LOCUS       NM_001245005            7847 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens nuclear factor I C (NFIC), transcript variant 4, mRNA.
ACCESSION   NM_001245005
VERSION     NM_001245005.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7847)
  AUTHORS   Polcaro,G., Liguori,L., Manzo,V., Chianese,A., Donadio,G.,
            Caputo,A., Scognamiglio,G., Dell'Annunziata,F., Langella,M.,
            Corbi,G., Ottaiano,A., Cascella,M., Perri,F., De Marco,M.,
            Col,J.D., Nassa,G., Giurato,G., Zeppa,P., Filippelli,A., Franci,G.,
            Piaz,F.D., Conti,V., Pepe,S. and Sabbatino,F.
  TITLE     rs822336 binding to C/EBPbeta and NFIC modulates induction of PD-L1
            expression and predicts anti-PD-1/PD-L1 therapy in advanced NSCLC
  JOURNAL   Mol Cancer 23 (1), 63 (2024)
   PUBMED   38528526
  REMARK    GeneRIF: rs822336 binding to C/EBPbeta and NFIC modulates induction
            of PD-L1 expression and predicts anti-PD-1/PD-L1 therapy in
            advanced NSCLC.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7847)
  AUTHORS   Wu,J., Wang,M., Zhang,Y., Liu,G. and Xing,Y.
  TITLE     Activation of CHPF by transcription factor NFIC promotes NLRP3
            activation during the progression of colorectal cancer
  JOURNAL   Funct Integr Genomics 24 (1), 20 (2024)
   PUBMED   38267731
  REMARK    GeneRIF: Activation of CHPF by transcription factor NFIC promotes
            NLRP3 activation during the progression of colorectal cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7847)
  AUTHORS   Huang,H., Zhu,W., Huang,Z., Zhao,D., Cao,L. and Gao,X.
  TITLE     Adipose-derived stem cell exosome NFIC improves diabetic foot
            ulcers by regulating miR-204-3p/HIPK2
  JOURNAL   J Orthop Surg Res 18 (1), 687 (2023)
   PUBMED   37710299
  REMARK    GeneRIF: Adipose-derived stem cell exosome NFIC improves diabetic
            foot ulcers by regulating miR-204-3p/HIPK2.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7847)
  AUTHORS   Cobo,I., Paliwal,S., Bodas,C., Felipe,I., Melia-Aloma,J.,
            Torres,A., Martinez-Villarreal,J., Malumbres,M., Garcia,F.,
            Millan,I., Del Pozo,N., Park,J.C., MacDonald,R.J., Munoz,J.,
            Mendez,R. and Real,F.X.
  TITLE     NFIC regulates ribosomal biology and ER stress in pancreatic acinar
            cells and restrains PDAC initiation
  JOURNAL   Nat Commun 14 (1), 3761 (2023)
   PUBMED   37353485
  REMARK    GeneRIF: NFIC regulates ribosomal biology and ER stress in
            pancreatic acinar cells and restrains PDAC initiation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7847)
  AUTHORS   Zhang,J., Wang,Z., Liang,Z., Jin,C., Shi,Y., Fan,M., Hu,X. and
            Wan,Y.
  TITLE     NFIC1 inhibits the migration and invasion of MDA-MB-231 cells
            through S100A2-mediated inactivation of MEK/ERK pathway
  JOURNAL   Arch Biochem Biophys 734, 109497 (2023)
   PUBMED   36574914
  REMARK    GeneRIF: NFIC1 inhibits the migration and invasion of MDA-MB-231
            cells through S100A2-mediated inactivation of MEK/ERK pathway.
REFERENCE   6  (bases 1 to 7847)
  AUTHORS   Wenzelides,S., Altmann,H., Wendler,W. and Winnacker,E.L.
  TITLE     CTF5--a new transcriptional activator of the NFI/CTF family
  JOURNAL   Nucleic Acids Res 24 (12), 2416-2421 (1996)
   PUBMED   8710515
REFERENCE   7  (bases 1 to 7847)
  AUTHORS   Blau,J., Xiao,H., McCracken,S., O'Hare,P., Greenblatt,J. and
            Bentley,D.
  TITLE     Three functional classes of transcriptional activation domain
  JOURNAL   Mol Cell Biol 16 (5), 2044-2055 (1996)
   PUBMED   8628270
REFERENCE   8  (bases 1 to 7847)
  AUTHORS   Qian,F., Kruse,U., Lichter,P. and Sippel,A.E.
  TITLE     Chromosomal localization of the four genes (NFIA, B, C, and X) for
            the human transcription factor nuclear factor I by FISH
  JOURNAL   Genomics 28 (1), 66-73 (1995)
   PUBMED   7590749
REFERENCE   9  (bases 1 to 7847)
  AUTHORS   Nehls,M.C., Grapilon,M.L. and Brenner,D.A.
  TITLE     NF-I/Sp1 switch elements regulate collagen alpha 1(I) gene
            expression
  JOURNAL   DNA Cell Biol 11 (6), 443-452 (1992)
   PUBMED   1524678
REFERENCE   10 (bases 1 to 7847)
  AUTHORS   Santoro,C., Mermod,N., Andrews,P.C. and Tjian,R.
  TITLE     A family of human CCAAT-box-binding proteins active in
            transcription and DNA replication: cloning and expression of
            multiple cDNAs
  JOURNAL   Nature 334 (6179), 218-224 (1988)
   PUBMED   3398920
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP279194.1, AK289885.1,
            CB053896.1, CK431049.1, AC005551.1, KF456476.1 and BU727954.1.
            
            On May 31, 2019 this sequence version replaced NM_001245005.1.
            
            Summary: The protein encoded by this gene belongs to the CTF/NF-I
            family. These are dimeric DNA-binding proteins, and function as
            cellular transcription factors and as replication factors for
            adenovirus DNA replication. Alternatively spliced transcript
            variants encoding different isoforms have been described for this
            gene. [provided by RefSeq, Oct 2011].
            
            Transcript Variant: This variant (4) contains an alternate 5'
            terminal exon, and lacks an exon in the 3' coding region (causing a
            frame-shift) compared to variant 1. This results in translation
            initiation from an alternate start codon, and a shorter isoform (4)
            with distinct N- and C- termini compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.542645.1,
                                           SRR3476690.827522.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                BP279194.1         68-87
            21-1295             AK289885.1         1-1275
            1296-1939           AK289885.1         1430-2073
            1940-2299           CB053896.1         51-410              c
            2300-2892           CK431049.1         45-637
            2893-7460           AC005551.1         12615-17182
            7461-7583           KF456476.1         1-123
            7584-7847           BU727954.1         19-282              c
FEATURES             Location/Qualifiers
     source          1..7847
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..7847
                     /gene="NFIC"
                     /gene_synonym="CTF; CTF5; NF-I; NFI"
                     /note="nuclear factor I C"
                     /db_xref="GeneID:4782"
                     /db_xref="HGNC:HGNC:7786"
                     /db_xref="MIM:600729"
     exon            1..56
                     /gene="NFIC"
                     /gene_synonym="CTF; CTF5; NF-I; NFI"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..1346
                     /gene="NFIC"
                     /gene_synonym="CTF; CTF5; NF-I; NFI"
                     /note="isoform 4 is encoded by transcript variant 4;
                     nuclear factor 1 C-type; NF1-C; NF-I/C; TGGCA-binding
                     protein; nuclear factor I/C (CCAAT-binding transcription
                     factor); CCAAT-box-binding transcription factor"
                     /codon_start=1
                     /product="nuclear factor 1 C-type isoform 4"
                     /protein_id="NP_001231934.1"
                     /db_xref="CCDS:CCDS58640.1"
                     /db_xref="GeneID:4782"
                     /db_xref="HGNC:HGNC:7786"
                     /db_xref="MIM:600729"
                     /translation="MDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKDE
                     ERAVKDELLGEKPEVKQKWASRLLAKLRKDIRPECREDFVLSITGKKAPGCVLSNPDQ
                     KGKMRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLVKAAQCGHPVLCVQPHHI
                     GVAVKELDLYLAYFVRERDAEQSGSPRTGMGSDQEDSKPITLDTTDFQESFVTSGVFS
                     VTELIQVSRTPVVTGTGPNFSLGELQGHLAYDLNPASTGLRRTLPSTSSSGSKRHKSG
                     SMEEDVDTSPGGDYYTSPSSPTSSSRNWTEDMEGGISSPVKKTEMDKSPFNSPSPQDS
                     PRLSSFTQHHRPVIAVHSGIARSPHPSSALHFPTTSILPQTASTYFPHTAIRYPPHLN
                     PQDPLKDLVSLACDPASQQPGPPTLRPTRPLQTVPLWD"
     exon            57..588
                     /gene="NFIC"
                     /gene_synonym="CTF; CTF5; NF-I; NFI"
                     /inference="alignment:Splign:2.1.0"
     exon            589..660
                     /gene="NFIC"
                     /gene_synonym="CTF; CTF5; NF-I; NFI"
                     /inference="alignment:Splign:2.1.0"
     exon            661..735
                     /gene="NFIC"
                     /gene_synonym="CTF; CTF5; NF-I; NFI"
                     /inference="alignment:Splign:2.1.0"
     exon            736..859
                     /gene="NFIC"
                     /gene_synonym="CTF; CTF5; NF-I; NFI"
                     /inference="alignment:Splign:2.1.0"
     exon            860..984
                     /gene="NFIC"
                     /gene_synonym="CTF; CTF5; NF-I; NFI"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1110
                     /gene="NFIC"
                     /gene_synonym="CTF; CTF5; NF-I; NFI"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1295
                     /gene="NFIC"
                     /gene_synonym="CTF; CTF5; NF-I; NFI"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1381
                     /gene="NFIC"
                     /gene_synonym="CTF; CTF5; NF-I; NFI"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..7847
                     /gene="NFIC"
                     /gene_synonym="CTF; CTF5; NF-I; NFI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3983..3988
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NFIC"
                     /gene_synonym="CTF; CTF5; NF-I; NFI"
                     /note="hexamer: AATAAA"
     polyA_site      4004
                     /gene="NFIC"
                     /gene_synonym="CTF; CTF5; NF-I; NFI"
     regulatory      7822..7827
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NFIC"
                     /gene_synonym="CTF; CTF5; NF-I; NFI"
                     /note="hexamer: ATTAAA"
     polyA_site      7847
                     /gene="NFIC"
                     /gene_synonym="CTF; CTF5; NF-I; NFI"
                     /note="major polyA site"
ORIGIN      
        1 ggggaccgag cgcgctcgct ccggcgccgg cctcgcctcc tcgcagcagc gccatggatg
       61 agttccaccc gttcatcgag gccctgctgc ctcacgtccg cgccttcgcc tacacctggt
      121 tcaacctgca ggcgcggaag cgcaagtact tcaagaagca cgagaagcgg atgtcgaagg
      181 acgaggagcg tgcggtcaag gacgagctgc tgggcgagaa gcccgaggtc aagcagaagt
      241 gggcgtcgcg gctgctggcc aagctgcgca aggacatccg gcccgagtgc cgcgaggact
      301 tcgtgctgag catcaccggc aagaaggcgc cgggctgcgt gctctccaac cccgaccaga
      361 agggcaagat gcggcgcatc gactgtctcc ggcaggcgga caaggtgtgg cggctggacc
      421 tggtcatggt catcctgttc aagggcatcc cgctggagag caccgacggc gagcgcctgg
      481 tcaaggctgc gcagtgcggt cacccggtcc tgtgcgtgca gccgcaccac attggcgtgg
      541 ccgtcaagga gctggacctc tacctggcct acttcgtgcg tgagcgagat gcagagcaaa
      601 gcggcagtcc ccggacaggg atgggctctg accaggagga cagcaagccc atcacgctgg
      661 acacgaccga cttccaggag agctttgtca cctccggcgt gttcagcgtc actgagctca
      721 tccaagtgtc ccggacaccc gtggtgactg gaacaggacc caacttctcc ctgggggagc
      781 tgcaggggca cctggcatac gacctgaacc cagccagcac tggcctcaga agaacgctgc
      841 ccagcacctc ctccagtggg agcaagcggc acaaatcggg ctcgatggag gaagacgtgg
      901 acacgagccc tggcggcgat tactacactt cgcccagctc gcccacgagt agcagccgca
      961 actggacgga ggacatggaa ggaggcatct cgtccccggt gaagaagaca gagatggaca
     1021 agtcaccatt caacagcccg tccccccagg actctccccg cctctccagc ttcacccagc
     1081 accaccggcc cgtcatcgcc gtgcacagcg ggatcgcccg gagcccacac ccgtcctccg
     1141 ctctgcattt ccctacgacg tccatcctac cccagacggc ctccacctac ttcccccaca
     1201 cggccatccg ctacccacct catctcaacc cccaggaccc gctcaaagat cttgtctcgc
     1261 tggcctgcga cccagccagc cagcaacctg gaccgcctac tctccgcccg acacgtcccc
     1321 tgcaaaccgt tcctttgtgg gattaggacc aagggatcct gcgggcattt atcaggcaca
     1381 gtcctggtat ctgggatagc aaaggtcttc ttccctcgcc ccttctccat cgtcccagga
     1441 atcccagggg gcagcacagc cggcccccgg cccacgtttt cggtggaaaa ttagagtgaa
     1501 caagaacacc cctgccgact cccagcccgg ccaaaaagac aaaacacata gacgcacaca
     1561 ctcaggagga aaagaaaaaa caaaggcaga agaagaagaa gaagaaataa aaacccaccc
     1621 aagcaagaag acaaaaggta aagacgcaac gtttccaact ctcgggacgc caaggccgca
     1681 ggactggagg gccaggcccc gccaccccca cgggagaccc gggacagggc gtcttcctaa
     1741 gttattcatc tcctctccgc ctgctgctcg ggaaggacag acgccggccg cccgcccgcg
     1801 ccccggaggc cctggctctg tccggagacc aggtgagcac agcctggagc ctgtgcccag
     1861 ggccgacagg cgcgacaccc agcaaggcca cctctccccg ggcccccgcg cctctgccgg
     1921 acacggaccg gcccctcagc ccccaccgag gacgcagcca ctggggggaa agggagacac
     1981 agcggacccc ggccgggcag cggagaccgc agaggcgggc agggtggggc aggcgagtgg
     2041 tgtcgcgggg gtgcgtggcg cttgcgagcc ctggccaggg gaggaagtga ggcccaggca
     2101 cctgctgccc ctcgaggggg ccctgcctgc cgcggggcct ccccacaagc ccctcccaaa
     2161 gcgccggccg actcgctgtc tcgctgggga ctctttcagc cctcgcgccc gcccgtttgg
     2221 gaggagaagt ctctatgcaa ttggccccgg cccctccacc ccccaccccc ggcataggag
     2281 gcccccccac ctcgcccggc tcacaccccc aaagggaggg acccacattg cacacactgt
     2341 aagaaatgca ctttccgagg aaggggatgg gggagcccgg acacccagag ctccccgagt
     2401 tgggggtgcc cgtctggagc gcccccgtca gcccctggcg gtgggaggtg agagcgagtg
     2461 gtttaagtgc ctgattacca ccacccgccc ccccctttgt ccagctggga cacggaatgg
     2521 ccgcgggcct cctccccctc ccctccagcc tctccaccag cccctccagt caaccctcat
     2581 cgccgtgccc ccccagagct agagagatgg ggcccctgcg tggcccgagg ggcagagctg
     2641 ggcgtcactt cgcaagcgtc ctgccctgcc ggggcgcggg ggtgggctct ggggaagccg
     2701 gtgcgccccc cacgcctccg ctgccagtgc cttacattct ggagcgaccc ccctccctgg
     2761 tgcctcccag cgaaggggga ccgccgtttg cactttcatc gcctaccccg acgcggggcc
     2821 cagctgcggg acgtgcatca cggctgggcc cccagaggag agaggaggcc gacgccagcg
     2881 gtccccgctc ggaacgggga gggttttcgg ggggttcggc gtcgcacctt ggggcccccc
     2941 gcagccgtgt agggggcctc ccatctgcta agcgtttttc cgttgagccg ctccaaaaac
     3001 actaagctgg ggacgccagg tgccccccca ccccggctcc ctggccctat ccacacctcc
     3061 acccccaccc caggatcgcc atctttaggg gaggcctggg agggggtgtt aggtgtttta
     3121 gggccaccga gctcaaacac aaggacccct ccccggccca cccagcccag ccccaactga
     3181 cctccatgcc tagggaaaaa ctccccccac cactgccccc tcccccgacc caggccaaag
     3241 ccagggcagg tctccgggtc tcacctgctc ctagcctcac ccccctgccc ccgaaaacca
     3301 gactctcctc ccaaactagc ctcaggagct tggcgaaccc gctcgctcct aaagagaaag
     3361 acccaggacc ctcccccatc acccccaaga gaggttcgcc atcctctggc ctcgagccct
     3421 tggtccctcc gtccgtctgt cctcggggcc cgctcccccg gtggcccttg gggatcaaag
     3481 cgtgggccgc tctccgggag ggcgggcggg ggagggggtg gtcgggttgt gccattgggg
     3541 tgtccggaag cttctcagcc agggtggggg tcgtggagtg ggggagggag gccagccggg
     3601 ctccagaggg gtcagggcgc gacgagaacc aactctttac ctaactttgc atggtgctta
     3661 gtcaaggact cctgcgacct ggctcccgag gtcagctggc ggcgctgaca cacatgcatg
     3721 gcagactatc cctggctcta tctccctgtt cctcgccccc tccacccccc acttcctctt
     3781 taaaaaaaaa aaaaaaaaaa aaaagataca agaaaaacct ttaaaaaaat tccatgtttc
     3841 ctaatttgca cgaaattttc taccacaaga tgtgccttgc cttccgagaa taagtattac
     3901 ctttaaacaa tatcagcgca cacacatagc tgcatgttct gctcgtgtag tttaaaaaaa
     3961 aaaagacaaa acagtgacat gaaataaaaa ataaaaattg aaaagggatg tatttctatt
     4021 tgtaaaaaaa ataaaataaa aaataagaaa gtgagaatct aaaaaaaaaa aaaaaaaaaa
     4081 aaaaggaaga aaaaccacgc taaaaatcaa gccactgaaa acaattgccc ccaggtctac
     4141 ccagcccctg gctgtccttg gtcctgtctc ccctcctgct gtattcaggg gtgccccctg
     4201 gtgctcagcc tctaccaccc ccaaccctgc tcttgggtac ccagaggggt catttctgaa
     4261 tcccttgccc agaggacaga cctccggggc ccatcttggc cctgggaaag ggctctcctc
     4321 tctgattggt ccctaggcca cgggccggcc cccagacacc attcaccgac ccactgcagg
     4381 ctgtcctcca accatggggt ggccactcca cccgcagcca gactccccgc tccccacttt
     4441 tcatgcaggc tggcataccc ctggctcagg gtcaaatgct gttccacacc cacctcagag
     4501 gcaccccctc tcccctgccc cgtgcatccc cacccttctt gccaaaggac ctcttttccc
     4561 ctatccagag accaccccag gtggcattct ctcccacctt ctcctttgtc ccccatcccc
     4621 tgtctctgtc ttccagctgt gaatatgaag ggtatcctgt atgaaacaaa aacaaaacct
     4681 gatatatgca atatctgtct gtctgtctgt acccatgggc ctggctcagc cattggaggc
     4741 ccagccgagg gtccggcagg gcacagggac agccaggtgg caccgagtca caggctgtgg
     4801 tccggtggct gagcatgctg ttgtcttgtc cttgatttta ttttcttttg ttcttttttt
     4861 ttttcttttc tttttgtttt taactccagc ttcctttgct ttttacttga ccaaagctaa
     4921 gacaatagcc agatggttag tggggcagcc aggcagggag gacccagggc tgggattctc
     4981 caaccttagg ccattcctgc agccctcacc acctccagcc cctccaagca tctcgtgtag
     5041 ggacccacgc agatggtccc attcattcac tattgccccc aaccccggga ttttgggtgg
     5101 tctccacagc caccatcata cactcatccc gtgttttctt ccaaaaagtc acctcagcag
     5161 cctccccagg cgatacagag ggagagccca gaccaccaca gctggccacg acattgccct
     5221 taagtaatat gcattggcca gagagcccgg gctggctgtg cacagcattc atgtagctga
     5281 tttctagctt tttttttttt tctgccccac tcctgagcaa atctgtcttg ccaaggaact
     5341 aggagcaacc ggaggcaaag ggagtgggtg gccccatcac tattgggacc atcgcgtccc
     5401 tgcacagccc acacccgggg gcccagagtc ctgggctgga cgccaccctt ctcaccccga
     5461 gcttgcctcc ttggctcact tggcaccttg gctgagtaca gcaggcaaaa gcccatacca
     5521 ggcagcatgt tgtggatggt ttagttctcc ccgcctccct gtttcttgga aaagctacag
     5581 ggtccctgta gggcaaaatt cccaggcgcc ttgctgcaga cagagtaaga caaaaacacc
     5641 aggaagcagg attccgtgcc catctctgca gtttgggttc acaaaagggg gtgccgtcat
     5701 ccctgggtgg aggagggagt gttggttttt tgtttttgtt tttttaacat gtatgaaact
     5761 gacatcttct caaatcttgt tccacccccc tctggaagcc cccatcaccc acccctgcta
     5821 tggacaccac acctatgcca ggcccccccc cccaccccag tctcattctg gggtctgccc
     5881 atgctgtggg aaagaatagg gaggcctccc aaatatatgc aaattgtccc cattccgtgg
     5941 gggcacctga caatgacccg ggtggagatg gggcatggag gagtaggaag acccagccct
     6001 atttgactgg ggagaggagg atctggagtc cttcatgccc aggtctggaa cccaggttct
     6061 gaccccaggg ccccaccctg ggctggacaa tcagatccca aaggaatgcc aaaggggact
     6121 cggttgggag agccgcttag gggccagacc tgggtccccc tgcaggtccc caggcagcag
     6181 acaattccac cttccctgcc ccaggacctt gagagacagc agcattccag gcacagacag
     6241 acttggctgc accccactgt cccttgcaag acaggttctg gagccaggag caactgtcca
     6301 gccctccaga agagacagca agcagccccc ctacccactc tggcctcccc aatggtactt
     6361 tgacctccag tgtagggcta tactatacat atatatatat atatatatat atatatataa
     6421 ttttggaatt tgtttctcat aatacagaat atatagtggc taccttgtat cttggtctgg
     6481 attctctctc tgagaccccg gattttactt tctctttgga gggcgctggg acatacatct
     6541 ctcaatccag cttcctccgc atcctcccat cttgccccat ttctgccacg tcagacactt
     6601 cctgagagtc tcaccttcaa aatgacaccg ctgcccatcc attgctcaat ggtacagagt
     6661 gtggggtcag tccaccaccc ttgacctccc ggcagggcaa ggtgaggagg cggacccaaa
     6721 gcagtaccag caggacttgt tgccagtgat accaaaacag acttttccca agcagtgcct
     6781 cacatgtctg ctggtgtggc tttgggattc tcctgcccca cccccccgtc catggcagcc
     6841 ccctccccaa ggctttgctc acacctgaga caggaaggag gaaggggatc caataggaat
     6901 atgggccccg gaggggaagt catgcacccc caagccacca ccccccagcc ttccacgcac
     6961 atctcctggc tggaagagag ccctccaaaa aggggacaca ggctgccccg gcccctcaac
     7021 tgcatccaca ccccatcctc tcatcttggg tcccagccag gcccccccaa aaccaaagcc
     7081 ccctcaagtc ctggggtccc agcctgtgcc cccagcttcc tgcccaccca gccctgagca
     7141 ttctcacaca gagaaagaac aagcaagggc tccaggggga caggatgggg cagggcatac
     7201 agtggggggt gggggggcag ctgggaggag ggagggacaa aacaaaacat tttcctttgg
     7261 gttttttttt tctttctttt ttctcccctt tactctttgg gtggtgttgc ttttcctttc
     7321 cttttccctt tgagattttt ttgttgttgt ttcctttttg tattttactg atatcaccag
     7381 gatagtttac tctccttcta gctttctgct taccgcacac tggataacac acacatacac
     7441 acccacaaaa atgctcatga acccaatccg gagaaggttc cagcaggtcc cccaccctcc
     7501 cctcctcctc ctacttctcc tcttgacagc gaggacagga gggggacaag gggacacctg
     7561 ggcagacccg ccggctctcc ccccacccca ccccgcccct cacatcatac tccaatcata
     7621 accttgtata ttacgcagtc attttggttt tcgcggacgc gcctacctaa gtaccattta
     7681 cagaaagtga ctctggctgt cattattttg tttatttgtt ccctatgcaa aaaaaaaatg
     7741 aaaatgaaaa aagggggatt ccataaaaga ttcaataaaa gacaaacaaa aaaaaaagaa
     7801 aaaagaaaaa aatgtataaa aattaaacaa gctatgcttc gactctt
//
