LOCUS       NM_001245004            7875 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens nuclear factor I C (NFIC), transcript variant 3, mRNA.
ACCESSION   NM_001245004
VERSION     NM_001245004.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7875)
  AUTHORS   Polcaro,G., Liguori,L., Manzo,V., Chianese,A., Donadio,G.,
            Caputo,A., Scognamiglio,G., Dell'Annunziata,F., Langella,M.,
            Corbi,G., Ottaiano,A., Cascella,M., Perri,F., De Marco,M.,
            Col,J.D., Nassa,G., Giurato,G., Zeppa,P., Filippelli,A., Franci,G.,
            Piaz,F.D., Conti,V., Pepe,S. and Sabbatino,F.
  TITLE     rs822336 binding to C/EBPbeta and NFIC modulates induction of PD-L1
            expression and predicts anti-PD-1/PD-L1 therapy in advanced NSCLC
  JOURNAL   Mol Cancer 23 (1), 63 (2024)
   PUBMED   38528526
  REMARK    GeneRIF: rs822336 binding to C/EBPbeta and NFIC modulates induction
            of PD-L1 expression and predicts anti-PD-1/PD-L1 therapy in
            advanced NSCLC.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7875)
  AUTHORS   Wu,J., Wang,M., Zhang,Y., Liu,G. and Xing,Y.
  TITLE     Activation of CHPF by transcription factor NFIC promotes NLRP3
            activation during the progression of colorectal cancer
  JOURNAL   Funct Integr Genomics 24 (1), 20 (2024)
   PUBMED   38267731
  REMARK    GeneRIF: Activation of CHPF by transcription factor NFIC promotes
            NLRP3 activation during the progression of colorectal cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7875)
  AUTHORS   Huang,H., Zhu,W., Huang,Z., Zhao,D., Cao,L. and Gao,X.
  TITLE     Adipose-derived stem cell exosome NFIC improves diabetic foot
            ulcers by regulating miR-204-3p/HIPK2
  JOURNAL   J Orthop Surg Res 18 (1), 687 (2023)
   PUBMED   37710299
  REMARK    GeneRIF: Adipose-derived stem cell exosome NFIC improves diabetic
            foot ulcers by regulating miR-204-3p/HIPK2.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7875)
  AUTHORS   Cobo,I., Paliwal,S., Bodas,C., Felipe,I., Melia-Aloma,J.,
            Torres,A., Martinez-Villarreal,J., Malumbres,M., Garcia,F.,
            Millan,I., Del Pozo,N., Park,J.C., MacDonald,R.J., Munoz,J.,
            Mendez,R. and Real,F.X.
  TITLE     NFIC regulates ribosomal biology and ER stress in pancreatic acinar
            cells and restrains PDAC initiation
  JOURNAL   Nat Commun 14 (1), 3761 (2023)
   PUBMED   37353485
  REMARK    GeneRIF: NFIC regulates ribosomal biology and ER stress in
            pancreatic acinar cells and restrains PDAC initiation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7875)
  AUTHORS   Zhang,J., Wang,Z., Liang,Z., Jin,C., Shi,Y., Fan,M., Hu,X. and
            Wan,Y.
  TITLE     NFIC1 inhibits the migration and invasion of MDA-MB-231 cells
            through S100A2-mediated inactivation of MEK/ERK pathway
  JOURNAL   Arch Biochem Biophys 734, 109497 (2023)
   PUBMED   36574914
  REMARK    GeneRIF: NFIC1 inhibits the migration and invasion of MDA-MB-231
            cells through S100A2-mediated inactivation of MEK/ERK pathway.
REFERENCE   6  (bases 1 to 7875)
  AUTHORS   Wenzelides,S., Altmann,H., Wendler,W. and Winnacker,E.L.
  TITLE     CTF5--a new transcriptional activator of the NFI/CTF family
  JOURNAL   Nucleic Acids Res 24 (12), 2416-2421 (1996)
   PUBMED   8710515
REFERENCE   7  (bases 1 to 7875)
  AUTHORS   Blau,J., Xiao,H., McCracken,S., O'Hare,P., Greenblatt,J. and
            Bentley,D.
  TITLE     Three functional classes of transcriptional activation domain
  JOURNAL   Mol Cell Biol 16 (5), 2044-2055 (1996)
   PUBMED   8628270
REFERENCE   8  (bases 1 to 7875)
  AUTHORS   Qian,F., Kruse,U., Lichter,P. and Sippel,A.E.
  TITLE     Chromosomal localization of the four genes (NFIA, B, C, and X) for
            the human transcription factor nuclear factor I by FISH
  JOURNAL   Genomics 28 (1), 66-73 (1995)
   PUBMED   7590749
REFERENCE   9  (bases 1 to 7875)
  AUTHORS   Nehls,M.C., Grapilon,M.L. and Brenner,D.A.
  TITLE     NF-I/Sp1 switch elements regulate collagen alpha 1(I) gene
            expression
  JOURNAL   DNA Cell Biol 11 (6), 443-452 (1992)
   PUBMED   1524678
REFERENCE   10 (bases 1 to 7875)
  AUTHORS   Santoro,C., Mermod,N., Andrews,P.C. and Tjian,R.
  TITLE     A family of human CCAAT-box-binding proteins active in
            transcription and DNA replication: cloning and expression of
            multiple cDNAs
  JOURNAL   Nature 334 (6179), 218-224 (1988)
   PUBMED   3398920
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC012120.1, AK289885.1,
            CB053896.1, CK431049.1, AC005551.1, KF456476.1 and BU727954.1.
            
            On May 31, 2019 this sequence version replaced NM_001245004.1.
            
            Summary: The protein encoded by this gene belongs to the CTF/NF-I
            family. These are dimeric DNA-binding proteins, and function as
            cellular transcription factors and as replication factors for
            adenovirus DNA replication. Alternatively spliced transcript
            variants encoding different isoforms have been described for this
            gene. [provided by RefSeq, Oct 2011].
            
            Transcript Variant: This variant (3) lacks an exon in the 3' coding
            region compared to variant 1. This results in a frame-shift, and a
            shorter isoform (3) with a distinct C-terminus compared to isoform
            1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK297867.1, SRR7346977.1934926.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1323              BC012120.1         9-1331
            1324-1967           AK289885.1         1430-2073
            1968-2327           CB053896.1         51-410              c
            2328-2920           CK431049.1         45-637
            2921-7488           AC005551.1         12615-17182
            7489-7611           KF456476.1         1-123
            7612-7875           BU727954.1         19-282              c
FEATURES             Location/Qualifiers
     source          1..7875
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..7875
                     /gene="NFIC"
                     /gene_synonym="CTF; CTF5; NF-I; NFI"
                     /note="nuclear factor I C"
                     /db_xref="GeneID:4782"
                     /db_xref="HGNC:HGNC:7786"
                     /db_xref="MIM:600729"
     exon            1..84
                     /gene="NFIC"
                     /gene_synonym="CTF; CTF5; NF-I; NFI"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..1374
                     /gene="NFIC"
                     /gene_synonym="CTF; CTF5; NF-I; NFI"
                     /note="isoform 3 is encoded by transcript variant 3;
                     nuclear factor 1 C-type; NF1-C; NF-I/C; TGGCA-binding
                     protein; nuclear factor I/C (CCAAT-binding transcription
                     factor); CCAAT-box-binding transcription factor"
                     /codon_start=1
                     /product="nuclear factor 1 C-type isoform 3"
                     /protein_id="NP_001231933.1"
                     /db_xref="CCDS:CCDS59331.1"
                     /db_xref="GeneID:4782"
                     /db_xref="HGNC:HGNC:7786"
                     /db_xref="MIM:600729"
                     /translation="MYSSPLCLTQDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKK
                     HEKRMSKDEERAVKDELLGEKPEVKQKWASRLLAKLRKDIRPECREDFVLSITGKKAP
                     GCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLVKAAQCGHP
                     VLCVQPHHIGVAVKELDLYLAYFVRERDAEQSGSPRTGMGSDQEDSKPITLDTTDFQE
                     SFVTSGVFSVTELIQVSRTPVVTGTGPNFSLGELQGHLAYDLNPASTGLRRTLPSTSS
                     SGSKRHKSGSMEEDVDTSPGGDYYTSPSSPTSSSRNWTEDMEGGISSPVKKTEMDKSP
                     FNSPSPQDSPRLSSFTQHHRPVIAVHSGIARSPHPSSALHFPTTSILPQTASTYFPHT
                     AIRYPPHLNPQDPLKDLVSLACDPASQQPGPPTLRPTRPLQTVPLWD"
     exon            85..616
                     /gene="NFIC"
                     /gene_synonym="CTF; CTF5; NF-I; NFI"
                     /inference="alignment:Splign:2.1.0"
     exon            617..688
                     /gene="NFIC"
                     /gene_synonym="CTF; CTF5; NF-I; NFI"
                     /inference="alignment:Splign:2.1.0"
     exon            689..763
                     /gene="NFIC"
                     /gene_synonym="CTF; CTF5; NF-I; NFI"
                     /inference="alignment:Splign:2.1.0"
     exon            764..887
                     /gene="NFIC"
                     /gene_synonym="CTF; CTF5; NF-I; NFI"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1012
                     /gene="NFIC"
                     /gene_synonym="CTF; CTF5; NF-I; NFI"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1138
                     /gene="NFIC"
                     /gene_synonym="CTF; CTF5; NF-I; NFI"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1323
                     /gene="NFIC"
                     /gene_synonym="CTF; CTF5; NF-I; NFI"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1409
                     /gene="NFIC"
                     /gene_synonym="CTF; CTF5; NF-I; NFI"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..7875
                     /gene="NFIC"
                     /gene_synonym="CTF; CTF5; NF-I; NFI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4011..4016
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NFIC"
                     /gene_synonym="CTF; CTF5; NF-I; NFI"
                     /note="hexamer: AATAAA"
     polyA_site      4032
                     /gene="NFIC"
                     /gene_synonym="CTF; CTF5; NF-I; NFI"
     regulatory      7850..7855
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NFIC"
                     /gene_synonym="CTF; CTF5; NF-I; NFI"
                     /note="hexamer: ATTAAA"
     polyA_site      7875
                     /gene="NFIC"
                     /gene_synonym="CTF; CTF5; NF-I; NFI"
                     /note="major polyA site"
ORIGIN      
        1 agtaagttca gcgcgcccgc tccggccggc cctgcgcctc ccgccgcgcc cgggatgtat
       61 tcgtccccgc tctgcctcac ccaggatgag ttccacccgt tcatcgaggc cctgctgcct
      121 cacgtccgcg ccttcgccta cacctggttc aacctgcagg cgcggaagcg caagtacttc
      181 aagaagcacg agaagcggat gtcgaaggac gaggagcgtg cggtcaagga cgagctgctg
      241 ggcgagaagc ccgaggtcaa gcagaagtgg gcgtcgcggc tgctggccaa gctgcgcaag
      301 gacatccggc ccgagtgccg cgaggacttc gtgctgagca tcaccggcaa gaaggcgccg
      361 ggctgcgtgc tctccaaccc cgaccagaag ggcaagatgc ggcgcatcga ctgtctccgg
      421 caggcggaca aggtgtggcg gctggacctg gtcatggtca tcctgttcaa gggcatcccg
      481 ctggagagca ccgacggcga gcgcctggtc aaggctgcgc agtgcggtca cccggtcctg
      541 tgcgtgcagc cgcaccacat tggcgtggcc gtcaaggagc tggacctcta cctggcctac
      601 ttcgtgcgtg agcgagatgc agagcaaagc ggcagtcccc ggacagggat gggctctgac
      661 caggaggaca gcaagcccat cacgctggac acgaccgact tccaggagag ctttgtcacc
      721 tccggcgtgt tcagcgtcac tgagctcatc caagtgtccc ggacacccgt ggtgactgga
      781 acaggaccca acttctccct gggggagctg caggggcacc tggcatacga cctgaaccca
      841 gccagcactg gcctcagaag aacgctgccc agcacctcct ccagtgggag caagcggcac
      901 aaatcgggct cgatggagga agacgtggac acgagccctg gcggcgatta ctacacttcg
      961 cccagctcgc ccacgagtag cagccgcaac tggacggagg acatggaagg aggcatctcg
     1021 tccccggtga agaagacaga gatggacaag tcaccattca acagcccgtc cccccaggac
     1081 tctccccgcc tctccagctt cacccagcac caccggcccg tcatcgccgt gcacagcggg
     1141 atcgcccgga gcccacaccc gtcctccgct ctgcatttcc ctacgacgtc catcctaccc
     1201 cagacggcct ccacctactt cccccacacg gccatccgct acccacctca tctcaacccc
     1261 caggacccgc tcaaagatct tgtctcgctg gcctgcgacc cagccagcca gcaacctgga
     1321 ccgcctactc tccgcccgac acgtcccctg caaaccgttc ctttgtggga ttaggaccaa
     1381 gggatcctgc gggcatttat caggcacagt cctggtatct gggatagcaa aggtcttctt
     1441 ccctcgcccc ttctccatcg tcccaggaat cccagggggc agcacagccg gcccccggcc
     1501 cacgttttcg gtggaaaatt agagtgaaca agaacacccc tgccgactcc cagcccggcc
     1561 aaaaagacaa aacacataga cgcacacact caggaggaaa agaaaaaaca aaggcagaag
     1621 aagaagaaga agaaataaaa acccacccaa gcaagaagac aaaaggtaaa gacgcaacgt
     1681 ttccaactct cgggacgcca aggccgcagg actggagggc caggccccgc cacccccacg
     1741 ggagacccgg gacagggcgt cttcctaagt tattcatctc ctctccgcct gctgctcggg
     1801 aaggacagac gccggccgcc cgcccgcgcc ccggaggccc tggctctgtc cggagaccag
     1861 gtgagcacag cctggagcct gtgcccaggg ccgacaggcg cgacacccag caaggccacc
     1921 tctccccggg cccccgcgcc tctgccggac acggaccggc ccctcagccc ccaccgagga
     1981 cgcagccact ggggggaaag ggagacacag cggaccccgg ccgggcagcg gagaccgcag
     2041 aggcgggcag ggtggggcag gcgagtggtg tcgcgggggt gcgtggcgct tgcgagccct
     2101 ggccagggga ggaagtgagg cccaggcacc tgctgcccct cgagggggcc ctgcctgccg
     2161 cggggcctcc ccacaagccc ctcccaaagc gccggccgac tcgctgtctc gctggggact
     2221 ctttcagccc tcgcgcccgc ccgtttggga ggagaagtct ctatgcaatt ggccccggcc
     2281 cctccacccc ccacccccgg cataggaggc ccccccacct cgcccggctc acacccccaa
     2341 agggagggac ccacattgca cacactgtaa gaaatgcact ttccgaggaa ggggatgggg
     2401 gagcccggac acccagagct ccccgagttg ggggtgcccg tctggagcgc ccccgtcagc
     2461 ccctggcggt gggaggtgag agcgagtggt ttaagtgcct gattaccacc acccgccccc
     2521 ccctttgtcc agctgggaca cggaatggcc gcgggcctcc tccccctccc ctccagcctc
     2581 tccaccagcc cctccagtca accctcatcg ccgtgccccc ccagagctag agagatgggg
     2641 cccctgcgtg gcccgagggg cagagctggg cgtcacttcg caagcgtcct gccctgccgg
     2701 ggcgcggggg tgggctctgg ggaagccggt gcgcccccca cgcctccgct gccagtgcct
     2761 tacattctgg agcgaccccc ctccctggtg cctcccagcg aagggggacc gccgtttgca
     2821 ctttcatcgc ctaccccgac gcggggccca gctgcgggac gtgcatcacg gctgggcccc
     2881 cagaggagag aggaggccga cgccagcggt ccccgctcgg aacggggagg gttttcgggg
     2941 ggttcggcgt cgcaccttgg ggccccccgc agccgtgtag ggggcctccc atctgctaag
     3001 cgtttttccg ttgagccgct ccaaaaacac taagctgggg acgccaggtg cccccccacc
     3061 ccggctccct ggccctatcc acacctccac ccccacccca ggatcgccat ctttagggga
     3121 ggcctgggag ggggtgttag gtgttttagg gccaccgagc tcaaacacaa ggacccctcc
     3181 ccggcccacc cagcccagcc ccaactgacc tccatgccta gggaaaaact ccccccacca
     3241 ctgccccctc ccccgaccca ggccaaagcc agggcaggtc tccgggtctc acctgctcct
     3301 agcctcaccc ccctgccccc gaaaaccaga ctctcctccc aaactagcct caggagcttg
     3361 gcgaacccgc tcgctcctaa agagaaagac ccaggaccct cccccatcac ccccaagaga
     3421 ggttcgccat cctctggcct cgagcccttg gtccctccgt ccgtctgtcc tcggggcccg
     3481 ctcccccggt ggcccttggg gatcaaagcg tgggccgctc tccgggaggg cgggcggggg
     3541 agggggtggt cgggttgtgc cattggggtg tccggaagct tctcagccag ggtgggggtc
     3601 gtggagtggg ggagggaggc cagccgggct ccagaggggt cagggcgcga cgagaaccaa
     3661 ctctttacct aactttgcat ggtgcttagt caaggactcc tgcgacctgg ctcccgaggt
     3721 cagctggcgg cgctgacaca catgcatggc agactatccc tggctctatc tccctgttcc
     3781 tcgccccctc caccccccac ttcctcttta aaaaaaaaaa aaaaaaaaaa aagatacaag
     3841 aaaaaccttt aaaaaaattc catgtttcct aatttgcacg aaattttcta ccacaagatg
     3901 tgccttgcct tccgagaata agtattacct ttaaacaata tcagcgcaca cacatagctg
     3961 catgttctgc tcgtgtagtt taaaaaaaaa aagacaaaac agtgacatga aataaaaaat
     4021 aaaaattgaa aagggatgta tttctatttg taaaaaaaat aaaataaaaa ataagaaagt
     4081 gagaatctaa aaaaaaaaaa aaaaaaaaaa aaggaagaaa aaccacgcta aaaatcaagc
     4141 cactgaaaac aattgccccc aggtctaccc agcccctggc tgtccttggt cctgtctccc
     4201 ctcctgctgt attcaggggt gccccctggt gctcagcctc taccaccccc aaccctgctc
     4261 ttgggtaccc agaggggtca tttctgaatc ccttgcccag aggacagacc tccggggccc
     4321 atcttggccc tgggaaaggg ctctcctctc tgattggtcc ctaggccacg ggccggcccc
     4381 cagacaccat tcaccgaccc actgcaggct gtcctccaac catggggtgg ccactccacc
     4441 cgcagccaga ctccccgctc cccacttttc atgcaggctg gcatacccct ggctcagggt
     4501 caaatgctgt tccacaccca cctcagaggc accccctctc ccctgccccg tgcatcccca
     4561 cccttcttgc caaaggacct cttttcccct atccagagac caccccaggt ggcattctct
     4621 cccaccttct cctttgtccc ccatcccctg tctctgtctt ccagctgtga atatgaaggg
     4681 tatcctgtat gaaacaaaaa caaaacctga tatatgcaat atctgtctgt ctgtctgtac
     4741 ccatgggcct ggctcagcca ttggaggccc agccgagggt ccggcagggc acagggacag
     4801 ccaggtggca ccgagtcaca ggctgtggtc cggtggctga gcatgctgtt gtcttgtcct
     4861 tgattttatt ttcttttgtt cttttttttt ttcttttctt tttgttttta actccagctt
     4921 cctttgcttt ttacttgacc aaagctaaga caatagccag atggttagtg gggcagccag
     4981 gcagggagga cccagggctg ggattctcca accttaggcc attcctgcag ccctcaccac
     5041 ctccagcccc tccaagcatc tcgtgtaggg acccacgcag atggtcccat tcattcacta
     5101 ttgcccccaa ccccgggatt ttgggtggtc tccacagcca ccatcataca ctcatcccgt
     5161 gttttcttcc aaaaagtcac ctcagcagcc tccccaggcg atacagaggg agagcccaga
     5221 ccaccacagc tggccacgac attgccctta agtaatatgc attggccaga gagcccgggc
     5281 tggctgtgca cagcattcat gtagctgatt tctagctttt tttttttttc tgccccactc
     5341 ctgagcaaat ctgtcttgcc aaggaactag gagcaaccgg aggcaaaggg agtgggtggc
     5401 cccatcacta ttgggaccat cgcgtccctg cacagcccac acccgggggc ccagagtcct
     5461 gggctggacg ccacccttct caccccgagc ttgcctcctt ggctcacttg gcaccttggc
     5521 tgagtacagc aggcaaaagc ccataccagg cagcatgttg tggatggttt agttctcccc
     5581 gcctccctgt ttcttggaaa agctacaggg tccctgtagg gcaaaattcc caggcgcctt
     5641 gctgcagaca gagtaagaca aaaacaccag gaagcaggat tccgtgccca tctctgcagt
     5701 ttgggttcac aaaagggggt gccgtcatcc ctgggtggag gagggagtgt tggttttttg
     5761 tttttgtttt tttaacatgt atgaaactga catcttctca aatcttgttc cacccccctc
     5821 tggaagcccc catcacccac ccctgctatg gacaccacac ctatgccagg cccccccccc
     5881 caccccagtc tcattctggg gtctgcccat gctgtgggaa agaataggga ggcctcccaa
     5941 atatatgcaa attgtcccca ttccgtgggg gcacctgaca atgacccggg tggagatggg
     6001 gcatggagga gtaggaagac ccagccctat ttgactgggg agaggaggat ctggagtcct
     6061 tcatgcccag gtctggaacc caggttctga ccccagggcc ccaccctggg ctggacaatc
     6121 agatcccaaa ggaatgccaa aggggactcg gttgggagag ccgcttaggg gccagacctg
     6181 ggtccccctg caggtcccca ggcagcagac aattccacct tccctgcccc aggaccttga
     6241 gagacagcag cattccaggc acagacagac ttggctgcac cccactgtcc cttgcaagac
     6301 aggttctgga gccaggagca actgtccagc cctccagaag agacagcaag cagcccccct
     6361 acccactctg gcctccccaa tggtactttg acctccagtg tagggctata ctatacatat
     6421 atatatatat atatatatat atatataatt ttggaatttg tttctcataa tacagaatat
     6481 atagtggcta ccttgtatct tggtctggat tctctctctg agaccccgga ttttactttc
     6541 tctttggagg gcgctgggac atacatctct caatccagct tcctccgcat cctcccatct
     6601 tgccccattt ctgccacgtc agacacttcc tgagagtctc accttcaaaa tgacaccgct
     6661 gcccatccat tgctcaatgg tacagagtgt ggggtcagtc caccaccctt gacctcccgg
     6721 cagggcaagg tgaggaggcg gacccaaagc agtaccagca ggacttgttg ccagtgatac
     6781 caaaacagac ttttcccaag cagtgcctca catgtctgct ggtgtggctt tgggattctc
     6841 ctgccccacc cccccgtcca tggcagcccc ctccccaagg ctttgctcac acctgagaca
     6901 ggaaggagga aggggatcca ataggaatat gggccccgga ggggaagtca tgcaccccca
     6961 agccaccacc ccccagcctt ccacgcacat ctcctggctg gaagagagcc ctccaaaaag
     7021 gggacacagg ctgccccggc ccctcaactg catccacacc ccatcctctc atcttgggtc
     7081 ccagccaggc ccccccaaaa ccaaagcccc ctcaagtcct ggggtcccag cctgtgcccc
     7141 cagcttcctg cccacccagc cctgagcatt ctcacacaga gaaagaacaa gcaagggctc
     7201 cagggggaca ggatggggca gggcatacag tggggggtgg gggggcagct gggaggaggg
     7261 agggacaaaa caaaacattt tcctttgggt tttttttttc tttctttttt ctccccttta
     7321 ctctttgggt ggtgttgctt ttcctttcct tttccctttg agattttttt gttgttgttt
     7381 cctttttgta ttttactgat atcaccagga tagtttactc tccttctagc tttctgctta
     7441 ccgcacactg gataacacac acatacacac ccacaaaaat gctcatgaac ccaatccgga
     7501 gaaggttcca gcaggtcccc caccctcccc tcctcctcct acttctcctc ttgacagcga
     7561 ggacaggagg gggacaaggg gacacctggg cagacccgcc ggctctcccc ccaccccacc
     7621 ccgcccctca catcatactc caatcataac cttgtatatt acgcagtcat tttggttttc
     7681 gcggacgcgc ctacctaagt accatttaca gaaagtgact ctggctgtca ttattttgtt
     7741 tatttgttcc ctatgcaaaa aaaaaatgaa aatgaaaaaa gggggattcc ataaaagatt
     7801 caataaaaga caaacaaaaa aaaaagaaaa aagaaaaaaa tgtataaaaa ttaaacaagc
     7861 tatgcttcga ctctt
//
