LOCUS       NM_005384               2055 bp    mRNA    linear   PRI 09-OCT-2024
DEFINITION  Homo sapiens nuclear factor, interleukin 3 regulated (NFIL3),
            transcript variant 3, mRNA.
ACCESSION   NM_005384
VERSION     NM_005384.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2055)
  AUTHORS   Qiang,F., Xuan,D., Liu,J. and Sheng,J.
  TITLE     Knockdown of NFIL3 modulates the AMPK pathway to suppress excessive
            cell proliferation, inflammation, and migration in rheumatoid
            arthritis
  JOURNAL   Int J Rheum Dis 27 (8), e15287 (2024)
   PUBMED   39175280
  REMARK    GeneRIF: Knockdown of NFIL3 modulates the AMPK pathway to suppress
            excessive cell proliferation, inflammation, and migration in
            rheumatoid arthritis.
REFERENCE   2  (bases 1 to 2055)
  AUTHORS   Chen,S., Lei,M., Liu,K. and Min,J.
  TITLE     Structural basis for specific DNA sequence recognition by the
            transcription factor NFIL3
  JOURNAL   J Biol Chem 300 (3), 105776 (2024)
   PUBMED   38382670
  REMARK    GeneRIF: Structural basis for specific DNA sequence recognition by
            the transcription factor NFIL3.
REFERENCE   3  (bases 1 to 2055)
  AUTHORS   Wang,L., Li,P., Zhang,X., Gu,Z., Pan,X., Wu,Y. and Li,H.
  TITLE     The role of basic leucine zipper transcription factor E4BP4 in
            cancer: a review and update
  JOURNAL   Mol Biol Rep 51 (1), 91 (2024)
   PUBMED   38193973
  REMARK    GeneRIF: The role of basic leucine zipper transcription factor
            E4BP4 in cancer: a review and update.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2055)
  AUTHORS   Zeng,G.G., Zhou,J., Jiang,W.L., Yu,J., Nie,G.Y., Li,J., Zhang,S.Q.
            and Tang,C.K.
  TITLE     A Potential Role of NFIL3 in Atherosclerosis
  JOURNAL   Curr Probl Cardiol 49 (1 Pt B), 102096 (2024)
   PUBMED   37741601
  REMARK    GeneRIF: A Potential Role of NFIL3 in Atherosclerosis.
            Review article
REFERENCE   5  (bases 1 to 2055)
  AUTHORS   Chen,L., Shangguan,Z., Dong,Z., Deng,Q., Ding,Y. and Yang,S.
  TITLE     NFIL3 aggravates human coronary artery endothelial cell injury by
            promoting ITGAM transcription in Kawasaki disease
  JOURNAL   Hematology 28 (1), 2277502 (2023)
   PUBMED   37933872
  REMARK    GeneRIF: NFIL3 aggravates human coronary artery endothelial cell
            injury by promoting ITGAM transcription in Kawasaki disease.
REFERENCE   6  (bases 1 to 2055)
  AUTHORS   Cowell,I.G. and Hurst,H.C.
  TITLE     Protein-protein interaction between the transcriptional repressor
            E4BP4 and the TBP-binding protein Dr1
  JOURNAL   Nucleic Acids Res 24 (18), 3607-3613 (1996)
   PUBMED   8836190
REFERENCE   7  (bases 1 to 2055)
  AUTHORS   Zhang,W., Zhang,J., Kornuc,M., Kwan,K., Frank,R. and Nimer,S.D.
  TITLE     Molecular cloning and characterization of NF-IL3A, a
            transcriptional activator of the human interleukin-3 promoter
  JOURNAL   Mol Cell Biol 15 (11), 6055-6063 (1995)
   PUBMED   7565758
REFERENCE   8  (bases 1 to 2055)
  AUTHORS   Matoba,R., Okubo,K., Hori,N., Fukushima,A. and Matsubara,K.
  TITLE     The addition of 5'-coding information to a 3'-directed cDNA library
            improves analysis of gene expression
  JOURNAL   Gene 146 (2), 199-207 (1994)
   PUBMED   8076819
REFERENCE   9  (bases 1 to 2055)
  AUTHORS   Cowell,I.G., Skinner,A. and Hurst,H.C.
  TITLE     Transcriptional repression by a novel member of the bZIP family of
            transcription factors
  JOURNAL   Mol Cell Biol 12 (7), 3070-3077 (1992)
   PUBMED   1620116
REFERENCE   10 (bases 1 to 2055)
  AUTHORS   Rehfuss,R.P., Walton,K.M., Loriaux,M.M. and Goodman,R.H.
  TITLE     The cAMP-regulated enhancer-binding protein ATF-1 activates
            transcription in response to cAMP-dependent protein kinase A
  JOURNAL   J Biol Chem 266 (28), 18431-18434 (1991)
   PUBMED   1655749
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BQ937243.1, AW163045.1 and
            BC008197.1.
            
            On Nov 22, 2018 this sequence version replaced NM_005384.2.
            
            Summary: The protein encoded by this gene is a transcriptional
            regulator that binds as a homodimer to activating transcription
            factor (ATF) sites in many cellular and viral promoters. The
            encoded protein represses PER1 and PER2 expression and therefore
            plays a role in the regulation of circadian rhythm. Three
            transcript variants encoding the same protein have been found for
            this gene. [provided by RefSeq, Feb 2014].
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. All three variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279872.3696.1, ERR279858.4433.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA2162895
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000297689.4/ ENSP00000297689.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                BQ937243.1         31-65
            36-332              AW163045.1         1-297
            333-2055            BC008197.1         1-1723
FEATURES             Location/Qualifiers
     source          1..2055
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q22.31"
     gene            1..2055
                     /gene="NFIL3"
                     /gene_synonym="E4BP4; IL3BP1; NF-IL3A; NFIL3A"
                     /note="nuclear factor, interleukin 3 regulated"
                     /db_xref="GeneID:4783"
                     /db_xref="HGNC:HGNC:7787"
                     /db_xref="MIM:605327"
     exon            1..193
                     /gene="NFIL3"
                     /gene_synonym="E4BP4; IL3BP1; NF-IL3A; NFIL3A"
                     /inference="alignment:Splign:2.1.0"
     exon            194..2055
                     /gene="NFIL3"
                     /gene_synonym="E4BP4; IL3BP1; NF-IL3A; NFIL3A"
                     /inference="alignment:Splign:2.1.0"
     CDS             366..1754
                     /gene="NFIL3"
                     /gene_synonym="E4BP4; IL3BP1; NF-IL3A; NFIL3A"
                     /note="interleukin-3 promoter transcriptional activator;
                     E4 promoter-binding protein 4; interleukin-3-binding
                     protein 1; transcriptional activator NF-IL3A; adenovirus
                     E4 promoter region binding protein"
                     /codon_start=1
                     /product="nuclear factor interleukin-3-regulated protein"
                     /protein_id="NP_005375.2"
                     /db_xref="CCDS:CCDS6690.1"
                     /db_xref="GeneID:4783"
                     /db_xref="HGNC:HGNC:7787"
                     /db_xref="MIM:605327"
                     /translation="MQLRKMQTVKKEQASLDASSNVDKMMVLNSALTEVSEDSTTGEE
                     LLLSEGSVGKNKSSACRRKREFIPDEKKDAMYWEKRRKNNEAAKRSREKRRLNDLVLE
                     NKLIALGEENATLKAELLSLKLKFGLISSTAYAQEIQKLSNSTAVYFQDYQTSKSNVS
                     SFVDEHEPSMVSSSCISVIKHSPQSSLSDVSEVSSVEHTQESSVQGSCRSPENKFQII
                     KQEPMELESYTREPRDDRGSYTASIYQNYMGNSFSGYSHSPPLLQVNRSSSNSPRTSE
                     TDDGVVGKSSDGEDEQQVPKGPIHSPVELKHVHATVVKVPEVNSSALPHKLRIKAKAM
                     QIKVEAFDNEFEATQKLSSPIDMTSKRHFELEKHSAPSMVHSSLTPFSVQVTNIQDWS
                     LKSEHWHQKELSGKTQNSFKTGVVEMKDSGYKVSDPENLYLKQGIANLSAEVVSLKRL
                     IATQPISASDSG"
     regulatory      2029..2034
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NFIL3"
                     /gene_synonym="E4BP4; IL3BP1; NF-IL3A; NFIL3A"
                     /note="hexamer: AATAAA"
     polyA_site      2055
                     /gene="NFIL3"
                     /gene_synonym="E4BP4; IL3BP1; NF-IL3A; NFIL3A"
                     /note="major polyA site"
ORIGIN      
        1 aacacacatc tctccgcgcg gccacggcgc ccgcggaccc ggcgcgcccg cccgcctccc
       61 gcgccgcgcc ctcgccgccg cccgcctccc gccgcggccc cggaggcccg gcccggcccg
      121 agccccgagc gccggcggcc cgactcccgg ccgccccttt ctttctcctc gccggcccga
      181 gagcaggaac acgataacga aggaggccca acttcattca ataaggagcc tgacggattt
      241 atcccagacg gtagaacaaa aggaagaata ttgatggatt ttaaaccaga gtttttaaag
      301 agcttgagaa tacggggaaa ttaatttgtt ctcctacaca catagatagg gtaaggttgt
      361 ttctgatgca gctgagaaaa atgcagaccg tcaaaaagga gcaggcgtct cttgatgcca
      421 gtagcaatgt ggacaagatg atggtcctta attctgcttt aacggaagtg tcagaagact
      481 ccacaacagg tgaggagctg cttctcagtg aaggaagtgt ggggaagaac aaatcttctg
      541 catgtcggag gaaacgggaa ttcattcctg atgaaaagaa agatgctatg tattgggaaa
      601 aaaggcggaa aaataatgaa gctgccaaaa gatctcgtga gaagcgtcga ctgaatgacc
      661 tggttttaga gaacaaacta attgcactgg gagaagaaaa cgccacttta aaagctgagc
      721 tgctttcact aaaattaaag tttggtttaa ttagctccac agcatatgct caagagattc
      781 agaaactcag taattctaca gctgtgtact ttcaagatta ccagacttcc aaatccaatg
      841 tgagttcatt tgtggacgag cacgaaccct cgatggtgtc aagtagttgt atttctgtca
      901 ttaaacactc tccacaaagc tcgctgtccg atgtttcaga agtgtcctca gtagaacaca
      961 cgcaggagag ctctgtgcag ggaagctgca gaagtcctga aaacaagttc cagattatca
     1021 agcaagagcc gatggaatta gagagctaca caagggagcc aagagatgac cgaggctctt
     1081 acacagcgtc catctatcaa aactatatgg ggaattcttt ctctgggtac tcacactctc
     1141 ccccactact gcaagtcaac cgatcctcca gcaactcccc gagaacgtcg gaaactgatg
     1201 atggtgtggt aggaaagtca tctgatggag aagacgagca acaggtcccc aagggcccca
     1261 tccattctcc agttgaactc aagcatgtgc atgcaactgt ggttaaagtt ccagaagtga
     1321 attcctctgc cttgccacac aagctccgga tcaaagccaa agccatgcag atcaaagtag
     1381 aagcctttga taatgaattt gaggccacgc aaaaactttc ctcacctatt gacatgacat
     1441 ctaaaagaca tttcgaactc gaaaagcata gtgccccaag tatggtacat tcttctctta
     1501 ctcctttctc agtgcaagtg actaacattc aagattggtc tctcaaatcg gagcactggc
     1561 atcaaaaaga actgagtggc aaaactcaga atagtttcaa aactggagtt gttgaaatga
     1621 aagacagtgg ctacaaagtt tctgacccag agaacttgta tttgaagcag gggatagcaa
     1681 acttatctgc agaggttgtc tcactcaaga gacttatagc cacacaacca atctctgctt
     1741 cagactctgg gtaaattact actgagtaag agctgggcat ttagaaagat gtcatttgca
     1801 atagagcagt ccattttgta ttatgctgaa ttttcactgg acctgtgatg tcatttcact
     1861 gtgatgtgca catgttgtct gtttggtgtc tttttgtgca cagattatga tgaagattag
     1921 attgtgttat cactctgcct gtgtatagtc agatagtcca tgcgaaggct gtatatattg
     1981 aacattattt ttgttgttct attataaagt gtgtaagtta ccagtttcaa taaaggattg
     2041 gtgacaaaca cagaa
//
