LOCUS       NM_001245002            8029 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens nuclear factor I C (NFIC), transcript variant 1, mRNA.
ACCESSION   NM_001245002
VERSION     NM_001245002.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8029)
  AUTHORS   Polcaro,G., Liguori,L., Manzo,V., Chianese,A., Donadio,G.,
            Caputo,A., Scognamiglio,G., Dell'Annunziata,F., Langella,M.,
            Corbi,G., Ottaiano,A., Cascella,M., Perri,F., De Marco,M.,
            Col,J.D., Nassa,G., Giurato,G., Zeppa,P., Filippelli,A., Franci,G.,
            Piaz,F.D., Conti,V., Pepe,S. and Sabbatino,F.
  TITLE     rs822336 binding to C/EBPbeta and NFIC modulates induction of PD-L1
            expression and predicts anti-PD-1/PD-L1 therapy in advanced NSCLC
  JOURNAL   Mol Cancer 23 (1), 63 (2024)
   PUBMED   38528526
  REMARK    GeneRIF: rs822336 binding to C/EBPbeta and NFIC modulates induction
            of PD-L1 expression and predicts anti-PD-1/PD-L1 therapy in
            advanced NSCLC.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8029)
  AUTHORS   Wu,J., Wang,M., Zhang,Y., Liu,G. and Xing,Y.
  TITLE     Activation of CHPF by transcription factor NFIC promotes NLRP3
            activation during the progression of colorectal cancer
  JOURNAL   Funct Integr Genomics 24 (1), 20 (2024)
   PUBMED   38267731
  REMARK    GeneRIF: Activation of CHPF by transcription factor NFIC promotes
            NLRP3 activation during the progression of colorectal cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8029)
  AUTHORS   Huang,H., Zhu,W., Huang,Z., Zhao,D., Cao,L. and Gao,X.
  TITLE     Adipose-derived stem cell exosome NFIC improves diabetic foot
            ulcers by regulating miR-204-3p/HIPK2
  JOURNAL   J Orthop Surg Res 18 (1), 687 (2023)
   PUBMED   37710299
  REMARK    GeneRIF: Adipose-derived stem cell exosome NFIC improves diabetic
            foot ulcers by regulating miR-204-3p/HIPK2.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8029)
  AUTHORS   Cobo,I., Paliwal,S., Bodas,C., Felipe,I., Melia-Aloma,J.,
            Torres,A., Martinez-Villarreal,J., Malumbres,M., Garcia,F.,
            Millan,I., Del Pozo,N., Park,J.C., MacDonald,R.J., Munoz,J.,
            Mendez,R. and Real,F.X.
  TITLE     NFIC regulates ribosomal biology and ER stress in pancreatic acinar
            cells and restrains PDAC initiation
  JOURNAL   Nat Commun 14 (1), 3761 (2023)
   PUBMED   37353485
  REMARK    GeneRIF: NFIC regulates ribosomal biology and ER stress in
            pancreatic acinar cells and restrains PDAC initiation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8029)
  AUTHORS   Zhang,J., Wang,Z., Liang,Z., Jin,C., Shi,Y., Fan,M., Hu,X. and
            Wan,Y.
  TITLE     NFIC1 inhibits the migration and invasion of MDA-MB-231 cells
            through S100A2-mediated inactivation of MEK/ERK pathway
  JOURNAL   Arch Biochem Biophys 734, 109497 (2023)
   PUBMED   36574914
  REMARK    GeneRIF: NFIC1 inhibits the migration and invasion of MDA-MB-231
            cells through S100A2-mediated inactivation of MEK/ERK pathway.
REFERENCE   6  (bases 1 to 8029)
  AUTHORS   Wenzelides,S., Altmann,H., Wendler,W. and Winnacker,E.L.
  TITLE     CTF5--a new transcriptional activator of the NFI/CTF family
  JOURNAL   Nucleic Acids Res 24 (12), 2416-2421 (1996)
   PUBMED   8710515
REFERENCE   7  (bases 1 to 8029)
  AUTHORS   Blau,J., Xiao,H., McCracken,S., O'Hare,P., Greenblatt,J. and
            Bentley,D.
  TITLE     Three functional classes of transcriptional activation domain
  JOURNAL   Mol Cell Biol 16 (5), 2044-2055 (1996)
   PUBMED   8628270
REFERENCE   8  (bases 1 to 8029)
  AUTHORS   Qian,F., Kruse,U., Lichter,P. and Sippel,A.E.
  TITLE     Chromosomal localization of the four genes (NFIA, B, C, and X) for
            the human transcription factor nuclear factor I by FISH
  JOURNAL   Genomics 28 (1), 66-73 (1995)
   PUBMED   7590749
REFERENCE   9  (bases 1 to 8029)
  AUTHORS   Nehls,M.C., Grapilon,M.L. and Brenner,D.A.
  TITLE     NF-I/Sp1 switch elements regulate collagen alpha 1(I) gene
            expression
  JOURNAL   DNA Cell Biol 11 (6), 443-452 (1992)
   PUBMED   1524678
REFERENCE   10 (bases 1 to 8029)
  AUTHORS   Santoro,C., Mermod,N., Andrews,P.C. and Tjian,R.
  TITLE     A family of human CCAAT-box-binding proteins active in
            transcription and DNA replication: cloning and expression of
            multiple cDNAs
  JOURNAL   Nature 334 (6179), 218-224 (1988)
   PUBMED   3398920
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC012120.1, AK297825.1,
            AK289885.1, CB053896.1, CK431049.1, AC005551.1, KF456476.1 and
            BU727954.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001245002.1.
            
            Summary: The protein encoded by this gene belongs to the CTF/NF-I
            family. These are dimeric DNA-binding proteins, and function as
            cellular transcription factors and as replication factors for
            adenovirus DNA replication. Alternatively spliced transcript
            variants encoding different isoforms have been described for this
            gene. [provided by RefSeq, Oct 2011].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.935241.1,
                                           SRR3476690.615288.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000443272.3/ ENSP00000396843.2
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1323              BC012120.1         9-1331
            1324-1719           AK297825.1         1322-1717
            1720-2121           AK289885.1         1672-2073
            2122-2481           CB053896.1         51-410              c
            2482-3074           CK431049.1         45-637
            3075-7642           AC005551.1         12615-17182
            7643-7765           KF456476.1         1-123
            7766-8029           BU727954.1         19-282              c
FEATURES             Location/Qualifiers
     source          1..8029
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..8029
                     /gene="NFIC"
                     /gene_synonym="CTF; CTF5; NF-I; NFI"
                     /note="nuclear factor I C"
                     /db_xref="GeneID:4782"
                     /db_xref="HGNC:HGNC:7786"
                     /db_xref="MIM:600729"
     exon            1..84
                     /gene="NFIC"
                     /gene_synonym="CTF; CTF5; NF-I; NFI"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..1581
                     /gene="NFIC"
                     /gene_synonym="CTF; CTF5; NF-I; NFI"
                     /note="isoform 1 is encoded by transcript variant 1;
                     nuclear factor 1 C-type; NF1-C; NF-I/C; TGGCA-binding
                     protein; nuclear factor I/C (CCAAT-binding transcription
                     factor); CCAAT-box-binding transcription factor"
                     /codon_start=1
                     /product="nuclear factor 1 C-type isoform 1"
                     /protein_id="NP_001231931.1"
                     /db_xref="CCDS:CCDS59330.1"
                     /db_xref="GeneID:4782"
                     /db_xref="HGNC:HGNC:7786"
                     /db_xref="MIM:600729"
                     /translation="MYSSPLCLTQDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKK
                     HEKRMSKDEERAVKDELLGEKPEVKQKWASRLLAKLRKDIRPECREDFVLSITGKKAP
                     GCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLVKAAQCGHP
                     VLCVQPHHIGVAVKELDLYLAYFVRERDAEQSGSPRTGMGSDQEDSKPITLDTTDFQE
                     SFVTSGVFSVTELIQVSRTPVVTGTGPNFSLGELQGHLAYDLNPASTGLRRTLPSTSS
                     SGSKRHKSGSMEEDVDTSPGGDYYTSPSSPTSSSRNWTEDMEGGISSPVKKTEMDKSP
                     FNSPSPQDSPRLSSFTQHHRPVIAVHSGIARSPHPSSALHFPTTSILPQTASTYFPHT
                     AIRYPPHLNPQDPLKDLVSLACDPASQQPGPLNGSGQLKMPSHCLSAQMLAPPPPGLP
                     RLALPPATKPATTSEGGATSPTSPSYSPPDTSPANRSFVGLGPRDPAGIYQAQSWYLG
                     "
     exon            85..616
                     /gene="NFIC"
                     /gene_synonym="CTF; CTF5; NF-I; NFI"
                     /inference="alignment:Splign:2.1.0"
     exon            617..688
                     /gene="NFIC"
                     /gene_synonym="CTF; CTF5; NF-I; NFI"
                     /inference="alignment:Splign:2.1.0"
     exon            689..763
                     /gene="NFIC"
                     /gene_synonym="CTF; CTF5; NF-I; NFI"
                     /inference="alignment:Splign:2.1.0"
     exon            764..887
                     /gene="NFIC"
                     /gene_synonym="CTF; CTF5; NF-I; NFI"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1012
                     /gene="NFIC"
                     /gene_synonym="CTF; CTF5; NF-I; NFI"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1138
                     /gene="NFIC"
                     /gene_synonym="CTF; CTF5; NF-I; NFI"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1323
                     /gene="NFIC"
                     /gene_synonym="CTF; CTF5; NF-I; NFI"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1477
                     /gene="NFIC"
                     /gene_synonym="CTF; CTF5; NF-I; NFI"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1563
                     /gene="NFIC"
                     /gene_synonym="CTF; CTF5; NF-I; NFI"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..8029
                     /gene="NFIC"
                     /gene_synonym="CTF; CTF5; NF-I; NFI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4165..4170
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NFIC"
                     /gene_synonym="CTF; CTF5; NF-I; NFI"
                     /note="hexamer: AATAAA"
     polyA_site      4186
                     /gene="NFIC"
                     /gene_synonym="CTF; CTF5; NF-I; NFI"
     regulatory      8004..8009
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NFIC"
                     /gene_synonym="CTF; CTF5; NF-I; NFI"
                     /note="hexamer: ATTAAA"
     polyA_site      8029
                     /gene="NFIC"
                     /gene_synonym="CTF; CTF5; NF-I; NFI"
                     /note="major polyA site"
ORIGIN      
        1 agtaagttca gcgcgcccgc tccggccggc cctgcgcctc ccgccgcgcc cgggatgtat
       61 tcgtccccgc tctgcctcac ccaggatgag ttccacccgt tcatcgaggc cctgctgcct
      121 cacgtccgcg ccttcgccta cacctggttc aacctgcagg cgcggaagcg caagtacttc
      181 aagaagcacg agaagcggat gtcgaaggac gaggagcgtg cggtcaagga cgagctgctg
      241 ggcgagaagc ccgaggtcaa gcagaagtgg gcgtcgcggc tgctggccaa gctgcgcaag
      301 gacatccggc ccgagtgccg cgaggacttc gtgctgagca tcaccggcaa gaaggcgccg
      361 ggctgcgtgc tctccaaccc cgaccagaag ggcaagatgc ggcgcatcga ctgtctccgg
      421 caggcggaca aggtgtggcg gctggacctg gtcatggtca tcctgttcaa gggcatcccg
      481 ctggagagca ccgacggcga gcgcctggtc aaggctgcgc agtgcggtca cccggtcctg
      541 tgcgtgcagc cgcaccacat tggcgtggcc gtcaaggagc tggacctcta cctggcctac
      601 ttcgtgcgtg agcgagatgc agagcaaagc ggcagtcccc ggacagggat gggctctgac
      661 caggaggaca gcaagcccat cacgctggac acgaccgact tccaggagag ctttgtcacc
      721 tccggcgtgt tcagcgtcac tgagctcatc caagtgtccc ggacacccgt ggtgactgga
      781 acaggaccca acttctccct gggggagctg caggggcacc tggcatacga cctgaaccca
      841 gccagcactg gcctcagaag aacgctgccc agcacctcct ccagtgggag caagcggcac
      901 aaatcgggct cgatggagga agacgtggac acgagccctg gcggcgatta ctacacttcg
      961 cccagctcgc ccacgagtag cagccgcaac tggacggagg acatggaagg aggcatctcg
     1021 tccccggtga agaagacaga gatggacaag tcaccattca acagcccgtc cccccaggac
     1081 tctccccgcc tctccagctt cacccagcac caccggcccg tcatcgccgt gcacagcggg
     1141 atcgcccgga gcccacaccc gtcctccgct ctgcatttcc ctacgacgtc catcctaccc
     1201 cagacggcct ccacctactt cccccacacg gccatccgct acccacctca tctcaacccc
     1261 caggacccgc tcaaagatct tgtctcgctg gcctgcgacc cagccagcca gcaacctgga
     1321 ccgttaaatg gaagtggtca gctcaaaatg cccagccact gcctttctgc tcagatgctg
     1381 gcacctccgc ccccggggct gccacggctg gcgctccccc ctgccaccaa acccgccacc
     1441 acctccgagg gaggagccac gtcgccgacc tcgccttcct actctccgcc cgacacgtcc
     1501 cctgcaaacc gttcctttgt gggattagga ccaagggatc ctgcgggcat ttatcaggca
     1561 cagtcctggt atctgggata gcaaaggtct tcttccctcg ccccttctcc atcgtcccag
     1621 gaatcccagg gggcagcaca gccggccccc ggcccacgtt ttcggtggaa aattagagtg
     1681 aacaagaaca cccctgccga ctcccagccc ggccaaaaag acaaaacaca tagacgcaca
     1741 cactcaggag gaaaagaaaa aacaaaggca gaagaagaag aagaagaaat aaaaacccac
     1801 ccaagcaaga agacaaaagg taaagacgca acgtttccaa ctctcgggac gccaaggccg
     1861 caggactgga gggccaggcc ccgccacccc cacgggagac ccgggacagg gcgtcttcct
     1921 aagttattca tctcctctcc gcctgctgct cgggaaggac agacgccggc cgcccgcccg
     1981 cgccccggag gccctggctc tgtccggaga ccaggtgagc acagcctgga gcctgtgccc
     2041 agggccgaca ggcgcgacac ccagcaaggc cacctctccc cgggcccccg cgcctctgcc
     2101 ggacacggac cggcccctca gcccccaccg aggacgcagc cactgggggg aaagggagac
     2161 acagcggacc ccggccgggc agcggagacc gcagaggcgg gcagggtggg gcaggcgagt
     2221 ggtgtcgcgg gggtgcgtgg cgcttgcgag ccctggccag gggaggaagt gaggcccagg
     2281 cacctgctgc ccctcgaggg ggccctgcct gccgcggggc ctccccacaa gcccctccca
     2341 aagcgccggc cgactcgctg tctcgctggg gactctttca gccctcgcgc ccgcccgttt
     2401 gggaggagaa gtctctatgc aattggcccc ggcccctcca ccccccaccc ccggcatagg
     2461 aggccccccc acctcgcccg gctcacaccc ccaaagggag ggacccacat tgcacacact
     2521 gtaagaaatg cactttccga ggaaggggat gggggagccc ggacacccag agctccccga
     2581 gttgggggtg cccgtctgga gcgcccccgt cagcccctgg cggtgggagg tgagagcgag
     2641 tggtttaagt gcctgattac caccacccgc cccccccttt gtccagctgg gacacggaat
     2701 ggccgcgggc ctcctccccc tcccctccag cctctccacc agcccctcca gtcaaccctc
     2761 atcgccgtgc ccccccagag ctagagagat ggggcccctg cgtggcccga ggggcagagc
     2821 tgggcgtcac ttcgcaagcg tcctgccctg ccggggcgcg ggggtgggct ctggggaagc
     2881 cggtgcgccc cccacgcctc cgctgccagt gccttacatt ctggagcgac ccccctccct
     2941 ggtgcctccc agcgaagggg gaccgccgtt tgcactttca tcgcctaccc cgacgcgggg
     3001 cccagctgcg ggacgtgcat cacggctggg cccccagagg agagaggagg ccgacgccag
     3061 cggtccccgc tcggaacggg gagggttttc ggggggttcg gcgtcgcacc ttggggcccc
     3121 ccgcagccgt gtagggggcc tcccatctgc taagcgtttt tccgttgagc cgctccaaaa
     3181 acactaagct ggggacgcca ggtgcccccc caccccggct ccctggccct atccacacct
     3241 ccacccccac cccaggatcg ccatctttag gggaggcctg ggagggggtg ttaggtgttt
     3301 tagggccacc gagctcaaac acaaggaccc ctccccggcc cacccagccc agccccaact
     3361 gacctccatg cctagggaaa aactcccccc accactgccc cctcccccga cccaggccaa
     3421 agccagggca ggtctccggg tctcacctgc tcctagcctc acccccctgc ccccgaaaac
     3481 cagactctcc tcccaaacta gcctcaggag cttggcgaac ccgctcgctc ctaaagagaa
     3541 agacccagga ccctccccca tcacccccaa gagaggttcg ccatcctctg gcctcgagcc
     3601 cttggtccct ccgtccgtct gtcctcgggg cccgctcccc cggtggccct tggggatcaa
     3661 agcgtgggcc gctctccggg agggcgggcg ggggaggggg tggtcgggtt gtgccattgg
     3721 ggtgtccgga agcttctcag ccagggtggg ggtcgtggag tgggggaggg aggccagccg
     3781 ggctccagag gggtcagggc gcgacgagaa ccaactcttt acctaacttt gcatggtgct
     3841 tagtcaagga ctcctgcgac ctggctcccg aggtcagctg gcggcgctga cacacatgca
     3901 tggcagacta tccctggctc tatctccctg ttcctcgccc cctccacccc ccacttcctc
     3961 tttaaaaaaa aaaaaaaaaa aaaaaagata caagaaaaac ctttaaaaaa attccatgtt
     4021 tcctaatttg cacgaaattt tctaccacaa gatgtgcctt gccttccgag aataagtatt
     4081 acctttaaac aatatcagcg cacacacata gctgcatgtt ctgctcgtgt agtttaaaaa
     4141 aaaaaagaca aaacagtgac atgaaataaa aaataaaaat tgaaaaggga tgtatttcta
     4201 tttgtaaaaa aaataaaata aaaaataaga aagtgagaat ctaaaaaaaa aaaaaaaaaa
     4261 aaaaaaggaa gaaaaaccac gctaaaaatc aagccactga aaacaattgc ccccaggtct
     4321 acccagcccc tggctgtcct tggtcctgtc tcccctcctg ctgtattcag gggtgccccc
     4381 tggtgctcag cctctaccac ccccaaccct gctcttgggt acccagaggg gtcatttctg
     4441 aatcccttgc ccagaggaca gacctccggg gcccatcttg gccctgggaa agggctctcc
     4501 tctctgattg gtccctaggc cacgggccgg cccccagaca ccattcaccg acccactgca
     4561 ggctgtcctc caaccatggg gtggccactc cacccgcagc cagactcccc gctccccact
     4621 tttcatgcag gctggcatac ccctggctca gggtcaaatg ctgttccaca cccacctcag
     4681 aggcaccccc tctcccctgc cccgtgcatc cccacccttc ttgccaaagg acctcttttc
     4741 ccctatccag agaccacccc aggtggcatt ctctcccacc ttctcctttg tcccccatcc
     4801 cctgtctctg tcttccagct gtgaatatga agggtatcct gtatgaaaca aaaacaaaac
     4861 ctgatatatg caatatctgt ctgtctgtct gtacccatgg gcctggctca gccattggag
     4921 gcccagccga gggtccggca gggcacaggg acagccaggt ggcaccgagt cacaggctgt
     4981 ggtccggtgg ctgagcatgc tgttgtcttg tccttgattt tattttcttt tgttcttttt
     5041 ttttttcttt tctttttgtt tttaactcca gcttcctttg ctttttactt gaccaaagct
     5101 aagacaatag ccagatggtt agtggggcag ccaggcaggg aggacccagg gctgggattc
     5161 tccaacctta ggccattcct gcagccctca ccacctccag cccctccaag catctcgtgt
     5221 agggacccac gcagatggtc ccattcattc actattgccc ccaaccccgg gattttgggt
     5281 ggtctccaca gccaccatca tacactcatc ccgtgttttc ttccaaaaag tcacctcagc
     5341 agcctcccca ggcgatacag agggagagcc cagaccacca cagctggcca cgacattgcc
     5401 cttaagtaat atgcattggc cagagagccc gggctggctg tgcacagcat tcatgtagct
     5461 gatttctagc tttttttttt tttctgcccc actcctgagc aaatctgtct tgccaaggaa
     5521 ctaggagcaa ccggaggcaa agggagtggg tggccccatc actattggga ccatcgcgtc
     5581 cctgcacagc ccacacccgg gggcccagag tcctgggctg gacgccaccc ttctcacccc
     5641 gagcttgcct ccttggctca cttggcacct tggctgagta cagcaggcaa aagcccatac
     5701 caggcagcat gttgtggatg gtttagttct ccccgcctcc ctgtttcttg gaaaagctac
     5761 agggtccctg tagggcaaaa ttcccaggcg ccttgctgca gacagagtaa gacaaaaaca
     5821 ccaggaagca ggattccgtg cccatctctg cagtttgggt tcacaaaagg gggtgccgtc
     5881 atccctgggt ggaggaggga gtgttggttt tttgtttttg tttttttaac atgtatgaaa
     5941 ctgacatctt ctcaaatctt gttccacccc cctctggaag cccccatcac ccacccctgc
     6001 tatggacacc acacctatgc caggcccccc cccccacccc agtctcattc tggggtctgc
     6061 ccatgctgtg ggaaagaata gggaggcctc ccaaatatat gcaaattgtc cccattccgt
     6121 gggggcacct gacaatgacc cgggtggaga tggggcatgg aggagtagga agacccagcc
     6181 ctatttgact ggggagagga ggatctggag tccttcatgc ccaggtctgg aacccaggtt
     6241 ctgaccccag ggccccaccc tgggctggac aatcagatcc caaaggaatg ccaaagggga
     6301 ctcggttggg agagccgctt aggggccaga cctgggtccc cctgcaggtc cccaggcagc
     6361 agacaattcc accttccctg ccccaggacc ttgagagaca gcagcattcc aggcacagac
     6421 agacttggct gcaccccact gtcccttgca agacaggttc tggagccagg agcaactgtc
     6481 cagccctcca gaagagacag caagcagccc ccctacccac tctggcctcc ccaatggtac
     6541 tttgacctcc agtgtagggc tatactatac atatatatat atatatatat atatatatat
     6601 aattttggaa tttgtttctc ataatacaga atatatagtg gctaccttgt atcttggtct
     6661 ggattctctc tctgagaccc cggattttac tttctctttg gagggcgctg ggacatacat
     6721 ctctcaatcc agcttcctcc gcatcctccc atcttgcccc atttctgcca cgtcagacac
     6781 ttcctgagag tctcaccttc aaaatgacac cgctgcccat ccattgctca atggtacaga
     6841 gtgtggggtc agtccaccac ccttgacctc ccggcagggc aaggtgagga ggcggaccca
     6901 aagcagtacc agcaggactt gttgccagtg ataccaaaac agacttttcc caagcagtgc
     6961 ctcacatgtc tgctggtgtg gctttgggat tctcctgccc cacccccccg tccatggcag
     7021 ccccctcccc aaggctttgc tcacacctga gacaggaagg aggaagggga tccaatagga
     7081 atatgggccc cggaggggaa gtcatgcacc cccaagccac caccccccag ccttccacgc
     7141 acatctcctg gctggaagag agccctccaa aaaggggaca caggctgccc cggcccctca
     7201 actgcatcca caccccatcc tctcatcttg ggtcccagcc aggccccccc aaaaccaaag
     7261 ccccctcaag tcctggggtc ccagcctgtg cccccagctt cctgcccacc cagccctgag
     7321 cattctcaca cagagaaaga acaagcaagg gctccagggg gacaggatgg ggcagggcat
     7381 acagtggggg gtgggggggc agctgggagg agggagggac aaaacaaaac attttccttt
     7441 gggttttttt tttctttctt ttttctcccc tttactcttt gggtggtgtt gcttttcctt
     7501 tccttttccc tttgagattt ttttgttgtt gtttcctttt tgtattttac tgatatcacc
     7561 aggatagttt actctccttc tagctttctg cttaccgcac actggataac acacacatac
     7621 acacccacaa aaatgctcat gaacccaatc cggagaaggt tccagcaggt cccccaccct
     7681 cccctcctcc tcctacttct cctcttgaca gcgaggacag gagggggaca aggggacacc
     7741 tgggcagacc cgccggctct ccccccaccc caccccgccc ctcacatcat actccaatca
     7801 taaccttgta tattacgcag tcattttggt tttcgcggac gcgcctacct aagtaccatt
     7861 tacagaaagt gactctggct gtcattattt tgtttatttg ttccctatgc aaaaaaaaaa
     7921 tgaaaatgaa aaaaggggga ttccataaaa gattcaataa aagacaaaca aaaaaaaaag
     7981 aaaaaagaaa aaaatgtata aaaattaaac aagctatgct tcgactctt
//
