LOCUS       NM_001369458            8163 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens nuclear factor I B (NFIB), transcript variant 5, mRNA.
ACCESSION   NM_001369458
VERSION     NM_001369458.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8163)
  AUTHORS   Smith,R.L., Wollmann,B.M., Storset,E., Lenk,H.C., O'Connell,K.S.,
            Kristiansen,M.K., Ingelman-Sundberg,M. and Molden,E.
  TITLE     Effect of the NFIB rs28379954 T>C polymorphism on CYP2D6-catalyzed
            metabolism of solanidine
  JOURNAL   Clin Transl Sci 17 (2), e13743 (2024)
   PUBMED   38385986
  REMARK    GeneRIF: Effect of the NFIB rs28379954 T>C polymorphism on
            CYP2D6-catalyzed metabolism of solanidine.
REFERENCE   2  (bases 1 to 8163)
  AUTHORS   Yu,H., Liu,P. and Chen,T.
  TITLE     CircIFFO1 suppresses tumor growth and metastasis of cutaneous
            squamous cell carcinoma by targeting the miR-424-5p/NFIB axis
  JOURNAL   Arch Dermatol Res 315 (9), 2585-2596 (2023)
   PUBMED   37405427
  REMARK    GeneRIF: CircIFFO1 suppresses tumor growth and metastasis of
            cutaneous squamous cell carcinoma by targeting the miR-424-5p/NFIB
            axis.
REFERENCE   3  (bases 1 to 8163)
  AUTHORS   Zhang,W., Wang,Y., Liu,Y., Liu,C., Wang,Y., He,L., Cheng,X.,
            Peng,Y., Xia,L., Wu,X., Wu,J., Zhang,Y., Sun,L., Chen,P., Li,G.,
            Tu,Q., Liang,J. and Shang,Y.
  TITLE     NFIB facilitates replication licensing by acting as a genome
            organizer
  JOURNAL   Nat Commun 14 (1), 5076 (2023)
   PUBMED   37604829
  REMARK    GeneRIF: NFIB facilitates replication licensing by acting as a
            genome organizer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8163)
  AUTHORS   Gana,S., Serpieri,V., Giorgio,E., Iorio,M., Rognone,E.,
            Pichiecchio,A., Chiappedi,M. and Valente,E.M.
  TITLE     Marked intrafamilial variability of clinical and neuroimaging
            manifestations in NFIB-related developmental disorder
  JOURNAL   Am J Med Genet A 191 (5), 1395-1400 (2023)
   PUBMED   36756855
  REMARK    GeneRIF: Marked intrafamilial variability of clinical and
            neuroimaging manifestations in NFIB-related developmental disorder.
REFERENCE   5  (bases 1 to 8163)
  AUTHORS   Sheng,H. and Wang,X.
  TITLE     Knockdown of circ-PIP5K1A overcomes resistance to cisplatin in
            ovarian cancer by miR-942-5p/NFIB axis
  JOURNAL   Anticancer Drugs 34 (2), 214-226 (2023)
   PUBMED   36730637
  REMARK    GeneRIF: Knockdown of circ-PIP5K1A overcomes resistance to
            cisplatin in ovarian cancer by miR-942-5p/NFIB axis.
REFERENCE   6  (bases 1 to 8163)
  AUTHORS   Mukhopadhyay,S.S. and Rosen,J.M.
  TITLE     The C-terminal domain of the nuclear factor I-B2 isoform is
            glycosylated and transactivates the WAP gene in the JEG-3 cells
  JOURNAL   Biochem Biophys Res Commun 358 (3), 770-776 (2007)
   PUBMED   17511965
  REMARK    GeneRIF: C-terminal domain of the nuclear factor I-B2 isoform is
            glycosylated and transactivates the WAP gene in tumor cells
REFERENCE   7  (bases 1 to 8163)
  AUTHORS   Sheeter,D., Du,P., Rought,S., Richman,D. and Corbeil,J.
  TITLE     Surface CD4 expression modulated by a cellular factor induced by
            HIV type 1 infection
  JOURNAL   AIDS Res Hum Retroviruses 19 (2), 117-123 (2003)
   PUBMED   12639247
  REMARK    GeneRIF: expression of NFI-B2 impairs CD4 transcription on
            CDd4-positive primary T-lymphocytes and cell lines in HIV-1
            infection
REFERENCE   8  (bases 1 to 8163)
  AUTHORS   Geurts,J.M., Schoenmakers,E.F., Roijer,E., Astrom,A.K., Stenman,G.
            and van de Ven,W.J.
  TITLE     Identification of NFIB as recurrent translocation partner gene of
            HMGIC in pleomorphic adenomas
  JOURNAL   Oncogene 16 (7), 865-872 (1998)
   PUBMED   9484777
REFERENCE   9  (bases 1 to 8163)
  AUTHORS   Liu,Y., Bernard,H.U. and Apt,D.
  TITLE     NFI-B3, a novel transcriptional repressor of the nuclear factor I
            family, is generated by alternative RNA processing
  JOURNAL   J Biol Chem 272 (16), 10739-10745 (1997)
   PUBMED   9099724
REFERENCE   10 (bases 1 to 8163)
  AUTHORS   Qian,F., Kruse,U., Lichter,P. and Sippel,A.E.
  TITLE     Chromosomal localization of the four genes (NFIA, B, C, and X) for
            the human transcription factor nuclear factor I by FISH
  JOURNAL   Genomics 28 (1), 66-73 (1995)
   PUBMED   7590749
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL159169.14, AL136366.24 and AL441963.7.
            
            Transcript Variant: This variant (5) encodes the longest isoform
            (5).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.21276.1,
                                           SRR14038195.2561013.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-131               AL159169.14        21344-21474         c
            132-663             AL136366.24        84054-84585         c
            664-717             AL441963.7         116262-116315       c
            718-786             AL441963.7         92360-92428         c
            787-907             AL441963.7         86680-86800         c
            908-1026            AL441963.7         83224-83342         c
            1027-1161           AL441963.7         62167-62301         c
            1162-1346           AL441963.7         56975-57159         c
            1347-1512           AL441963.7         52716-52881         c
            1513-1595           AL441963.7         49534-49616         c
            1596-1684           AL441963.7         38957-39045         c
            1685-8163           AL441963.7         18383-24861         c
FEATURES             Location/Qualifiers
     source          1..8163
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p23-p22.3"
     gene            1..8163
                     /gene="NFIB"
                     /gene_synonym="CTF; HMGIC/NFIB; MACID; NF-I/B; NF1-B;
                     NFI-B; NFI-RED; NFIB2; NFIB3"
                     /note="nuclear factor I B"
                     /db_xref="GeneID:4781"
                     /db_xref="HGNC:HGNC:7785"
                     /db_xref="MIM:600728"
     exon            1..131
                     /gene="NFIB"
                     /gene_synonym="CTF; HMGIC/NFIB; MACID; NF-I/B; NF1-B;
                     NFI-B; NFI-RED; NFIB2; NFIB3"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..1814
                     /gene="NFIB"
                     /gene_synonym="CTF; HMGIC/NFIB; MACID; NF-I/B; NF1-B;
                     NFI-B; NFI-RED; NFIB2; NFIB3"
                     /note="isoform 5 is encoded by transcript variant 5;
                     nuclear factor 1 B-type; nuclear factor 1/B; TGGCA-binding
                     protein; CCAAT-box-binding transcription factor"
                     /codon_start=1
                     /product="nuclear factor 1 B-type isoform 5"
                     /protein_id="NP_001356387.1"
                     /db_xref="GeneID:4781"
                     /db_xref="HGNC:HGNC:7785"
                     /db_xref="MIM:600728"
                     /translation="MKVADSIMAGKTSDSSIKWQLCYDMSARTWWMDEFHPFIEALLP
                     HVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLLAKL
                     RKDIRQEYREDFVLTVTGKKHPCCVLSNPDQKGKIRRIDCLRQADKVWRLDLVMVILF
                     KGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFLAYYVQEQDSGQSGSPS
                     HNDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMN
                     SGVNLQRSLSSPPSSKRPKTISIDENMEPSPTGDFYPSPSSPAAGSRTWHERDQDMSS
                     PTTMKKPEKPLFSSASPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPLPFPT
                     QAILPPAPSSYFSHPTIRYPPHLNPQDTLKNYVPSYDPSSPQTSQPNGSGQVVGKVPG
                     HFTPVLAPSPHPSAVRPVTLSMTDTKPITTSTEGEAASPTATTYTASGTSQANRYVGL
                     SPRDPSFLHQQQLRICDWTMNQNGRHLYPSTSEDTLGITWQSPGTWASLVPFQVSNRT
                     PILPANVQNYGLNIIGEPFLQAETSN"
     exon            132..663
                     /gene="NFIB"
                     /gene_synonym="CTF; HMGIC/NFIB; MACID; NF-I/B; NF1-B;
                     NFI-B; NFI-RED; NFIB2; NFIB3"
                     /inference="alignment:Splign:2.1.0"
     exon            664..717
                     /gene="NFIB"
                     /gene_synonym="CTF; HMGIC/NFIB; MACID; NF-I/B; NF1-B;
                     NFI-B; NFI-RED; NFIB2; NFIB3"
                     /inference="alignment:Splign:2.1.0"
     exon            718..786
                     /gene="NFIB"
                     /gene_synonym="CTF; HMGIC/NFIB; MACID; NF-I/B; NF1-B;
                     NFI-B; NFI-RED; NFIB2; NFIB3"
                     /inference="alignment:Splign:2.1.0"
     exon            787..907
                     /gene="NFIB"
                     /gene_synonym="CTF; HMGIC/NFIB; MACID; NF-I/B; NF1-B;
                     NFI-B; NFI-RED; NFIB2; NFIB3"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1026
                     /gene="NFIB"
                     /gene_synonym="CTF; HMGIC/NFIB; MACID; NF-I/B; NF1-B;
                     NFI-B; NFI-RED; NFIB2; NFIB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1161
                     /gene="NFIB"
                     /gene_synonym="CTF; HMGIC/NFIB; MACID; NF-I/B; NF1-B;
                     NFI-B; NFI-RED; NFIB2; NFIB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1346
                     /gene="NFIB"
                     /gene_synonym="CTF; HMGIC/NFIB; MACID; NF-I/B; NF1-B;
                     NFI-B; NFI-RED; NFIB2; NFIB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1512
                     /gene="NFIB"
                     /gene_synonym="CTF; HMGIC/NFIB; MACID; NF-I/B; NF1-B;
                     NFI-B; NFI-RED; NFIB2; NFIB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..1595
                     /gene="NFIB"
                     /gene_synonym="CTF; HMGIC/NFIB; MACID; NF-I/B; NF1-B;
                     NFI-B; NFI-RED; NFIB2; NFIB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..1684
                     /gene="NFIB"
                     /gene_synonym="CTF; HMGIC/NFIB; MACID; NF-I/B; NF1-B;
                     NFI-B; NFI-RED; NFIB2; NFIB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..8163
                     /gene="NFIB"
                     /gene_synonym="CTF; HMGIC/NFIB; MACID; NF-I/B; NF1-B;
                     NFI-B; NFI-RED; NFIB2; NFIB3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8141..8146
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NFIB"
                     /gene_synonym="CTF; HMGIC/NFIB; MACID; NF-I/B; NF1-B;
                     NFI-B; NFI-RED; NFIB2; NFIB3"
                     /note="hexamer: AATAAA"
     polyA_site      8163
                     /gene="NFIB"
                     /gene_synonym="CTF; HMGIC/NFIB; MACID; NF-I/B; NF1-B;
                     NFI-B; NFI-RED; NFIB2; NFIB3"
                     /note="major polyA site"
ORIGIN      
        1 gattaggtgt cttatcttcc attgagctgc atctgatgaa ggttgctgac agcataatgg
       61 ctgggaaaac gtcggacagc tccataaaat ggcagctatg ttatgacatg tcagccagga
      121 cctggtggat ggatgaattt cacccattca tcgaggcact tcttccacat gtccgtgcaa
      181 ttgcctatac ttggttcaac ctgcaggctc gaaaacgcaa gtactttaaa aagcatgaga
      241 agcgaatgtc aaaggatgaa gaaagagcag tcaaagatga gcttctcagt gaaaagcctg
      301 aaatcaaaca gaagtgggca tccaggctcc ttgccaaact gcgcaaagat attcgccagg
      361 agtatcgaga ggactttgtg ctcaccgtga ctggcaagaa gcacccgtgc tgtgtcttat
      421 ccaatcccga ccagaagggt aagattagga gaatcgactg cctgcgacag gcagacaaag
      481 tctggcgtct ggatctagtc atggtgatcc tgttcaaagg catccccttg gaaagtaccg
      541 atggagagcg gctcatgaaa tccccacatt gcacaaaccc agcactttgt gtccagccac
      601 atcatatcac agtatcagtt aaggagcttg atttgttttt ggcatactac gtgcaggagc
      661 aagattctgg acaatcagga agtccaagcc acaatgatcc tgccaagaat cctccaggtt
      721 accttgagga tagttttgta aaatctggag tcttcaatgt atcagaactt gtaagagtat
      781 ccagaacgcc cataacccag ggaactggag tcaacttccc aattggagaa atcccaagcc
      841 aaccatacta tcatgacatg aactcggggg tcaatcttca gaggtctctg tcttctccac
      901 caagcagcaa aagacccaaa actatatcca tagatgaaaa tatggaacca agtcctacag
      961 gagactttta cccctctcca agttcaccag ctgctggaag tcgaacatgg cacgaaagag
     1021 atcaagatat gtcttctccg actactatga agaagcctga aaagccattg ttcagctctg
     1081 catctccaca ggattcttcc ccaagactga gcactttccc ccagcaccac catcccggaa
     1141 tacctggagt tgcacacagt gtcatctcaa ctcgaactcc acctccacct tcaccgttgc
     1201 catttccaac acaagctatc cttcctccag ccccatcgag ctacttttct catccaacaa
     1261 tcagatatcc tccccacctg aatcctcagg atactctgaa gaactatgta ccttcttatg
     1321 acccatccag tccacaaacc agccagccta acggcagtgg tcaagtagta gggaaagtgc
     1381 ctggccattt cactcctgtc ttggcaccct ctccccatcc cagtgcagtg cgacctgtga
     1441 ccctgagcat gacagatact aaacccatca ctacatccac tgaaggtgag gcagcttcac
     1501 ctacagcaac cacctacaca gcctcaggca catctcaagc caatcgatat gtgggactaa
     1561 gcccaagaga cccatccttc ctacatcagc aacagctgag gatttgtgac tggaccatga
     1621 atcaaaacgg caggcattta taccccagta ccagtgagga tacattggga attacttggc
     1681 aaagtcctgg tacctgggct agcttggttc ctttccaagt gtcaaatagg acacccatct
     1741 taccggccaa tgtccaaaat tacggtttga acataattgg agaacctttc cttcaagcag
     1801 aaacaagcaa ctgagggaaa aagaaacaca acaatagttt aagaaatttt ttttttaaat
     1861 aaaaaaaaag gaaaagagga agactggaca aaacaacaca aaggcagaaa ggaaagaaac
     1921 tgaagaaaga agataataga ccagcaattg cagcacttac aatcactaat tcccttaagg
     1981 ttgaaactgt aatgacataa aaagggtcga tgatatttca ctgatggtag atcgcagccc
     2041 ctgcaacgta gcctttgtta catgaagtcc gctgggaaat agatgttctg tctctatgac
     2101 aatatatttt aactgacttt ctagatgcct taatatttgc atgataagct agttttattg
     2161 gtttagtatt cttgttgttt acgcatggaa tcactattcc tggttatctc accaacgaag
     2221 gctaggaggc ggcgtcagag gtgctgggtg acagagccat gagccagcca ttttataagc
     2281 actctgattt ctaaaagtta aaaaaaatat atgaaatctc tgtagccttt agttatcagt
     2341 acagatttat taaatttcgg cccttaaccc agccttttcc agtgtgtaac ccagtttgaa
     2401 atcttaaaaa aagaaaaaat gaaaaaaaaa ggaaaaaaag aaaaaaggaa aaaaacagtt
     2461 tgaacacaaa ggctctatgg aagaaatgcc tctatgtagg tgaagtgttc tctctgcatg
     2521 caacagtaaa aattaatata atattttccc cacaaaagaa acacttaaca gaggcaagtg
     2581 caatttataa atttatatct aaaggggaat catgattata agtccttcag cccttggact
     2641 ctaaattgag gggattaaaa agaatttaaa ataattttga acgaatttat tttcccctca
     2701 gtttttgagg gcattaaaaa ggcattaaat caagacaaat catgtgcttg agaaaaataa
     2761 aattaatgaa aacacagcac ttatgttggt ttagctgcag cctccttgga ggtagaattt
     2821 atttatttaa aattactggt tgcatcaaga acccataggg tgtacaaaag gttctataaa
     2881 atctgcatta tagagacaaa gaggcaggca aatccatgtc acaagggtaa agcttacagt
     2941 ttacaaactg ggaacgccag ggtgtaggat ataaaaacgc actcttgaga aaacaaatgt
     3001 aatcagggtg ctgaaaactt gcatggtgct ttcagacatt agccttgttc aacaaatttc
     3061 ttgtattgac agatccatag tgtgcatggg cagacacatt ttgcctctat gtctcttaaa
     3121 attttaatta aaaatactct ttccagtaat cctaatttgc acgaagatat aatgtccaca
     3181 ttacgtgcct tgccttgaaa tctaaaaaac aaaaaacaaa aaaaaaaaaa caaaaaaata
     3241 caacaaagtg acatcactac acttgttttg ctgcatttat tatcatttta aatctttacc
     3301 atttttatga caaaatattt tgtactccag acgaagaaaa atgtgtgaca tcatggattt
     3361 tttagacagt tataccttta tctcacattt ataaagcata tcatggctgt gtatagttgc
     3421 cgcttaaaaa ttgtaatcga ccagcaatat tttcagtatt ttggtgtttt tttctattaa
     3481 cctttcatgt ttttcatctt ccaattaata tttggggggg aggggtttca aatttatacg
     3541 aattatgcaa taccaagttt tgcctatgta ggtagtgctt ttagctgtat tggttattat
     3601 aggtaagtac acagatttaa aaaaaaaata atgtatgctt ttttgtttgt ttgtttgttt
     3661 taattgacca aagtgggtac tgctattttt gcagtgtgat gaggtccttt tgtgtactga
     3721 gagatggaca ggggattttt tttaatatac atatatatat attctggggt gggtgggagg
     3781 atttttaaca ctttgcagtg tagctgtgaa gcagtgcacc ctgagatggg cctgggctgc
     3841 aaagcgactg ttctgcctac tgtgacaaac ttcaacttac acaggttccc ctctctaact
     3901 tcccacctgg gttgcaagct gaactcatta ctggttttca taacaacaca atagtaagaa
     3961 caagcaaaca caacaaattc tcctggaggc agacttggct taaaaaggca gacttggctt
     4021 ggtgatagtt tttcttgaaa gttccagatc cacagtggag agtgagcctg tctcatattt
     4081 ggcaaaaata tttgttgaaa tgtccacata ggggatgttg gatgtttaac acttttgaga
     4141 gtttaacaca tgaatattct ttctcctaga aaacacatta gacctgttgg agggagtctc
     4201 ccgtattcct tttctgccac ttttcgtccc catttcattt cattaatgat aggatatgat
     4261 ttacctgtga cttactactt caaatggatg gcagtgcact tggatttttt tttaatatcc
     4321 agaagattga acagagggtt gctattgttg aatgtatttg gactgataga ttaaaatcaa
     4381 agttcaattt ttaaggaaca aaaaagtaaa tcctgttttc attttatctc cccttttaaa
     4441 actgagaacc agagcagaag ggaaatatag aattttaagc aattaatctt cctgtggatg
     4501 aattaaaccc attagatgct gatgggattt ttttaaggaa tggtacctta actatatatt
     4561 tgatttcgtt tcccctgagg gctagaggct gaatggaggc tggttttatt ttgcctttcc
     4621 ctcaccgccc agtcccattg agtgtattca ttactagaag gaaaatcttt cagaattggt
     4681 gacacatggt aggctgtctt aaggagtccc ctggccccct tcccctaggc catggcctaa
     4741 taaaataaac tgtcaattgt tctcacagca tatcatttaa taatgaatac tttagaacaa
     4801 tgcttatggg ctggagaatt gtatttgatt agcccattca gtttgatagc ccaaatgctg
     4861 aacagcacag cgggatccta gcagtgcaag ttcaaaagta agtccaatca tttctgtgat
     4921 actcgccctg gtagcaaaca gatcatctca gccaagctct tcatgtatct ttgacctatt
     4981 aggtgaacaa atgaacctca caggacacac agtatttttt aaaggcagac tcgctctctt
     5041 ttttgccagt gagcagttct agctaaccaa gttacacact gtgggtattc ctgcctgcct
     5101 cttgaataca aaggcctagt tcaagtgttg ctttttttat ttcaaatcaa ttttttcttc
     5161 tttccttttt gagataaaac tattaaaagt actactatat atataaaatc tcaaatcaac
     5221 ttttcggcct cctcctcgtg taccaggaag tatattctga cgaagggccc cacttttgca
     5281 ggtcttgcac gcccctccct tacccagaac tgcagagctt caggatggcg aaggtcaccc
     5341 aagggcatga gtagggagtg gtgtctccaa ccatcagttc cgtggcactg ttcagccttt
     5401 gtgtgctgcc ctgccaccca ccactcacag tgcctctgaa gcgtgttacc cctggagtga
     5461 cgtgagcatt tgaggcttgt ctaaggaaaa aaataaaagg cagtgaagga gactgtacat
     5521 aaagacatgg caaaaatctt aattatagca atatagttat cgggtaatgt tcgggtgggc
     5581 agctccatta aaaaatatgt gaatgaatct gtgaagctgc aagtagcgag aagagcgaaa
     5641 ggtcttctta atgaaccgcc taccttgtag acagtaattt gtacactgta tagttttgtt
     5701 aagaattttt tttaaattaa aattcccatg tttgtaaagc taacttttta acaattataa
     5761 tggaactata tgttgtttcc atttttaaag taaacaagaa tattccttgt ttagagactg
     5821 gacttgagtt aaaactctcc agtctcttaa gttatgtatt aaaaagaaaa tctgtccatg
     5881 ttaggagtta tttcacagat tcctgtgctt gaaaagcata ggatactaat cctttaaaaa
     5941 agtgtaaatg gagaaaagtt atattttatg aaggttattt tgttgtattt agtattggaa
     6001 aagttggttt ccagagcatt tcagaatgtc gaagcaccac tgtcttttta ttagtatata
     6061 cggcctttag caaaagtttt tgtgattgtt acgtgatggt atttaaggtt aagtttcaca
     6121 gagcattcag gataggcaga aaactaaaac agtgctatgt ctcacataac gtgtcctcag
     6181 ggagcagaat cttggatttg tgacttgtag cttcataagg actcaacgaa agagattgca
     6241 cagggacatc ttcagcggtg tgacagcagg acatgttctt tacctagatt caaattctat
     6301 gtactgtgtg aaatgatgaa ggctgcagaa agttatccca tattcagtgt acagtattca
     6361 tttttaatga aacaactcta caatattgct ggcagatagg ccccaagcat gacattcaat
     6421 atagtttaca tgttcctgtc aaggtctttt gttaacatta accagctgca tgctttctgg
     6481 actttaagaa attgggtttc tatagaaaac tttttttttt tttttttttt taatgtgcag
     6541 gctattcaag ttcaatagta aaagctcaaa aatgaatgtt ctactccatg ctgaaggagc
     6601 tgaaagctgc cttcttcata ttttgcactt tctggtagtt cccctgtttt ttctaattcc
     6661 ctaaaattgt gtgggtggag tggagccctg cagttggggg gtaacatgga ccactgattt
     6721 tgccctttga ccctgcacaa tgacctttgc atcagccaaa ctcattgcca tgacaactct
     6781 ttgtactgtg tccgtgccac agatctgttg gtcacattgt taatagtaaa ggggacaagt
     6841 tggagacggt caatttttac attttttgtt gcaatttttt cttcaatggt tgtaagtagt
     6901 tttttttttt ttttaataat aaaagggttc actagttaat actctagaaa tatctgtgtg
     6961 ttgcaattca aatgtatgtt gagattgtga aaagcgcttc agtgccacta gcttaccggt
     7021 acactagact aagcccttga tgacttattg catgatacag taccaggaac aacaggtggc
     7081 ctaaatacat gaaaagcagt gtaagctagt gacactaaag ccagtcttgt attactgtat
     7141 ttttgacaga atggttttga aaactgtgct acagggactg atgtggcaaa tatatctctt
     7201 tatgcagaag gaagtctttt tttttctttt tttttttttt aagaagtatg gctttttatg
     7261 catccttcat cgagggcatt gaagttgcat ggactgataa aagttgatgc aaaacaagaa
     7321 agaaacaaac aaaaaaaaaa aaccagcaaa atgtttacca aaaaactcaa acaaatgagc
     7381 agtgcctgtt caatttcaca gtctctgttg agttcagttg taaatatgtt tcaaatgaca
     7441 ttttcttggg aaaaaaaatc tctacaacat tgtagaatgt gaggggtaac tacatcccag
     7501 gcataggttt ctcaaagctg cagtagatta tgtcttcatc aagctgttaa tttgtgctta
     7561 tatcatatag aacttttagc atcctgggaa gagctgcccc cacctcaatg atatttctct
     7621 gagaacaact tttgtaggac tgtgtgtttc tttagataca tttagtacaa ctgtaggtga
     7681 cgagtagtca gttattgctt gctagctaca caccagggtt gatccatttt aaaacttttg
     7741 gcattttgtc ctcatgggcc ataaatacag aaccttgtat tttaattaaa tttttttaca
     7801 aaaggaggca catgcacaat ctccatgtaa caaaccttta gcagtaggat gtattatacg
     7861 acagttactt aatttctaga gttcaggcct ctgggatcaa ccccagactg ggccagaatg
     7921 ttagtgaagg ttttattgtg cccggttgga ggataacgtt ctttgggtac tttttgtggg
     7981 ttgcaaatga actcaattgc cacaagtttt aaactggtgt aaatcaagct tgacttaatg
     8041 tgattgttac tgttatatcc agcctatact gctagcagct gctcatactg cagtcaatta
     8101 ctggaagcgg atatatttcc tatgcaaaaa ctgtttaaac aataaaatga gctatgctac
     8161 aga
//
