LOCUS       NM_004554               4762 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens nuclear factor of activated T cells 4 (NFATC4),
            transcript variant 2, mRNA.
ACCESSION   NM_004554
VERSION     NM_004554.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4762)
  AUTHORS   Yu,S., Sun,Z., Ju,T., Liu,Y., Mei,Z., Wang,C., Qu,Z., Li,N., Wu,F.,
            Liu,K., Lu,M., Huang,M., Pang,X., Jia,Y., Li,Y., Zhang,Y., Dou,S.,
            Jiang,J., Dong,X., Huang,C., Li,W., Zhang,Y., Yuan,Y., Yang,B. and
            Du,W.
  TITLE     The m7G Methyltransferase Mettl1 Drives Cardiac Hypertrophy by
            Regulating SRSF9-Mediated Splicing of NFATc4
  JOURNAL   Adv Sci (Weinh) 11 (29), e2308769 (2024)
   PUBMED   38810124
  REMARK    GeneRIF: The m7G Methyltransferase Mettl1 Drives Cardiac
            Hypertrophy by Regulating SRSF9-Mediated Splicing of NFATc4.
REFERENCE   2  (bases 1 to 4762)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   3  (bases 1 to 4762)
  AUTHORS   Zhang,X., Lei,F., Wang,X.M., Deng,K.Q., Ji,Y.X., Zhang,Y., Li,H.,
            Zhang,X.D., Lu,Z. and Zhang,P.
  TITLE     NULP1 Alleviates Cardiac Hypertrophy by Suppressing NFAT3
            Transcriptional Activity
  JOURNAL   J Am Heart Assoc 9 (16), e016419 (2020)
   PUBMED   32805187
  REMARK    GeneRIF: NULP1 Alleviates Cardiac Hypertrophy by Suppressing NFAT3
            Transcriptional Activity.
REFERENCE   4  (bases 1 to 4762)
  AUTHORS   Cole,A.J., Iyengar,M., Panesso-Gomez,S., O'Hayer,P., Chan,D.,
            Delgoffe,G.M., Aird,K.M., Yoon,E., Bai,S. and Buckanovich,R.J.
  TITLE     NFATC4 promotes quiescence and chemotherapy resistance in ovarian
            cancer
  JOURNAL   JCI Insight 5 (7), 131486 (2020)
   PUBMED   32182216
  REMARK    GeneRIF: NFATC4 promotes quiescence and chemotherapy resistance in
            ovarian cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4762)
  AUTHORS   Kaminuma,O., Kitamura,N., Nishito,Y., Nemoto,S., Tatsumi,H.,
            Mori,A. and Hiroi,T.
  TITLE     Downregulation of NFAT3 Due to Lack of T-Box Transcription Factor
            TBX5 Is Crucial for Cytokine Expression in T Cells
  JOURNAL   J Immunol 200 (1), 92-100 (2018)
   PUBMED   29180489
  REMARK    GeneRIF: TBX5 deficiency-mediated downregulation of NFAT3 is
            crucial for the high cytokine-producing activity of T cells
REFERENCE   6  (bases 1 to 4762)
  AUTHORS   Molkentin,J.D., Lu,J.R., Antos,C.L., Markham,B., Richardson,J.,
            Robbins,J., Grant,S.R. and Olson,E.N.
  TITLE     A calcineurin-dependent transcriptional pathway for cardiac
            hypertrophy
  JOURNAL   Cell 93 (2), 215-228 (1998)
   PUBMED   9568714
REFERENCE   7  (bases 1 to 4762)
  AUTHORS   Aramburu,J., Garcia-Cozar,F., Raghavan,A., Okamura,H., Rao,A. and
            Hogan,P.G.
  TITLE     Selective inhibition of NFAT activation by a peptide spanning the
            calcineurin targeting site of NFAT
  JOURNAL   Mol Cell 1 (5), 627-637 (1998)
   PUBMED   9660947
REFERENCE   8  (bases 1 to 4762)
  AUTHORS   Rao,A., Luo,C. and Hogan,P.G.
  TITLE     Transcription factors of the NFAT family: regulation and function
  JOURNAL   Annu Rev Immunol 15, 707-747 (1997)
   PUBMED   9143705
  REMARK    Review article
REFERENCE   9  (bases 1 to 4762)
  AUTHORS   Hoey,T., Sun,Y.L., Williamson,K. and Xu,X.
  TITLE     Isolation of two new members of the NF-AT gene family and
            functional characterization of the NF-AT proteins
  JOURNAL   Immunity 2 (5), 461-472 (1995)
   PUBMED   7749981
REFERENCE   10 (bases 1 to 4762)
  AUTHORS   Vacca,A., Farina,M., Maroder,M., Alesse,E., Screpanti,I., Frati,L.
            and Gulino,A.
  TITLE     Human immunodeficiency virus type-1 tat enhances interleukin-2
            promoter activity through synergism with phorbol ester and
            calcium-mediated activation of the NF-AT cis-regulatory motif
  JOURNAL   Biochem Biophys Res Commun 205 (1), 467-474 (1994)
   PUBMED   7999066
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC318153.1, BC053855.1,
            BC008857.2 and DB372155.1.
            
            On Nov 22, 2018 this sequence version replaced NM_004554.4.
            
            Summary: This gene encodes a member of the nuclear factor of
            activated T cells (NFAT) protein family. The encoded protein is
            part of a DNA-binding transcription complex. This complex consists
            of at least two components: a preexisting cytosolic component that
            translocates to the nucleus upon T cell receptor stimulation and an
            inducible nuclear component. NFAT proteins are activated by the
            calmodulin-dependent phosphatase, calcineurin. The encoded protein
            plays a role in the inducible expression of cytokine genes in T
            cells, especially in the induction of interleukin-2 and
            interleukin-4. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Jan 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053855.1, L41066.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000250373.9/ ENSP00000250373.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-382               DC318153.1         165-546
            383-717             BC053855.1         363-697
            718-1977            BC008857.2         383-1642
            1978-2915           BC053855.1         1958-2895
            2916-3216           BC008857.2         2581-2881
            3217-4118           BC053855.1         3197-4098
            4119-4236           DB372155.1         318-435             c
            4237-4762           BC053855.1         4217-4742
FEATURES             Location/Qualifiers
     source          1..4762
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q12"
     gene            1..4762
                     /gene="NFATC4"
                     /gene_synonym="NF-AT3; NF-ATC4; NFAT3"
                     /note="nuclear factor of activated T cells 4"
                     /db_xref="GeneID:4776"
                     /db_xref="HGNC:HGNC:7778"
                     /db_xref="MIM:602699"
     exon            1..257
                     /gene="NFATC4"
                     /gene_synonym="NF-AT3; NF-ATC4; NFAT3"
                     /inference="alignment:Splign:2.1.0"
     CDS             158..2866
                     /gene="NFATC4"
                     /gene_synonym="NF-AT3; NF-ATC4; NFAT3"
                     /note="isoform 2 is encoded by transcript variant 2;
                     nuclear factor of activated T-cells, cytoplasmic 4; T-cell
                     transcription factor NFAT3; nuclear factor of activated
                     T-cells, cytoplasmic, calcineurin-dependent 4"
                     /codon_start=1
                     /product="nuclear factor of activated T-cells, cytoplasmic
                     4 isoform 2"
                     /protein_id="NP_004545.2"
                     /db_xref="CCDS:CCDS9629.1"
                     /db_xref="GeneID:4776"
                     /db_xref="HGNC:HGNC:7778"
                     /db_xref="MIM:602699"
                     /translation="MGAASCEDEELEFKLVFGEEKEAPPLGAGGLGEELDSEDAPPCC
                     RLALGEPPPYGAAPIGIPRPPPPRPGMHSPPPRPAPSPGTWESQPARSVRLGGPGGGA
                     GGAGGGRVLECPSIRITSISPTPEPPAALEDNPDAWGDGSPRDYPPPEGFGGYREAGG
                     QGGGAFFSPSPGSSSLSSWSFFSDASDEAALYAACDEVESELNEAASRFGLGSPLPSP
                     RASPRPWTPEDPWSLYGPSPGGRGPEDSWLLLSAPGPTPASPRPASPCGKRRYSSSGT
                     PSSASPALSRRGSLGEEGSEPPPPPPLPLARDPGSPGPFDYVGAPPAESIPQKTRRTS
                     SEQAVALPRSEEPASCNGKLPLGAEESVAPPGGSRKEVAGMDYLAVPSPLAWSKARIG
                     GHSPIFRTSALPPLDWPLPSQYEQLELRIEVQPRAHHRAHYETEGSRGAVKAAPGGHP
                     VVKLLGYSEKPLTLQMFIGTADERNLRPHAFYQVHRITGKMVATASYEAVVSGTKVLE
                     MTLLPENNMAANIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHVPQGGGKVV
                     SVQAASVPIECSQRSAQELPQVEAYSPSACSVRGGEELVLTGSNFLPDSKVVFIERGP
                     DGKLQWEEEATVNRLQSNEVTLTLTVPEYSNKRVSRPVQVYFYVSNGRRKRSPTQSFR
                     FLPVICKEEPLPDSSLRGFPSASATPFGTDMDFSPPRPPYPSYPHEDPACETPYLSEG
                     FGYGMPPLYPQTGPPPSYRPGLRMFPETRGTTGCAQPPAVSFLPRPFPSDPYGGRGSS
                     FSLGLPFSPPAPFRPPPLPASPPLEGPFPSQSDVHPLPAEGYNKVGPGYGPGEGAPEQ
                     EKSRGGYSSGFRDSVPIQGITLEEVSEIIGRDLSGFPAPPGEEPPA"
     exon            258..1353
                     /gene="NFATC4"
                     /gene_synonym="NF-AT3; NF-ATC4; NFAT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1516
                     /gene="NFATC4"
                     /gene_synonym="NF-AT3; NF-ATC4; NFAT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1716
                     /gene="NFATC4"
                     /gene_synonym="NF-AT3; NF-ATC4; NFAT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..1889
                     /gene="NFATC4"
                     /gene_synonym="NF-AT3; NF-ATC4; NFAT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1890..2030
                     /gene="NFATC4"
                     /gene_synonym="NF-AT3; NF-ATC4; NFAT3"
                     /inference="alignment:Splign:2.1.0"
     exon            2031..2086
                     /gene="NFATC4"
                     /gene_synonym="NF-AT3; NF-ATC4; NFAT3"
                     /inference="alignment:Splign:2.1.0"
     exon            2087..2213
                     /gene="NFATC4"
                     /gene_synonym="NF-AT3; NF-ATC4; NFAT3"
                     /inference="alignment:Splign:2.1.0"
     exon            2214..2798
                     /gene="NFATC4"
                     /gene_synonym="NF-AT3; NF-ATC4; NFAT3"
                     /inference="alignment:Splign:2.1.0"
     exon            2799..4762
                     /gene="NFATC4"
                     /gene_synonym="NF-AT3; NF-ATC4; NFAT3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3195..3200
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NFATC4"
                     /gene_synonym="NF-AT3; NF-ATC4; NFAT3"
                     /note="hexamer: AATAAA"
     polyA_site      3217
                     /gene="NFATC4"
                     /gene_synonym="NF-AT3; NF-ATC4; NFAT3"
                     /note="major polyA site"
     regulatory      4739..4744
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NFATC4"
                     /gene_synonym="NF-AT3; NF-ATC4; NFAT3"
                     /note="hexamer: AATAAA"
     polyA_site      4762
                     /gene="NFATC4"
                     /gene_synonym="NF-AT3; NF-ATC4; NFAT3"
ORIGIN      
        1 ctataataac gagggggctt ctggagggag gcggcagcga cggaggaggg ggcttctcag
       61 agaaagggag ggagggagcc acccgggtga agatacagca gcctcctgaa ctcccccctc
      121 ccacccaggc cgggacctgg gggctcctgc cggatccatg ggggcggcca gctgcgagga
      181 tgaggagctg gaatttaagc tggtgttcgg ggaggaaaag gaggcccccc cgctgggcgc
      241 ggggggattg ggggaagaac tggactcaga ggatgccccg ccatgctgcc gtctggcctt
      301 gggagagccc cctccctatg gcgctgcacc tatcggtatt ccccgacctc caccccctcg
      361 gcctggcatg cattcgccac cgccgcgacc agccccctca cctggcacct gggagagcca
      421 gcccgccagg tcggtgaggc tgggaggacc aggagggggt gctgggggtg ctgggggtgg
      481 ccgtgttctc gagtgtccca gcatccgcat cacctccatc tctcccacgc cggagccgcc
      541 agcagcgctg gaggacaacc ctgatgcctg gggggacggc tctcctagag attacccccc
      601 accagaaggc tttgggggct acagagaagc agggggccag ggtggggggg ccttcttcag
      661 cccaagccct ggcagcagca gcctgtcctc gtggagcttc ttctccgatg cctctgacga
      721 ggcagccctg tatgcagcct gcgacgaggt ggagtctgag ctaaatgagg cggcctcccg
      781 ctttggcctg ggctccccgc tgccctcgcc ccgggcctcc cctcggccat ggacccccga
      841 agatccctgg agcctgtatg gtccaagccc cggaggccga gggccagagg atagctggct
      901 actcctcagt gctcctgggc ccaccccagc ctccccgcgg cctgcctctc catgtggcaa
      961 gcggcgctat tccagctcgg gaaccccatc ttcagcctcc ccagctctgt cccgccgtgg
     1021 cagcctgggg gaagaggggt ctgagccacc tccaccaccc ccattgcctc tggcccggga
     1081 cccgggctcc cctggtccct ttgactatgt gggggcccca ccagctgaga gcatccctca
     1141 gaagacacgg cggacttcca gcgagcaggc agtggctctg cctcggtctg aggagcctgc
     1201 ctcatgcaat gggaagctgc ccttgggagc agaggagtct gtggctcctc caggaggttc
     1261 ccggaaggag gtggctggca tggactacct ggcagtgccc tccccactcg cttggtccaa
     1321 ggcccggatt gggggacaca gccctatctt caggacctct gccctacccc cactggactg
     1381 gcctctgccc agccaatatg agcagctgga gctgaggatc gaggtacagc ctagagccca
     1441 ccaccgggcc cactatgaga cagaaggcag ccgtggagct gtcaaagctg cccctggcgg
     1501 tcaccccgta gtcaagctcc taggctacag tgagaagcca ctgaccctac agatgttcat
     1561 cggcactgca gatgaaagga acctgcggcc tcatgccttc tatcaggtgc accgtatcac
     1621 aggcaagatg gtggccacgg ccagctatga agccgtagtc agtggcacca aggtgttgga
     1681 gatgactctg ctgcctgaga acaacatggc ggccaacatt gactgcgcgg gaatcctgaa
     1741 gcttcggaat tcagacattg agcttcggaa gggtgagacg gacatcgggc gcaaaaacac
     1801 acgtgtacgg ctggtgttcc gggtacacgt gccccagggc ggcgggaagg tcgtctcagt
     1861 acaggcagca tcggtgccca tcgagtgctc ccagcgctca gcccaggagc tgccccaggt
     1921 ggaggcctac agccccagtg cctgctctgt gagaggaggc gaggaactgg tactgactgg
     1981 ctccaacttc ctgccagact ccaaggtggt gttcattgag aggggtcctg atgggaagct
     2041 gcaatgggag gaggaggcca cagtgaaccg actgcagagc aacgaggtga cgctgaccct
     2101 gactgtcccc gagtacagca acaagagggt ttcccggcca gtccaggtct acttttatgt
     2161 ctccaatggg cggaggaaac gcagtcctac ccagagtttc aggtttctgc ctgtgatctg
     2221 caaagaggag cccctaccgg actcatctct gcggggtttc ccttcagcat cggcaacccc
     2281 ctttggcact gacatggact tctcaccacc caggcccccc tacccctcct atccccatga
     2341 agaccctgct tgcgaaactc cttacctatc agaaggcttc ggctatggca tgccccctct
     2401 gtacccccag acggggcccc caccatccta cagaccgggc ctgcggatgt tccctgagac
     2461 taggggtacc acaggttgtg cccaaccacc tgcagtttcc ttccttcccc gccccttccc
     2521 tagtgacccg tatggagggc ggggctcctc tttctccctg gggctgccat tctctccgcc
     2581 agcccccttt cggccgcctc ctcttcctgc atccccaccg cttgaaggcc ccttcccttc
     2641 ccagagtgat gtgcatcccc tacctgctga gggatacaat aaggtagggc caggctatgg
     2701 ccctggggag ggggctccgg agcaggagaa atccaggggt ggctacagca gcggcttccg
     2761 agacagtgtc cctatccagg gtatcacgct ggaggaagtg agtgagatca ttggccgaga
     2821 cctgagtggc ttccctgcac ctcctggaga agagcctcct gcctgaacca cgtgaactgt
     2881 catcacctgg caaccccagc cccagcctca gccctgcccc ctttccctcc ttcctggagt
     2941 ggtggctaca gaagcttggg gccaaccctg gctcctcttt ccccagcttc tgtctgtctc
     3001 actgtcttcc ctcccctccc ccagctgagg tgtggccctc aggcctggtg ctgccttgga
     3061 gggctggggg aaggagtgtg tggaggaggg aggagggtga agactgaggc taggtgccag
     3121 aatggactgg agtgaaggcg tgtctagagt gtgggctggc tgttgtgctg gaaagctggg
     3181 gacaggttga tggtaataaa ctgctcaatg accagtgctt caggctccag agctctttgg
     3241 agagatgggt tggggcagct tactccagcc ctggcccaag gaggcccaga agttggaaag
     3301 agatggaatg tggctgggaa cattgcatcc caaagagctt ctcagtggag gaggctgggg
     3361 aaggcatgag ggggctcaga ggctccttga ctgggaccag gattgggggc cagggcttga
     3421 gtaggcctct ccactctcct ccttgggggt ccagattcct taggagcttt gggatgaggc
     3481 ccaggaggct gcatttttcc aggtccttag tcttgccacc acacagatga ttctgattca
     3541 tagccaagat gaggacacac tgatgtagct gatctctcat ttacagagga ggattctaaa
     3601 gttcagagag ggaaaggggc ttgcctgagg tcacgtagat aatcagcagc acattgaacg
     3661 ctgcactcct gggctcctgt ccccagcccc cattcagaca cgctgactca ggaggtccag
     3721 gcctctaagg cttctctccc tggagtgagg gtggaggtga gggagagctg gcacaagccc
     3781 tccctctgga tcctccactc ctggggatta tgaagatatt ctggaaagat ttgtgcttca
     3841 gaggtagact gcagaaagca aacagtctac ccagcagctc tgaatgtcac ctgccctggg
     3901 gcttacagca ctatatgagt tcctggccta tcctgcaaat atgcccatgc tggccttcta
     3961 aatagctggt acatccatca ccactgacgg gcctggcctg gaaacctggt ttgtcccctg
     4021 tcttgatggc ctacgagagg ccaagttcca ctgggctggg aaaagtcact ttgtctgtct
     4081 tgttcacctg gagcctgaca caccgtaggt actgagtaca aatagcttga tttggctagg
     4141 cttggctgca gggggacgtg cctaaaagac attccgggca tttgcacttg ggaaacttgc
     4201 ctcaccttca ggcttgtggg gcctctctat gcccaatgag tccaggcagt cctagcaagt
     4261 actcaggaga gcaggggtgg gtgtgacaga ggctggctct ggattggggg acaacagaac
     4321 cagagtaact cctcgcctgt tgctgctttg caatgaattt cctttacctt tctggaacac
     4381 aagctgctgt gaaccaaact gatatcaagt gattagctca ccgggccttg gttgcttttc
     4441 aaagatcccc ttcagccccc tgccagagtc actgccccat aatcaccatg tcagaaggga
     4501 ccctagggca ttcgtgtcct atttatcaat cttcagcacc acctctaaga tctctgagag
     4561 agggtggatc agcctctgtg taaacaaaaa gctgttagga cttgttgcct ctcaaggtgg
     4621 actattctgt tttctgccag gacactgcca ttcatgcatt gtcagatatt tattaaacag
     4681 cagcaaagtg ccagccaatt tgtcctggag gaattcatag cctcatgggg caaaagtaaa
     4741 taaacagctt attacaattc aa
//
