LOCUS       NM_001369465            8032 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens nuclear factor I B (NFIB), transcript variant 12,
            mRNA.
ACCESSION   NM_001369465
VERSION     NM_001369465.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8032)
  AUTHORS   Smith,R.L., Wollmann,B.M., Storset,E., Lenk,H.C., O'Connell,K.S.,
            Kristiansen,M.K., Ingelman-Sundberg,M. and Molden,E.
  TITLE     Effect of the NFIB rs28379954 T>C polymorphism on CYP2D6-catalyzed
            metabolism of solanidine
  JOURNAL   Clin Transl Sci 17 (2), e13743 (2024)
   PUBMED   38385986
  REMARK    GeneRIF: Effect of the NFIB rs28379954 T>C polymorphism on
            CYP2D6-catalyzed metabolism of solanidine.
REFERENCE   2  (bases 1 to 8032)
  AUTHORS   Yu,H., Liu,P. and Chen,T.
  TITLE     CircIFFO1 suppresses tumor growth and metastasis of cutaneous
            squamous cell carcinoma by targeting the miR-424-5p/NFIB axis
  JOURNAL   Arch Dermatol Res 315 (9), 2585-2596 (2023)
   PUBMED   37405427
  REMARK    GeneRIF: CircIFFO1 suppresses tumor growth and metastasis of
            cutaneous squamous cell carcinoma by targeting the miR-424-5p/NFIB
            axis.
REFERENCE   3  (bases 1 to 8032)
  AUTHORS   Zhang,W., Wang,Y., Liu,Y., Liu,C., Wang,Y., He,L., Cheng,X.,
            Peng,Y., Xia,L., Wu,X., Wu,J., Zhang,Y., Sun,L., Chen,P., Li,G.,
            Tu,Q., Liang,J. and Shang,Y.
  TITLE     NFIB facilitates replication licensing by acting as a genome
            organizer
  JOURNAL   Nat Commun 14 (1), 5076 (2023)
   PUBMED   37604829
  REMARK    GeneRIF: NFIB facilitates replication licensing by acting as a
            genome organizer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8032)
  AUTHORS   Gana,S., Serpieri,V., Giorgio,E., Iorio,M., Rognone,E.,
            Pichiecchio,A., Chiappedi,M. and Valente,E.M.
  TITLE     Marked intrafamilial variability of clinical and neuroimaging
            manifestations in NFIB-related developmental disorder
  JOURNAL   Am J Med Genet A 191 (5), 1395-1400 (2023)
   PUBMED   36756855
  REMARK    GeneRIF: Marked intrafamilial variability of clinical and
            neuroimaging manifestations in NFIB-related developmental disorder.
REFERENCE   5  (bases 1 to 8032)
  AUTHORS   Sheng,H. and Wang,X.
  TITLE     Knockdown of circ-PIP5K1A overcomes resistance to cisplatin in
            ovarian cancer by miR-942-5p/NFIB axis
  JOURNAL   Anticancer Drugs 34 (2), 214-226 (2023)
   PUBMED   36730637
  REMARK    GeneRIF: Knockdown of circ-PIP5K1A overcomes resistance to
            cisplatin in ovarian cancer by miR-942-5p/NFIB axis.
REFERENCE   6  (bases 1 to 8032)
  AUTHORS   Mukhopadhyay,S.S. and Rosen,J.M.
  TITLE     The C-terminal domain of the nuclear factor I-B2 isoform is
            glycosylated and transactivates the WAP gene in the JEG-3 cells
  JOURNAL   Biochem Biophys Res Commun 358 (3), 770-776 (2007)
   PUBMED   17511965
  REMARK    GeneRIF: C-terminal domain of the nuclear factor I-B2 isoform is
            glycosylated and transactivates the WAP gene in tumor cells
REFERENCE   7  (bases 1 to 8032)
  AUTHORS   Sheeter,D., Du,P., Rought,S., Richman,D. and Corbeil,J.
  TITLE     Surface CD4 expression modulated by a cellular factor induced by
            HIV type 1 infection
  JOURNAL   AIDS Res Hum Retroviruses 19 (2), 117-123 (2003)
   PUBMED   12639247
  REMARK    GeneRIF: expression of NFI-B2 impairs CD4 transcription on
            CDd4-positive primary T-lymphocytes and cell lines in HIV-1
            infection
REFERENCE   8  (bases 1 to 8032)
  AUTHORS   Geurts,J.M., Schoenmakers,E.F., Roijer,E., Astrom,A.K., Stenman,G.
            and van de Ven,W.J.
  TITLE     Identification of NFIB as recurrent translocation partner gene of
            HMGIC in pleomorphic adenomas
  JOURNAL   Oncogene 16 (7), 865-872 (1998)
   PUBMED   9484777
REFERENCE   9  (bases 1 to 8032)
  AUTHORS   Liu,Y., Bernard,H.U. and Apt,D.
  TITLE     NFI-B3, a novel transcriptional repressor of the nuclear factor I
            family, is generated by alternative RNA processing
  JOURNAL   J Biol Chem 272 (16), 10739-10745 (1997)
   PUBMED   9099724
REFERENCE   10 (bases 1 to 8032)
  AUTHORS   Qian,F., Kruse,U., Lichter,P. and Sippel,A.E.
  TITLE     Chromosomal localization of the four genes (NFIA, B, C, and X) for
            the human transcription factor nuclear factor I by FISH
  JOURNAL   Genomics 28 (1), 66-73 (1995)
   PUBMED   7590749
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL136366.24 and AL441963.7.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1058730.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-116               AL136366.24        84985-85100         c
            117-648             AL136366.24        84054-84585         c
            649-702             AL441963.7         116262-116315       c
            703-771             AL441963.7         92360-92428         c
            772-892             AL441963.7         86680-86800         c
            893-1011            AL441963.7         83224-83342         c
            1012-1146           AL441963.7         62167-62301         c
            1147-1331           AL441963.7         56975-57159         c
            1332-1470           AL441963.7         52743-52881         c
            1471-1553           AL441963.7         49534-49616         c
            1554-8032           AL441963.7         18383-24861         c
FEATURES             Location/Qualifiers
     source          1..8032
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p23-p22.3"
     gene            1..8032
                     /gene="NFIB"
                     /gene_synonym="CTF; HMGIC/NFIB; MACID; NF-I/B; NF1-B;
                     NFI-B; NFI-RED; NFIB2; NFIB3"
                     /note="nuclear factor I B"
                     /db_xref="GeneID:4781"
                     /db_xref="HGNC:HGNC:7785"
                     /db_xref="MIM:600728"
     exon            1..116
                     /gene="NFIB"
                     /gene_synonym="CTF; HMGIC/NFIB; MACID; NF-I/B; NF1-B;
                     NFI-B; NFI-RED; NFIB2; NFIB3"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..1571
                     /gene="NFIB"
                     /gene_synonym="CTF; HMGIC/NFIB; MACID; NF-I/B; NF1-B;
                     NFI-B; NFI-RED; NFIB2; NFIB3"
                     /note="isoform 12 is encoded by transcript variant 12;
                     nuclear factor 1 B-type; nuclear factor 1/B; TGGCA-binding
                     protein; CCAAT-box-binding transcription factor"
                     /codon_start=1
                     /product="nuclear factor 1 B-type isoform 12"
                     /protein_id="NP_001356394.1"
                     /db_xref="GeneID:4781"
                     /db_xref="HGNC:HGNC:7785"
                     /db_xref="MIM:600728"
                     /translation="MDEFHPFIEALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDE
                     ERAVKDELLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTVTGKKHPCCVLSNPDQ
                     KGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHI
                     TVSVKELDLFLAYYVQEQDSGQSGSPSHNDPAKNPPGYLEDSFVKSGVFNVSELVRVS
                     RTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTISIDENMEPSP
                     TGDFYPSPSSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSASPQDSSPRLSTFPQHH
                     HPGIPGVAHSVISTRTPPPPSPLPFPTQAILPPAPSSYFSHPTIRYPPHLNPQDTLKN
                     YVPSYDPSSPQTSQPNGSGQVVGKVPGHFTPVLAPSPHPSAVRPVTLSMTDTKPITTS
                     TEAYTASGTSQANRYVGLSPRDPSFLHQQQSWYLG"
     exon            117..648
                     /gene="NFIB"
                     /gene_synonym="CTF; HMGIC/NFIB; MACID; NF-I/B; NF1-B;
                     NFI-B; NFI-RED; NFIB2; NFIB3"
                     /inference="alignment:Splign:2.1.0"
     exon            649..702
                     /gene="NFIB"
                     /gene_synonym="CTF; HMGIC/NFIB; MACID; NF-I/B; NF1-B;
                     NFI-B; NFI-RED; NFIB2; NFIB3"
                     /inference="alignment:Splign:2.1.0"
     exon            703..771
                     /gene="NFIB"
                     /gene_synonym="CTF; HMGIC/NFIB; MACID; NF-I/B; NF1-B;
                     NFI-B; NFI-RED; NFIB2; NFIB3"
                     /inference="alignment:Splign:2.1.0"
     exon            772..892
                     /gene="NFIB"
                     /gene_synonym="CTF; HMGIC/NFIB; MACID; NF-I/B; NF1-B;
                     NFI-B; NFI-RED; NFIB2; NFIB3"
                     /inference="alignment:Splign:2.1.0"
     exon            893..1011
                     /gene="NFIB"
                     /gene_synonym="CTF; HMGIC/NFIB; MACID; NF-I/B; NF1-B;
                     NFI-B; NFI-RED; NFIB2; NFIB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1146
                     /gene="NFIB"
                     /gene_synonym="CTF; HMGIC/NFIB; MACID; NF-I/B; NF1-B;
                     NFI-B; NFI-RED; NFIB2; NFIB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1331
                     /gene="NFIB"
                     /gene_synonym="CTF; HMGIC/NFIB; MACID; NF-I/B; NF1-B;
                     NFI-B; NFI-RED; NFIB2; NFIB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1470
                     /gene="NFIB"
                     /gene_synonym="CTF; HMGIC/NFIB; MACID; NF-I/B; NF1-B;
                     NFI-B; NFI-RED; NFIB2; NFIB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1553
                     /gene="NFIB"
                     /gene_synonym="CTF; HMGIC/NFIB; MACID; NF-I/B; NF1-B;
                     NFI-B; NFI-RED; NFIB2; NFIB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1554..8032
                     /gene="NFIB"
                     /gene_synonym="CTF; HMGIC/NFIB; MACID; NF-I/B; NF1-B;
                     NFI-B; NFI-RED; NFIB2; NFIB3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8010..8015
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NFIB"
                     /gene_synonym="CTF; HMGIC/NFIB; MACID; NF-I/B; NF1-B;
                     NFI-B; NFI-RED; NFIB2; NFIB3"
                     /note="hexamer: AATAAA"
     polyA_site      8032
                     /gene="NFIB"
                     /gene_synonym="CTF; HMGIC/NFIB; MACID; NF-I/B; NF1-B;
                     NFI-B; NFI-RED; NFIB2; NFIB3"
                     /note="major polyA site"
ORIGIN      
        1 atgctttgtg tttctgtgcc acagagaaga gaaatgaact gtggcatcgc tcctgccttc
       61 tgaacagctc tactccgatt aaaaaaaaaa aatctcactg tgttctttgt aaaatggatg
      121 aatttcaccc attcatcgag gcacttcttc cacatgtccg tgcaattgcc tatacttggt
      181 tcaacctgca ggctcgaaaa cgcaagtact ttaaaaagca tgagaagcga atgtcaaagg
      241 atgaagaaag agcagtcaaa gatgagcttc tcagtgaaaa gcctgaaatc aaacagaagt
      301 gggcatccag gctccttgcc aaactgcgca aagatattcg ccaggagtat cgagaggact
      361 ttgtgctcac cgtgactggc aagaagcacc cgtgctgtgt cttatccaat cccgaccaga
      421 agggtaagat taggagaatc gactgcctgc gacaggcaga caaagtctgg cgtctggatc
      481 tagtcatggt gatcctgttc aaaggcatcc ccttggaaag taccgatgga gagcggctca
      541 tgaaatcccc acattgcaca aacccagcac tttgtgtcca gccacatcat atcacagtat
      601 cagttaagga gcttgatttg tttttggcat actacgtgca ggagcaagat tctggacaat
      661 caggaagtcc aagccacaat gatcctgcca agaatcctcc aggttacctt gaggatagtt
      721 ttgtaaaatc tggagtcttc aatgtatcag aacttgtaag agtatccaga acgcccataa
      781 cccagggaac tggagtcaac ttcccaattg gagaaatccc aagccaacca tactatcatg
      841 acatgaactc gggggtcaat cttcagaggt ctctgtcttc tccaccaagc agcaaaagac
      901 ccaaaactat atccatagat gaaaatatgg aaccaagtcc tacaggagac ttttacccct
      961 ctccaagttc accagctgct ggaagtcgaa catggcacga aagagatcaa gatatgtctt
     1021 ctccgactac tatgaagaag cctgaaaagc cattgttcag ctctgcatct ccacaggatt
     1081 cttccccaag actgagcact ttcccccagc accaccatcc cggaatacct ggagttgcac
     1141 acagtgtcat ctcaactcga actccacctc caccttcacc gttgccattt ccaacacaag
     1201 ctatccttcc tccagcccca tcgagctact tttctcatcc aacaatcaga tatcctcccc
     1261 acctgaatcc tcaggatact ctgaagaact atgtaccttc ttatgaccca tccagtccac
     1321 aaaccagcca gcctaacggc agtggtcaag tagtagggaa agtgcctggc catttcactc
     1381 ctgtcttggc accctctccc catcccagtg cagtgcgacc tgtgaccctg agcatgacag
     1441 atactaaacc catcactaca tccactgaag cctacacagc ctcaggcaca tctcaagcca
     1501 atcgatatgt gggactaagc ccaagagacc catccttcct acatcagcaa cagtcctggt
     1561 acctgggcta gcttggttcc tttccaagtg tcaaatagga cacccatctt accggccaat
     1621 gtccaaaatt acggtttgaa cataattgga gaacctttcc ttcaagcaga aacaagcaac
     1681 tgagggaaaa agaaacacaa caatagttta agaaattttt tttttaaata aaaaaaaagg
     1741 aaaagaggaa gactggacaa aacaacacaa aggcagaaag gaaagaaact gaagaaagaa
     1801 gataatagac cagcaattgc agcacttaca atcactaatt cccttaaggt tgaaactgta
     1861 atgacataaa aagggtcgat gatatttcac tgatggtaga tcgcagcccc tgcaacgtag
     1921 cctttgttac atgaagtccg ctgggaaata gatgttctgt ctctatgaca atatatttta
     1981 actgactttc tagatgcctt aatatttgca tgataagcta gttttattgg tttagtattc
     2041 ttgttgttta cgcatggaat cactattcct ggttatctca ccaacgaagg ctaggaggcg
     2101 gcgtcagagg tgctgggtga cagagccatg agccagccat tttataagca ctctgatttc
     2161 taaaagttaa aaaaaatata tgaaatctct gtagccttta gttatcagta cagatttatt
     2221 aaatttcggc ccttaaccca gccttttcca gtgtgtaacc cagtttgaaa tcttaaaaaa
     2281 agaaaaaatg aaaaaaaaag gaaaaaaaga aaaaaggaaa aaaacagttt gaacacaaag
     2341 gctctatgga agaaatgcct ctatgtaggt gaagtgttct ctctgcatgc aacagtaaaa
     2401 attaatataa tattttcccc acaaaagaaa cacttaacag aggcaagtgc aatttataaa
     2461 tttatatcta aaggggaatc atgattataa gtccttcagc ccttggactc taaattgagg
     2521 ggattaaaaa gaatttaaaa taattttgaa cgaatttatt ttcccctcag tttttgaggg
     2581 cattaaaaag gcattaaatc aagacaaatc atgtgcttga gaaaaataaa attaatgaaa
     2641 acacagcact tatgttggtt tagctgcagc ctccttggag gtagaattta tttatttaaa
     2701 attactggtt gcatcaagaa cccatagggt gtacaaaagg ttctataaaa tctgcattat
     2761 agagacaaag aggcaggcaa atccatgtca caagggtaaa gcttacagtt tacaaactgg
     2821 gaacgccagg gtgtaggata taaaaacgca ctcttgagaa aacaaatgta atcagggtgc
     2881 tgaaaacttg catggtgctt tcagacatta gccttgttca acaaatttct tgtattgaca
     2941 gatccatagt gtgcatgggc agacacattt tgcctctatg tctcttaaaa ttttaattaa
     3001 aaatactctt tccagtaatc ctaatttgca cgaagatata atgtccacat tacgtgcctt
     3061 gccttgaaat ctaaaaaaca aaaaacaaaa aaaaaaaaac aaaaaaatac aacaaagtga
     3121 catcactaca cttgttttgc tgcatttatt atcattttaa atctttacca tttttatgac
     3181 aaaatatttt gtactccaga cgaagaaaaa tgtgtgacat catggatttt ttagacagtt
     3241 atacctttat ctcacattta taaagcatat catggctgtg tatagttgcc gcttaaaaat
     3301 tgtaatcgac cagcaatatt ttcagtattt tggtgttttt ttctattaac ctttcatgtt
     3361 tttcatcttc caattaatat ttggggggga ggggtttcaa atttatacga attatgcaat
     3421 accaagtttt gcctatgtag gtagtgcttt tagctgtatt ggttattata ggtaagtaca
     3481 cagatttaaa aaaaaaataa tgtatgcttt tttgtttgtt tgtttgtttt aattgaccaa
     3541 agtgggtact gctatttttg cagtgtgatg aggtcctttt gtgtactgag agatggacag
     3601 gggatttttt ttaatataca tatatatata ttctggggtg ggtgggagga tttttaacac
     3661 tttgcagtgt agctgtgaag cagtgcaccc tgagatgggc ctgggctgca aagcgactgt
     3721 tctgcctact gtgacaaact tcaacttaca caggttcccc tctctaactt cccacctggg
     3781 ttgcaagctg aactcattac tggttttcat aacaacacaa tagtaagaac aagcaaacac
     3841 aacaaattct cctggaggca gacttggctt aaaaaggcag acttggcttg gtgatagttt
     3901 ttcttgaaag ttccagatcc acagtggaga gtgagcctgt ctcatatttg gcaaaaatat
     3961 ttgttgaaat gtccacatag gggatgttgg atgtttaaca cttttgagag tttaacacat
     4021 gaatattctt tctcctagaa aacacattag acctgttgga gggagtctcc cgtattcctt
     4081 ttctgccact tttcgtcccc atttcatttc attaatgata ggatatgatt tacctgtgac
     4141 ttactacttc aaatggatgg cagtgcactt ggattttttt ttaatatcca gaagattgaa
     4201 cagagggttg ctattgttga atgtatttgg actgatagat taaaatcaaa gttcaatttt
     4261 taaggaacaa aaaagtaaat cctgttttca ttttatctcc ccttttaaaa ctgagaacca
     4321 gagcagaagg gaaatataga attttaagca attaatcttc ctgtggatga attaaaccca
     4381 ttagatgctg atgggatttt tttaaggaat ggtaccttaa ctatatattt gatttcgttt
     4441 cccctgaggg ctagaggctg aatggaggct ggttttattt tgcctttccc tcaccgccca
     4501 gtcccattga gtgtattcat tactagaagg aaaatctttc agaattggtg acacatggta
     4561 ggctgtctta aggagtcccc tggccccctt cccctaggcc atggcctaat aaaataaact
     4621 gtcaattgtt ctcacagcat atcatttaat aatgaatact ttagaacaat gcttatgggc
     4681 tggagaattg tatttgatta gcccattcag tttgatagcc caaatgctga acagcacagc
     4741 gggatcctag cagtgcaagt tcaaaagtaa gtccaatcat ttctgtgata ctcgccctgg
     4801 tagcaaacag atcatctcag ccaagctctt catgtatctt tgacctatta ggtgaacaaa
     4861 tgaacctcac aggacacaca gtatttttta aaggcagact cgctctcttt tttgccagtg
     4921 agcagttcta gctaaccaag ttacacactg tgggtattcc tgcctgcctc ttgaatacaa
     4981 aggcctagtt caagtgttgc tttttttatt tcaaatcaat tttttcttct ttcctttttg
     5041 agataaaact attaaaagta ctactatata tataaaatct caaatcaact tttcggcctc
     5101 ctcctcgtgt accaggaagt atattctgac gaagggcccc acttttgcag gtcttgcacg
     5161 cccctccctt acccagaact gcagagcttc aggatggcga aggtcaccca agggcatgag
     5221 tagggagtgg tgtctccaac catcagttcc gtggcactgt tcagcctttg tgtgctgccc
     5281 tgccacccac cactcacagt gcctctgaag cgtgttaccc ctggagtgac gtgagcattt
     5341 gaggcttgtc taaggaaaaa aataaaaggc agtgaaggag actgtacata aagacatggc
     5401 aaaaatctta attatagcaa tatagttatc gggtaatgtt cgggtgggca gctccattaa
     5461 aaaatatgtg aatgaatctg tgaagctgca agtagcgaga agagcgaaag gtcttcttaa
     5521 tgaaccgcct accttgtaga cagtaatttg tacactgtat agttttgtta agaatttttt
     5581 ttaaattaaa attcccatgt ttgtaaagct aactttttaa caattataat ggaactatat
     5641 gttgtttcca tttttaaagt aaacaagaat attccttgtt tagagactgg acttgagtta
     5701 aaactctcca gtctcttaag ttatgtatta aaaagaaaat ctgtccatgt taggagttat
     5761 ttcacagatt cctgtgcttg aaaagcatag gatactaatc ctttaaaaaa gtgtaaatgg
     5821 agaaaagtta tattttatga aggttatttt gttgtattta gtattggaaa agttggtttc
     5881 cagagcattt cagaatgtcg aagcaccact gtctttttat tagtatatac ggcctttagc
     5941 aaaagttttt gtgattgtta cgtgatggta tttaaggtta agtttcacag agcattcagg
     6001 ataggcagaa aactaaaaca gtgctatgtc tcacataacg tgtcctcagg gagcagaatc
     6061 ttggatttgt gacttgtagc ttcataagga ctcaacgaaa gagattgcac agggacatct
     6121 tcagcggtgt gacagcagga catgttcttt acctagattc aaattctatg tactgtgtga
     6181 aatgatgaag gctgcagaaa gttatcccat attcagtgta cagtattcat ttttaatgaa
     6241 acaactctac aatattgctg gcagataggc cccaagcatg acattcaata tagtttacat
     6301 gttcctgtca aggtcttttg ttaacattaa ccagctgcat gctttctgga ctttaagaaa
     6361 ttgggtttct atagaaaact tttttttttt tttttttttt aatgtgcagg ctattcaagt
     6421 tcaatagtaa aagctcaaaa atgaatgttc tactccatgc tgaaggagct gaaagctgcc
     6481 ttcttcatat tttgcacttt ctggtagttc ccctgttttt tctaattccc taaaattgtg
     6541 tgggtggagt ggagccctgc agttgggggg taacatggac cactgatttt gccctttgac
     6601 cctgcacaat gacctttgca tcagccaaac tcattgccat gacaactctt tgtactgtgt
     6661 ccgtgccaca gatctgttgg tcacattgtt aatagtaaag gggacaagtt ggagacggtc
     6721 aatttttaca ttttttgttg caattttttc ttcaatggtt gtaagtagtt tttttttttt
     6781 tttaataata aaagggttca ctagttaata ctctagaaat atctgtgtgt tgcaattcaa
     6841 atgtatgttg agattgtgaa aagcgcttca gtgccactag cttaccggta cactagacta
     6901 agcccttgat gacttattgc atgatacagt accaggaaca acaggtggcc taaatacatg
     6961 aaaagcagtg taagctagtg acactaaagc cagtcttgta ttactgtatt tttgacagaa
     7021 tggttttgaa aactgtgcta cagggactga tgtggcaaat atatctcttt atgcagaagg
     7081 aagtcttttt ttttcttttt ttttttttta agaagtatgg ctttttatgc atccttcatc
     7141 gagggcattg aagttgcatg gactgataaa agttgatgca aaacaagaaa gaaacaaaca
     7201 aaaaaaaaaa accagcaaaa tgtttaccaa aaaactcaaa caaatgagca gtgcctgttc
     7261 aatttcacag tctctgttga gttcagttgt aaatatgttt caaatgacat tttcttggga
     7321 aaaaaaatct ctacaacatt gtagaatgtg aggggtaact acatcccagg cataggtttc
     7381 tcaaagctgc agtagattat gtcttcatca agctgttaat ttgtgcttat atcatataga
     7441 acttttagca tcctgggaag agctgccccc acctcaatga tatttctctg agaacaactt
     7501 ttgtaggact gtgtgtttct ttagatacat ttagtacaac tgtaggtgac gagtagtcag
     7561 ttattgcttg ctagctacac accagggttg atccatttta aaacttttgg cattttgtcc
     7621 tcatgggcca taaatacaga accttgtatt ttaattaaat ttttttacaa aaggaggcac
     7681 atgcacaatc tccatgtaac aaacctttag cagtaggatg tattatacga cagttactta
     7741 atttctagag ttcaggcctc tgggatcaac cccagactgg gccagaatgt tagtgaaggt
     7801 tttattgtgc ccggttggag gataacgttc tttgggtact ttttgtgggt tgcaaatgaa
     7861 ctcaattgcc acaagtttta aactggtgta aatcaagctt gacttaatgt gattgttact
     7921 gttatatcca gcctatactg ctagcagctg ctcatactgc agtcaattac tggaagcgga
     7981 tatatttcct atgcaaaaac tgtttaaaca ataaaatgag ctatgctaca ga
//
