LOCUS       NP_003195                772 aa            linear   PRI 08-MAY-2025
DEFINITION  endoplasmic reticulum membrane sensor NFE2L1 isoform 1 [Homo
            sapiens].
ACCESSION   NP_003195
VERSION     NP_003195.1
DBSOURCE    REFSEQ: accession NM_003204.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 772)
  AUTHORS   Zhao,X., Xu,C., Ding,Y. and Yan,N.
  TITLE     The multifaceted functions of NFE2L1 in metabolism and associated
            disorders
  JOURNAL   Life Sci 352, 122906 (2024)
   PUBMED   38992575
  REMARK    GeneRIF: The multifaceted functions of NFE2L1 in metabolism and
            associated disorders.
            Review article
REFERENCE   2  (residues 1 to 772)
  AUTHORS   Ward,M.A., Vangala,J.R., Kamber Kaya,H.E., Byers,H.A., Hosseini,N.,
            Diaz,A., Cuervo,A.M., Kaushik,S. and Radhakrishnan,S.K.
  TITLE     Transcription factor Nrf1 regulates proteotoxic stress-induced
            autophagy
  JOURNAL   J Cell Biol 223 (6) (2024)
   PUBMED   38656405
  REMARK    GeneRIF: Transcription factor Nrf1 regulates proteotoxic
            stress-induced autophagy.
REFERENCE   3  (residues 1 to 772)
  AUTHORS   Deng,R., Zheng,Z., Hu,S., Wang,M., Feng,J., Mattjus,P., Zhang,Z.
            and Zhang,Y.
  TITLE     Loss of Nrf1 rather than Nrf2 leads to inflammatory accumulation of
            lipids and reactive oxygen species in human hepatoma cells, which
            is alleviated by 2-bromopalmitate
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1871 (2), 119644 (2024)
   PUBMED   37996059
  REMARK    GeneRIF: Loss of Nrf1 rather than Nrf2 leads to inflammatory
            accumulation of lipids and reactive oxygen species in human
            hepatoma cells, which is alleviated by 2-bromopalmitate.
REFERENCE   4  (residues 1 to 772)
  AUTHORS   Liu,K., Hu,S., Qiu,L., Wang,M., Zhang,Z., Sun,G. and Zhang,Y.
  TITLE     Nrf1 is not a direct target gene of SREBP1, albeit both are
            integrated into the rapamycin-responsive regulatory network in
            human hepatoma cells
  JOURNAL   PLoS One 18 (11), e0294508 (2023)
   PUBMED   38011090
  REMARK    GeneRIF: Nrf1 is not a direct target gene of SREBP1, albeit both
            are integrated into the rapamycin-responsive regulatory network in
            human hepatoma cells.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 772)
  AUTHORS   Toki,T., Itoh,J., Kitazawa,J., Arai,K., Hatakeyama,K., Akasaka,J.,
            Igarashi,K., Nomura,N., Yokoyama,M., Yamamoto,M. and Ito,E.
  TITLE     Human small Maf proteins form heterodimers with CNC family
            transcription factors and recognize the NF-E2 motif
  JOURNAL   Oncogene 14 (16), 1901-1910 (1997)
   PUBMED   9150357
REFERENCE   6  (residues 1 to 772)
  AUTHORS   Johnsen,O., Skammelsrud,N., Luna,L., Nishizawa,M., Prydz,H. and
            Kolsto,A.B.
  TITLE     Small Maf proteins interact with the human transcription factor
            TCF11/Nrf1/LCR-F1
  JOURNAL   Nucleic Acids Res 24 (21), 4289-4297 (1996)
   PUBMED   8932385
REFERENCE   7  (residues 1 to 772)
  AUTHORS   Luna,L., Skammelsrud,N., Johnsen,O., Abel,K.J., Weber,B.L.,
            Prydz,H. and Kolsto,A.B.
  TITLE     Structural organization and mapping of the human TCF11 gene
  JOURNAL   Genomics 27 (2), 237-244 (1995)
   PUBMED   7557987
REFERENCE   8  (residues 1 to 772)
  AUTHORS   Luna,L., Johnsen,O., Skartlien,A.H., Pedeutour,F., Turc-Carel,C.,
            Prydz,H. and Kolsto,A.B.
  TITLE     Molecular cloning of a putative novel human bZIP transcription
            factor on chromosome 17q22
  JOURNAL   Genomics 22 (3), 553-562 (1994)
   PUBMED   8001966
REFERENCE   9  (residues 1 to 772)
  AUTHORS   Caterina,J.J., Donze,D., Sun,C.W., Ciavatta,D.J. and Townes,T.M.
  TITLE     Cloning and functional characterization of LCR-F1: a bZIP
            transcription factor that activates erythroid-specific, human
            globin gene expression
  JOURNAL   Nucleic Acids Res 22 (12), 2383-2391 (1994)
   PUBMED   8036168
REFERENCE   10 (residues 1 to 772)
  AUTHORS   Chan,J.Y., Han,X.L. and Kan,Y.W.
  TITLE     Cloning of Nrf1, an NF-E2-related transcription factor, by genetic
            selection in yeast
  JOURNAL   Proc Natl Acad Sci U S A 90 (23), 11371-11375 (1993)
   PUBMED   8248256
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB097304.1, DA230932.1, AK090459.1, U08853.1, AC004477.2 and
            BM983473.1.
            
            Summary: This gene encodes a protein that is involved in globin
            gene expression in erythrocytes. Confusion has occurred in
            bibliographic databases due to the shared symbol of NRF1 for this
            gene, NFE2L1, and for 'nuclear respiratory factor 1' which has an
            official symbol of NRF1. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK090459.1, X77366.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000362042.8/ ENSP00000354855.3
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..772
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.32"
     Protein         1..772
                     /product="endoplasmic reticulum membrane sensor NFE2L1
                     isoform 1"
                     /note="transcription factor 11 (basic leucine zipper
                     type); nuclear factor erythroid 2-related factor 1;
                     TCF-11; NFE2-related factor 1; NF-E2-related factor 1;
                     transcription factor HBZ17; transcription factor LCR-F1;
                     locus control region-factor 1; nuclear factor, erythroid
                     derived 2, like 1; protein NRF1, p120 form; endoplasmic
                     reticulum membrane sensor NFE2L1; nuclear factor,
                     erythroid 2 like 1"
                     /calculated_mol_wt=84573
     Site            7..24
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q14494.1)"
     Site            103..104
                     /site_type="cleavage"
                     /note="Cleavage, by DDI2.
                     /evidence=ECO:0000269|PubMed:24448410; propagated from
                     UniProtKB/Swiss-Prot (Q14494.1)"
     mat_peptide     104..772
                     /product="Transcription factor NRF1.
                     /evidence=ECO:0000305|PubMed:24448410. /id=PRO_0000443103"
                     /note="propagated from UniProtKB/Swiss-Prot (Q14494.1)"
                     /calculated_mol_wt=72941
     Region          108..148
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q14494.1)"
     Region          191..199
                     /region_name="Cholesterol recognition/amino acid consensus
                     (CRAC) region. /evidence=ECO:0000250|UniProtKB:Q61985"
                     /note="propagated from UniProtKB/Swiss-Prot (Q14494.1)"
     Site            348
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q14494.1)"
     Site            360
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q14494.1)"
     Region          379..383
                     /region_name="CPD. /evidence=ECO:0000250|UniProtKB:Q61985"
                     /note="propagated from UniProtKB/Swiss-Prot (Q14494.1)"
     Site            412
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q14494.1)"
     Site            423
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q14494.1)"
     Region          470..532
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q14494.1)"
     Region          476..480
                     /region_name="Destruction motif.
                     /evidence=ECO:0000250|UniProtKB:Q61985"
                     /note="propagated from UniProtKB/Swiss-Prot (Q14494.1)"
     Site            528
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000250|UniProtKB:Q61985; propagated from
                     UniProtKB/Swiss-Prot (Q14494.1)"
     Region          582..613
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q14494.1)"
     Site            599
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PKA.
                     /evidence=ECO:0000269|PubMed:15308669; propagated from
                     UniProtKB/Swiss-Prot (Q14494.1)"
     Region          651..718
                     /region_name="bZIP_NFE2-like"
                     /note="Basic leucine zipper (bZIP) domain of Nuclear
                     Factor, Erythroid-derived 2 (NFE2) and similar proteins: a
                     DNA-binding and dimerization domain; cd14720"
                     /db_xref="CDD:269868"
     Region          652..714
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:269868"
     Region          656..675
                     /region_name="Basic motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00978"
                     /note="propagated from UniProtKB/Swiss-Prot (Q14494.1)"
     Site            order(660..661,663..665,667..672,674..676)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:269868"
     Site            order(675,678..679,682..683,685..686,689..690,692..693,
                     696..697,699..700,703..704,706..707)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:269868"
     Region          682..696
                     /region_name="Leucine-zipper.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00978"
                     /note="propagated from UniProtKB/Swiss-Prot (Q14494.1)"
     CDS             1..772
                     /gene="NFE2L1"
                     /gene_synonym="LCR-F1; NRF-1; NRF1; TCF11"
                     /coded_by="NM_003204.3:617..2935"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS11524.1"
                     /db_xref="GeneID:4779"
                     /db_xref="HGNC:HGNC:7781"
                     /db_xref="MIM:163260"
ORIGIN      
        1 mlslkkylte gllqftills ligvrvdvdt yltsqlpplr eiilgpssay tqtqfhnlrn
       61 tldgygihpk sidldnyfta rrllsqvral drfqvpttev nawlvhrdpe gsvsgsqpns
      121 glalesssgl qdvtgpdngv reseteqgfg edledlgava ppvsgdltke didlidilwr
      181 qdidlgagre vfdyshrqke qdvekelrdg geqdtwageg aealarnllv dgetgesfpa
      241 qvpsgedqta lsleeclrll eatcpfgena efpadissit eavpsesepp alqnnllspl
      301 ltgtespfdl eqqwqdlmsi memqamevnt saseilysap pgdplstnys lapntpinqn
      361 vslhqaslgg csqdfllfsp eveslpvass stllplapsn stslnstfgs tnltglffpp
      421 qlngtandta gpelpdplgg lldeamldei slmdlaieeg fnpvqasqle eefdsdsgls
      481 ldsshspssl sssegsssss sssssssssa sssasssfse egavgyssds etldleeaeg
      541 avgyqpeysk fcrmsyqdpa qlsclpyleh vghnhtynma psaldsadlp ppsalkkgsk
      601 ekqadfldkq msrdehrara mkipftndki inlpveefne llskyqlsea qlslirdirr
      661 rgknkmaaqn crkrkldtil nlerdvedlq rdkarllrek veflrslrqm kqkvqslyqe
      721 vfgrlrdeng rpyspsqyal qyagdgsvll iprtmadqqa rrqerkpkdr rk
//
