LOCUS       NM_006164               2446 bp    mRNA    linear   PRI 17-NOV-2024
DEFINITION  Homo sapiens NFE2 like bZIP transcription factor 2 (NFE2L2),
            transcript variant 1, mRNA.
ACCESSION   NM_006164
VERSION     NM_006164.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2446)
  AUTHORS   Liu,X., Zhang,F., Fan,Y., Qiu,C. and Wang,K.
  TITLE     MCM4 potentiates evasion of hepatocellular carcinoma from
            sorafenib-induced ferroptosis through Nrf2 signaling pathway
  JOURNAL   Int Immunopharmacol 142 (Pt A), 113107 (2024)
   PUBMED   39276458
  REMARK    GeneRIF: MCM4 potentiates evasion of hepatocellular carcinoma from
            sorafenib-induced ferroptosis through Nrf2 signaling pathway.
REFERENCE   2  (bases 1 to 2446)
  AUTHORS   Dewanjee,S., Bhattacharya,H., Bhattacharyya,C., Chakraborty,P.,
            Fleishman,J., Alexiou,A., Papadakis,M. and Jha,S.K.
  TITLE     Nrf2/Keap1/ARE regulation by plant secondary metabolites: a new
            horizon in brain tumor management
  JOURNAL   Cell Commun Signal 22 (1), 497 (2024)
   PUBMED   39407193
  REMARK    GeneRIF: Nrf2/Keap1/ARE regulation by plant secondary metabolites:
            a new horizon in brain tumor management.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2446)
  AUTHORS   Blot,C., Lavernhe,M., Lugo-Villarino,G., Coulson,K., Salon,M.,
            Tertrais,M., Planes,R., Santoni,K., Authier,H., Jacquemin,G.,
            Rahabi,M., Parny,M., Letron,I.R., Meunier,E., Lefevre,L. and
            Coste,A.
  TITLE     Leishmania infantum exploits the anti-ferroptosis effects of Nrf2
            to escape cell death in macrophages
  JOURNAL   Cell Rep 43 (9), 114720 (2024)
   PUBMED   39244752
  REMARK    GeneRIF: Leishmania infantum exploits the anti-ferroptosis effects
            of Nrf2 to escape cell death in macrophages.
REFERENCE   4  (bases 1 to 2446)
  AUTHORS   Onoki,T., Kanczler,J., Rawlings,A., Smith,M., Kim,Y.H.,
            Hashimoto,K., Aizawa,T. and Oreffo,R.O.C.
  TITLE     Modulation of osteoblastogenesis by NRF2: NRF2 activation
            suppresses osteogenic differentiation and enhances mineralization
            in human bone marrow-derived mesenchymal stromal cells
  JOURNAL   FASEB J 38 (17), e23892 (2024)
   PUBMED   39230563
  REMARK    GeneRIF: Modulation of osteoblastogenesis by NRF2: NRF2 activation
            suppresses osteogenic differentiation and enhances mineralization
            in human bone marrow-derived mesenchymal stromal cells.
REFERENCE   5  (bases 1 to 2446)
  AUTHORS   Shen,J., Lai,Y., Lu,Y., Liu,Y., Zhang,J., Wu,Y., Pan,Y., Chen,H.,
            Gao,Q., Wei,Q., Chen,Y., Ye,J., Lin,Y., Liu,B., Jiang,J. and Nan,J.
  TITLE     NRF2-HIF2alpha Signaling Attenuates Endothelial Cell Senescence and
            Maintains Intercellular Junctions in Diabetes
  JOURNAL   Int J Biol Sci 20 (10), 4055-4073 (2024)
   PUBMED   39113713
  REMARK    GeneRIF: NRF2-HIF2alpha Signaling Attenuates Endothelial Cell
            Senescence and Maintains Intercellular Junctions in Diabetes.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2446)
  AUTHORS   Itoh,K., Wakabayashi,N., Katoh,Y., Ishii,T., Igarashi,K.,
            Engel,J.D. and Yamamoto,M.
  TITLE     Keap1 represses nuclear activation of antioxidant responsive
            elements by Nrf2 through binding to the amino-terminal Neh2 domain
  JOURNAL   Genes Dev 13 (1), 76-86 (1999)
   PUBMED   9887101
REFERENCE   7  (bases 1 to 2446)
  AUTHORS   Venugopal,R. and Jaiswal,A.K.
  TITLE     Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant
            response element-mediated expression and coordinated induction of
            genes encoding detoxifying enzymes
  JOURNAL   Oncogene 17 (24), 3145-3156 (1998)
   PUBMED   9872330
REFERENCE   8  (bases 1 to 2446)
  AUTHORS   Toki,T., Itoh,J., Kitazawa,J., Arai,K., Hatakeyama,K., Akasaka,J.,
            Igarashi,K., Nomura,N., Yokoyama,M., Yamamoto,M. and Ito,E.
  TITLE     Human small Maf proteins form heterodimers with CNC family
            transcription factors and recognize the NF-E2 motif
  JOURNAL   Oncogene 14 (16), 1901-1910 (1997)
   PUBMED   9150357
REFERENCE   9  (bases 1 to 2446)
  AUTHORS   Chan,J.Y., Cheung,M.C., Moi,P., Chan,K. and Kan,Y.W.
  TITLE     Chromosomal localization of the human NF-E2 family of bZIP
            transcription factors by fluorescence in situ hybridization
  JOURNAL   Hum Genet 95 (3), 265-269 (1995)
   PUBMED   7868116
REFERENCE   10 (bases 1 to 2446)
  AUTHORS   Moi,P., Chan,K., Asunis,I., Cao,A. and Kan,Y.W.
  TITLE     Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic
            leucine zipper transcriptional activator that binds to the tandem
            NF-E2/AP1 repeat of the beta-globin locus control region
  JOURNAL   Proc Natl Acad Sci U S A 91 (21), 9926-9930 (1994)
   PUBMED   7937919
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA438735.1 and BC011558.1.
            
            On Dec 7, 2018 this sequence version replaced NM_006164.4.
            
            Summary: This gene encodes a transcription factor which is a member
            of a small family of basic leucine zipper (bZIP) proteins. The
            encoded transcription factor regulates genes which contain
            antioxidant response elements (ARE) in their promoters; many of
            these genes encode proteins involved in response to injury and
            inflammation which includes the production of free radicals.
            Multiple transcript variants encoding different isoforms have been
            characterized for this gene. [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.909655.1,
                                           SRR1660807.61784.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000397062.8/ ENSP00000380252.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                DA438735.1         405-466
            63-2446             BC011558.1         25-2408
FEATURES             Location/Qualifiers
     source          1..2446
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q31.2"
     gene            1..2446
                     /gene="NFE2L2"
                     /gene_synonym="HEBP1; IMDDHH; Nrf-2; NRF2"
                     /note="NFE2 like bZIP transcription factor 2"
                     /db_xref="GeneID:4780"
                     /db_xref="HGNC:HGNC:7782"
                     /db_xref="MIM:600492"
     exon            1..196
                     /gene="NFE2L2"
                     /gene_synonym="HEBP1; IMDDHH; Nrf-2; NRF2"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..1969
                     /gene="NFE2L2"
                     /gene_synonym="HEBP1; IMDDHH; Nrf-2; NRF2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     nuclear factor erythroid 2-related factor 2; nuclear
                     factor erythroid-derived 2-like 2; nuclear factor,
                     erythroid 2 like 2"
                     /codon_start=1
                     /product="nuclear factor erythroid 2-related factor 2
                     isoform 1"
                     /protein_id="NP_006155.2"
                     /db_xref="CCDS:CCDS42782.1"
                     /db_xref="GeneID:4780"
                     /db_xref="HGNC:HGNC:7782"
                     /db_xref="MIM:600492"
                     /translation="MMDLELPPPGLPSQQDMDLIDILWRQDIDLGVSREVFDFSQRRK
                     EYELEKQKKLEKERQEQLQKEQEKAFFAQLQLDEETGEFLPIQPAQHIQSETSGSANY
                     SQVAHIPKSDALYFDDCMQLLAQTFPFVDDNEVSSATFQSLVPDIPGHIESPVFIATN
                     QAQSPETSVAQVAPVDLDGMQQDIEQVWEELLSIPELQCLNIENDKLVETTMVPSPEA
                     KLTEVDNYHFYSSIPSMEKEVGNCSPHFLNAFEDSFSSILSTEDPNQLTVNSLNSDAT
                     VNTDFGDEFYSAFIAEPSISNSMPSPATLSHSLSELLNGPIDVSDLSLCKAFNQNHPE
                     STAEFNDSDSGISLNTSPSVASPEHSVESSSYGDTLLGLSDSEVEELDSAPGSVKQNG
                     PKTPVHSSGDMVQPLSPSQGQSTHVHDAQCENTPEKELPVSPGHRKTPFTKDKHSSRL
                     EAHLTRDELRAKALHIPFPVEKIINLPVVDFNEMMSKEQFNEAQLALIRDIRRRGKNK
                     VAAQNCRKRKLENIVELEQDLDHLKDEKEKLLKEKGENDKSLHLLKKQLSTLYLEVFS
                     MLRDEDGKPYSPSEYSLQQTRDGNVFLVPKSKKPDVKKN"
     exon            197..463
                     /gene="NFE2L2"
                     /gene_synonym="HEBP1; IMDDHH; Nrf-2; NRF2"
                     /inference="alignment:Splign:2.1.0"
     exon            464..553
                     /gene="NFE2L2"
                     /gene_synonym="HEBP1; IMDDHH; Nrf-2; NRF2"
                     /inference="alignment:Splign:2.1.0"
     exon            554..745
                     /gene="NFE2L2"
                     /gene_synonym="HEBP1; IMDDHH; Nrf-2; NRF2"
                     /inference="alignment:Splign:2.1.0"
     exon            746..2446
                     /gene="NFE2L2"
                     /gene_synonym="HEBP1; IMDDHH; Nrf-2; NRF2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2421..2426
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NFE2L2"
                     /gene_synonym="HEBP1; IMDDHH; Nrf-2; NRF2"
                     /note="hexamer: AATAAA"
     polyA_site      2446
                     /gene="NFE2L2"
                     /gene_synonym="HEBP1; IMDDHH; Nrf-2; NRF2"
                     /note="major polyA site"
ORIGIN      
        1 gattaccgag tgccggggag cccggaggag ccgccgacgc agccgccacc gccgccgccg
       61 ccgccaccag agccgccctg tccgcgccgc gcctcggcag ccggaacagg gccgccgtcg
      121 gggagcccca acacacggtc cacagctcat catgatggac ttggagctgc cgccgccggg
      181 actcccgtcc cagcaggaca tggatttgat tgacatactt tggaggcaag atatagatct
      241 tggagtaagt cgagaagtat ttgacttcag tcagcgacgg aaagagtatg agctggaaaa
      301 acagaaaaaa cttgaaaagg aaagacaaga acaactccaa aaggagcaag agaaagcctt
      361 tttcgctcag ttacaactag atgaagagac aggtgaattt ctcccaattc agccagccca
      421 gcacatccag tcagaaacca gtggatctgc caactactcc caggttgccc acattcccaa
      481 atcagatgct ttgtactttg atgactgcat gcagcttttg gcgcagacat tcccgtttgt
      541 agatgacaat gaggtttctt cggctacgtt tcagtcactt gttcctgata ttcccggtca
      601 catcgagagc ccagtcttca ttgctactaa tcaggctcag tcacctgaaa cttctgttgc
      661 tcaggtagcc cctgttgatt tagacggtat gcaacaggac attgagcaag tttgggagga
      721 gctattatcc attcctgagt tacagtgtct taatattgaa aatgacaagc tggttgagac
      781 taccatggtt ccaagtccag aagccaaact gacagaagtt gacaattatc atttttactc
      841 atctataccc tcaatggaaa aagaagtagg taactgtagt ccacattttc ttaatgcttt
      901 tgaggattcc ttcagcagca tcctctccac agaagacccc aaccagttga cagtgaactc
      961 attaaattca gatgccacag tcaacacaga ttttggtgat gaattttatt ctgctttcat
     1021 agctgagccc agtatcagca acagcatgcc ctcacctgct actttaagcc attcactctc
     1081 tgaacttcta aatgggccca ttgatgtttc tgatctatca ctttgcaaag ctttcaacca
     1141 aaaccaccct gaaagcacag cagaattcaa tgattctgac tccggcattt cactaaacac
     1201 aagtcccagt gtggcatcac cagaacactc agtggaatct tccagctatg gagacacact
     1261 acttggcctc agtgattctg aagtggaaga gctagatagt gcccctggaa gtgtcaaaca
     1321 gaatggtcct aaaacaccag tacattcttc tggggatatg gtacaaccct tgtcaccatc
     1381 tcaggggcag agcactcacg tgcatgatgc ccaatgtgag aacacaccag agaaagaatt
     1441 gcctgtaagt cctggtcatc ggaaaacccc attcacaaaa gacaaacatt caagccgctt
     1501 ggaggctcat ctcacaagag atgaacttag ggcaaaagct ctccatatcc cattccctgt
     1561 agaaaaaatc attaacctcc ctgttgttga cttcaacgaa atgatgtcca aagagcagtt
     1621 caatgaagct caacttgcat taattcggga tatacgtagg aggggtaaga ataaagtggc
     1681 tgctcagaat tgcagaaaaa gaaaactgga aaatatagta gaactagagc aagatttaga
     1741 tcatttgaaa gatgaaaaag aaaaattgct caaagaaaaa ggagaaaatg acaaaagcct
     1801 tcacctactg aaaaaacaac tcagcacctt atatctcgaa gttttcagca tgctacgtga
     1861 tgaagatgga aaaccttatt ctcctagtga atactccctg cagcaaacaa gagatggcaa
     1921 tgttttcctt gttcccaaaa gtaagaagcc agatgttaag aaaaactaga tttaggagga
     1981 tttgaccttt tctgagctag tttttttgta ctattatact aaaagctcct actgtgatgt
     2041 gaaatgctca tactttataa gtaattctat gcaaaatcat agccaaaact agtatagaaa
     2101 ataatacgaa actttaaaaa gcattggagt gtcagtatgt tgaatcagta gtttcacttt
     2161 aactgtaaac aatttcttag gacaccattt gggctagttt ctgtgtaagt gtaaatacta
     2221 caaaaactta tttatactgt tcttatgtca tttgttatat tcatagattt atatgatgat
     2281 atgacatctg gctaaaaaga aattattgca aaactaacca ctatgtactt ttttataaat
     2341 actgtatgga caaaaaatgg cattttttat attaaattgt ttagctctgg caaaaaaaaa
     2401 aaattttaag agctggtact aataaaggat tattatgact gttaaa
//
