LOCUS       NM_001134673            9229 bp    mRNA    linear   PRI 04-OCT-2024
DEFINITION  Homo sapiens nuclear factor I A (NFIA), transcript variant 1, mRNA.
ACCESSION   NM_001134673
VERSION     NM_001134673.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9229)
  AUTHORS   Tauziede-Espariat,A., Lew-Derivry,L., Abbou,S., Metais,A.,
            Pierron,G., Reynaud,S., Masliah-Planchon,J., Mariet,C., Hasty,L.,
            Dangouloff-Ros,V., Boddaert,N., Csanyi,M., Aline-Fardin,A.,
            Lamaison,C., Chretien,F., Beccaria,K., Puget,S. and Varlet,P.
  TITLE     CNS erythroblastic sarcoma: a potential emerging pediatric tumor
            type characterized by NFIA::RUNX1T1/3 fusions
  JOURNAL   Acta Neuropathol Commun 12 (1), 12 (2024)
   PUBMED   38243303
  REMARK    GeneRIF: CNS erythroblastic sarcoma: a potential emerging pediatric
            tumor type characterized by NFIA::RUNX1T1/3 fusions.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9229)
  AUTHORS   Kong,S., Chen,T.X., Jia,X.L., Cheng,X.L., Zeng,M.L., Liang,J.Y.,
            He,X.H., Yin,J., Han,S., Liu,W.H., Fan,Y.T., Zhou,T., Liu,Y.M. and
            Peng,B.W.
  TITLE     Cell-specific NFIA upregulation promotes epileptogenesis by
            TRPV4-mediated astrocyte reactivity
  JOURNAL   J Neuroinflammation 20 (1), 247 (2023)
   PUBMED   37880726
  REMARK    GeneRIF: Cell-specific NFIA upregulation promotes epileptogenesis
            by TRPV4-mediated astrocyte reactivity.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9229)
  AUTHORS   Lu,R., Tang,P., Zhang,D., Lin,S., Li,H., Feng,X., Sun,M. and
            Zhang,H.
  TITLE     SOX9/NFIA promotes human ovarian cancer metastasis through the
            Wnt/beta-catenin signaling pathway
  JOURNAL   Pathol Res Pract 248, 154602 (2023)
   PUBMED   37315400
  REMARK    GeneRIF: SOX9/NFIA promotes human ovarian cancer metastasis through
            the Wnt/beta-catenin signaling pathway.
REFERENCE   4  (bases 1 to 9229)
  AUTHORS   Santo,M., Rigoldi,L., Falcone,C., Tuccillo,M., Calabrese,M.,
            Martinez-Cerdeno,V. and Mallamaci,A.
  TITLE     Spatial control of astrogenesis progression by cortical
            arealization genes
  JOURNAL   Cereb Cortex 33 (6), 3107-3123 (2023)
   PUBMED   35818636
  REMARK    GeneRIF: Spatial control of astrogenesis progression by cortical
            arealization genes.
REFERENCE   5  (bases 1 to 9229)
  AUTHORS   Malczewska-Lenczowska,J., Orysiak,J., Majorczyk,E., Sitkowski,D.,
            Starczewski,M. and Zmijewski,P.
  TITLE     HIF-1alpha and NFIA-AS2 Polymorphisms as Potential Determinants of
            Total Hemoglobin Mass in Endurance Athletes
  JOURNAL   J Strength Cond Res 36 (6), 1596-1604 (2022)
   PUBMED   35622109
  REMARK    GeneRIF: HIF-1alpha and NFIA-AS2 Polymorphisms as Potential
            Determinants of Total Hemoglobin Mass in Endurance Athletes.
REFERENCE   6  (bases 1 to 9229)
  AUTHORS   Xu,H., Uno,J.K., Inouye,M., Collins,J.F. and Ghishan,F.K.
  TITLE     NF1 transcriptional factor(s) is required for basal promoter
            activation of the human intestinal NaPi-IIb cotransporter gene
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 288 (2), G175-G181 (2005)
   PUBMED   15458926
  REMARK    GeneRIF: Role in the expression mechanism of hNaPi-IIb gene
            transcription.
REFERENCE   7  (bases 1 to 9229)
  AUTHORS   das Neves,L., Duchala,C.S., Tolentino-Silva,F., Haxhiu,M.A.,
            Colmenares,C., Macklin,W.B., Campbell,C.E., Butz,K.G. and
            Gronostajski,R.M.
  TITLE     Disruption of the murine nuclear factor I-A gene (Nfia) results in
            perinatal lethality, hydrocephalus, and agenesis of the corpus
            callosum
  JOURNAL   Proc Natl Acad Sci U S A 96 (21), 11946-11951 (1999)
   PUBMED   10518556
  REMARK    GeneRIF: Disruption of the Nfia gene in the mouse causes perinatal
            lethality, agenesis of the corpus callosum and hydrocephalus.
            Erratum:[Proc Natl Acad Sci U S A 2001 Mar 27;98(7):4276. Godinho F
            [corrected to Tolentino-Silva F]]
REFERENCE   8  (bases 1 to 9229)
  AUTHORS   Leahy,P., Crawford,D.R., Grossman,G., Gronostajski,R.M. and
            Hanson,R.W.
  TITLE     CREB binding protein coordinates the function of multiple
            transcription factors including nuclear factor I to regulate
            phosphoenolpyruvate carboxykinase (GTP) gene transcription
  JOURNAL   J Biol Chem 274 (13), 8813-8822 (1999)
   PUBMED   10085123
REFERENCE   9  (bases 1 to 9229)
  AUTHORS   Qian,F., Kruse,U., Lichter,P. and Sippel,A.E.
  TITLE     Chromosomal localization of the four genes (NFIA, B, C, and X) for
            the human transcription factor nuclear factor I by FISH
  JOURNAL   Genomics 28 (1), 66-73 (1995)
   PUBMED   7590749
REFERENCE   10 (bases 1 to 9229)
  AUTHORS   Senaratne,T.N. and Quintero-Rivera,F.
  TITLE     NFIA-Related Disorder
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   31194316
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB037860.1, AL096888.30 and
            AA974652.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001134673.3.
            
            Summary: This gene encodes a member of the NF1 (nuclear factor 1)
            family of transcription factors. Multiple transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Sep 2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.200273.1,
                                           SRR1660809.95677.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000403491.8/ ENSP00000384523.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2810              AB037860.1         254-3063
            2811-8933           AL096888.30        3243-9365           c
            8934-9229           AA974652.1         14-309              c
FEATURES             Location/Qualifiers
     source          1..9229
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p31.3"
     gene            1..9229
                     /gene="NFIA"
                     /gene_synonym="BRMUTD; C1DELp32p31; CTF; DEL1P32P31;
                     NF-I/A; NF1-A; NFI-A; NFI-L"
                     /note="nuclear factor I A"
                     /db_xref="GeneID:4774"
                     /db_xref="HGNC:HGNC:7784"
                     /db_xref="MIM:600727"
     exon            1..258
                     /gene="NFIA"
                     /gene_synonym="BRMUTD; C1DELp32p31; CTF; DEL1P32P31;
                     NF-I/A; NF1-A; NFI-A; NFI-L"
                     /inference="alignment:Splign:2.1.0"
     CDS             232..1761
                     /gene="NFIA"
                     /gene_synonym="BRMUTD; C1DELp32p31; CTF; DEL1P32P31;
                     NF-I/A; NF1-A; NFI-A; NFI-L"
                     /note="isoform 1 is encoded by transcript variant 1;
                     nuclear factor 1 A-type; TGGCA-binding protein;
                     CCAAT-box-binding transcription factor"
                     /codon_start=1
                     /product="nuclear factor 1 A-type isoform 1"
                     /protein_id="NP_001128145.1"
                     /db_xref="CCDS:CCDS44156.1"
                     /db_xref="GeneID:4774"
                     /db_xref="HGNC:HGNC:7784"
                     /db_xref="MIM:600727"
                     /translation="MYSPLCLTQDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKH
                     EKRMSKEEERAVKDELLSEKPEVKQKWASRLLAKLRKDIRPEYREDFVLTVTGKKPPC
                     CVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLVKSPQCSNPG
                     LCVQPHHIGVSVKELDLYLAYFVHAADSSQSESPSQPSDADIKDQPENGHLGFQDSFV
                     TSGVFSVTELVRVSQTPIAAGTGPNFSLSDLESSSYYSMSPGAMRRSLPSTSSTSSTK
                     RLKSVEDEMDSPGEEPFYTGQGRSPGSGSQSSGWHEVEPGMPSPTTLKKSEKSGFSSP
                     SPSQTSSLGTAFTQHHRPVITGPRASPHATPSTLHFPTSPIIQQPGPYFSHPAIRYHP
                     QETLKEFVQLVCPDAGQQAGQVGFLNPNGSSQGKVHNPFLPTPMLPPPPPPPMARPVP
                     LPVPDTKPPTTSTEGGAASPTSPTYSTPSTSPANRFVSVGPRDPSFVNIPQQTQSWYL
                     G"
     exon            259..790
                     /gene="NFIA"
                     /gene_synonym="BRMUTD; C1DELp32p31; CTF; DEL1P32P31;
                     NF-I/A; NF1-A; NFI-A; NFI-L"
                     /inference="alignment:Splign:2.1.0"
     exon            791..856
                     /gene="NFIA"
                     /gene_synonym="BRMUTD; C1DELp32p31; CTF; DEL1P32P31;
                     NF-I/A; NF1-A; NFI-A; NFI-L"
                     /inference="alignment:Splign:2.1.0"
     exon            857..931
                     /gene="NFIA"
                     /gene_synonym="BRMUTD; C1DELp32p31; CTF; DEL1P32P31;
                     NF-I/A; NF1-A; NFI-A; NFI-L"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1049
                     /gene="NFIA"
                     /gene_synonym="BRMUTD; C1DELp32p31; CTF; DEL1P32P31;
                     NF-I/A; NF1-A; NFI-A; NFI-L"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1177
                     /gene="NFIA"
                     /gene_synonym="BRMUTD; C1DELp32p31; CTF; DEL1P32P31;
                     NF-I/A; NF1-A; NFI-A; NFI-L"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1306
                     /gene="NFIA"
                     /gene_synonym="BRMUTD; C1DELp32p31; CTF; DEL1P32P31;
                     NF-I/A; NF1-A; NFI-A; NFI-L"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1485
                     /gene="NFIA"
                     /gene_synonym="BRMUTD; C1DELp32p31; CTF; DEL1P32P31;
                     NF-I/A; NF1-A; NFI-A; NFI-L"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..1651
                     /gene="NFIA"
                     /gene_synonym="BRMUTD; C1DELp32p31; CTF; DEL1P32P31;
                     NF-I/A; NF1-A; NFI-A; NFI-L"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1743
                     /gene="NFIA"
                     /gene_synonym="BRMUTD; C1DELp32p31; CTF; DEL1P32P31;
                     NF-I/A; NF1-A; NFI-A; NFI-L"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..9229
                     /gene="NFIA"
                     /gene_synonym="BRMUTD; C1DELp32p31; CTF; DEL1P32P31;
                     NF-I/A; NF1-A; NFI-A; NFI-L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9209..9214
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NFIA"
                     /gene_synonym="BRMUTD; C1DELp32p31; CTF; DEL1P32P31;
                     NF-I/A; NF1-A; NFI-A; NFI-L"
                     /note="hexamer: AATAAA"
     polyA_site      9229
                     /gene="NFIA"
                     /gene_synonym="BRMUTD; C1DELp32p31; CTF; DEL1P32P31;
                     NF-I/A; NF1-A; NFI-A; NFI-L"
                     /note="major polyA site"
ORIGIN      
        1 ggggttaaag ttcagctcat ggagcggcaa tagcgctggc tggctggctg cagttgagcc
       61 gacttggaaa tgtgaacgca agaagcaggc ttgatttttt tttctccccc cttctctctc
      121 tctctctctc tctctcttcc tctctccctc tttctcctct ctcacccaca ctcacgcaca
      181 cctccaaacc gcacacccag acgcacacgc ataccccagc gcccggcagt tatgtattct
      241 ccgctctgtc tcacccagga tgaatttcat cctttcatcg aagcacttct gccccacgtc
      301 cgagcctttg cctacacatg gttcaacctg caggcccgaa aacgaaaata cttcaaaaaa
      361 catgaaaagc gtatgtcaaa agaagaagag agagccgtga aggatgaatt gctaagtgaa
      421 aaaccagagg tcaagcagaa gtgggcatct cgacttctgg caaagttgcg gaaagatatc
      481 cgacccgaat atcgagagga ttttgttctt acagttacag ggaaaaaacc tccatgttgt
      541 gttctttcca acccagacca gaaaggcaag atgcgaagaa ttgactgcct ccgccaggca
      601 gataaagtct ggaggttgga ccttgttatg gtgattttgt ttaaaggtat tccgctggaa
      661 agtactgatg gcgagcgcct tgtaaagtcc ccacaatgct ctaatccagg gctctgtgtc
      721 caaccccatc acataggggt ttctgttaag gaactcgatt tatatttggc atactttgtg
      781 catgcagcag attcaagtca atctgaaagt cccagccagc caagtgacgc tgacattaag
      841 gaccagccag aaaatggaca tttgggcttc caggacagtt ttgtcacatc aggtgttttt
      901 agtgtcactg agctagtaag agtgtcacag acaccaatag ctgcaggaac tggcccaaat
      961 ttttctctct cagatttgga aagttcttca tactacagca tgagtccagg agcaatgagg
     1021 aggtctttac ccagcacatc ctctacgagc tccacaaagc gcctcaagtc tgtggaggat
     1081 gaaatggaca gtcctggtga ggagccattt tatacaggcc aagggcgctc cccaggaagt
     1141 ggcagtcagt caagtggatg gcatgaagtg gagccaggaa tgccatctcc aaccacactg
     1201 aagaagtcgg agaagtctgg tttcagcagc ccctcccctt cacagacctc ctccctggga
     1261 acggcgttca cacagcatca ccgacctgtc attacaggac ccagagcaag tccgcatgca
     1321 acaccatcga ctcttcattt cccgacatca cccattatcc agcagcctgg gccttacttc
     1381 tcacacccag ccatccgcta tcaccctcag gagacgctga aagaatttgt ccaacttgtc
     1441 tgccctgatg ctggtcagca ggctggacag gtggggttcc tcaatcccaa tgggagcagc
     1501 caaggcaagg tgcacaaccc attccttccc accccaatgt tgccaccgcc accgccacca
     1561 ccgatggcca ggcctgtgcc tctgccggtg ccagacacaa agcctccaac cacgtcaaca
     1621 gaaggaggtg cagcctcccc cacgtcacca acctactcga cacccagcac ctcccccgca
     1681 aaccgattcg tcagtgttgg accacgggat ccaagctttg taaatatccc tcaacagaca
     1741 cagtcctggt acctgggata aaagttgcag cgtcccacca tccaccagac agaccacctg
     1801 accccttctc aactctgtaa catggacgca acctcaaccc agcgcagtta caacttcact
     1861 atcagcggaa ggggagaaaa accgattcaa atcaacttgt acatggaaac agcaagcatt
     1921 atggtcaaac agcaaaggcc ataacctttt gggatttttt tttttttaaa atactttagg
     1981 gactgttgta atttctcata tggtgctgga aatggttggg ctttgtaaca tttgaagtgt
     2041 ttccatggta gcgtgagcat taggtgacgt ggctagcgga ggactaccct tgctcactga
     2101 cttcctgttg taacacactt tccttacgga gcctggctgt ttcacagtat ttcatgaatt
     2161 tacccacaca ggtgtgatcc tccttgagca ttgaggaggc acatggagaa ctaaatcttt
     2221 tgtagtagct gagatctgca atatataacg ggacagtcaa agggcaatgt ttttctgtaa
     2281 catattggaa aaagaaaatg cagttatatt ccttttttat ttgttccttt agtttgtttt
     2341 ggttcagcag tcagcagtta agtatataac atggcccgca aggacaatga atccactcac
     2401 attgcagaac aattccgaaa atggcaaact actactacta ctgttcagtt ttttaaaagt
     2461 tttgaaatgc tgcacttaca tttaaaaaaa caacaacaac attttttcaa caatttcaac
     2521 aatgacacaa aaattcacat ggaaatgggg aagatggtct gttttgacag aaactgacag
     2581 gaatcaatca aaacaatcga attttgaatt gagtaaagtg caatttcatt ggatagctaa
     2641 atatctttgt aagatagaga ttgttgaaaa ttctattttt gtttttctag tcctttcacc
     2701 ccaggactct aaattattgg ggtaaaaaac agccttgcaa gaaaaagggg agctattttt
     2761 gctttttatg ttttttattg ttaaacttgt atccctttaa aaactgaagg aaattaaaaa
     2821 aaaaaaacaa aaaaacaaat ctaatggtgc ttttaccaca atatgttaac tacattaaat
     2881 gctaattaat tattttctgt tatcaaagca catgactaaa atgaaatcat ggtatctgtt
     2941 aattttataa gctagaagtc actataatgg attacgccaa ttctaaaaaa ttttacacct
     3001 atctggcatc ataggattta tcagttatca gacacctcat tgtaccagag attgtccaga
     3061 agttttaaag acctttgcat ccctgaactg ggctatggga aataataata gtaataataa
     3121 taataataat aatgatgaaa ccaatactga cacaaatgct ggtgcccatt cagatcaagg
     3181 gtacttgtta gggaaaaaaa aaaaagtttg cacccccaaa cgtcctgtat cttatgaaaa
     3241 aaaaaacaaa aaacaaaaac aaaaaaaaaa cacaaaaaac cacagaaaca aaaacaaaaa
     3301 aaagtgcaag tgatttttct accagacagc gaagcacccc tttgcttccc atgcgacttc
     3361 aagaaggttt cctatactat acatatatat acgttctggt tggcaagccc tgctgatcag
     3421 agaaagtctc tgcatgttct agtgttagta actaattttt atatagttaa tgtaggataa
     3481 agtagagtgc attaagacac aatattgtaa tccctactct aggcacttgc ctttaaacta
     3541 tgtttttcag cccttcagaa gggttctact actgtcctat acaatcaagt aactgaaatt
     3601 cttgggaaga cactttgctc ctcatctttc tccccgaaac aatgttgttt tgttttgttt
     3661 tttttcctta atttgcacga aaacaaaaat tccatatcaa tgtgccttgc cctggatagc
     3721 gattatttgt ggaattgttg cacatgctcc tctattgaaa ggggtttttc cctagtcaag
     3781 catttggaga cactttttgt aaatgtgact tttatgtcag ccatcgtcag tttcaacatc
     3841 tagaactaaa tagaaagcta gttgttccgc agataggagt agtctttatt gtcctgtacg
     3901 gtcggtggca gtgctattct gagatctgta gatgcttaga atatcagtat tttggatgtt
     3961 gctgcatttt acaatttatt tggagtcttc ctttattttc ccccagatat atgaaaatat
     4021 gcaatacctg cttatatcat gtagaaaagc ttagcaatta ttaatttttc ttttattttt
     4081 ttttatttga ccaaagtcgg tgctgcactt gacgcagtgt gttttaggtg tttgtctttg
     4141 tacttttttg tgatttttga atgcacgtgc gcaggaaggg ctcctcttag agaagcagtc
     4201 aaactgtgaa gcactaagct gaccctgctt caagcaattt tgtttttaca actgttcctt
     4261 tcacaagcaa gccttaaaaa aaaaaaagac aacttccttt ttcttcagct cccacacccc
     4321 atttttctta gcagactgca gtcaatccac attcaataaa aagtatataa tgcccatttt
     4381 tatatgcacg tttttaaact tccaagttct gaaaattgtt tactggttat ctctatttaa
     4441 ggaaaaaaaa ataaaataaa acattttgga ttttcatatg tgtctgataa gtggttgaat
     4501 agtcgtttgg cgctgttgta tggtgtgatt gtcagtgtat ggtgtcactt cctatagcca
     4561 gccagcatac tttgccttcc cctatagcac ttagctgggc attactttat tatgacatat
     4621 gtgcactaaa aaatgaaaaa aaggaaaaaa agaaaaaaaa aaagaaaaaa tagcagcttt
     4681 cagtgcttca cagtgaaggg aaaaaagcct agacaaacat tttgtcagaa ccttgcaata
     4741 agccaaggta ttaccagtaa attggttgta tatacaataa aattgcaccc ttttttaaac
     4801 aaaacaaact aagcaatagt ttgggcagtt ttagttgttt ttagtgagca tgttgtagtc
     4861 atgactgcaa agagagagaa taaactgccc gctcagaaga tatgtaattt gtattgttgt
     4921 atagttttat tgattacact gatttattct accctatttt ataatgcagg acttttgtaa
     4981 tgttgtttaa atgaggaaaa atttctgtca aattagccta gtaaaatttc tgatcgttca
     5041 ttataaaggc agcgttcata gaattgcttt tctttctttt taccccccct ttgggaactg
     5101 gatttaagtt taaaactttc ctgtttcctt tttttttttt tttttgtaag tatttaaata
     5161 caattatttt tttctctcaa tggtatagca tattcctatg cttgagaagt ataggtctac
     5221 tgaaaaacca ttgtaaatgg acgttacagg tatgctgtat ttttgaaggt attttgttgt
     5281 attaagtttg atgaagctaa aattagggaa ctctgaacag atttgcagga aaaaatgttt
     5341 taaaggcttt aaaacattag ggaggcagtc tagggtgata acgaacaggg gttaagtatt
     5401 aaatacacga agttacattt ttgttcatgt ttcattgtcc agaaagcagc aggaaactat
     5461 tcagttgtga tcaagcagga aaaaagaaac accaacagtt gccagtgttt ttgcttttta
     5521 gcttaaaagc atagtgaaga tgcttgagga agactttgct acctggggtg tgtagacaga
     5581 cagactgaga gctatcagca tttgaaggcc cagcccttga ctctgagaca catttgaatt
     5641 ttttctttcc catcaaatgg cattaacaag attgggcaaa gatgagtccc tcaaatttct
     5701 gtgttttttg tttgtttgtt tgtttgtttt ttctttggga actgaagtca gaggcacgaa
     5761 cactaactct tagcattttt ctgtagactt tttcttctgg cccttgtccc tgccagcaaa
     5821 acgccccttt tctgatcatt cgtgcgcaga gggcctccca gtaatgccac gctctccatg
     5881 ctagagagcc ttctctttcc tctgaggttt gaactgatgt tctgtgtctt cacaccctgg
     5941 catgacagtt acgtgtggtc agcccgctcc ccaggcccgt ccctgccgcc gccaggtgtg
     6001 ggctctaggc aggccgacaa ggttacacct cccagagctt gtgatcttca ttttctgaca
     6061 gtcaaagtgt gaaggaaccc agacttcccc gagccacggt gttcagtcag cccacaggaa
     6121 tatgcaagac ccatctccaa aagtttgtct ttgatttttt ccaagccctt agccccataa
     6181 gctttgaatc ctgtagttac agtggcataa aggactgaca aaacctggat aaggaaaaac
     6241 cttttttttc tatgaatttt ttttgttttt taggggaaag ggattctaag aatgtcattt
     6301 aatgtacttt gcatcatgtc tctagaaata tctttgtcca tagtggtggt ggagtctctc
     6361 tctctctctc tctttttgtt tgcttctgtt ttctttcttg tcttcattct ttcttttctt
     6421 ttttatttct ggtagcaggc ctccatagaa caaatctaaa acacaaccac catagtaatg
     6481 taaggagagc ttcagtggca cctcaaaacc cacccttcga gatctgtcca aagacagtct
     6541 cagaaagctg cactgcccac cggctcagct ttcattcaaa aaggcttcca aggccaattc
     6601 tgtcttgaag tcaatgcatg tatttactgt ttgacagtaa acccgctctg ccttctccac
     6661 gtccaaggct gtgcattcgt ctaattagcg tcgtgtatgt tttcctttta ttttttccaa
     6721 taaaaaagca gtgggatgaa aattgctttg atatatagca ggtaacattg aagctattcc
     6781 atagcactta actgtagtga atactgtgtc accaattttg aaatcaattt aatgtttaat
     6841 gcaaatccat tacatggtgc tattataggc tgacaaaatg atttacacaa atgtgacaac
     6901 ttgggctcaa ttcactctgc tttccaacag tgtaaatgca tagcagtgtt tatctgcatg
     6961 agaactatgc actaatctat ctgaagaaaa aaactatatc aactttggta tctactttcc
     7021 gtttacttca atccttgcct ttttggtcat tgttataatg ccagctttag gacagaaaga
     7081 attataagaa aaccagcata atacctgata tattaaaatg tagtgcctgt gaaatctgta
     7141 ttatattgct cttctgaagt aagatttttc tacaccggta gccttcgctg tctgtcagtc
     7201 aggaccttct ggtataggtg atgtaaaata accgtacaat attaatgcat gcgattccat
     7261 aatgcttagt gaactgtatg aatattactc aaagttatgt tagtcttttt ttccgacttg
     7321 gttcttgtca gctaggttta aaggtatttc actgagaacg caaattctgt cttttcttga
     7381 tttcggctgt tttcagtatt ttggaggtat acatttactt aaattcagta ttactcgtgt
     7441 tttgtttttg tttttgtttt ttgttttctt tttcctaggg gacaagcatg ggtgtttgat
     7501 ttcagaaatc agtacctggc gagatttttg tctcaaaacg actatttgaa tttcaagaac
     7561 tgtgctgcga agacactctg agaacatttg caagtcaggg gcattttcct tgacccttga
     7621 ctgatgctat gcggagactg atacattttc ttaatggaca atgttcaagc caggtaccca
     7681 tgcttgatct gtcttcacac cagacctcct catattaaaa ggaaaaataa gaaaaaaaat
     7741 gtaagaaatc acatggctat ttagtttcat gcacagttgc aatattttct tcaaaaataa
     7801 aactctgtac aaactttggg cccgattcat aagaaaaaga agtttgctat taacacggga
     7861 tttttttaat atactttttt tggtctaaat ttgaaattac ttgcttccca aattaaataa
     7921 atttcatctc atttttttcc ctaaaccagc acccatctgc cttttattcc ccaaagagtt
     7981 acctttccca gattaggggg atggtatgtg gggagcagat agcggaaatg cttagaaaga
     8041 taagggggac cacccacagc tggtcgtgag aacagggaga cagtgtgtgg gggtgggacc
     8101 tcatctgtgt gcctggtatc ctgagtttta catgtagatg cattcgccta tttgattcag
     8161 aaaaataaac tttcccaaaa tgtgtctgaa ccacaagagc atacagtgga agtgctacct
     8221 ctaatctaac cagagcacct tcatggtgga agacacccac caggtcatac aatgtgaact
     8281 tttgtatctc tgcagtggtt tcaaggacaa atagtgtcca atgtattggg ccatttttcc
     8341 tgctgttttt atactcaact tctcaaaatg aaaaaagctt ttatttttcc tttgacttat
     8401 ttgtgttgtt cttatttttt aaatttttat tttttgataa tagtctgtaa gttagccttt
     8461 ttgggttttt tttttttttt tttggctttt ttttttgttt gttttttttt cttttgacat
     8521 tgcaaccgaa ggtcataagg ccgctagctc cgctgggaca gaggcttgag agaactaacg
     8581 gctcggtgcc ttctccctgg tctcagacca tcgtctctgc actgcgaagg catttggtag
     8641 cctcgccact gagatactaa ctagacctag actaggagct ttatcaggtt ctaggaggtc
     8701 ctttaggaag actctcaaag gcaaatccct gatcccccgc cccaccctta gccctgccct
     8761 ctcaccagag caaaattcac tggggacttt tcccaccaca catggaaatc tgtccactcg
     8821 gaatacctct gttttccatt tcaaattgta gggggagggg atggaacact tccagtgatg
     8881 gtaagagatc tgttatgaaa cgaaacaccc cccgtgttaa taacttggtc tgaaatctgt
     8941 ttttatgagc cgggccccct gtgcctctag tatacttgta ttgactctca tagttaccct
     9001 tttagtttta ctgtgttctg tgaaaatttg taattggttg agaatcactg tgggcgtcca
     9061 ttcttattca actaaatctc cacaggtttt ttgagctggt gtggattagt ttaactcttg
     9121 tattcaacca ttagtgctac caccttctca cattacaata caattactgg aagcaagtac
     9181 tgcatttcct atgcaacaaa aaaggaaaaa taaaaaattg ctaatgcta
//
