LOCUS       NM_003204               4839 bp    mRNA    linear   PRI 05-AUG-2024
DEFINITION  Homo sapiens NFE2 like bZIP transcription factor 1 (NFE2L1),
            transcript variant 1, mRNA.
ACCESSION   NM_003204
VERSION     NM_003204.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4839)
  AUTHORS   Zhao,X., Xu,C., Ding,Y. and Yan,N.
  TITLE     The multifaceted functions of NFE2L1 in metabolism and associated
            disorders
  JOURNAL   Life Sci 352, 122906 (2024)
   PUBMED   38992575
  REMARK    GeneRIF: The multifaceted functions of NFE2L1 in metabolism and
            associated disorders.
            Review article
REFERENCE   2  (bases 1 to 4839)
  AUTHORS   Ward,M.A., Vangala,J.R., Kamber Kaya,H.E., Byers,H.A., Hosseini,N.,
            Diaz,A., Cuervo,A.M., Kaushik,S. and Radhakrishnan,S.K.
  TITLE     Transcription factor Nrf1 regulates proteotoxic stress-induced
            autophagy
  JOURNAL   J Cell Biol 223 (6) (2024)
   PUBMED   38656405
  REMARK    GeneRIF: Transcription factor Nrf1 regulates proteotoxic
            stress-induced autophagy.
REFERENCE   3  (bases 1 to 4839)
  AUTHORS   Deng,R., Zheng,Z., Hu,S., Wang,M., Feng,J., Mattjus,P., Zhang,Z.
            and Zhang,Y.
  TITLE     Loss of Nrf1 rather than Nrf2 leads to inflammatory accumulation of
            lipids and reactive oxygen species in human hepatoma cells, which
            is alleviated by 2-bromopalmitate
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1871 (2), 119644 (2024)
   PUBMED   37996059
  REMARK    GeneRIF: Loss of Nrf1 rather than Nrf2 leads to inflammatory
            accumulation of lipids and reactive oxygen species in human
            hepatoma cells, which is alleviated by 2-bromopalmitate.
REFERENCE   4  (bases 1 to 4839)
  AUTHORS   Liu,K., Hu,S., Qiu,L., Wang,M., Zhang,Z., Sun,G. and Zhang,Y.
  TITLE     Nrf1 is not a direct target gene of SREBP1, albeit both are
            integrated into the rapamycin-responsive regulatory network in
            human hepatoma cells
  JOURNAL   PLoS One 18 (11), e0294508 (2023)
   PUBMED   38011090
  REMARK    GeneRIF: Nrf1 is not a direct target gene of SREBP1, albeit both
            are integrated into the rapamycin-responsive regulatory network in
            human hepatoma cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4839)
  AUTHORS   Toki,T., Itoh,J., Kitazawa,J., Arai,K., Hatakeyama,K., Akasaka,J.,
            Igarashi,K., Nomura,N., Yokoyama,M., Yamamoto,M. and Ito,E.
  TITLE     Human small Maf proteins form heterodimers with CNC family
            transcription factors and recognize the NF-E2 motif
  JOURNAL   Oncogene 14 (16), 1901-1910 (1997)
   PUBMED   9150357
REFERENCE   6  (bases 1 to 4839)
  AUTHORS   Johnsen,O., Skammelsrud,N., Luna,L., Nishizawa,M., Prydz,H. and
            Kolsto,A.B.
  TITLE     Small Maf proteins interact with the human transcription factor
            TCF11/Nrf1/LCR-F1
  JOURNAL   Nucleic Acids Res 24 (21), 4289-4297 (1996)
   PUBMED   8932385
REFERENCE   7  (bases 1 to 4839)
  AUTHORS   Luna,L., Skammelsrud,N., Johnsen,O., Abel,K.J., Weber,B.L.,
            Prydz,H. and Kolsto,A.B.
  TITLE     Structural organization and mapping of the human TCF11 gene
  JOURNAL   Genomics 27 (2), 237-244 (1995)
   PUBMED   7557987
REFERENCE   8  (bases 1 to 4839)
  AUTHORS   Luna,L., Johnsen,O., Skartlien,A.H., Pedeutour,F., Turc-Carel,C.,
            Prydz,H. and Kolsto,A.B.
  TITLE     Molecular cloning of a putative novel human bZIP transcription
            factor on chromosome 17q22
  JOURNAL   Genomics 22 (3), 553-562 (1994)
   PUBMED   8001966
REFERENCE   9  (bases 1 to 4839)
  AUTHORS   Caterina,J.J., Donze,D., Sun,C.W., Ciavatta,D.J. and Townes,T.M.
  TITLE     Cloning and functional characterization of LCR-F1: a bZIP
            transcription factor that activates erythroid-specific, human
            globin gene expression
  JOURNAL   Nucleic Acids Res 22 (12), 2383-2391 (1994)
   PUBMED   8036168
REFERENCE   10 (bases 1 to 4839)
  AUTHORS   Chan,J.Y., Han,X.L. and Kan,Y.W.
  TITLE     Cloning of Nrf1, an NF-E2-related transcription factor, by genetic
            selection in yeast
  JOURNAL   Proc Natl Acad Sci U S A 90 (23), 11371-11375 (1993)
   PUBMED   8248256
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB097304.1, DA230932.1, AK090459.1, U08853.1, AC004477.2 and
            BM983473.1.
            
            On Nov 22, 2018 this sequence version replaced NM_003204.2.
            
            Summary: This gene encodes a protein that is involved in globin
            gene expression in erythrocytes. Confusion has occurred in
            bibliographic databases due to the shared symbol of NRF1 for this
            gene, NFE2L1, and for 'nuclear respiratory factor 1' which has an
            official symbol of NRF1. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK090459.1, X77366.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000362042.8/ ENSP00000354855.3
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-221               DB097304.1         36-256
            222-568             DA230932.1         224-570
            569-1429            AK090459.1         569-1429
            1430-3337           U08853.1           199-2106
            3338-4314           AC004477.2         104176-105152
            4315-4839           BM983473.1         18-542              c
FEATURES             Location/Qualifiers
     source          1..4839
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.32"
     gene            1..4839
                     /gene="NFE2L1"
                     /gene_synonym="LCR-F1; NRF-1; NRF1; TCF11"
                     /note="NFE2 like bZIP transcription factor 1"
                     /db_xref="GeneID:4779"
                     /db_xref="HGNC:HGNC:7781"
                     /db_xref="MIM:163260"
     exon            1..104
                     /gene="NFE2L1"
                     /gene_synonym="LCR-F1; NRF-1; NRF1; TCF11"
                     /inference="alignment:Splign:2.1.0"
     exon            105..1126
                     /gene="NFE2L1"
                     /gene_synonym="LCR-F1; NRF-1; NRF1; TCF11"
                     /inference="alignment:Splign:2.1.0"
     CDS             617..2935
                     /gene="NFE2L1"
                     /gene_synonym="LCR-F1; NRF-1; NRF1; TCF11"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transcription factor 11 (basic leucine zipper type);
                     nuclear factor erythroid 2-related factor 1; TCF-11;
                     NFE2-related factor 1; NF-E2-related factor 1;
                     transcription factor HBZ17; transcription factor LCR-F1;
                     locus control region-factor 1; nuclear factor, erythroid
                     derived 2, like 1; protein NRF1, p120 form; endoplasmic
                     reticulum membrane sensor NFE2L1; nuclear factor,
                     erythroid 2 like 1"
                     /codon_start=1
                     /product="endoplasmic reticulum membrane sensor NFE2L1
                     isoform 1"
                     /protein_id="NP_003195.1"
                     /db_xref="CCDS:CCDS11524.1"
                     /db_xref="GeneID:4779"
                     /db_xref="HGNC:HGNC:7781"
                     /db_xref="MIM:163260"
                     /translation="MLSLKKYLTEGLLQFTILLSLIGVRVDVDTYLTSQLPPLREIIL
                     GPSSAYTQTQFHNLRNTLDGYGIHPKSIDLDNYFTARRLLSQVRALDRFQVPTTEVNA
                     WLVHRDPEGSVSGSQPNSGLALESSSGLQDVTGPDNGVRESETEQGFGEDLEDLGAVA
                     PPVSGDLTKEDIDLIDILWRQDIDLGAGREVFDYSHRQKEQDVEKELRDGGEQDTWAG
                     EGAEALARNLLVDGETGESFPAQVPSGEDQTALSLEECLRLLEATCPFGENAEFPADI
                     SSITEAVPSESEPPALQNNLLSPLLTGTESPFDLEQQWQDLMSIMEMQAMEVNTSASE
                     ILYSAPPGDPLSTNYSLAPNTPINQNVSLHQASLGGCSQDFLLFSPEVESLPVASSST
                     LLPLAPSNSTSLNSTFGSTNLTGLFFPPQLNGTANDTAGPELPDPLGGLLDEAMLDEI
                     SLMDLAIEEGFNPVQASQLEEEFDSDSGLSLDSSHSPSSLSSSEGSSSSSSSSSSSSS
                     SASSSASSSFSEEGAVGYSSDSETLDLEEAEGAVGYQPEYSKFCRMSYQDPAQLSCLP
                     YLEHVGHNHTYNMAPSALDSADLPPPSALKKGSKEKQADFLDKQMSRDEHRARAMKIP
                     FTNDKIINLPVEEFNELLSKYQLSEAQLSLIRDIRRRGKNKMAAQNCRKRKLDTILNL
                     ERDVEDLQRDKARLLREKVEFLRSLRQMKQKVQSLYQEVFGRLRDENGRPYSPSQYAL
                     QYAGDGSVLLIPRTMADQQARRQERKPKDRRK"
     exon            1127..1339
                     /gene="NFE2L1"
                     /gene_synonym="LCR-F1; NRF-1; NRF1; TCF11"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1429
                     /gene="NFE2L1"
                     /gene_synonym="LCR-F1; NRF-1; NRF1; TCF11"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1588
                     /gene="NFE2L1"
                     /gene_synonym="LCR-F1; NRF-1; NRF1; TCF11"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..4839
                     /gene="NFE2L1"
                     /gene_synonym="LCR-F1; NRF-1; NRF1; TCF11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4224..4229
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NFE2L1"
                     /gene_synonym="LCR-F1; NRF-1; NRF1; TCF11"
                     /note="hexamer: CATAAA"
     polyA_site      4250
                     /gene="NFE2L1"
                     /gene_synonym="LCR-F1; NRF-1; NRF1; TCF11"
                     /note="major polyA site"
     regulatory      4752..4757
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NFE2L1"
                     /gene_synonym="LCR-F1; NRF-1; NRF1; TCF11"
                     /note="hexamer: AATAAA"
     regulatory      4757..4762
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NFE2L1"
                     /gene_synonym="LCR-F1; NRF-1; NRF1; TCF11"
                     /note="hexamer: AATAAA"
     polyA_site      4774
                     /gene="NFE2L1"
                     /gene_synonym="LCR-F1; NRF-1; NRF1; TCF11"
     polyA_site      4786
                     /gene="NFE2L1"
                     /gene_synonym="LCR-F1; NRF-1; NRF1; TCF11"
     regulatory      4816..4821
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NFE2L1"
                     /gene_synonym="LCR-F1; NRF-1; NRF1; TCF11"
                     /note="hexamer: AATAAA"
     polyA_site      4839
                     /gene="NFE2L1"
                     /gene_synonym="LCR-F1; NRF-1; NRF1; TCF11"
ORIGIN      
        1 aagcggaggc tccgagctct aggccggccg gcggtggcgg cggcgaggcc gggactcggg
       61 cttagggcct gctgtggagg cagcggcgga cgccgagcta agcagtttct ctggaaaccc
      121 ccctggtaag tgtggaggag gcgggacact ctgacccaag acgaaaggcc tgtagctcca
      181 gccaaagaaa ataaacctta ggagggagaa ggaaaaaaaa aatccatcag ctgttcctga
      241 gaacagcctg cattggaatc tacagagagg acaactaatg tgagtgagga agtgactgta
      301 tgtggactgt ggagaaagta agtcacgtgg gcccttgagg acctggactg ggttaggaac
      361 agttgtactt tcagaggtga ggtgtcgaga agggaaagtg aatgtggtct ggagtgtgtc
      421 cttggccttg gctccacagg gtgtgctttc ctctggggcc gtcagggagc tcatcccttg
      481 tgttctgcca gggtggggta cggggtttga cactgaggag ggtaacctgc tggctggagc
      541 ggcagagcag tggccttgat ttgtcttttg gaagatttta aaaaccaaaa agcataaaca
      601 ttctggtcct tcagcaatgc tttctctgaa gaaatactta acggaaggac ttctccagtt
      661 caccattctg ctgagtttga ttggggtacg ggtggacgtg gatacttacc tgacctcaca
      721 gcttccccca ctccgggaga tcatcctggg gcccagttct gcctatactc agacccagtt
      781 ccacaacctg aggaatacct tggatggcta tggtatccac cccaagagca tagacctgga
      841 caattacttc actgcccggc ggctcctcag tcaggtgagg gccctggaca ggttccaggt
      901 gccaaccact gaggtaaatg cctggctggt tcaccgagac ccagaggggt ctgtctctgg
      961 cagtcagccc aactcaggcc tcgccctcga gagttccagt ggcctccaag atgtgacagg
     1021 cccagacaac ggggtgcgag aaagcgaaac ggagcaggga ttcggtgaag atttggagga
     1081 tttgggggct gtagcccccc cagtcagtgg agacttaacc aaagaggaca tagatctgat
     1141 tgacatcctt tggcgacagg atattgatct gggggctggg cgtgaggttt ttgactatag
     1201 tcaccgccag aaggagcagg atgtggagaa ggagctgcga gatggaggcg agcaggacac
     1261 ctgggcaggc gagggcgcgg aagctctggc acggaacctg ctagtggatg gagagactgg
     1321 ggagagcttc cctgcacagg tgcctagtgg ggaggaccag acggccctgt ccctggaaga
     1381 gtgccttagg ctgctggaag ccacctgccc ctttggggag aatgctgagt ttccagcaga
     1441 catttccagc ataacagaag cagtgcctag tgagagtgag ccccctgctc ttcaaaacaa
     1501 cctcttgtct cctcttctga ccgggacaga gtcaccattt gatttggaac agcagtggca
     1561 agatctcatg tccatcatgg aaatgcaggc catggaagtg aacacatcag caagtgaaat
     1621 cctgtacagt gcccctcctg gagacccact gagcaccaac tacagccttg cccccaacac
     1681 tcccatcaat cagaatgtca gcctgcatca ggcgtccctg gggggctgca gccaggactt
     1741 cttactcttc agccccgagg tggaaagcct gcctgtggcc agtagctcca cgctgctccc
     1801 gttggccccc agcaattcta ccagcctcaa ctccaccttc ggctccacca acctgacagg
     1861 gctcttcttt ccaccccagc tcaatggcac agccaatgac acagcaggcc cagagctgcc
     1921 tgaccctttg gggggtctgt tagatgaagc tatgttggat gagatcagcc ttatggacct
     1981 ggccattgaa gaaggcttta accctgtgca ggcctcccag ctggaggagg aatttgactc
     2041 tgactcaggc ctttccttag actcgagcca tagcccttct tccctaagca gctctgaagg
     2101 cagttcttcc tcttcttcct cctcctcttc ctcttcttcc tctgcttctt cctctgcctc
     2161 ttcctccttt tctgaggaag gtgcggttgg ctacagctct gactctgaga ccctggatct
     2221 ggaagaggcc gagggtgctg tgggctacca gcctgagtat tccaagttct gccgcatgag
     2281 ctaccaggat ccagctcagc tctcatgcct gccctacctg gagcacgtgg gccacaacca
     2341 cacatacaac atggcaccca gtgccctgga ctcagccgac ctgccaccac ccagtgccct
     2401 caagaaaggc agcaaggaga agcaggctga cttcctggac aagcagatga gccgggatga
     2461 gcaccgagcc cgagccatga agatcccttt caccaatgac aaaatcatca acctgcctgt
     2521 ggaggagttc aatgaactgc tgtccaaata ccagttgagt gaagcccagc tgagcctcat
     2581 ccgagacatc cggcgccggg gcaagaacaa gatggcggcg cagaactgcc gcaagcgcaa
     2641 gctggacacc atcctgaatc tggagcgtga tgtggaggac ctgcagcgtg acaaagcccg
     2701 gctgctgcgg gagaaagtgg agttcctgcg ctccctgcga cagatgaagc agaaggtcca
     2761 gagcctgtac caggaggtgt ttgggcggct gcgagatgag aacggacgac cctactcgcc
     2821 cagtcagtat gcgctccagt acgccgggga cggcagtgtc ctcctcatcc cccgcacgat
     2881 ggccgaccag caggcccggc ggcaggagag gaagccaaag gaccggagaa agtgagcctg
     2941 gggaagaagg gggtttgaag cccaccaaga ccgaaactgg agaagggctg gacctggacc
     3001 tggacctgga cctacagcgg ggacttaaat gccttcttat ccaatatatc ttctcagatg
     3061 ggatgactgc gggtcagtgt acaggaagag gcaggcactg gctggctcag ctccactcgg
     3121 gtggagtgga agtggccaga ccatttagac ggacagggtc ctcaccctac ccctttcctg
     3181 tgaggcaggg gtggtggtgg agttgctgga ggtagaggag ctatgtggag caaaggccga
     3241 cagaggggaa ggaatggacc tgtgagagga agggaaggtg gcagaaagtc tcatttcagg
     3301 aaggagggat agaaggaagg aaggaaggaa cccccccccc cccgaaaaaa aaatcaaagc
     3361 gggaagaaaa tcagagggaa ggttaaggtt ggctctggcc aggattccag gcagcaggtt
     3421 ggagtgactg gtgggcctag atcactggtg tgataaaccc caattttcac cccggggggg
     3481 gtggggtaca cagacacagg gtgggggtgg ggagggacgg tgttaactct ttctgctcct
     3541 tgcattttga catccctgaa ggggagctct tggatatcat tggccatgtt tcaatcgaat
     3601 ggagccactg ggccccaaca ctggctttga gatttagagt caaagggtag agtgaacagg
     3661 aaagggtcac gtggtcccat gttgcaacag ccccaacatc acgcatgtca ttcactgcct
     3721 tgccactcca tctccctccg tgctccagcc acccctgagc tgaggctccc attgtctcca
     3781 tcagagcctg catgtgtatg ccgtcctccc ctggtccggt gtttgtgttc cccacccctc
     3841 acagactgcc tgagctcttc tgtaagctgg ggtagggtga tggcagtgct ccgggaactg
     3901 ggcctgcagc cttcctcttc tgggactgct gtgaggcaga ggaatgatgg agaatctagt
     3961 gtagcagcct ccaggcagga ttcagcacaa cactggggag tcacccttcc ctcgggcctc
     4021 tgcctaccaa caactgggct tatcactggg aaaacacaaa aaattacaca acccagcaac
     4081 aacaaaagaa ctagtcctct tagaatttct tgcgctttga tttttttagg gcttgtgccc
     4141 tgtttcactt atagggtcta gaatgcttgt gttgagtaaa aaggagatgc ccaatattca
     4201 aagctgctaa atgttctctt tgccataaag actccgtgta actgtgtgaa cacttgggat
     4261 ttttctcctc tgtcccgagg tcgtcgtctg ctttcttttt tgggtttctt tctagaagat
     4321 tgagaagtgc atatgacagg ctgagagcac ctccccaaac acacaagctc tcagccacag
     4381 gcagcttctc cacagcccca gcttcgcaca ggctcctgga gggctgcctg ggggaggcag
     4441 acatgggagt gccaaggtgg ccagatggtt ccaggactac aatgtcttta tttttaactg
     4501 tttgccactg ctgccctcac ccctgcccgg ctctggagta ccgtctgccc cagacaagtg
     4561 ggagtgaaat gggggtgggg ggaagcactg attcccagtt agggggtgcc taactgagca
     4621 gtagggatag aaggtgtgaa cctgggagtg cttttataaa ttattttcct tgtagatttt
     4681 atttttaatt tatctctgtg acctgccagg gagaggggag agagagagag atgctgttga
     4741 gcacatgaca aaataaaata aaatggatga ttcattctta agtgcacttt ttccccactt
     4801 tgaatttaaa ttgagaataa aggaaatgga ctcattgta
//
