LOCUS       NM_032815               4564 bp    mRNA    linear   PRI 08-FEB-2025
DEFINITION  Homo sapiens nuclear factor of activated T cells 2 interacting
            protein (NFATC2IP), transcript variant 1, mRNA.
ACCESSION   NM_032815 XM_939369 XM_944125 XM_944127
VERSION     NM_032815.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4564)
  AUTHORS   Cho,T., Hoeg,L., Setiaputra,D. and Durocher,D.
  TITLE     NFATC2IP is a mediator of SUMO-dependent genome integrity
  JOURNAL   Genes Dev 38 (5-6), 233-252 (2024)
   PUBMED   38503515
  REMARK    GeneRIF: NFATC2IP is a mediator of SUMO-dependent genome integrity.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4564)
  AUTHORS   Xu,X., Li,N., Wang,Y., Yu,J. and Mi,J.
  TITLE     Calcium channel TRPV6 promotes breast cancer metastasis by NFATC2IP
  JOURNAL   Cancer Lett 519, 150-160 (2021)
   PUBMED   34265397
  REMARK    GeneRIF: Calcium channel TRPV6 promotes breast cancer metastasis by
            NFATC2IP.
REFERENCE   3  (bases 1 to 4564)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 4564)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 4564)
  AUTHORS   Koch,S., Knipfer,L., Kolle,J., Mirzakhani,H., Graser,A.,
            Zimmermann,T., Kiefer,A., Melichar,V.O., Rascher,W.,
            Papadopoulos,N.G., Rieker,R.J., Raby,B.A., Weiss,S.T., Wirtz,S. and
            Finotto,S.
  TITLE     Targeted deletion of NFAT-Interacting-Protein-(NIP) 45 resolves
            experimental asthma by inhibiting Innate Lymphoid Cells group 2
            (ILC2)
  JOURNAL   Sci Rep 9 (1), 15695 (2019)
   PUBMED   31666531
  REMARK    GeneRIF: Targeted deletion of NFAT-Interacting-Protein-(NIP) 45
            resolves experimental asthma by inhibiting Innate Lymphoid Cells
            group 2 (ILC2).
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4564)
  AUTHORS   Rietveld,C.A., Esko,T., Davies,G., Pers,T.H., Turley,P.,
            Benyamin,B., Chabris,C.F., Emilsson,V., Johnson,A.D., Lee,J.J., de
            Leeuw,C., Marioni,R.E., Medland,S.E., Miller,M.B., Rostapshova,O.,
            van der Lee,S.J., Vinkhuyzen,A.A., Amin,N., Conley,D.,
            Derringer,J., van Duijn,C.M., Fehrmann,R., Franke,L., Glaeser,E.L.,
            Hansell,N.K., Hayward,C., Iacono,W.G., Ibrahim-Verbaas,C.,
            Jaddoe,V., Karjalainen,J., Laibson,D., Lichtenstein,P.,
            Liewald,D.C., Magnusson,P.K., Martin,N.G., McGue,M., McMahon,G.,
            Pedersen,N.L., Pinker,S., Porteous,D.J., Posthuma,D.,
            Rivadeneira,F., Smith,B.H., Starr,J.M., Tiemeier,H., Timpson,N.J.,
            Trzaskowski,M., Uitterlinden,A.G., Verhulst,F.C., Ward,M.E.,
            Wright,M.J., Davey Smith,G., Deary,I.J., Johannesson,M., Plomin,R.,
            Visscher,P.M., Benjamin,D.J., Cesarini,D. and Koellinger,P.D.
  TITLE     Common genetic variants associated with cognitive performance
            identified using the proxy-phenotype method
  JOURNAL   Proc Natl Acad Sci U S A 111 (38), 13790-13794 (2014)
   PUBMED   25201988
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):E380. doi:
            10.1073/pnas.1424631112.. PMID: 25572966]
REFERENCE   7  (bases 1 to 4564)
  AUTHORS   Benita,Y., Cao,Z., Giallourakis,C., Li,C., Gardet,A. and
            Xavier,R.J.
  TITLE     Gene enrichment profiles reveal T-cell development,
            differentiation, and lineage-specific transcription factors
            including ZBTB25 as a novel NF-AT repressor
  JOURNAL   Blood 115 (26), 5376-5384 (2010)
   PUBMED   20410506
  REMARK    GeneRIF: ZBTB25 functions as a negative regulator of nuclear factor
            of activated T cells (NF-AT) activation, such that RNA interference
            mediated knockdown resulted in enhanced activation of target genes.
REFERENCE   8  (bases 1 to 4564)
  AUTHORS   Beausoleil,S.A., Villen,J., Gerber,S.A., Rush,J. and Gygi,S.P.
  TITLE     A probability-based approach for high-throughput protein
            phosphorylation analysis and site localization
  JOURNAL   Nat Biotechnol 24 (10), 1285-1292 (2006)
   PUBMED   16964243
REFERENCE   9  (bases 1 to 4564)
  AUTHORS   Novatchkova,M., Bachmair,A., Eisenhaber,B. and Eisenhaber,F.
  TITLE     Proteins with two SUMO-like domains in chromatin-associated
            complexes: the RENi (Rad60-Esc2-NIP45) family
  JOURNAL   BMC Bioinformatics 6, 22 (2005)
   PUBMED   15698469
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 4564)
  AUTHORS   Hodge,M.R., Chun,H.J., Rengarajan,J., Alt,A., Lieberson,R. and
            Glimcher,L.H.
  TITLE     NF-AT-Driven interleukin-4 transcription potentiated by NIP45
  JOURNAL   Science 274 (5294), 1903-1905 (1996)
   PUBMED   8943202
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC109460.3.
            
            On May 5, 2021 this sequence version replaced NM_032815.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038195.1784700.1,
                                           SRR14038191.378559.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000320805.9/ ENSP00000324792.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-462               AC109460.3         83490-83951
            463-535             AC109460.3         84685-84757
            536-653             AC109460.3         87118-87235
            654-734             AC109460.3         88531-88611
            735-921             AC109460.3         88704-88890
            922-1066            AC109460.3         91270-91414
            1067-1176           AC109460.3         91544-91653
            1177-4564           AC109460.3         96258-99645
FEATURES             Location/Qualifiers
     source          1..4564
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p11.2"
     gene            1..4564
                     /gene="NFATC2IP"
                     /gene_synonym="ESC2; NIP45; RAD60"
                     /note="nuclear factor of activated T cells 2 interacting
                     protein"
                     /db_xref="GeneID:84901"
                     /db_xref="HGNC:HGNC:25906"
                     /db_xref="MIM:614525"
     exon            1..462
                     /gene="NFATC2IP"
                     /gene_synonym="ESC2; NIP45; RAD60"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..1335
                     /gene="NFATC2IP"
                     /gene_synonym="ESC2; NIP45; RAD60"
                     /note="isoform 1 is encoded by transcript variant 1;
                     NFATC2-interacting protein; nuclear factor of activated
                     T-cells, cytoplasmic 2-interacting protein; 45 kDa
                     NFAT-interacting protein; nuclear factor of activated
                     T-cells, cytoplasmic, calcineurin-dependent 2 interacting
                     protein; 45 kDa NF-AT-interacting protein"
                     /codon_start=1
                     /product="NFATC2-interacting protein isoform 1"
                     /protein_id="NP_116204.3"
                     /db_xref="CCDS:CCDS10645.1"
                     /db_xref="GeneID:84901"
                     /db_xref="HGNC:HGNC:25906"
                     /db_xref="MIM:614525"
                     /translation="MAEPVGKRGRWSGGSGAGRGGRGGWGGRGRRPRAQRSPSRGTLD
                     VVSVDLVTDSDEEILEVATARGAADEVEVEPPEPPGPVASRDNSNSDSEGEDRRPAGP
                     PREPVRRRRRLVLDPGEAPLVPVYSGKVKSSLRLIPDDLSLLKLYPPGDEEEAELADS
                     SGLYHEGSPSPGSPWKTKLRTKDKEEKKKTEFLDLDNSPLSPPSPRTKSRTHTRALKK
                     LSEVNKRLQDLRSCLSPKPPQGQEQQGQEDEVVLVEGPTLPETPRLFPLKIRCRADLV
                     RLPLRMSEPLQSVVDHMATHLGVSPSRILLLFGETELSPTATPRTLKLGVADIIDCVV
                     LTSSPEATETSQQLQLRVQGKEKHQTLEVSLSRDSPLKTLMSHYEEAMGLSGRKLSFF
                     FDGTKLSGRELPADLGMESGDLIEVWG"
     exon            463..535
                     /gene="NFATC2IP"
                     /gene_synonym="ESC2; NIP45; RAD60"
                     /inference="alignment:Splign:2.1.0"
     exon            536..653
                     /gene="NFATC2IP"
                     /gene_synonym="ESC2; NIP45; RAD60"
                     /inference="alignment:Splign:2.1.0"
     exon            654..734
                     /gene="NFATC2IP"
                     /gene_synonym="ESC2; NIP45; RAD60"
                     /inference="alignment:Splign:2.1.0"
     exon            735..921
                     /gene="NFATC2IP"
                     /gene_synonym="ESC2; NIP45; RAD60"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1066
                     /gene="NFATC2IP"
                     /gene_synonym="ESC2; NIP45; RAD60"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1176
                     /gene="NFATC2IP"
                     /gene_synonym="ESC2; NIP45; RAD60"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..4564
                     /gene="NFATC2IP"
                     /gene_synonym="ESC2; NIP45; RAD60"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2142
                     /gene="NFATC2IP"
                     /gene_synonym="ESC2; NIP45; RAD60"
                     /note="major polyA site"
     regulatory      4544..4549
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NFATC2IP"
                     /gene_synonym="ESC2; NIP45; RAD60"
                     /note="hexamer: AATAAA"
     polyA_site      4564
                     /gene="NFATC2IP"
                     /gene_synonym="ESC2; NIP45; RAD60"
                     /note="major polyA site"
ORIGIN      
        1 tgcaaggcga aagtcgctga agggggcggg gcgaggcgag aggaggcggg cgtgtgttgt
       61 ggaggaaagt gtgccatggc ggagcctgtg gggaagcggg gccgctggtc cggaggtagc
      121 ggtgccggcc gagggggtcg gggcggctgg ggcggtcggg gccggcgtcc tcgggcccag
      181 cggtctccat cccggggcac gctggacgta gtgtctgtgg acttggtcac cgacagcgat
      241 gaggaaattc tggaggtcgc caccgctcgc ggtgccgcgg acgaggttga ggtggagccc
      301 ccggagcccc cggggccggt cgcgtcccgg gataacagca acagtgacag cgaaggggag
      361 gacaggcggc ccgcaggacc cccgcgggag ccggtcaggc ggcggcggcg gctggtgctg
      421 gatccggggg aggcgccgct ggttccggtg tactcgggga aggttaaaag cagccttcgc
      481 cttatcccag atgatctatc cctcctgaaa ctctaccctc caggggatga ggaagaggca
      541 gagctggcag attcgagtgg tctctaccat gagggctccc catcaccagg ctctccctgg
      601 aagacaaagc tgaggactaa ggataaagaa gagaagaaaa agacagagtt tctggatctg
      661 gacaactctc ctctgtcccc accttcacca aggaccaaaa gcagaacgca tactcgggca
      721 ctcaagaagt taagtgaggt gaacaagcgc ctccaggatc tccgttcctg tctgagcccc
      781 aagccacctc agggtcaaga gcaacagggc caagaggatg aagtggtctt ggtggaaggg
      841 cccaccctcc cagagacccc ccgactcttc ccactcaaaa tccgttgccg ggctgacctg
      901 gtcagattgc ccctcaggat gtcggagccc ctgcagagtg tggtggacca catggccacc
      961 caccttgggg tgtccccaag caggatcctt ttgctttttg gagagacaga gctatcacct
     1021 actgccactc ccaggaccct aaagctcgga gtggctgaca tcattgactg tgtggtacta
     1081 acaagttctc cagaggccac agagacgtcc caacagctcc agctccgggt gcagggaaag
     1141 gagaaacacc agacactgga agtctcactg tctcgagatt cccctctaaa gaccctcatg
     1201 tcccactatg aggaggccat gggactgtcg ggacggaagc tctccttctt ctttgatggg
     1261 acaaagcttt caggcaggga gctgccagct gacctgggca tggaatctgg ggacctcatt
     1321 gaggtctggg gctgacaccc cactccctgt ttgacggccc agcctggact tggggagaat
     1381 gactttccct tttttgcccc ataagggcta gcataagctg aggtagaact tatctttaag
     1441 ctgcagcaaa atcaaggagt gacttttgtc ccctctcctg ttgaccctgg tttagagccg
     1501 ttaaccactt ggtgagttat gtgggtgttg ttgccctggg tggcctgtgg ctccgtccac
     1561 aagtcatgct gagttttgca gcctctgtga cttggagatg tcccttcacc cctccccttt
     1621 caccaccatc ctcttttcct catggaaatg tctgctttat gaaactatgc acatattgaa
     1681 agtgagttga aacaaatgag ggttgggtag gagcttccag gcctgggatt tacaccacgc
     1741 ctagcccagc agaggcctta gtcccatttg gggcttggga gtgacatttg cttgaggctt
     1801 atacactggt gtggttgcct ggcttgcagg aaatgaccaa gctcacacat gctggctgaa
     1861 gcgtaagcag acaactgagg tactcttttg aaggatgaag gtggtggatt ctcagccctg
     1921 ggggtcttcc tcacctgagg acccttcaga gccacccttt ctagtttgca tttcctggtg
     1981 cacacattta aggcataaca gcacattcat ccctttggtt tgggatctca ggaatacagt
     2041 cccatgcaaa gattctctgg ttttatggct tttttccctt tctttacacc atcctctccc
     2101 ataagcaccc atgtctttga atatgaatgt atttgtaaaa taccacgttt catgtgtgaa
     2161 tatgtgcttt tactgtacat agtgctattg tgcaataggt cttatgctgt tttcactcaa
     2221 tgtgtgctaa gatctagccc cattgactct tctagaaatg cagtattgct ttgacctgcc
     2281 atgtggcact ccacaatgtc aattgcagtt tacacacatt gcctaaagtg ggggacacct
     2341 gggtgcccct gaccccttgg caccggatac aggccacgat aaacatcctt tcgtgtgttc
     2401 ccttctgtgc ttgtgtggca tgtgtaccca ggatgggcct ataggtcaca gaggtcagtt
     2461 tctctttggt tttccagatt ttctttagaa cggtgactga ccctcctact tgaggccgcc
     2521 cttttctcct tatccttgcc agcacttgta ttgccagact acctaatttt tgccagtctc
     2581 atgggtagat agtggtgcag tgctttaaca tacattcatc tgatcagcat taatttgggg
     2641 aattttttca cttagccttt ctggtttccc ttcctgtgca ttgcccattt tctcatggag
     2701 tttcttatct tttttggttt attctcagga gttgcttgta cattcttggg caattgcaga
     2761 taattccaag aatgcatatt tgggctgggt atggaggttc actggtaatc ccagcacttt
     2821 gggaggccca ggcagaagga tcgctgcagc ccaggagttc gagactagcc tgggcaacat
     2881 agcgagacct cgtctctaca aaaaaaaatt aaaaaggggg ctttgggagg ccaaggcggg
     2941 cagatcatga gggcaggaga ttgagaccct cctggccaac atggtgaaac cccgtctcta
     3001 ctaaaataca aaaaattagc tgggcatggt ggcgcacacc tgtagtccca gctactctgg
     3061 aggctgaggc aggggaatcg cttaaaccca ggaggcggag attgcagtga gccaaggttc
     3121 caccactgca ctccagcctg gcgacagagc aaggctccac tcaaaaaaaa gatttaaagg
     3181 ggaaaaaatt gaaattttct ttgtatctag gggtatccgt cactgaacag aaattcttaa
     3241 ttttggctag gcgtgatggc tcaggtctgt aatcccagca ctttcggtgg ccggggtggg
     3301 tggatcactt gaggccagga gttcaagacc accctgacca acttggtgaa atcccatctc
     3361 tactaaaaat acaaaaatta gctgggtgca gtggcgcatg cttgtaatcc cagctactca
     3421 ggaggcagag gcaggagaat cacttgaacc cgggaggtgg aggctgcagt gaacagagac
     3481 agtgccactg cacatcagcc tgagtgacag agagactttg tctcaaaaaa aaaagaaaat
     3541 tttaatttta atgtagacag tatgaattat cttgttctgc agttggttgc tttttgattg
     3601 cttatttaat agagttgtta agatatttta catcttctcc tgttagctgt tcagcttttc
     3661 ctttcatatt gagaacacta cacagtgctg aagtccagct ggtacacacc ggggtgacac
     3721 cttggctgca tctgttctca acagtcagac acttcttcta attggttgat gctgggctgt
     3781 actggttgct aaatattgca catcatttta aaactatttg agatgcactt ttgtactcag
     3841 gaggccaagg caggaggatt gcttgagccc aggagtttga gaccagcctg ggcaacacag
     3901 cgagaccttg tctcttaaaa aaaaaaaaaa aaaaaaatga gagaaatcgg ctgggcatgg
     3961 tttctcatgc ctgtaatccc agaactttgg gaggctgagg caggtggatc accggaggtt
     4021 aggaattcaa gactgaaacc ttgtctctac tgaaaataca aaaaaaaaaa aaaaaaaaaa
     4081 tgagctaggt gtggtggcag gcgcctgtaa tcccagttac ttcgggaggc tgaggcagga
     4141 gaatcgcttg aacccaggag gcagaggttg cagtgagcca agatcgcgcc attgcactcc
     4201 agcctgggcg acaagagtgg aaactctgtc tcaaaaaaaa aaaaaaaaat tcagtgaaat
     4261 acacctttat atatgagatc caagtttcac tttttgtgat ataatgagcc agttttctca
     4321 gtaatgtcta ctaaaaaaaa agccattaac ctttctctaa tatttgcatg attctaataa
     4381 aagtatgtca acttcttaaa atgttttatt gaaatgtggc attcctttga attttatgac
     4441 attaaaataa tccacgacat ggtacagctc ttcacttttt cagcttttta aatgtccatt
     4501 aataagtttg aatacgttaa aattatatgt ttaacctcaa caaaataaat ggcaatatgt
     4561 tcaa
//
