LOCUS       NM_001369459            8136 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens nuclear factor I B (NFIB), transcript variant 6, mRNA.
ACCESSION   NM_001369459
VERSION     NM_001369459.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8136)
  AUTHORS   Smith,R.L., Wollmann,B.M., Storset,E., Lenk,H.C., O'Connell,K.S.,
            Kristiansen,M.K., Ingelman-Sundberg,M. and Molden,E.
  TITLE     Effect of the NFIB rs28379954 T>C polymorphism on CYP2D6-catalyzed
            metabolism of solanidine
  JOURNAL   Clin Transl Sci 17 (2), e13743 (2024)
   PUBMED   38385986
  REMARK    GeneRIF: Effect of the NFIB rs28379954 T>C polymorphism on
            CYP2D6-catalyzed metabolism of solanidine.
REFERENCE   2  (bases 1 to 8136)
  AUTHORS   Yu,H., Liu,P. and Chen,T.
  TITLE     CircIFFO1 suppresses tumor growth and metastasis of cutaneous
            squamous cell carcinoma by targeting the miR-424-5p/NFIB axis
  JOURNAL   Arch Dermatol Res 315 (9), 2585-2596 (2023)
   PUBMED   37405427
  REMARK    GeneRIF: CircIFFO1 suppresses tumor growth and metastasis of
            cutaneous squamous cell carcinoma by targeting the miR-424-5p/NFIB
            axis.
REFERENCE   3  (bases 1 to 8136)
  AUTHORS   Zhang,W., Wang,Y., Liu,Y., Liu,C., Wang,Y., He,L., Cheng,X.,
            Peng,Y., Xia,L., Wu,X., Wu,J., Zhang,Y., Sun,L., Chen,P., Li,G.,
            Tu,Q., Liang,J. and Shang,Y.
  TITLE     NFIB facilitates replication licensing by acting as a genome
            organizer
  JOURNAL   Nat Commun 14 (1), 5076 (2023)
   PUBMED   37604829
  REMARK    GeneRIF: NFIB facilitates replication licensing by acting as a
            genome organizer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8136)
  AUTHORS   Gana,S., Serpieri,V., Giorgio,E., Iorio,M., Rognone,E.,
            Pichiecchio,A., Chiappedi,M. and Valente,E.M.
  TITLE     Marked intrafamilial variability of clinical and neuroimaging
            manifestations in NFIB-related developmental disorder
  JOURNAL   Am J Med Genet A 191 (5), 1395-1400 (2023)
   PUBMED   36756855
  REMARK    GeneRIF: Marked intrafamilial variability of clinical and
            neuroimaging manifestations in NFIB-related developmental disorder.
REFERENCE   5  (bases 1 to 8136)
  AUTHORS   Sheng,H. and Wang,X.
  TITLE     Knockdown of circ-PIP5K1A overcomes resistance to cisplatin in
            ovarian cancer by miR-942-5p/NFIB axis
  JOURNAL   Anticancer Drugs 34 (2), 214-226 (2023)
   PUBMED   36730637
  REMARK    GeneRIF: Knockdown of circ-PIP5K1A overcomes resistance to
            cisplatin in ovarian cancer by miR-942-5p/NFIB axis.
REFERENCE   6  (bases 1 to 8136)
  AUTHORS   Mukhopadhyay,S.S. and Rosen,J.M.
  TITLE     The C-terminal domain of the nuclear factor I-B2 isoform is
            glycosylated and transactivates the WAP gene in the JEG-3 cells
  JOURNAL   Biochem Biophys Res Commun 358 (3), 770-776 (2007)
   PUBMED   17511965
  REMARK    GeneRIF: C-terminal domain of the nuclear factor I-B2 isoform is
            glycosylated and transactivates the WAP gene in tumor cells
REFERENCE   7  (bases 1 to 8136)
  AUTHORS   Sheeter,D., Du,P., Rought,S., Richman,D. and Corbeil,J.
  TITLE     Surface CD4 expression modulated by a cellular factor induced by
            HIV type 1 infection
  JOURNAL   AIDS Res Hum Retroviruses 19 (2), 117-123 (2003)
   PUBMED   12639247
  REMARK    GeneRIF: expression of NFI-B2 impairs CD4 transcription on
            CDd4-positive primary T-lymphocytes and cell lines in HIV-1
            infection
REFERENCE   8  (bases 1 to 8136)
  AUTHORS   Geurts,J.M., Schoenmakers,E.F., Roijer,E., Astrom,A.K., Stenman,G.
            and van de Ven,W.J.
  TITLE     Identification of NFIB as recurrent translocation partner gene of
            HMGIC in pleomorphic adenomas
  JOURNAL   Oncogene 16 (7), 865-872 (1998)
   PUBMED   9484777
REFERENCE   9  (bases 1 to 8136)
  AUTHORS   Liu,Y., Bernard,H.U. and Apt,D.
  TITLE     NFI-B3, a novel transcriptional repressor of the nuclear factor I
            family, is generated by alternative RNA processing
  JOURNAL   J Biol Chem 272 (16), 10739-10745 (1997)
   PUBMED   9099724
REFERENCE   10 (bases 1 to 8136)
  AUTHORS   Qian,F., Kruse,U., Lichter,P. and Sippel,A.E.
  TITLE     Chromosomal localization of the four genes (NFIA, B, C, and X) for
            the human transcription factor nuclear factor I by FISH
  JOURNAL   Genomics 28 (1), 66-73 (1995)
   PUBMED   7590749
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL159169.14, AL136366.24 and AL441963.7.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.220180.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-131               AL159169.14        21344-21474         c
            132-663             AL136366.24        84054-84585         c
            664-717             AL441963.7         116262-116315       c
            718-786             AL441963.7         92360-92428         c
            787-907             AL441963.7         86680-86800         c
            908-1026            AL441963.7         83224-83342         c
            1027-1161           AL441963.7         62167-62301         c
            1162-1346           AL441963.7         56975-57159         c
            1347-1485           AL441963.7         52743-52881         c
            1486-1568           AL441963.7         49534-49616         c
            1569-1657           AL441963.7         38957-39045         c
            1658-8136           AL441963.7         18383-24861         c
FEATURES             Location/Qualifiers
     source          1..8136
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p23-p22.3"
     gene            1..8136
                     /gene="NFIB"
                     /gene_synonym="CTF; HMGIC/NFIB; MACID; NF-I/B; NF1-B;
                     NFI-B; NFI-RED; NFIB2; NFIB3"
                     /note="nuclear factor I B"
                     /db_xref="GeneID:4781"
                     /db_xref="HGNC:HGNC:7785"
                     /db_xref="MIM:600728"
     exon            1..131
                     /gene="NFIB"
                     /gene_synonym="CTF; HMGIC/NFIB; MACID; NF-I/B; NF1-B;
                     NFI-B; NFI-RED; NFIB2; NFIB3"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..1787
                     /gene="NFIB"
                     /gene_synonym="CTF; HMGIC/NFIB; MACID; NF-I/B; NF1-B;
                     NFI-B; NFI-RED; NFIB2; NFIB3"
                     /note="isoform 6 is encoded by transcript variant 6;
                     nuclear factor 1 B-type; nuclear factor 1/B; TGGCA-binding
                     protein; CCAAT-box-binding transcription factor"
                     /codon_start=1
                     /product="nuclear factor 1 B-type isoform 6"
                     /protein_id="NP_001356388.1"
                     /db_xref="GeneID:4781"
                     /db_xref="HGNC:HGNC:7785"
                     /db_xref="MIM:600728"
                     /translation="MKVADSIMAGKTSDSSIKWQLCYDMSARTWWMDEFHPFIEALLP
                     HVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLLAKL
                     RKDIRQEYREDFVLTVTGKKHPCCVLSNPDQKGKIRRIDCLRQADKVWRLDLVMVILF
                     KGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFLAYYVQEQDSGQSGSPS
                     HNDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMN
                     SGVNLQRSLSSPPSSKRPKTISIDENMEPSPTGDFYPSPSSPAAGSRTWHERDQDMSS
                     PTTMKKPEKPLFSSASPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPLPFPT
                     QAILPPAPSSYFSHPTIRYPPHLNPQDTLKNYVPSYDPSSPQTSQPNGSGQVVGKVPG
                     HFTPVLAPSPHPSAVRPVTLSMTDTKPITTSTEAYTASGTSQANRYVGLSPRDPSFLH
                     QQQLRICDWTMNQNGRHLYPSTSEDTLGITWQSPGTWASLVPFQVSNRTPILPANVQN
                     YGLNIIGEPFLQAETSN"
     exon            132..663
                     /gene="NFIB"
                     /gene_synonym="CTF; HMGIC/NFIB; MACID; NF-I/B; NF1-B;
                     NFI-B; NFI-RED; NFIB2; NFIB3"
                     /inference="alignment:Splign:2.1.0"
     exon            664..717
                     /gene="NFIB"
                     /gene_synonym="CTF; HMGIC/NFIB; MACID; NF-I/B; NF1-B;
                     NFI-B; NFI-RED; NFIB2; NFIB3"
                     /inference="alignment:Splign:2.1.0"
     exon            718..786
                     /gene="NFIB"
                     /gene_synonym="CTF; HMGIC/NFIB; MACID; NF-I/B; NF1-B;
                     NFI-B; NFI-RED; NFIB2; NFIB3"
                     /inference="alignment:Splign:2.1.0"
     exon            787..907
                     /gene="NFIB"
                     /gene_synonym="CTF; HMGIC/NFIB; MACID; NF-I/B; NF1-B;
                     NFI-B; NFI-RED; NFIB2; NFIB3"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1026
                     /gene="NFIB"
                     /gene_synonym="CTF; HMGIC/NFIB; MACID; NF-I/B; NF1-B;
                     NFI-B; NFI-RED; NFIB2; NFIB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1161
                     /gene="NFIB"
                     /gene_synonym="CTF; HMGIC/NFIB; MACID; NF-I/B; NF1-B;
                     NFI-B; NFI-RED; NFIB2; NFIB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1346
                     /gene="NFIB"
                     /gene_synonym="CTF; HMGIC/NFIB; MACID; NF-I/B; NF1-B;
                     NFI-B; NFI-RED; NFIB2; NFIB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1485
                     /gene="NFIB"
                     /gene_synonym="CTF; HMGIC/NFIB; MACID; NF-I/B; NF1-B;
                     NFI-B; NFI-RED; NFIB2; NFIB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..1568
                     /gene="NFIB"
                     /gene_synonym="CTF; HMGIC/NFIB; MACID; NF-I/B; NF1-B;
                     NFI-B; NFI-RED; NFIB2; NFIB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1657
                     /gene="NFIB"
                     /gene_synonym="CTF; HMGIC/NFIB; MACID; NF-I/B; NF1-B;
                     NFI-B; NFI-RED; NFIB2; NFIB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..8136
                     /gene="NFIB"
                     /gene_synonym="CTF; HMGIC/NFIB; MACID; NF-I/B; NF1-B;
                     NFI-B; NFI-RED; NFIB2; NFIB3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8114..8119
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NFIB"
                     /gene_synonym="CTF; HMGIC/NFIB; MACID; NF-I/B; NF1-B;
                     NFI-B; NFI-RED; NFIB2; NFIB3"
                     /note="hexamer: AATAAA"
     polyA_site      8136
                     /gene="NFIB"
                     /gene_synonym="CTF; HMGIC/NFIB; MACID; NF-I/B; NF1-B;
                     NFI-B; NFI-RED; NFIB2; NFIB3"
                     /note="major polyA site"
ORIGIN      
        1 gattaggtgt cttatcttcc attgagctgc atctgatgaa ggttgctgac agcataatgg
       61 ctgggaaaac gtcggacagc tccataaaat ggcagctatg ttatgacatg tcagccagga
      121 cctggtggat ggatgaattt cacccattca tcgaggcact tcttccacat gtccgtgcaa
      181 ttgcctatac ttggttcaac ctgcaggctc gaaaacgcaa gtactttaaa aagcatgaga
      241 agcgaatgtc aaaggatgaa gaaagagcag tcaaagatga gcttctcagt gaaaagcctg
      301 aaatcaaaca gaagtgggca tccaggctcc ttgccaaact gcgcaaagat attcgccagg
      361 agtatcgaga ggactttgtg ctcaccgtga ctggcaagaa gcacccgtgc tgtgtcttat
      421 ccaatcccga ccagaagggt aagattagga gaatcgactg cctgcgacag gcagacaaag
      481 tctggcgtct ggatctagtc atggtgatcc tgttcaaagg catccccttg gaaagtaccg
      541 atggagagcg gctcatgaaa tccccacatt gcacaaaccc agcactttgt gtccagccac
      601 atcatatcac agtatcagtt aaggagcttg atttgttttt ggcatactac gtgcaggagc
      661 aagattctgg acaatcagga agtccaagcc acaatgatcc tgccaagaat cctccaggtt
      721 accttgagga tagttttgta aaatctggag tcttcaatgt atcagaactt gtaagagtat
      781 ccagaacgcc cataacccag ggaactggag tcaacttccc aattggagaa atcccaagcc
      841 aaccatacta tcatgacatg aactcggggg tcaatcttca gaggtctctg tcttctccac
      901 caagcagcaa aagacccaaa actatatcca tagatgaaaa tatggaacca agtcctacag
      961 gagactttta cccctctcca agttcaccag ctgctggaag tcgaacatgg cacgaaagag
     1021 atcaagatat gtcttctccg actactatga agaagcctga aaagccattg ttcagctctg
     1081 catctccaca ggattcttcc ccaagactga gcactttccc ccagcaccac catcccggaa
     1141 tacctggagt tgcacacagt gtcatctcaa ctcgaactcc acctccacct tcaccgttgc
     1201 catttccaac acaagctatc cttcctccag ccccatcgag ctacttttct catccaacaa
     1261 tcagatatcc tccccacctg aatcctcagg atactctgaa gaactatgta ccttcttatg
     1321 acccatccag tccacaaacc agccagccta acggcagtgg tcaagtagta gggaaagtgc
     1381 ctggccattt cactcctgtc ttggcaccct ctccccatcc cagtgcagtg cgacctgtga
     1441 ccctgagcat gacagatact aaacccatca ctacatccac tgaagcctac acagcctcag
     1501 gcacatctca agccaatcga tatgtgggac taagcccaag agacccatcc ttcctacatc
     1561 agcaacagct gaggatttgt gactggacca tgaatcaaaa cggcaggcat ttatacccca
     1621 gtaccagtga ggatacattg ggaattactt ggcaaagtcc tggtacctgg gctagcttgg
     1681 ttcctttcca agtgtcaaat aggacaccca tcttaccggc caatgtccaa aattacggtt
     1741 tgaacataat tggagaacct ttccttcaag cagaaacaag caactgaggg aaaaagaaac
     1801 acaacaatag tttaagaaat ttttttttta aataaaaaaa aaggaaaaga ggaagactgg
     1861 acaaaacaac acaaaggcag aaaggaaaga aactgaagaa agaagataat agaccagcaa
     1921 ttgcagcact tacaatcact aattccctta aggttgaaac tgtaatgaca taaaaagggt
     1981 cgatgatatt tcactgatgg tagatcgcag cccctgcaac gtagcctttg ttacatgaag
     2041 tccgctggga aatagatgtt ctgtctctat gacaatatat tttaactgac tttctagatg
     2101 ccttaatatt tgcatgataa gctagtttta ttggtttagt attcttgttg tttacgcatg
     2161 gaatcactat tcctggttat ctcaccaacg aaggctagga ggcggcgtca gaggtgctgg
     2221 gtgacagagc catgagccag ccattttata agcactctga tttctaaaag ttaaaaaaaa
     2281 tatatgaaat ctctgtagcc tttagttatc agtacagatt tattaaattt cggcccttaa
     2341 cccagccttt tccagtgtgt aacccagttt gaaatcttaa aaaaagaaaa aatgaaaaaa
     2401 aaaggaaaaa aagaaaaaag gaaaaaaaca gtttgaacac aaaggctcta tggaagaaat
     2461 gcctctatgt aggtgaagtg ttctctctgc atgcaacagt aaaaattaat ataatatttt
     2521 ccccacaaaa gaaacactta acagaggcaa gtgcaattta taaatttata tctaaagggg
     2581 aatcatgatt ataagtcctt cagcccttgg actctaaatt gaggggatta aaaagaattt
     2641 aaaataattt tgaacgaatt tattttcccc tcagtttttg agggcattaa aaaggcatta
     2701 aatcaagaca aatcatgtgc ttgagaaaaa taaaattaat gaaaacacag cacttatgtt
     2761 ggtttagctg cagcctcctt ggaggtagaa tttatttatt taaaattact ggttgcatca
     2821 agaacccata gggtgtacaa aaggttctat aaaatctgca ttatagagac aaagaggcag
     2881 gcaaatccat gtcacaaggg taaagcttac agtttacaaa ctgggaacgc cagggtgtag
     2941 gatataaaaa cgcactcttg agaaaacaaa tgtaatcagg gtgctgaaaa cttgcatggt
     3001 gctttcagac attagccttg ttcaacaaat ttcttgtatt gacagatcca tagtgtgcat
     3061 gggcagacac attttgcctc tatgtctctt aaaattttaa ttaaaaatac tctttccagt
     3121 aatcctaatt tgcacgaaga tataatgtcc acattacgtg ccttgccttg aaatctaaaa
     3181 aacaaaaaac aaaaaaaaaa aaacaaaaaa atacaacaaa gtgacatcac tacacttgtt
     3241 ttgctgcatt tattatcatt ttaaatcttt accattttta tgacaaaata ttttgtactc
     3301 cagacgaaga aaaatgtgtg acatcatgga ttttttagac agttatacct ttatctcaca
     3361 tttataaagc atatcatggc tgtgtatagt tgccgcttaa aaattgtaat cgaccagcaa
     3421 tattttcagt attttggtgt ttttttctat taacctttca tgtttttcat cttccaatta
     3481 atatttgggg gggaggggtt tcaaatttat acgaattatg caataccaag ttttgcctat
     3541 gtaggtagtg cttttagctg tattggttat tataggtaag tacacagatt taaaaaaaaa
     3601 ataatgtatg cttttttgtt tgtttgtttg ttttaattga ccaaagtggg tactgctatt
     3661 tttgcagtgt gatgaggtcc ttttgtgtac tgagagatgg acaggggatt ttttttaata
     3721 tacatatata tatattctgg ggtgggtggg aggattttta acactttgca gtgtagctgt
     3781 gaagcagtgc accctgagat gggcctgggc tgcaaagcga ctgttctgcc tactgtgaca
     3841 aacttcaact tacacaggtt cccctctcta acttcccacc tgggttgcaa gctgaactca
     3901 ttactggttt tcataacaac acaatagtaa gaacaagcaa acacaacaaa ttctcctgga
     3961 ggcagacttg gcttaaaaag gcagacttgg cttggtgata gtttttcttg aaagttccag
     4021 atccacagtg gagagtgagc ctgtctcata tttggcaaaa atatttgttg aaatgtccac
     4081 ataggggatg ttggatgttt aacacttttg agagtttaac acatgaatat tctttctcct
     4141 agaaaacaca ttagacctgt tggagggagt ctcccgtatt ccttttctgc cacttttcgt
     4201 ccccatttca tttcattaat gataggatat gatttacctg tgacttacta cttcaaatgg
     4261 atggcagtgc acttggattt ttttttaata tccagaagat tgaacagagg gttgctattg
     4321 ttgaatgtat ttggactgat agattaaaat caaagttcaa tttttaagga acaaaaaagt
     4381 aaatcctgtt ttcattttat ctcccctttt aaaactgaga accagagcag aagggaaata
     4441 tagaatttta agcaattaat cttcctgtgg atgaattaaa cccattagat gctgatggga
     4501 tttttttaag gaatggtacc ttaactatat atttgatttc gtttcccctg agggctagag
     4561 gctgaatgga ggctggtttt attttgcctt tccctcaccg cccagtccca ttgagtgtat
     4621 tcattactag aaggaaaatc tttcagaatt ggtgacacat ggtaggctgt cttaaggagt
     4681 cccctggccc ccttccccta ggccatggcc taataaaata aactgtcaat tgttctcaca
     4741 gcatatcatt taataatgaa tactttagaa caatgcttat gggctggaga attgtatttg
     4801 attagcccat tcagtttgat agcccaaatg ctgaacagca cagcgggatc ctagcagtgc
     4861 aagttcaaaa gtaagtccaa tcatttctgt gatactcgcc ctggtagcaa acagatcatc
     4921 tcagccaagc tcttcatgta tctttgacct attaggtgaa caaatgaacc tcacaggaca
     4981 cacagtattt tttaaaggca gactcgctct cttttttgcc agtgagcagt tctagctaac
     5041 caagttacac actgtgggta ttcctgcctg cctcttgaat acaaaggcct agttcaagtg
     5101 ttgctttttt tatttcaaat caattttttc ttctttcctt tttgagataa aactattaaa
     5161 agtactacta tatatataaa atctcaaatc aacttttcgg cctcctcctc gtgtaccagg
     5221 aagtatattc tgacgaaggg ccccactttt gcaggtcttg cacgcccctc ccttacccag
     5281 aactgcagag cttcaggatg gcgaaggtca cccaagggca tgagtaggga gtggtgtctc
     5341 caaccatcag ttccgtggca ctgttcagcc tttgtgtgct gccctgccac ccaccactca
     5401 cagtgcctct gaagcgtgtt acccctggag tgacgtgagc atttgaggct tgtctaagga
     5461 aaaaaataaa aggcagtgaa ggagactgta cataaagaca tggcaaaaat cttaattata
     5521 gcaatatagt tatcgggtaa tgttcgggtg ggcagctcca ttaaaaaata tgtgaatgaa
     5581 tctgtgaagc tgcaagtagc gagaagagcg aaaggtcttc ttaatgaacc gcctaccttg
     5641 tagacagtaa tttgtacact gtatagtttt gttaagaatt ttttttaaat taaaattccc
     5701 atgtttgtaa agctaacttt ttaacaatta taatggaact atatgttgtt tccattttta
     5761 aagtaaacaa gaatattcct tgtttagaga ctggacttga gttaaaactc tccagtctct
     5821 taagttatgt attaaaaaga aaatctgtcc atgttaggag ttatttcaca gattcctgtg
     5881 cttgaaaagc ataggatact aatcctttaa aaaagtgtaa atggagaaaa gttatatttt
     5941 atgaaggtta ttttgttgta tttagtattg gaaaagttgg tttccagagc atttcagaat
     6001 gtcgaagcac cactgtcttt ttattagtat atacggcctt tagcaaaagt ttttgtgatt
     6061 gttacgtgat ggtatttaag gttaagtttc acagagcatt caggataggc agaaaactaa
     6121 aacagtgcta tgtctcacat aacgtgtcct cagggagcag aatcttggat ttgtgacttg
     6181 tagcttcata aggactcaac gaaagagatt gcacagggac atcttcagcg gtgtgacagc
     6241 aggacatgtt ctttacctag attcaaattc tatgtactgt gtgaaatgat gaaggctgca
     6301 gaaagttatc ccatattcag tgtacagtat tcatttttaa tgaaacaact ctacaatatt
     6361 gctggcagat aggccccaag catgacattc aatatagttt acatgttcct gtcaaggtct
     6421 tttgttaaca ttaaccagct gcatgctttc tggactttaa gaaattgggt ttctatagaa
     6481 aacttttttt tttttttttt ttttaatgtg caggctattc aagttcaata gtaaaagctc
     6541 aaaaatgaat gttctactcc atgctgaagg agctgaaagc tgccttcttc atattttgca
     6601 ctttctggta gttcccctgt tttttctaat tccctaaaat tgtgtgggtg gagtggagcc
     6661 ctgcagttgg ggggtaacat ggaccactga ttttgccctt tgaccctgca caatgacctt
     6721 tgcatcagcc aaactcattg ccatgacaac tctttgtact gtgtccgtgc cacagatctg
     6781 ttggtcacat tgttaatagt aaaggggaca agttggagac ggtcaatttt tacatttttt
     6841 gttgcaattt tttcttcaat ggttgtaagt agtttttttt tttttttaat aataaaaggg
     6901 ttcactagtt aatactctag aaatatctgt gtgttgcaat tcaaatgtat gttgagattg
     6961 tgaaaagcgc ttcagtgcca ctagcttacc ggtacactag actaagccct tgatgactta
     7021 ttgcatgata cagtaccagg aacaacaggt ggcctaaata catgaaaagc agtgtaagct
     7081 agtgacacta aagccagtct tgtattactg tatttttgac agaatggttt tgaaaactgt
     7141 gctacaggga ctgatgtggc aaatatatct ctttatgcag aaggaagtct ttttttttct
     7201 tttttttttt tttaagaagt atggcttttt atgcatcctt catcgagggc attgaagttg
     7261 catggactga taaaagttga tgcaaaacaa gaaagaaaca aacaaaaaaa aaaaaccagc
     7321 aaaatgttta ccaaaaaact caaacaaatg agcagtgcct gttcaatttc acagtctctg
     7381 ttgagttcag ttgtaaatat gtttcaaatg acattttctt gggaaaaaaa atctctacaa
     7441 cattgtagaa tgtgaggggt aactacatcc caggcatagg tttctcaaag ctgcagtaga
     7501 ttatgtcttc atcaagctgt taatttgtgc ttatatcata tagaactttt agcatcctgg
     7561 gaagagctgc ccccacctca atgatatttc tctgagaaca acttttgtag gactgtgtgt
     7621 ttctttagat acatttagta caactgtagg tgacgagtag tcagttattg cttgctagct
     7681 acacaccagg gttgatccat tttaaaactt ttggcatttt gtcctcatgg gccataaata
     7741 cagaaccttg tattttaatt aaattttttt acaaaaggag gcacatgcac aatctccatg
     7801 taacaaacct ttagcagtag gatgtattat acgacagtta cttaatttct agagttcagg
     7861 cctctgggat caaccccaga ctgggccaga atgttagtga aggttttatt gtgcccggtt
     7921 ggaggataac gttctttggg tactttttgt gggttgcaaa tgaactcaat tgccacaagt
     7981 tttaaactgg tgtaaatcaa gcttgactta atgtgattgt tactgttata tccagcctat
     8041 actgctagca gctgctcata ctgcagtcaa ttactggaag cggatatatt tcctatgcaa
     8101 aaactgttta aacaataaaa tgagctatgc tacaga
//
