LOCUS       NM_001190737            8576 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens nuclear factor I B (NFIB), transcript variant 1, mRNA.
ACCESSION   NM_001190737
VERSION     NM_001190737.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8576)
  AUTHORS   Smith,R.L., Wollmann,B.M., Storset,E., Lenk,H.C., O'Connell,K.S.,
            Kristiansen,M.K., Ingelman-Sundberg,M. and Molden,E.
  TITLE     Effect of the NFIB rs28379954 T>C polymorphism on CYP2D6-catalyzed
            metabolism of solanidine
  JOURNAL   Clin Transl Sci 17 (2), e13743 (2024)
   PUBMED   38385986
  REMARK    GeneRIF: Effect of the NFIB rs28379954 T>C polymorphism on
            CYP2D6-catalyzed metabolism of solanidine.
REFERENCE   2  (bases 1 to 8576)
  AUTHORS   Yu,H., Liu,P. and Chen,T.
  TITLE     CircIFFO1 suppresses tumor growth and metastasis of cutaneous
            squamous cell carcinoma by targeting the miR-424-5p/NFIB axis
  JOURNAL   Arch Dermatol Res 315 (9), 2585-2596 (2023)
   PUBMED   37405427
  REMARK    GeneRIF: CircIFFO1 suppresses tumor growth and metastasis of
            cutaneous squamous cell carcinoma by targeting the miR-424-5p/NFIB
            axis.
REFERENCE   3  (bases 1 to 8576)
  AUTHORS   Zhang,W., Wang,Y., Liu,Y., Liu,C., Wang,Y., He,L., Cheng,X.,
            Peng,Y., Xia,L., Wu,X., Wu,J., Zhang,Y., Sun,L., Chen,P., Li,G.,
            Tu,Q., Liang,J. and Shang,Y.
  TITLE     NFIB facilitates replication licensing by acting as a genome
            organizer
  JOURNAL   Nat Commun 14 (1), 5076 (2023)
   PUBMED   37604829
  REMARK    GeneRIF: NFIB facilitates replication licensing by acting as a
            genome organizer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8576)
  AUTHORS   Gana,S., Serpieri,V., Giorgio,E., Iorio,M., Rognone,E.,
            Pichiecchio,A., Chiappedi,M. and Valente,E.M.
  TITLE     Marked intrafamilial variability of clinical and neuroimaging
            manifestations in NFIB-related developmental disorder
  JOURNAL   Am J Med Genet A 191 (5), 1395-1400 (2023)
   PUBMED   36756855
  REMARK    GeneRIF: Marked intrafamilial variability of clinical and
            neuroimaging manifestations in NFIB-related developmental disorder.
REFERENCE   5  (bases 1 to 8576)
  AUTHORS   Sheng,H. and Wang,X.
  TITLE     Knockdown of circ-PIP5K1A overcomes resistance to cisplatin in
            ovarian cancer by miR-942-5p/NFIB axis
  JOURNAL   Anticancer Drugs 34 (2), 214-226 (2023)
   PUBMED   36730637
  REMARK    GeneRIF: Knockdown of circ-PIP5K1A overcomes resistance to
            cisplatin in ovarian cancer by miR-942-5p/NFIB axis.
REFERENCE   6  (bases 1 to 8576)
  AUTHORS   Mukhopadhyay,S.S. and Rosen,J.M.
  TITLE     The C-terminal domain of the nuclear factor I-B2 isoform is
            glycosylated and transactivates the WAP gene in the JEG-3 cells
  JOURNAL   Biochem Biophys Res Commun 358 (3), 770-776 (2007)
   PUBMED   17511965
  REMARK    GeneRIF: C-terminal domain of the nuclear factor I-B2 isoform is
            glycosylated and transactivates the WAP gene in tumor cells
REFERENCE   7  (bases 1 to 8576)
  AUTHORS   Sheeter,D., Du,P., Rought,S., Richman,D. and Corbeil,J.
  TITLE     Surface CD4 expression modulated by a cellular factor induced by
            HIV type 1 infection
  JOURNAL   AIDS Res Hum Retroviruses 19 (2), 117-123 (2003)
   PUBMED   12639247
  REMARK    GeneRIF: expression of NFI-B2 impairs CD4 transcription on
            CDd4-positive primary T-lymphocytes and cell lines in HIV-1
            infection
REFERENCE   8  (bases 1 to 8576)
  AUTHORS   Geurts,J.M., Schoenmakers,E.F., Roijer,E., Astrom,A.K., Stenman,G.
            and van de Ven,W.J.
  TITLE     Identification of NFIB as recurrent translocation partner gene of
            HMGIC in pleomorphic adenomas
  JOURNAL   Oncogene 16 (7), 865-872 (1998)
   PUBMED   9484777
REFERENCE   9  (bases 1 to 8576)
  AUTHORS   Liu,Y., Bernard,H.U. and Apt,D.
  TITLE     NFI-B3, a novel transcriptional repressor of the nuclear factor I
            family, is generated by alternative RNA processing
  JOURNAL   J Biol Chem 272 (16), 10739-10745 (1997)
   PUBMED   9099724
REFERENCE   10 (bases 1 to 8576)
  AUTHORS   Qian,F., Kruse,U., Lichter,P. and Sippel,A.E.
  TITLE     Chromosomal localization of the four genes (NFIA, B, C, and X) for
            the human transcription factor nuclear factor I by FISH
  JOURNAL   Genomics 28 (1), 66-73 (1995)
   PUBMED   7590749
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL136366.24, BX648845.1, AL441963.7 and AI140312.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001190737.1.
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX648845.1, SRR11853559.31764.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380953.6/ ENSP00000370340.1
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-660               AL136366.24        90547-91206         c
            661-1192            AL136366.24        84054-84585         c
            1193-1436           BX648845.1         1098-1341
            1437-1555           AL441963.7         83224-83342         c
            1556-2097           BX648845.1         1461-2002
            2098-8099           AL441963.7         18860-24861         c
            8100-8576           AI140312.1         29-505              c
FEATURES             Location/Qualifiers
     source          1..8576
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p23-p22.3"
     gene            1..8576
                     /gene="NFIB"
                     /gene_synonym="CTF; HMGIC/NFIB; MACID; NF-I/B; NF1-B;
                     NFI-B; NFI-RED; NFIB2; NFIB3"
                     /note="nuclear factor I B"
                     /db_xref="GeneID:4781"
                     /db_xref="HGNC:HGNC:7785"
                     /db_xref="MIM:600728"
     exon            1..660
                     /gene="NFIB"
                     /gene_synonym="CTF; HMGIC/NFIB; MACID; NF-I/B; NF1-B;
                     NFI-B; NFI-RED; NFIB2; NFIB3"
                     /inference="alignment:Splign:2.1.0"
     CDS             631..2115
                     /gene="NFIB"
                     /gene_synonym="CTF; HMGIC/NFIB; MACID; NF-I/B; NF1-B;
                     NFI-B; NFI-RED; NFIB2; NFIB3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     nuclear factor 1 B-type; nuclear factor 1/B; TGGCA-binding
                     protein; CCAAT-box-binding transcription factor"
                     /codon_start=1
                     /product="nuclear factor 1 B-type isoform 1"
                     /protein_id="NP_001177666.1"
                     /db_xref="CCDS:CCDS55291.1"
                     /db_xref="GeneID:4781"
                     /db_xref="HGNC:HGNC:7785"
                     /db_xref="MIM:600728"
                     /translation="MMYSPICLTQDEFHPFIEALLPHVRAIAYTWFNLQARKRKYFKK
                     HEKRMSKDEERAVKDELLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTVTGKKHP
                     CCVLSNPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNP
                     ALCVQPHHITVSVKELDLFLAYYVQEQDSGQSGSPSHNDPAKNPPGYLEDSFVKSGVF
                     NVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTIS
                     IDENMEPSPTGDFYPSPSSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSASPQDSSP
                     RLSTFPQHHHPGIPGVAHSVISTRTPPPPSPLPFPTQAILPPAPSSYFSHPTIRYPPH
                     LNPQDTLKNYVPSYDPSSPQTSQPNGSGQVVGKVPGHFTPVLAPSPHPSAVRPVTLSM
                     TDTKPITTSTEAYTASGTSQANRYVGLSPRDPSFLHQQQSWYLG"
     exon            661..1192
                     /gene="NFIB"
                     /gene_synonym="CTF; HMGIC/NFIB; MACID; NF-I/B; NF1-B;
                     NFI-B; NFI-RED; NFIB2; NFIB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1246
                     /gene="NFIB"
                     /gene_synonym="CTF; HMGIC/NFIB; MACID; NF-I/B; NF1-B;
                     NFI-B; NFI-RED; NFIB2; NFIB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1315
                     /gene="NFIB"
                     /gene_synonym="CTF; HMGIC/NFIB; MACID; NF-I/B; NF1-B;
                     NFI-B; NFI-RED; NFIB2; NFIB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1436
                     /gene="NFIB"
                     /gene_synonym="CTF; HMGIC/NFIB; MACID; NF-I/B; NF1-B;
                     NFI-B; NFI-RED; NFIB2; NFIB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1555
                     /gene="NFIB"
                     /gene_synonym="CTF; HMGIC/NFIB; MACID; NF-I/B; NF1-B;
                     NFI-B; NFI-RED; NFIB2; NFIB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1690
                     /gene="NFIB"
                     /gene_synonym="CTF; HMGIC/NFIB; MACID; NF-I/B; NF1-B;
                     NFI-B; NFI-RED; NFIB2; NFIB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..1875
                     /gene="NFIB"
                     /gene_synonym="CTF; HMGIC/NFIB; MACID; NF-I/B; NF1-B;
                     NFI-B; NFI-RED; NFIB2; NFIB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1876..2014
                     /gene="NFIB"
                     /gene_synonym="CTF; HMGIC/NFIB; MACID; NF-I/B; NF1-B;
                     NFI-B; NFI-RED; NFIB2; NFIB3"
                     /inference="alignment:Splign:2.1.0"
     exon            2015..2097
                     /gene="NFIB"
                     /gene_synonym="CTF; HMGIC/NFIB; MACID; NF-I/B; NF1-B;
                     NFI-B; NFI-RED; NFIB2; NFIB3"
                     /inference="alignment:Splign:2.1.0"
     exon            2098..8576
                     /gene="NFIB"
                     /gene_synonym="CTF; HMGIC/NFIB; MACID; NF-I/B; NF1-B;
                     NFI-B; NFI-RED; NFIB2; NFIB3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8554..8559
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NFIB"
                     /gene_synonym="CTF; HMGIC/NFIB; MACID; NF-I/B; NF1-B;
                     NFI-B; NFI-RED; NFIB2; NFIB3"
                     /note="hexamer: AATAAA"
     polyA_site      8576
                     /gene="NFIB"
                     /gene_synonym="CTF; HMGIC/NFIB; MACID; NF-I/B; NF1-B;
                     NFI-B; NFI-RED; NFIB2; NFIB3"
                     /note="major polyA site"
ORIGIN      
        1 gcactcgctc acgctgcccc tcgcgcacac acatggtcgg ctcgcggcaa agtttcgcct
       61 gcgatcacca ctccgggatc ctgccgcagt gcttggggct gtaaccttga actttcccag
      121 cgcggtgaca cattctcccc gctctccctc ccgcccgccc gctcgccctc ctgcgccctc
      181 ccgcgccccc ctccccgcct tttttgaaaa agcattttac caccaaccac caccccaatc
      241 caacccacac cgaaccttcg cgcaccccct acaccccaac aacaacaaca actgcaaaat
      301 agaaaacaaa tccccaaacc caggcgaaaa gcagccaaca ccggcggcgg cggcggcctc
      361 ggcaagcacg gccagcgcgc tcggactgca agagggttaa aagtgtagat tggatttcac
      421 ccctggaaat ctagcacgcc gagtgaactt gaatctttgg ctatttaagg aggactgggt
      481 ttgttgtgaa gttgcggtga tccagcgcag agccccgtcc tgattgatcg catcgcgggg
      541 ctcagatgac tgtaaaatga atagatgaaa ttcttgcttc tcgaagattt tcttgggcat
      601 ctcccggaaa gtgcgtttta aggcgaagtc atgatgtatt ctcccatctg tctcactcag
      661 gatgaatttc acccattcat cgaggcactt cttccacatg tccgtgcaat tgcctatact
      721 tggttcaacc tgcaggctcg aaaacgcaag tactttaaaa agcatgagaa gcgaatgtca
      781 aaggatgaag aaagagcagt caaagatgag cttctcagtg aaaagcctga aatcaaacag
      841 aagtgggcat ccaggctcct tgccaaactg cgcaaagata ttcgccagga gtatcgagag
      901 gactttgtgc tcaccgtgac tggcaagaag cacccgtgct gtgtcttatc caatcccgac
      961 cagaagggta agattaggag aatcgactgc ctgcgacagg cagacaaagt ctggcgtctg
     1021 gatctagtca tggtgatcct gttcaaaggc atccccttgg aaagtaccga tggagagcgg
     1081 ctcatgaaat ccccacattg cacaaaccca gcactttgtg tccagccaca tcatatcaca
     1141 gtatcagtta aggagcttga tttgtttttg gcatactacg tgcaggagca agattctgga
     1201 caatcaggaa gtccaagcca caatgatcct gccaagaatc ctccaggtta ccttgaggat
     1261 agttttgtaa aatctggagt cttcaatgta tcagaacttg taagagtatc cagaacgccc
     1321 ataacccagg gaactggagt caacttccca attggagaaa tcccaagcca accatactat
     1381 catgacatga actcgggggt caatcttcag aggtctctgt cttctccacc aagcagcaaa
     1441 agacccaaaa ctatatccat agatgaaaat atggaaccaa gtcctacagg agacttttac
     1501 ccctctccaa gttcaccagc tgctggaagt cgaacatggc acgaaagaga tcaagatatg
     1561 tcttctccga ctactatgaa gaagcctgaa aagccattgt tcagctctgc atctccacag
     1621 gattcttccc caagactgag cactttcccc cagcaccacc atcccggaat acctggagtt
     1681 gcacacagtg tcatctcaac tcgaactcca cctccacctt caccgttgcc atttccaaca
     1741 caagctatcc ttcctccagc cccatcgagc tacttttctc atccaacaat cagatatcct
     1801 ccccacctga atcctcagga tactctgaag aactatgtac cttcttatga cccatccagt
     1861 ccacaaacca gccagcctaa cggcagtggt caagtagtag ggaaagtgcc tggccatttc
     1921 actcctgtct tggcaccctc tccccatccc agtgcagtgc gacctgtgac cctgagcatg
     1981 acagatacta aacccatcac tacatccact gaagcctaca cagcctcagg cacatctcaa
     2041 gccaatcgat atgtgggact aagcccaaga gacccatcct tcctacatca gcaacagtcc
     2101 tggtacctgg gctagcttgg ttcctttcca agtgtcaaat aggacaccca tcttaccggc
     2161 caatgtccaa aattacggtt tgaacataat tggagaacct ttccttcaag cagaaacaag
     2221 caactgaggg aaaaagaaac acaacaatag tttaagaaat ttttttttta aataaaaaaa
     2281 aaggaaaaga ggaagactgg acaaaacaac acaaaggcag aaaggaaaga aactgaagaa
     2341 agaagataat agaccagcaa ttgcagcact tacaatcact aattccctta aggttgaaac
     2401 tgtaatgaca taaaaagggt cgatgatatt tcactgatgg tagatcgcag cccctgcaac
     2461 gtagcctttg ttacatgaag tccgctggga aatagatgtt ctgtctctat gacaatatat
     2521 tttaactgac tttctagatg ccttaatatt tgcatgataa gctagtttta ttggtttagt
     2581 attcttgttg tttacgcatg gaatcactat tcctggttat ctcaccaacg aaggctagga
     2641 ggcggcgtca gaggtgctgg gtgacagagc catgagccag ccattttata agcactctga
     2701 tttctaaaag ttaaaaaaaa tatatgaaat ctctgtagcc tttagttatc agtacagatt
     2761 tattaaattt cggcccttaa cccagccttt tccagtgtgt aacccagttt gaaatcttaa
     2821 aaaaagaaaa aatgaaaaaa aaaggaaaaa aagaaaaaag gaaaaaaaca gtttgaacac
     2881 aaaggctcta tggaagaaat gcctctatgt aggtgaagtg ttctctctgc atgcaacagt
     2941 aaaaattaat ataatatttt ccccacaaaa gaaacactta acagaggcaa gtgcaattta
     3001 taaatttata tctaaagggg aatcatgatt ataagtcctt cagcccttgg actctaaatt
     3061 gaggggatta aaaagaattt aaaataattt tgaacgaatt tattttcccc tcagtttttg
     3121 agggcattaa aaaggcatta aatcaagaca aatcatgtgc ttgagaaaaa taaaattaat
     3181 gaaaacacag cacttatgtt ggtttagctg cagcctcctt ggaggtagaa tttatttatt
     3241 taaaattact ggttgcatca agaacccata gggtgtacaa aaggttctat aaaatctgca
     3301 ttatagagac aaagaggcag gcaaatccat gtcacaaggg taaagcttac agtttacaaa
     3361 ctgggaacgc cagggtgtag gatataaaaa cgcactcttg agaaaacaaa tgtaatcagg
     3421 gtgctgaaaa cttgcatggt gctttcagac attagccttg ttcaacaaat ttcttgtatt
     3481 gacagatcca tagtgtgcat gggcagacac attttgcctc tatgtctctt aaaattttaa
     3541 ttaaaaatac tctttccagt aatcctaatt tgcacgaaga tataatgtcc acattacgtg
     3601 ccttgccttg aaatctaaaa aacaaaaaac aaaaaaaaaa aaacaaaaaa atacaacaaa
     3661 gtgacatcac tacacttgtt ttgctgcatt tattatcatt ttaaatcttt accattttta
     3721 tgacaaaata ttttgtactc cagacgaaga aaaatgtgtg acatcatgga ttttttagac
     3781 agttatacct ttatctcaca tttataaagc atatcatggc tgtgtatagt tgccgcttaa
     3841 aaattgtaat cgaccagcaa tattttcagt attttggtgt ttttttctat taacctttca
     3901 tgtttttcat cttccaatta atatttgggg gggaggggtt tcaaatttat acgaattatg
     3961 caataccaag ttttgcctat gtaggtagtg cttttagctg tattggttat tataggtaag
     4021 tacacagatt taaaaaaaaa ataatgtatg cttttttgtt tgtttgtttg ttttaattga
     4081 ccaaagtggg tactgctatt tttgcagtgt gatgaggtcc ttttgtgtac tgagagatgg
     4141 acaggggatt ttttttaata tacatatata tatattctgg ggtgggtggg aggattttta
     4201 acactttgca gtgtagctgt gaagcagtgc accctgagat gggcctgggc tgcaaagcga
     4261 ctgttctgcc tactgtgaca aacttcaact tacacaggtt cccctctcta acttcccacc
     4321 tgggttgcaa gctgaactca ttactggttt tcataacaac acaatagtaa gaacaagcaa
     4381 acacaacaaa ttctcctgga ggcagacttg gcttaaaaag gcagacttgg cttggtgata
     4441 gtttttcttg aaagttccag atccacagtg gagagtgagc ctgtctcata tttggcaaaa
     4501 atatttgttg aaatgtccac ataggggatg ttggatgttt aacacttttg agagtttaac
     4561 acatgaatat tctttctcct agaaaacaca ttagacctgt tggagggagt ctcccgtatt
     4621 ccttttctgc cacttttcgt ccccatttca tttcattaat gataggatat gatttacctg
     4681 tgacttacta cttcaaatgg atggcagtgc acttggattt ttttttaata tccagaagat
     4741 tgaacagagg gttgctattg ttgaatgtat ttggactgat agattaaaat caaagttcaa
     4801 tttttaagga acaaaaaagt aaatcctgtt ttcattttat ctcccctttt aaaactgaga
     4861 accagagcag aagggaaata tagaatttta agcaattaat cttcctgtgg atgaattaaa
     4921 cccattagat gctgatggga tttttttaag gaatggtacc ttaactatat atttgatttc
     4981 gtttcccctg agggctagag gctgaatgga ggctggtttt attttgcctt tccctcaccg
     5041 cccagtccca ttgagtgtat tcattactag aaggaaaatc tttcagaatt ggtgacacat
     5101 ggtaggctgt cttaaggagt cccctggccc ccttccccta ggccatggcc taataaaata
     5161 aactgtcaat tgttctcaca gcatatcatt taataatgaa tactttagaa caatgcttat
     5221 gggctggaga attgtatttg attagcccat tcagtttgat agcccaaatg ctgaacagca
     5281 cagcgggatc ctagcagtgc aagttcaaaa gtaagtccaa tcatttctgt gatactcgcc
     5341 ctggtagcaa acagatcatc tcagccaagc tcttcatgta tctttgacct attaggtgaa
     5401 caaatgaacc tcacaggaca cacagtattt tttaaaggca gactcgctct cttttttgcc
     5461 agtgagcagt tctagctaac caagttacac actgtgggta ttcctgcctg cctcttgaat
     5521 acaaaggcct agttcaagtg ttgctttttt tatttcaaat caattttttc ttctttcctt
     5581 tttgagataa aactattaaa agtactacta tatatataaa atctcaaatc aacttttcgg
     5641 cctcctcctc gtgtaccagg aagtatattc tgacgaaggg ccccactttt gcaggtcttg
     5701 cacgcccctc ccttacccag aactgcagag cttcaggatg gcgaaggtca cccaagggca
     5761 tgagtaggga gtggtgtctc caaccatcag ttccgtggca ctgttcagcc tttgtgtgct
     5821 gccctgccac ccaccactca cagtgcctct gaagcgtgtt acccctggag tgacgtgagc
     5881 atttgaggct tgtctaagga aaaaaataaa aggcagtgaa ggagactgta cataaagaca
     5941 tggcaaaaat cttaattata gcaatatagt tatcgggtaa tgttcgggtg ggcagctcca
     6001 ttaaaaaata tgtgaatgaa tctgtgaagc tgcaagtagc gagaagagcg aaaggtcttc
     6061 ttaatgaacc gcctaccttg tagacagtaa tttgtacact gtatagtttt gttaagaatt
     6121 ttttttaaat taaaattccc atgtttgtaa agctaacttt ttaacaatta taatggaact
     6181 atatgttgtt tccattttta aagtaaacaa gaatattcct tgtttagaga ctggacttga
     6241 gttaaaactc tccagtctct taagttatgt attaaaaaga aaatctgtcc atgttaggag
     6301 ttatttcaca gattcctgtg cttgaaaagc ataggatact aatcctttaa aaaagtgtaa
     6361 atggagaaaa gttatatttt atgaaggtta ttttgttgta tttagtattg gaaaagttgg
     6421 tttccagagc atttcagaat gtcgaagcac cactgtcttt ttattagtat atacggcctt
     6481 tagcaaaagt ttttgtgatt gttacgtgat ggtatttaag gttaagtttc acagagcatt
     6541 caggataggc agaaaactaa aacagtgcta tgtctcacat aacgtgtcct cagggagcag
     6601 aatcttggat ttgtgacttg tagcttcata aggactcaac gaaagagatt gcacagggac
     6661 atcttcagcg gtgtgacagc aggacatgtt ctttacctag attcaaattc tatgtactgt
     6721 gtgaaatgat gaaggctgca gaaagttatc ccatattcag tgtacagtat tcatttttaa
     6781 tgaaacaact ctacaatatt gctggcagat aggccccaag catgacattc aatatagttt
     6841 acatgttcct gtcaaggtct tttgttaaca ttaaccagct gcatgctttc tggactttaa
     6901 gaaattgggt ttctatagaa aacttttttt tttttttttt ttttaatgtg caggctattc
     6961 aagttcaata gtaaaagctc aaaaatgaat gttctactcc atgctgaagg agctgaaagc
     7021 tgccttcttc atattttgca ctttctggta gttcccctgt tttttctaat tccctaaaat
     7081 tgtgtgggtg gagtggagcc ctgcagttgg ggggtaacat ggaccactga ttttgccctt
     7141 tgaccctgca caatgacctt tgcatcagcc aaactcattg ccatgacaac tctttgtact
     7201 gtgtccgtgc cacagatctg ttggtcacat tgttaatagt aaaggggaca agttggagac
     7261 ggtcaatttt tacatttttt gttgcaattt tttcttcaat ggttgtaagt agtttttttt
     7321 tttttttaat aataaaaggg ttcactagtt aatactctag aaatatctgt gtgttgcaat
     7381 tcaaatgtat gttgagattg tgaaaagcgc ttcagtgcca ctagcttacc ggtacactag
     7441 actaagccct tgatgactta ttgcatgata cagtaccagg aacaacaggt ggcctaaata
     7501 catgaaaagc agtgtaagct agtgacacta aagccagtct tgtattactg tatttttgac
     7561 agaatggttt tgaaaactgt gctacaggga ctgatgtggc aaatatatct ctttatgcag
     7621 aaggaagtct ttttttttct tttttttttt tttaagaagt atggcttttt atgcatcctt
     7681 catcgagggc attgaagttg catggactga taaaagttga tgcaaaacaa gaaagaaaca
     7741 aacaaaaaaa aaaaaccagc aaaatgttta ccaaaaaact caaacaaatg agcagtgcct
     7801 gttcaatttc acagtctctg ttgagttcag ttgtaaatat gtttcaaatg acattttctt
     7861 gggaaaaaaa atctctacaa cattgtagaa tgtgaggggt aactacatcc caggcatagg
     7921 tttctcaaag ctgcagtaga ttatgtcttc atcaagctgt taatttgtgc ttatatcata
     7981 tagaactttt agcatcctgg gaagagctgc ccccacctca atgatatttc tctgagaaca
     8041 acttttgtag gactgtgtgt ttctttagat acatttagta caactgtagg tgacgagtag
     8101 tcagttattg cttgctagct acacaccagg gttgatccat tttaaaactt ttggcatttt
     8161 gtcctcatgg gccataaata cagaaccttg tattttaatt aaattttttt acaaaaggag
     8221 gcacatgcac aatctccatg taacaaacct ttagcagtag gatgtattat acgacagtta
     8281 cttaatttct agagttcagg cctctgggat caaccccaga ctgggccaga atgttagtga
     8341 aggttttatt gtgcccggtt ggaggataac gttctttggg tactttttgt gggttgcaaa
     8401 tgaactcaat tgccacaagt tttaaactgg tgtaaatcaa gcttgactta atgtgattgt
     8461 tactgttata tccagcctat actgctagca gctgctcata ctgcagtcaa ttactggaag
     8521 cggatatatt tcctatgcaa aaactgttta aacaataaaa tgagctatgc tacaga
//
