LOCUS       NM_004289               3740 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens NFE2 like bZIP transcription factor 3 (NFE2L3), mRNA.
ACCESSION   NM_004289
VERSION     NM_004289.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3740)
  AUTHORS   Xing,P., Chen,Z., Zhu,W., Lin,B. and Quan,M.
  TITLE     NRF3 suppresses the malignant progression of TNBC by promoting M1
            polarization of macrophages via ROS/HMGB1 axis
  JOURNAL   Cancer Biol Ther 25 (1), 2416221 (2024)
   PUBMED   39443820
  REMARK    GeneRIF: NRF3 suppresses the malignant progression of TNBC by
            promoting M1 polarization of macrophages via ROS/HMGB1 axis.
REFERENCE   2  (bases 1 to 3740)
  AUTHORS   Li,F. and Wen,Z.
  TITLE     Identification roles of NFE2L3 in digestive system cancers
  JOURNAL   J Cancer Res Clin Oncol 150 (3), 150 (2024)
   PUBMED   38514488
  REMARK    GeneRIF: Identification roles of NFE2L3 in digestive system
            cancers.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3740)
  AUTHORS   Hou,X., Liao,Q., Wu,Y., Wang,L., Zhao,J. and Liao,X.
  TITLE     Hypomethylation-Mediated Upregulation of NFE2L3 Promotes Malignant
            Phenotypes of Clear Cell Renal Cell Carcinoma Cells
  JOURNAL   Mol Biotechnol 66 (2), 198-207 (2024)
   PUBMED   37071304
  REMARK    GeneRIF: Hypomethylation-Mediated Upregulation of NFE2L3 Promotes
            Malignant Phenotypes of Clear Cell Renal Cell Carcinoma Cells.
REFERENCE   4  (bases 1 to 3740)
  AUTHORS   Gurri,S., Siegenthaler,B., Cangkrama,M., Restivo,G., Huber,M.,
            Saliba,J., Dummer,R., Blank,V., Hohl,D. and Werner,S.
  TITLE     NRF3 suppresses squamous carcinogenesis, involving the unfolded
            protein response regulator HSPA5
  JOURNAL   EMBO Mol Med 15 (11), e17761 (2023)
   PUBMED   37807968
  REMARK    GeneRIF: NRF3 suppresses squamous carcinogenesis, involving the
            unfolded protein response regulator HSPA5.
REFERENCE   5  (bases 1 to 3740)
  AUTHORS   Zhang,Q., Tang,D., Zha,A., He,J., Li,D., Chen,Y., Cai,W., Dai,J.,
            Luan,S., Yin,L., Zhang,W. and Dai,Y.
  TITLE     NFE2L3 as a Potential Functional Gene Regulating Immune
            Microenvironment in Human Kidney Cancer
  JOURNAL   Biomed Res Int 2022, 9085186 (2022)
   PUBMED   36337840
  REMARK    GeneRIF: NFE2L3 as a Potential Functional Gene Regulating Immune
            Microenvironment in Human Kidney Cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3740)
  AUTHORS   Zhang,Y., Kobayashi,A., Yamamoto,M. and Hayes,J.D.
  TITLE     The Nrf3 transcription factor is a membrane-bound glycoprotein
            targeted to the endoplasmic reticulum through its N-terminal
            homology box 1 sequence
  JOURNAL   J Biol Chem 284 (5), 3195-3210 (2009)
   PUBMED   19047052
REFERENCE   7  (bases 1 to 3740)
  AUTHORS   Nouhi,Z., Chevillard,G., Derjuga,A. and Blank,V.
  TITLE     Endoplasmic reticulum association and N-linked glycosylation of the
            human Nrf3 transcription factor
  JOURNAL   FEBS Lett 581 (28), 5401-5406 (2007)
   PUBMED   17976382
  REMARK    GeneRIF: Nrf3 is an N-glycosylated protein associated with the
            endoplasmic reticulum
REFERENCE   8  (bases 1 to 3740)
  AUTHORS   Chenais,B., Derjuga,A., Massrieh,W., Red-Horse,K., Bellingard,V.,
            Fisher,S.J. and Blank,V.
  TITLE     Functional and placental expression analysis of the human NRF3
            transcription factor
  JOURNAL   Mol Endocrinol 19 (1), 125-137 (2005)
   PUBMED   15388789
  REMARK    GeneRIF: NRF3 is highly expressed in primary placental
            cytotrophoblasts
REFERENCE   9  (bases 1 to 3740)
  AUTHORS   Sankaranarayanan,K. and Jaiswal,A.K.
  TITLE     Nrf3 negatively regulates antioxidant-response element-mediated
            expression and antioxidant induction of NAD(P)H:quinone
            oxidoreductase1 gene
  JOURNAL   J Biol Chem 279 (49), 50810-50817 (2004)
   PUBMED   15385560
  REMARK    GeneRIF: Nrf3 is a negative regulator of ARE-mediated gene
            expression of NQO1
REFERENCE   10 (bases 1 to 3740)
  AUTHORS   Kobayashi,A., Ito,E., Toki,T., Kogame,K., Takahashi,S.,
            Igarashi,K., Hayashi,N. and Yamamoto,M.
  TITLE     Molecular cloning and functional characterization of a new Cap'n'
            collar family transcription factor Nrf3
  JOURNAL   J Biol Chem 274 (10), 6443-6452 (1999)
   PUBMED   10037736
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC004520.2, BX396198.2,
            AF134891.1, BC056142.1 and AA603252.1.
            
            On Nov 23, 2018 this sequence version replaced NM_004289.6.
            
            Summary: This gene encodes a member of the cap 'n' collar
            basic-region leucine zipper family of transcription factors. The
            encoded protein heterodimerizes with small musculoaponeurotic
            fibrosarcoma factors to bind antioxidant response elements in
            target genes. This protein is a membrane bound glycoprotein that is
            targeted to the endoplasmic reticulum and the nuclear envelope.
            Pseudogenes of this gene are found on chromosomes 16, 17, and 18.
            [provided by RefSeq, Mar 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC068455.1, AF134891.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000056233.4/ ENSP00000056233.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                AC004520.2         92321-92349
            30-301              BX396198.2         1-272
            302-2919            AF134891.1         1-2618
            2920-3728           BC056142.1         1935-2743
            3729-3740           AA603252.1         10-21               c
FEATURES             Location/Qualifiers
     source          1..3740
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p15.2"
     gene            1..3740
                     /gene="NFE2L3"
                     /gene_synonym="NRF3"
                     /note="NFE2 like bZIP transcription factor 3"
                     /db_xref="GeneID:9603"
                     /db_xref="HGNC:HGNC:7783"
                     /db_xref="MIM:604135"
     exon            1..871
                     /gene="NFE2L3"
                     /gene_synonym="NRF3"
                     /inference="alignment:Splign:2.1.0"
     CDS             302..2386
                     /gene="NFE2L3"
                     /gene_synonym="NRF3"
                     /note="nuclear factor-erythroid 2 p45-related factor 3;
                     NFE2-related factor 3; NF-E2-related factor 3; nuclear
                     factor, erythroid derived 2, like 3; nuclear factor,
                     erythroid 2 like 3"
                     /codon_start=1
                     /product="nuclear factor erythroid 2-related factor 3"
                     /protein_id="NP_004280.5"
                     /db_xref="CCDS:CCDS5396.1"
                     /db_xref="GeneID:9603"
                     /db_xref="HGNC:HGNC:7783"
                     /db_xref="MIM:604135"
                     /translation="MKHLKRWWSAGGGLLHLTLLLSLAGLRVDLDLYLLLPPPTLLQD
                     ELLFLGGPASSAYALSPFSASGGWGRAGHLHPKGRELDPAAPPEGQLLREVRALGVPF
                     VPRTSVDAWLVHSVAAGSADEAHGLLGAAAASSTGGAGASVDGGSQAVQGGGGDPRAA
                     RSGPLDAGEEEKAPAEPTAQVPDAGGCASEENGVLREKHEAVDHSSQHEENEERVSAQ
                     KENSLQQNDDDENKIAEKPDWEAEKTTESRNERHLNGTDTSFSLEDLFQLLSSQPENS
                     LEGISLGDIPLPGSISDGMNSSAHYHVNFSQAISQDVNLHEAILLCPNNTFRRDPTAR
                     TSQSQEPFLQLNSHTTNPEQTLPGTNLTGFLSPVDNHMRNLTSQDLLYDLDINIFDEI
                     NLMSLATEDNFDPIDVSQLFDEPDSDSGLSLDSSHNNTSVIKSNSSHSVCDEGAIGYC
                     TDHESSSHHDLEGAVGGYYPEPSKLCHLDQSDSDFHGDLTFQHVFHNHTYHLQPTAPE
                     STSEPFPWPGKSQKIRSRYLEDTDRNLSRDEQRAKALHIPFSVDEIVGMPVDSFNSML
                     SRYYLTDLQVSLIRDIRRRGKNKVAAQNCRKRKLDIILNLEDDVCNLQAKKETLKREQ
                     AQCNKAINIMKQKLHDLYHDIFSRLRDDQGRPVNPNHYALQCTHDGSILIVPKELVAS
                     GHKKETQKGKRK"
     exon            872..1051
                     /gene="NFE2L3"
                     /gene_synonym="NRF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1135
                     /gene="NFE2L3"
                     /gene_synonym="NRF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..3740
                     /gene="NFE2L3"
                     /gene_synonym="NRF3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3705..3710
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NFE2L3"
                     /gene_synonym="NRF3"
                     /note="hexamer: AATAAA"
     polyA_site      3740
                     /gene="NFE2L3"
                     /gene_synonym="NRF3"
                     /note="major polyA site"
ORIGIN      
        1 ggagcttggc caccgcgccg ggctgcgggc ggctgggcga acgggctcgg cgctcaggtg
       61 gctccttctt cgcttctccc gatccccggc ggtgccaggc acggtgccgg ctgccgaggg
      121 aacgcctttg tgcccggtgc tgggaacccg cgacggccgc cacgcgcccc ggtccattgt
      181 ttcgcttatc tgggttccag gcaggtgcgg gcggcgcgcg gggtccgcac gtgtcacccc
      241 ggcggctggg gcgccgggac ccgcgggcgc cggcaggggc gttcccgggc gcgcggcggc
      301 gatgaagcac ctgaagcggt ggtggtcggc cggcggcggc ctcctgcacc tcaccctcct
      361 gctgagcttg gcggggctcc gcgtagacct agatctttac ctgctgctgc cgccgcccac
      421 cctgctgcag gacgagctgc tgttcctggg cggcccggcc agctccgcct acgcgctcag
      481 ccccttctcg gcctcgggag ggtgggggcg cgcgggccac ttgcacccca agggccggga
      541 gctggaccct gccgcgccgc ccgagggcca gctgctccgg gaggtgcgcg cgctcggggt
      601 ccccttcgtc cctcgcacca gcgtggatgc atggctggtg cacagcgtgg ctgccgggag
      661 cgcggacgag gcccacgggc tgctcggcgc cgccgccgcc tcgtccaccg gaggagccgg
      721 cgccagcgtg gacggcggca gccaggctgt gcaggggggc ggcggggacc cccgagcggc
      781 tcggagtggc cccttggacg ccggggaaga ggagaaggca cccgcggaac cgacggctca
      841 ggtgccggac gctggcggat gtgcgagcga ggagaatggg gtactaagag aaaagcacga
      901 agctgtggat catagttccc agcatgagga aaatgaagaa agggtgtcag cccagaagga
      961 gaactcactt cagcagaatg atgatgatga aaacaaaata gcagagaaac ctgactggga
     1021 ggcagaaaag accactgaat ctagaaatga gagacatctg aatgggacag atacttcttt
     1081 ctctctggaa gacttattcc agttgctttc atcacagcct gaaaattcac tggagggcat
     1141 ctcattggga gatattcctc ttccaggcag tatcagtgat ggcatgaatt cttcagcaca
     1201 ttatcatgta aacttcagcc aggctataag tcaggatgtg aatcttcatg aggccatctt
     1261 gctttgtccc aacaatacat ttagaagaga tccaacagca aggacttcac agtcacaaga
     1321 accatttctg cagttaaatt ctcataccac caatcctgag caaacccttc ctggaactaa
     1381 tttgacagga tttctttcac cggttgacaa tcatatgagg aatctaacaa gccaagacct
     1441 actgtatgac cttgacataa atatatttga tgagataaac ttaatgtcat tggccacaga
     1501 agacaacttt gatccaatcg atgtttctca gctttttgat gaaccagatt ctgattctgg
     1561 cctttcttta gattcaagtc acaataatac ctctgtcatc aagtctaatt cctctcactc
     1621 tgtgtgtgat gaaggtgcta taggttattg cactgaccat gaatctagtt cccatcatga
     1681 cttagaaggt gctgtaggtg gctactaccc agaacccagt aagctttgtc acttggatca
     1741 aagtgattct gatttccatg gagatcttac atttcaacac gtatttcata accacactta
     1801 ccacttacag ccaactgcac cagaatctac ttctgaacct tttccgtggc ctgggaagtc
     1861 acagaagata aggagtagat accttgaaga cacagataga aacttgagcc gtgatgaaca
     1921 gcgtgctaaa gctttgcata tccctttttc tgtagatgaa attgtcggca tgcctgttga
     1981 ttctttcaat agcatgttaa gtagatatta tctgacagac ctacaagtct cacttatccg
     2041 tgacatcaga cgaagaggga aaaataaagt tgctgcgcag aactgtcgta aacgcaaatt
     2101 ggacataatt ttgaatttag aagatgatgt atgtaacttg caagcaaaga aggaaactct
     2161 taagagagag caagcacaat gtaacaaagc tattaacata atgaaacaga aactgcatga
     2221 cctttatcat gatattttta gtagattaag agatgaccaa ggtaggccag tcaatcccaa
     2281 ccactatgct ctccagtgta cccatgatgg aagtatcttg atagtaccca aagaactggt
     2341 ggcctcaggc cacaaaaagg aaacccaaaa gggaaagaga aagtgagaag aaactgaaga
     2401 tggactctat tatgtgaagt agtaatgttc agaaactgat tatttggatc agaaaccatt
     2461 gaaactgctt caagaattgt atctttaagt actgctactt gaataactca gttaacgctg
     2521 ttttgaagct tacatggaca aatgtttagg acttcaagat cacacttgtg ggcaatctgg
     2581 gggagccaca acttttcatg aagtgcattg tatacaaaat tcatagttat gtccaaagaa
     2641 taggttaaca tgaaaaccca gtaagacttt ccatcttggc agccatcctt tttaagagta
     2701 agttggttac ttcaaaaaga gcaaacactg gggatcaaat tattttaaga ggtatttcag
     2761 ttttaaatgc aaaatagcct tattttcatt tagtttgtta gcactatagt gagcttttca
     2821 aacactattt taatctttat atttaactta taaattttgc tttctatgga aataaatttt
     2881 gtatttgtat taaaaattaa cttttccctt ttatacagaa tctgaaccaa atttacctta
     2941 ctttccttcc aaaatatcca cattcaggaa tataggtgaa taacaaataa ggcagcatag
     3001 caaactgctc agactcaagc caaattgagg tcaacatagt atgccaaatc catagtaagg
     3061 caaatccacc cccctacccc aatacttaac acacagaata ctatgtgata tagaatgcac
     3121 tgaagaccta cggtcactgg tagtttgagc cacaggcctt cctcatgtaa ccagagacag
     3181 aatgggctac ttgcaaaaac gtaactcctt gtgtgtatat taaatccata aaatctctgg
     3241 cagtaaagcc agcctgaagg gatggcctca ccatcttaga atactgagat ctcaccagaa
     3301 cactgtaagc catataaaca gtagggaaag agtcagcaac agtgaaacca tctgtttaaa
     3361 atgggcaaaa gcgattaagg gaaaaaaaac aggtgaattt gaaaataaac cagggtaagg
     3421 taaattctag aaataatagc atttgaaatg aaaacctcac ttaagttcac tagaacagta
     3481 aacaggagat tgctgaattt tttgaagaca gcaatgacct cacctagatg actcaagttt
     3541 ggggaacatc aagattttga cgggtactat aatgcttaat atgtccaaat tttcaaaatg
     3601 aagtttctca gatattattt ctgccatagg agctacagtg tagagtatca cataagtatc
     3661 ttgggctaga gaaatgcagt ttatatatac cgttggattt ttataataaa gtttcccaag
     3721 acctgttatt ttgccagaaa
//
