound to DNA
  JOURNAL   Nature 373 (6512), 311-317 (1995)
   PUBMED   7830764
REFERENCE   7  (bases 1 to 3934)
  AUTHORS   Rice,N.R., MacKichan,M.L. and Israel,A.
  TITLE     The precursor of NF-kappa B p50 has I kappa B-like functions
  JOURNAL   Cell 71 (2), 243-253 (1992)
   PUBMED   1423592
REFERENCE   8  (bases 1 to 3934)
  AUTHORS   Kunsch,C., Ruben,S.M. and Rosen,C.A.
  TITLE     Selection of optimal kappa B/Rel DNA-binding motifs: interaction of
            both subunits of NF-kappa B with DNA is required for
            transcriptional activation
  JOURNAL   Mol Cell Biol 12 (10), 4412-4421 (1992)
   PUBMED   1406630
REFERENCE   9  (bases 1 to 3934)
  AUTHORS   Urban,M.B., Schreck,R. and Baeuerle,P.A.
  TITLE     NF-kappa B contacts DNA by a heterodimer of the p50 and p65 subunit
  JOURNAL   EMBO J 10 (7), 1817-1825 (1991)
   PUBMED   2050119
REFERENCE   10 (bases 1 to 3934)
  AUTHORS   Bours,V., Villalobos,J., Burd,P.R., Kelly,K. and Siebenlist,U.
  TITLE     Cloning of a mitogen-inducible gene encoding a kappa B DNA-binding
            protein with homology to the rel oncogene and to cell-cycle motifs
  JOURNAL   Nature 348 (6296), 76-80 (1990)
   PUBMED   2234062
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF213884.2.
            
            Summary: This gene encodes a 105 kD protein which can undergo
            cotranslational processing by the 26S proteasome to produce a 50 kD
            protein. The 105 kD protein is a Rel protein-specific transcription
            inhibitor and the 50 kD protein is a DNA binding subunit of the
            NF-kappa-B (NFKB) protein complex. NFKB is a transcription
            regulator that is activated by various intra- and extra-cellular
            stimuli such as cytokines, oxidant-free radicals, ultraviolet
            irradiation, and bacterial or viral products. Activated NFKB
            translocates into the nucleus and stimulates the expression of
            genes involved in a wide variety of biological functions.
            Inappropriate activation of NFKB has been associated with a number
            of inflammatory diseases while persistent inhibition of NFKB leads
            to inappropriate immune cell development or delayed cell growth.
            NFKB is a critical regulator of the immediate-early response to
            viral infection. Alternative splicing results in multiple
            transcript variants encoding different isoforms, at least one of
            which is proteolytically processed. [provided by RefSeq, Aug 2020].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR7346977.1402510.1 [ECO:0000331]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            coronavirus related              :: involved in immune response or
                                                antiviral activity
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-239               AF213884.2         66678-66916
            240-309             AF213884.2         75624-75693
            310-355             AF213884.2         90256-90301
            356-434             AF213884.2         94580-94658
            435-475             AF213884.2         98589-98629
            476-574             AF213884.2         102602-102700
            575-723             AF213884.2         131731-131879
            724-887             AF213884.2         141620-141783
            888-1046            AF213884.2         143625-143783
            1047-1151           AF213884.2         145279-145383
            1152-1243           AF213884.2         147610-147701
            1244-1382           AF213884.2         149426-149564
            1383-1526           AF213884.2         158169-158312
            1527-1616           AF213884.2         159636-159725
            1617-1811           AF213884.2         160882-161076
            1812-1953           AF213884.2         162264-162405
            1954-2068           AF213884.2         165639-165753
            2069-2270           AF213884.2         171240-171441
            2271-2440           AF213884.2         171894-172063
            2441-2543           AF213884.2         172393-172495
            2544-2668           AF213884.2         175319-175443
            2669-2735           AF213884.2         176788-176854
            2736-2908           AF213884.2         177178-177350
            2909-3065           AF213884.2         178169-178325
            3066-3934           AF213884.2         181178-182046
FEATURES             Location/Qualifiers
     source          1..3934
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q24"
     gene            1..3934
                     /gene="NFKB1"
                     /gene_synonym="CVID12; EBP-1; KBF1; NF-kappa-B1;
                     NF-kappaB; NF-kappabeta; NF-kB; NF-kB1; NFkappaB;
                     NFKB-p105; NFKB-p50"
                     /note="nuclear factor kappa B subunit 1"
                     /db_xref="GeneID:4790"
                     /db_xref="HGNC:HGNC:7794"
                     /db_xref="MIM:164011"
     exon            1..239
                     /gene="NFKB1"
                     /gene_synonym="CVID12; EBP-1; KBF1; NF-kappa-B1;
                     NF-kappaB; NF-kappabeta; NF-kB; NF-kB1; NFkappaB;
                     NFKB-p105; NFKB-p50"
                     /inference="alignment:Splign:2.1.0"
     exon            240..309
                     /gene="NFKB1"
                     /gene_synonym="CVID12; EBP-1; KBF1; NF-kappa-B1;
                     NF-kappaB; NF-kappabeta; NF-kB; NF-kB1; NFkappaB;
                     NFKB-p105; NFKB-p50"
                     /inference="alignment:Splign:2.1.0"
     exon            310..355
                     /gene="NFKB1"
                     /gene_synonym="CVID12; EBP-1; KBF1; NF-kappa-B1;
                     NF-kappaB; NF-kappabeta; NF-kB; NF-kB1; NFkappaB;
                     NFKB-p105; NFKB-p50"
                     /inference="alignment:Splign:2.1.0"
     CDS             317..3226
                     /gene="NFKB1"
                     /gene_synonym="CVID12; EBP-1; KBF1; NF-kappa-B1;
                     NF-kappaB; NF-kappabeta; NF-kB; NF-kB1; NFkappaB;
                     NFKB-p105; NFKB-p50"
                     /note="isoform 1 is encoded by transcript variant 4;
                     nuclear factor kappa-B DNA binding subunit; nuclear factor
                     NF-kappa-B p50 subunit; nuclear factor NF-kappa-B p105
                     subunit; DNA-binding factor KBF1; nuclear factor of kappa
                     light polypeptide gene enhancer in B-cells 1"
                     /codon_start=1
                     /product="nuclear factor NF-kappa-B p105 subunit isoform
                     1"
                     /protein_id="NP_001369554.1"
                     /db_xref="CCDS:CCDS3657.1"
                     /db_xref="GeneID:4790"
                     /db_xref="HGNC:HGNC:7794"
                     /db_xref="MIM:164011"
                     /translation="MAEDDPYLGRPEQMFHLDPSLTHTIFNPEVFQPQMALPTADGPY
                     LQILEQPKQRGFRFRYVCEGPSHGGLPGASSEKNKKSYPQVKICNYVGPAKVIVQLVT
                     NGKNIHLHAHSLVGKHCEDGICTVTAGPKDMVVGFANLGILHVTKKKVFETLEARMTE
                     ACIRGYNPGLLVHPDLAYLQAEGGGDRQLGDREKELIRQAALQQTKEMDLSVVRLMFT
                     AFLPDSTGSFTRRLEPVVSDAIYDSKAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKV
                     QKDDIQIRFYEEEENGGVWEGFGDFSPTDVHRQFAIVFKTPKYKDINITKPASVFVQL
                     RRKSDLETSEPKPFLYYPEIKDKEEVQRKRQKLMPNFSDSFGGGSGAGAGGGGMFGSG
                     GGGGGTGSTGPGYSFPHYGFPTYGGITFHPGTTKSNAGMKHGTMDTESKKDPEGCDKS
                     DDKNTVNLFGKVIETTEQDQEPSEATVGNGEVTLTYATGTKEESAGVQDNLFLEKAMQ
                     LAKRHANALFDYAVTGDVKMLLAVQRHLTAVQDENGDSVLHLAIIHLHSQLVRDLLEV
                     TSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAA
                     KEGHDKVLSILLKHKKAALLLDHPNGDGLNAIHLAMMSNSLPCLLLLVAAGADVNAQE
                     QKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLK
                     AAGADPLVENFEPLYDLDDSWENAGEDEGVVPGTTPLDMATSWQVFDILNGKPYEPEF
                     TSDDLLAQGDMKQLAEDVKLQLYKLLEIPDPDKNWATLAQKLGLGILNNAFRLSPAPS
                     KTLMDNYEVSGGTVRELVEALRQMGYTEAIEVIQAASSPVKTTSQAHSLPLSPASTRQ
                     QIDELRDSDSVCDSGVETSFRKLSFTESLTSGASLLTLNKMPHDYGQEGPLEGKI"
     exon            356..434
                     /gene="NFKB1"
                     /gene_synonym="CVID12; EBP-1; KBF1; NF-kappa-B1;
                     NF-kappaB; NF-kappabeta; NF-kB; NF-kB1; NFkappaB;
                     NFKB-p105; NFKB-p50"
                     /inference="alignment:Splign:2.1.0"
     exon            435..475
                     /gene="NFKB1"
                     /gene_synonym="CVID12; EBP-1; KBF1; NF-kappa-B1;
                     NF-kappaB; NF-kappabeta; NF-kB; NF-kB1; NFkappaB;
                     NFKB-p105; NFKB-p50"
                     /inference="alignment:Splign:2.1.0"
     exon            476..574
                     /gene="NFKB1"
                     /gene_synonym="CVID12; EBP-1; KBF1; NF-kappa-B1;
                     NF-kappaB; NF-kappabeta; NF-kB; NF-kB1; NFkappaB;
                     NFKB-p105; NFKB-p50"
                     /inference="alignment:Splign:2.1.0"
     exon            575..723
                     /gene="NFKB1"
                     /gene_synonym="CVID12; EBP-1; KBF1; NF-kappa-B1;
                     NF-kappaB; NF-kappabeta; NF-kB; NF-kB1; NFkappaB;
                     NFKB-p105; NFKB-p50"
                     /inference="alignment:Splign:2.1.0"
     exon            724..887
                     /gene="NFKB1"
                     /gene_synonym="CVID12; EBP-1; KBF1; NF-kappa-B1;
                     NF-kappaB; NF-kappabeta; NF-kB; NF-kB1; NFkappaB;
                     NFKB-p105; NFKB-p50"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1046
                     /gene="NFKB1"
                     /gene_synonym="CVID12; EBP-1; KBF1; NF-kappa-B1;
                     NF-kappaB; NF-kappabeta; NF-kB; NF-kB1; NFkappaB;
                     NFKB-p105; NFKB-p50"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1151
                     /gene="NFKB1"
                     /gene_synonym="CVID12; EBP-1; KBF1; NF-kappa-B1;
                     NF-kappaB; NF-kappabeta; NF-kB; NF-kB1; NFkappaB;
                     NFKB-p105; NFKB-p50"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1243
                     /gene="NFKB1"
                     /gene_synonym="CVID12; EBP-1; KBF1; NF-kappa-B1;
                     NF-kappaB; NF-kappabeta; NF-kB; NF-kB1; NFkappaB;
                     NFKB-p105; NFKB-p50"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1382
                     /gene="NFKB1"
                     /gene_synonym="CVID12; EBP-1; KBF1; NF-kappa-B1;
                     NF-kappaB; NF-kappabeta; NF-kB; NF-kB1; NFkappaB;
                     NFKB-p105; NFKB-p50"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1526
                     /gene="NFKB1"
                     /gene_synonym="CVID12; EBP-1; KBF1; NF-kappa-B1;
                     NF-kappaB; NF-kappabeta; NF-kB; NF-kB1; NFkappaB;
                     NFKB-p105; NFKB-p50"
                     /inference="alignment:Splign:2.1.0"
     exon            1527..1616
                     /gene="NFKB1"
                     /gene_synonym="CVID12; EBP-1; KBF1; NF-kappa-B1;
                     NF-kappaB; NF-kappabeta; NF-kB; NF-kB1; NFkappaB;
                     NFKB-p105; NFKB-p50"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..1811
                     /gene="NFKB1"
                     /gene_synonym="CVID12; EBP-1; KBF1; NF-kappa-B1;
                     NF-kappaB; NF-kappabeta; NF-kB; NF-kB1; NFkappaB;
                     NFKB-p105; NFKB-p50"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..1953
                     /gene="NFKB1"
                     /gene_synonym="CVID12; EBP-1; KBF1; NF-kappa-B1;
                     NF-kappaB; NF-kappabeta; NF-kB; NF-kB1; NFkappaB;
                     NFKB-p105; NFKB-p50"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..2068
                     /gene="NFKB1"
                     /gene_synonym="CVID12; EBP-1; KBF1; NF-kappa-B1;
                     NF-kappaB; NF-kappabeta; NF-kB; NF-kB1; NFkappaB;
                     NFKB-p105; NFKB-p50"
                     /inference="alignment:Splign:2.1.0"
     exon            2069..2270
                     /gene="NFKB1"
                     /gene_synonym="CVID12; EBP-1; KBF1; NF-kappa-B1;
                     NF-kappaB; NF-kappabeta; NF-kB; NF-kB1; NFkappaB;
                     NFKB-p105; NFKB-p50"
                     /inference="alignment:Splign:2.1.0"
     exon            2271..2440
                     /gene="NFKB1"
                     /gene_synonym="CVID12; EBP-1; KBF1; NF-kappa-B1;
                     NF-kappaB; NF-kappabeta; NF-kB; NF-kB1; NFkappaB;
                     NFKB-p105; NFKB-p50"
                     /inference="alignment:Splign:2.1.0"
     exon            2441..2543
                     /gene="NFKB1"
                     /gene_synonym="CVID12; EBP-1; KBF1; NF-kappa-B1;
                     NF-kappaB; NF-kappabeta; NF-kB; NF-kB1; NFkappaB;
                     NFKB-p105; NFKB-p50"
                     /inference="alignment:Splign:2.1.0"
     exon            2544..2668
                     /gene="NFKB1"
                     /gene_synonym="CVID12; EBP-1; KBF1; NF-kappa-B1;
                     NF-kappaB; NF-kappabeta; NF-kB; NF-kB1; NFkappaB;
                     NFKB-p105; NFKB-p50"
                     /inference="alignment:Splign:2.1.0"
     exon            2669..2735
                     /gene="NFKB1"
                     /gene_synonym="CVID12; EBP-1; KBF1; NF-kappa-B1;
                     NF-kappaB; NF-kappabeta; NF-kB; NF-kB1; NFkappaB;
                     NFKB-p105; NFKB-p50"
                     /inference="alignment:Splign:2.1.0"
     exon            2736..2908
                     /gene="NFKB1"
                     /gene_synonym="CVID12; EBP-1; KBF1; NF-kappa-B1;
                     NF-kappaB; NF-kappabeta; NF-kB; NF-kB1; NFkappaB;
                     NFKB-p105; NFKB-p50"
                     /inference="alignment:Splign:2.1.0"
     exon            2909..3065
                     /gene="NFKB1"
                     /gene_synonym="CVID12; EBP-1; KBF1; NF-kappa-B1;
                     NF-kappaB; NF-kappabeta; NF-kB; NF-kB1; NFkappaB;
                     NFKB-p105; NFKB-p50"
                     /inference="alignment:Splign:2.1.0"
     exon            3066..3934
                     /gene="NFKB1"
                     /gene_synonym="CVID12; EBP-1; KBF1; NF-kappa-B1;
                     NF-kappaB; NF-kappabeta; NF-kB; NF-kB1; NFkappaB;
                     NFKB-p105; NFKB-p50"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3905..3910
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NFKB1"
                     /gene_synonym="CVID12; EBP-1; KBF1; NF-kappa-B1;
                     NF-kappaB; NF-kappabeta; NF-kB; NF-kB1; NFkappaB;
                     NFKB-p105; NFKB-p50"
                     /note="hexamer: AATAAA"
     polyA_site      3934
                     /gene="NFKB1"
                     /gene_synonym="CVID12; EBP-1; KBF1; NF-kappa-B1;
                     NF-kappaB; NF-kappabeta; NF-kB; NF-kB1; NFkappaB;
                     NFKB-p105; NFKB-p50"
                     /note="major polyA site"
ORIGIN      
        1 agtagctgag aggcacatgg gattagcgac agcggggaaa gacacatccg gacctcgcag
       61 gggctagtcg gccgaagggc cgcggccgcc cggcggtcat ttctcttcac gtccctccgc
      121 ggggcgggaa cgcgaaccgg aggggaactc ttacaaactt ttaaaatccc caaccccagc
      181 cccacctggg ggatggtgag aaggttggag tgcgctgcgg cgcggaggag agagggaaga
      241 aggaacacaa cgtcctacat caagaaaaaa gacagaagca tatcttggag atatgaaaag
      301 aaccaccagc ttcagaatgg cagaagatga tccatatttg ggaaggcctg aacaaatgtt
      361 tcatttggat ccttctttga ctcatacaat atttaatcca gaagtatttc aaccacagat
      421 ggcactgcca acagcagatg gcccatacct tcaaatatta gagcaaccta aacagagagg
      481 atttcgtttc cgttatgtat gtgaaggccc atcccatggt ggactacctg gtgcctctag
      541 tgaaaagaac aagaagtctt accctcaggt caaaatctgc aactatgtgg gaccagcaaa
      601 ggttattgtt cagttggtca caaatggaaa aaatatccac ctgcatgccc acagcctggt
      661 gggaaaacac tgtgaggatg ggatctgcac tgtaactgct ggacccaagg acatggtggt
      721 cggcttcgca aacctgggta tacttcatgt gacaaagaaa aaagtatttg aaacactgga
      781 agcacgaatg acagaggcgt gtataagggg ctataatcct ggactcttgg tgcaccctga
      841 ccttgcctat ttgcaagcag aaggtggagg ggaccggcag ctgggagatc gggaaaaaga
      901 gctaatccgc caagcagctc tgcagcagac caaggagatg gacctcagcg tggtgcggct
      961 catgtttaca gcttttcttc cggatagcac tggcagcttc acaaggcgcc tggaacccgt
     1021 ggtatcagac gccatctatg acagtaaagc ccccaatgca tccaacttga aaattgtaag
     1081 aatggacagg acagctggat gtgtgactgg aggggaggaa atttatcttc tttgtgacaa
     1141 agttcagaaa gatgacatcc agattcgatt ttatgaagag gaagaaaatg gtggagtctg
     1201 ggaaggattt ggagattttt cccccacaga tgttcataga caatttgcca ttgtcttcaa
     1261 aactccaaag tataaagata ttaatattac aaaaccagcc tctgtgtttg tccagcttcg
     1321 gaggaaatct gacttggaaa ctagtgaacc aaaacctttc ctctactatc ctgaaatcaa
     1381 agataaagaa gaagtgcaga ggaaacgtca gaagctcatg cccaattttt cggatagttt
     1441 cggcggtggt agtggtgctg gagctggagg cggaggcatg tttggtagtg gcggtggagg
     1501 agggggcact ggaagtacag gtccagggta tagcttccca cactatggat ttcctactta
     1561 tggtgggatt actttccatc ctggaactac taaatctaat gctgggatga agcatggaac
     1621 catggacact gaatctaaaa aggaccctga aggttgtgac aaaagtgatg acaaaaacac
     1681 tgtaaacctc tttgggaaag ttattgaaac cacagagcaa gatcaggagc ccagcgaggc
     1741 caccgttggg aatggtgagg tcactctaac gtatgcaaca ggaacaaaag aagagagtgc
     1801 tggagttcag gataacctct ttctagagaa ggctatgcag cttgcaaaga ggcatgccaa
     1861 tgcccttttc gactacgcgg tgacaggaga cgtgaagatg ctgctggccg tccagcgcca
     1921 tctcactgct gtgcaggatg agaatgggga cagtgtctta cacttagcaa tcatccacct
     1981 tcattctcaa cttgtgaggg atctactaga agtcacatct ggtttgattt ctgatgacat
     2041 tatcaacatg agaaatgatc tgtaccagac gcccttgcac ttggcagtga tcactaagca
     2101 ggaagatgtg gtggaggatt tgctgagggc tggggccgac ctgagccttc tggaccgctt
     2161 gggtaactct gttttgcacc tagctgccaa agaaggacat gataaagttc tcagtatctt
     2221 actcaagcac aaaaaggcag cactacttct tgaccacccc aacggggacg gtctgaatgc
     2281 cattcatcta gccatgatga gcaatagcct gccatgtttg ctgctgctgg tggccgctgg
     2341 ggctgacgtc aatgctcagg agcagaagtc cgggcgcaca gcactgcacc tggctgtgga
     2401 gcacgacaac atctcattgg caggctgcct gctcctggag ggtgatgccc atgtggacag
     2461 tactacctac gatggaacca cacccctgca tatagcagct gggagagggt ccaccaggct
     2521 ggcagctctt ctcaaagcag caggagcaga tcccctggtg gagaactttg agcctctcta
     2581 tgacctggat gactcttggg aaaatgcagg agaggatgaa ggagttgtgc ctggaaccac
     2641 gcctctagat atggccacca gctggcaggt atttgacata ttaaatggga aaccatatga
     2701 gccagagttt acatctgatg atttactagc acaaggagac atgaaacagc tggctgaaga
     2761 tgtgaagctg cagctgtata agttactaga aattcctgat ccagacaaaa actgggctac
     2821 tctggcgcag aaattaggtc tggggatact taataatgcc ttccggctga gtcctgctcc
     2881 ttccaaaaca cttatggaca actatgaggt ctctgggggt acagtcagag agctggtgga
     2941 ggccctgaga caaatgggct acaccgaagc aattgaagtg atccaggcag cctccagccc
     3001 agtgaagacc acctctcagg cccactcgct gcctctctcg cctgcctcca caaggcagca
     3061 aatagacgag ctccgagaca gtgacagtgt ctgcgacagc ggcgtggaga catccttccg
     3121 caaactcagc tttaccgagt ctctgaccag tggtgcctca ctgctaactc tcaacaaaat
     3181 gccccatgat tatgggcagg aaggacctct agaaggcaaa atttagcctg ctgacaattt
     3241 cccacaccgt gtaaaccaaa gccctaaaat tccactgcgt tgtccacaag acagaagctg
     3301 aagtgcatcc aaaggtgctc agagagccgg cccgcctgaa tcattctcga tttaactcga
     3361 gaccttttca acttggcttc ctttcttggt tcataaatga attttagttt ggttcactta
     3421 cagatagtat ctagcaatca caacactggc tgagcggatg catctgggga tgaggttgct
     3481 tactaagctt tgccagctgc tgctggatca cagctgcttt ctgttgtcat tgctgttgtc
     3541 cctctgctac gttcctattg tcattaaagg tatcacggtc gccacctggc attccttctg
     3601 accacagcat cattttgcat tcaaattaag ggttaagaaa agagatattt taaaatgaga
     3661 gtcacttgat gtgccatttt aaaaaaaaag gcatattgct ttttctaatg tggttatttc
     3721 tctgatttgc aaaaaaaaaa aaaaaaaaaa tacttgtcaa tatttaaaca tggttacaat
     3781 cattgctgaa aatggtattt tccccctttt ctgcattttg ctattgtaaa tatgtttttt
     3841 agatcaaata ctttaaagga aaaaatgttg gatttataaa tgctattttt tattttactt
     3901 ttataataaa aggaaaagca aattgatgac ctca
//
