LOCUS       NM_012340               7519 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens nuclear factor of activated T cells 2 (NFATC2),
            transcript variant 1, mRNA.
ACCESSION   NM_012340
VERSION     NM_012340.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7519)
  AUTHORS   Xiao,Z.J., Wang,S.Q., Chen,J.J., Li,Y., Jiang,Y., Tin,V.P., Liu,J.,
            Hu,H., Wong,M.P., Pan,Y. and Yam,J.W.P.
  TITLE     The Dual Role of the NFATc2/galectin-9 Axis in Modulating
            Tumor-Initiating Cell Phenotypes and Immune Suppression in Lung
            Adenocarcinoma
  JOURNAL   Adv Sci (Weinh) 11 (20), e2306059 (2024)
   PUBMED   38528665
  REMARK    GeneRIF: The Dual Role of the NFATc2/galectin-9 Axis in Modulating
            Tumor-Initiating Cell Phenotypes and Immune Suppression in Lung
            Adenocarcinoma.
REFERENCE   2  (bases 1 to 7519)
  AUTHORS   Ge,L., Rui,Y., Wang,C., Wu,Y., Wang,H. and Wang,J.
  TITLE     The RNA m6A reader IGF2BP3 regulates NFAT1/IRF1 axis-mediated
            anti-tumor activity in gastric cancer
  JOURNAL   Cell Death Dis 15 (3), 192 (2024)
   PUBMED   38448411
  REMARK    GeneRIF: The RNA m[6]A reader IGF2BP3 regulates NFAT1/IRF1
            axis-mediated anti-tumor activity in gastric cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7519)
  AUTHORS   Liu,L., Li,L., Ding,Y., Kong,F., Mo,W., Ye,H. and Shen,D.
  TITLE     Report and literature review of four cases of EWSR1::NFATC2 round
            cell sarcoma
  JOURNAL   Diagn Pathol 19 (1), 19 (2024)
   PUBMED   38254207
  REMARK    GeneRIF: Report and literature review of four cases of
            EWSR1::NFATC2 round cell sarcoma.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7519)
  AUTHORS   Vittal,R., Walker,N.M., McLinden,A.P., Braeuer,R.R., Ke,F.,
            Fattahi,F., Combs,M.P., Misumi,K., Aoki,Y., Wheeler,D.S.,
            Wilke,C.A., Huang,S.K., Moore,B.B., Cao,P. and Lama,V.N.
  TITLE     Genetic deficiency of the transcription factor NFAT1 confers
            protection against fibrogenic responses independent of immune
            influx
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 326 (1), L39-L51 (2024)
   PUBMED   37933452
  REMARK    GeneRIF: Genetic deficiency of the transcription factor NFAT1
            confers protection against fibrogenic responses independent of
            immune influx.
REFERENCE   5  (bases 1 to 7519)
  AUTHORS   Malsy,M., Graf,B., Bruendl,E., Maier-Stocker,C. and Bundscherer,A.
  TITLE     Effect of NFATc2- and Sp1-mediated TNFalpha Regulation on the
            Proliferation and Migration Behavior of Pancreatic Cancer Cells
  JOURNAL   Cancer Genomics Proteomics 20 (6suppl), 706-711 (2023)
   PUBMED   38035702
  REMARK    GeneRIF: Effect of NFATc2- and Sp1-mediated TNFalpha Regulation on
            the Proliferation and Migration Behavior of Pancreatic Cancer
            Cells.
REFERENCE   6  (bases 1 to 7519)
  AUTHORS   Aramburu,J., Azzoni,L., Rao,A. and Perussia,B.
  TITLE     Activation and expression of the nuclear factors of activated T
            cells, NFATp and NFATc, in human natural killer cells: regulation
            upon CD16 ligand binding
  JOURNAL   J Exp Med 182 (3), 801-810 (1995)
   PUBMED   7650486
REFERENCE   7  (bases 1 to 7519)
  AUTHORS   Auffray,C., Behar,G., Bois,F., Bouchier,C., Da Silva,C.,
            Devignes,M.D., Duprat,S., Houlgatte,R., Jumeau,M.N., Lamy,B. et al.
  TITLE     [IMAGE: molecular integration of the analysis of the human genome
            and its expression]
  JOURNAL   C R Acad Sci III 318 (2), 263-272 (1995)
   PUBMED   7757816
REFERENCE   8  (bases 1 to 7519)
  AUTHORS   Li,X., Ho,S.N., Luna,J., Giacalone,J., Thomas,D.J., Timmerman,L.A.,
            Crabtree,G.R. and Francke,U.
  TITLE     Cloning and chromosomal localization of the human and murine genes
            for the T-cell transcription factors NFATc and NFATp
  JOURNAL   Cytogenet Cell Genet 68 (3-4), 185-191 (1995)
   PUBMED   7842733
REFERENCE   9  (bases 1 to 7519)
  AUTHORS   Vacca,A., Farina,M., Maroder,M., Alesse,E., Screpanti,I., Frati,L.
            and Gulino,A.
  TITLE     Human immunodeficiency virus type-1 tat enhances interleukin-2
            promoter activity through synergism with phorbol ester and
            calcium-mediated activation of the NF-AT cis-regulatory motif
  JOURNAL   Biochem Biophys Res Commun 205 (1), 467-474 (1994)
   PUBMED   7999066
REFERENCE   10 (bases 1 to 7519)
  AUTHORS   Ho,S., Timmerman,L., Northrop,J. and Crabtree,G.R.
  TITLE     Cloning and characterization of NF-ATc and NF-ATp: the cytoplasmic
            components of NF-AT
  JOURNAL   Adv Exp Med Biol 365, 167-173 (1994)
   PUBMED   7887301
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from EU887576.1, EU887573.1,
            AL035682.16 and BE674599.1.
            
            On Nov 22, 2018 this sequence version replaced NM_012340.4.
            
            Summary: This gene is a member of the nuclear factor of activated T
            cells (NFAT) family. The product of this gene is a DNA-binding
            protein with a REL-homology region (RHR) and an NFAT-homology
            region (NHR). This protein is present in the cytosol and only
            translocates to the nucleus upon T cell receptor (TCR) stimulation,
            where it becomes a member of the nuclear factors of activated T
            cells transcription complex. This complex plays a central role in
            inducing gene transcription during the immune response. Alternate
            transcriptional splice variants encoding different isoforms have
            been characterized. [provided by RefSeq, Apr 2012].
            
            Transcript Variant: This variant (1) contains an alternate exon in
            the 3' end compared to variant 2, that causes a frameshift. The
            resulting isoform (B) has a shorter and distinct C-terminus
            compared to isoform C.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EU887573.1, BC144074.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371564.8/ ENSP00000360619.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-220               EU887576.1         1-220
            221-3254            EU887573.1         1-3034
            3255-7281           AL035682.16        6936-10962          c
            7282-7519           BE674599.1         12-249              c
FEATURES             Location/Qualifiers
     source          1..7519
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.2"
     gene            1..7519
                     /gene="NFATC2"
                     /gene_synonym="JCOSL; NFAT1; NFATP"
                     /note="nuclear factor of activated T cells 2"
                     /db_xref="GeneID:4773"
                     /db_xref="HGNC:HGNC:7776"
                     /db_xref="MIM:600490"
     exon            1..350
                     /gene="NFATC2"
                     /gene_synonym="JCOSL; NFAT1; NFATP"
                     /inference="alignment:Splign:2.1.0"
     CDS             221..2986
                     /gene="NFATC2"
                     /gene_synonym="JCOSL; NFAT1; NFATP"
                     /note="isoform B is encoded by transcript variant 1;
                     nuclear factor of activated T-cells, preexisting
                     component; NFAT transcription complex, preexisting
                     component; nuclear factor of activated T-cells,
                     cytoplasmic 2; T cell transcription factor NFAT1; NFAT
                     pre-existing subunit; preexisting nuclear factor of
                     activated T-cells 2; NF-ATc2; nuclear factor of activated
                     T-cells, cytoplasmic, calcineurin-dependent 2"
                     /codon_start=1
                     /product="nuclear factor of activated T-cells, cytoplasmic
                     2 isoform B"
                     /protein_id="NP_036472.2"
                     /db_xref="CCDS:CCDS33488.1"
                     /db_xref="GeneID:4773"
                     /db_xref="HGNC:HGNC:7776"
                     /db_xref="MIM:600490"
                     /translation="MNAPERQPQPDGGDAPGHEPGGSPQDELDFSILFDYEYLNPNEE
                     EPNAHKVASPPSGPAYPDDVLDYGLKPYSPLASLSGEPPGRFGEPDRVGPQKFLSAAK
                     PAGASGLSPRIEITPSHELIQAVGPLRMRDAGLLVEQPPLAGVAASPRFTLPVPGFEG
                     YREPLCLSPASSGSSASFISDTFSPYTSPCVSPNNGGPDDLCPQFQNIPAHYSPRTSP
                     IMSPRTSLAEDSCLGRHSPVPRPASRSSSPGAKRRHSCAEALVALPPGASPQRSRSPS
                     PQPSSHVAPQDHGSPAGYPPVAGSAVIMDALNSLATDSPCGIPPKMWKTSPDPSPVSA
                     APSKAGLPRHIYPAVEFLGPCEQGERRNSAPESILLVPPTWPKPLVPAIPICSIPVTA
                     SLPPLEWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLHGYME
                     NKPLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEIPLEPKNN
                     MRATIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSLQTASNP
                     IECSQRSAHELPMVERQDTDSCLVYGGQQMILTGQNFTSESKVVFTEKTTDGQQIWEM
                     EATVDKDKSQPNMLFVEIPEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPVPAIK
                     TEPTDEYDPTLICSPTHGGLGSQPYYPQHPMVAESPSCLVATMAPCQQFRTGLSSPDA
                     RYQQQNPAAVLYQRSKSLSPSLLGYQQPALMAAPLSLADAHRSVLVHAGSQGQSSALL
                     HPSPTNQQASPVIHYSPTNQQLRCGSHQEFQHIMYCENFAPGTTRPGPPPVSQGQRLS
                     PGSYPTVIQQQNATSQRAAKNGPPVSDQKEVLPAGVTIKQEQNLDQTYLDDELIDTHL
                     SWIQNIL"
     exon            351..1380
                     /gene="NFATC2"
                     /gene_synonym="JCOSL; NFAT1; NFATP"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1552
                     /gene="NFATC2"
                     /gene_synonym="JCOSL; NFAT1; NFATP"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1755
                     /gene="NFATC2"
                     /gene_synonym="JCOSL; NFAT1; NFATP"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..1928
                     /gene="NFATC2"
                     /gene_synonym="JCOSL; NFAT1; NFATP"
                     /inference="alignment:Splign:2.1.0"
     exon            1929..2069
                     /gene="NFATC2"
                     /gene_synonym="JCOSL; NFAT1; NFATP"
                     /inference="alignment:Splign:2.1.0"
     exon            2070..2125
                     /gene="NFATC2"
                     /gene_synonym="JCOSL; NFAT1; NFATP"
                     /inference="alignment:Splign:2.1.0"
     exon            2126..2252
                     /gene="NFATC2"
                     /gene_synonym="JCOSL; NFAT1; NFATP"
                     /inference="alignment:Splign:2.1.0"
     exon            2253..2942
                     /gene="NFATC2"
                     /gene_synonym="JCOSL; NFAT1; NFATP"
                     /inference="alignment:Splign:2.1.0"
     exon            2943..3030
                     /gene="NFATC2"
                     /gene_synonym="JCOSL; NFAT1; NFATP"
                     /inference="alignment:Splign:2.1.0"
     exon            3031..7519
                     /gene="NFATC2"
                     /gene_synonym="JCOSL; NFAT1; NFATP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7500..7505
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NFATC2"
                     /gene_synonym="JCOSL; NFAT1; NFATP"
                     /note="hexamer: AATAAA"
     polyA_site      7519
                     /gene="NFATC2"
                     /gene_synonym="JCOSL; NFAT1; NFATP"
                     /note="major polyA site"
ORIGIN      
        1 agcaggaagc tcgcgccgcc gtcgccgccg ccgctcagct tccccgggcg cgtccaggac
       61 ccgctgcgcc aggcgcgccg tccccggacc cggcgtgcgt ccctacgagg aaagggaccc
      121 cgccgctcga gccgcctccg ccagccccac tgcgaggggt cccagagcca gccgcgcccg
      181 ccctcgcccc cggccccgca gccttcccgc cctgcgcgcc atgaacgccc ccgagcggca
      241 gccccaaccc gacggcgggg acgccccagg ccacgagcct gggggcagcc cccaagacga
      301 gcttgacttc tccatcctct tcgactatga gtatttgaat ccgaacgaag aagagccgaa
      361 tgcacataag gtcgccagcc caccctccgg acccgcatac cccgatgatg tcctggacta
      421 tggcctcaag ccatacagcc cccttgctag tctctctggc gagccccccg gccgattcgg
      481 agagccggat agggtagggc cgcagaagtt tctgagcgcg gccaagccag caggggcctc
      541 gggcctgagc cctcggatcg agatcactcc gtcccacgaa ctgatccagg cagtggggcc
      601 cctccgcatg agagacgcgg gcctcctggt ggagcagccg cccctggccg gggtggccgc
      661 cagcccgagg ttcaccctgc ccgtgcccgg cttcgagggc taccgcgagc cgctttgctt
      721 gagccccgct agcagcggct cctctgccag cttcatttct gacaccttct ccccctacac
      781 ctcgccctgc gtctcgccca ataacggcgg gcccgacgac ctgtgtccgc agtttcaaaa
      841 catccctgct cattattccc ccagaacctc gccaataatg tcacctcgaa ccagcctcgc
      901 cgaggacagc tgcctgggcc gccactcgcc cgtgccccgt ccggcctccc gctcctcatc
      961 gcctggtgcc aagcggaggc attcgtgcgc cgaggccttg gttgccctgc cgcccggagc
     1021 ctcaccccag cgctcccgga gcccctcgcc gcagccctca tctcacgtgg caccccagga
     1081 ccacggctcc ccggctgggt acccccctgt ggctggctct gccgtgatca tggatgccct
     1141 gaacagcctc gccacggact cgccttgtgg gatccccccc aagatgtgga agaccagccc
     1201 tgacccctcg ccggtgtctg ccgccccatc caaggccggc ctgcctcgcc acatctaccc
     1261 ggccgtggag ttcctggggc cctgcgagca gggcgagagg agaaactcgg ctccagaatc
     1321 catcctgctg gttccgccca cttggcccaa gccgctggtg cctgccattc ccatctgcag
     1381 catcccagtg actgcatccc tccctccact tgagtggccg ctgtccagtc agtcaggctc
     1441 ttacgagctg cggatcgagg tgcagcccaa gccacatcac cgggcccact atgagacaga
     1501 aggcagccga ggggctgtca aagctccaac tggaggccac cctgtggttc agctccatgg
     1561 ctacatggaa aacaagcctc tgggacttca gatcttcatt gggacagctg atgagcggat
     1621 ccttaagccg cacgccttct accaggtgca ccgaatcacg gggaaaactg tcaccaccac
     1681 cagctatgag aagatagtgg gcaacaccaa agtcctggag atacccttgg agcccaaaaa
     1741 caacatgagg gcaaccatcg actgtgcggg gatcttgaag cttagaaacg ccgacattga
     1801 gctgcggaaa ggcgagacgg acattggaag aaagaacacg cgggtgagac tggttttccg
     1861 agttcacatc ccagagtcca gtggcagaat cgtctcttta cagactgcat ctaaccccat
     1921 cgagtgctcc cagcgatctg ctcacgagct gcccatggtt gaaagacaag acacagacag
     1981 ctgcctggtc tatggcggcc agcaaatgat cctcacgggg cagaacttta catccgagtc
     2041 caaagttgtg tttactgaga agaccacaga tggacagcaa atttgggaga tggaagccac
     2101 ggtggataag gacaagagcc agcccaacat gctttttgtt gagatccctg aatatcggaa
     2161 caagcatatc cgcacacctg taaaagtgaa cttctacgtc atcaatggga agagaaaacg
     2221 aagtcagcct cagcacttta cctaccaccc agtcccagcc atcaagacgg agcccacgga
     2281 tgaatatgac cccactctga tctgcagccc cacccatgga ggcctgggga gccagcctta
     2341 ctacccccag cacccgatgg tggccgagtc cccctcctgc ctcgtggcca ccatggctcc
     2401 ctgccagcag ttccgcacgg ggctctcatc ccctgacgcc cgctaccagc aacagaaccc
     2461 agcggccgta ctctaccagc ggagcaagag cctgagcccc agcctgctgg gctatcagca
     2521 gccggccctc atggccgccc cgctgtccct tgcggacgct caccgctctg tgctggtgca
     2581 cgccggctcc cagggccaga gctcagccct gctccacccc tctccgacca accagcaggc
     2641 ctcgcctgtg atccactact cacccaccaa ccagcagctg cgctgcggaa gccaccagga
     2701 gttccagcac atcatgtact gcgagaattt cgcaccaggc accaccagac ctggcccgcc
     2761 cccggtcagt caaggtcaga ggctgagccc gggttcctac cccacagtca ttcagcagca
     2821 gaatgccacg agccaaagag ccgccaaaaa cggacccccg gtcagtgacc aaaaggaagt
     2881 attacctgcg ggggtgacca ttaaacagga gcagaacttg gaccagacct acttggatga
     2941 tgagctgata gacacacacc ttagctggat acaaaacata ttatgaaaca gaatgactgt
     3001 gatctttgat ccgagaaatc aaagttaaag ttaatgaaat tatcaggaag gagttttcag
     3061 gacctcctgc cagaaatcag acgtaaaaga agccattata gcaagacacc ttctgtatct
     3121 gacccctcgg agccctccac agcccctcac cttctgtctc ctttcatgtt catctcccag
     3181 cccggagtcc acacgcggat caatgtatgg gcactaagcg gactctcact taaggagctc
     3241 gccacctccc tctaaacacc agagagaact cttcttttcg gtttatgttt taaatcccag
     3301 agagcatcct ggttgatctt aatggtgttc cgtccaaata gtaagcacct gctgaccaaa
     3361 agcacattct acatgagaca ggacactgga actctcctga gaacagagtg actggagctt
     3421 ggggggatgg acgggggaca gaagatgtgg gcactgtgat taaaccccag cccttgcgtt
     3481 cgtttttcca ggtcacagat acagctcctg taccttttga aggcaaggag ttctcagagc
     3541 aaccaaagga acgtgaccca agagcccagc ttacaggctg aagaaaccca aaaccctcga
     3601 tagagacaga aactgaactg tcagtcctta gagctcgccc agtccatgcc acaactgggc
     3661 cacagctaaa gctttatttt tgaattctca ttccaaaacc aaactgtctt gcccagacaa
     3721 gatcacctgt taagacttct tggcgttaag ttatgacatg tatacgcgtt tgttattatt
     3781 attttttctg ctttaaaagg ctgaccaggg cacctagccc tggagctgtc ttggcgagct
     3841 gttctttaac ccctgcagca cgcagtcctg ctaacacaat ttccatagac ttggggggct
     3901 gacccaggct gcagagagca agcacctgtc tgctgcagct gtacaacctg gatgctttgc
     3961 aaggttccgg cttgctttct tcctagcagc cagagtgctt ttccgtaaag cggtggagaa
     4021 tctcaagcat gtgcatttaa ttgaggaata gcagaagggc taaagcaacc aagaaaagaa
     4081 gtgtgggtat ttttgttaag taaaacagcc caagtgcttc tggaggtggg tttctaccaa
     4141 gatagaggaa aagggctgaa ttccctctaa gtgggacagc cgagctcagg atgtgcttcc
     4201 cagcttcact ggttaatttg acctgaacct atttaaagat cccttctgcc cctgaagacc
     4261 tatccgcact caaattctaa catgaagaaa tctactcgaa tgcatccttt actttgaatg
     4321 agctctattc ggttgcatgt tatatgtgat ttccttcctc ccaactgttt ccactgagcg
     4381 cacccagtct cccctagtct tcctctgtgg gtgtgatttt tgtgattttt acaaacaaaa
     4441 cccttgaagt tcttggcaga tgtgtttgtt tctgtttgca tgtactgcag ataccccagg
     4501 acaagcgggg gattcatttt tcagccattc agttgtttcc tcaataatcc gcagcaaagt
     4561 gaaaatattc ttagcactca gactgtactt agagtgtttt ctcagtccag tctgtacagt
     4621 ctgtaggcag aaggcctcag aagaaagtca tggccactca gtgcccactg tgggctttgt
     4681 aagtcctggc tctcccgtca aggttaccca gaggtaaaag cttcctggga gtggggccag
     4741 gtgtgtttgg cactccagat agaaggcaaa atgctcagat tcgggcctgt gcacttgtat
     4801 gcaacctgtc ggtcgatacc tagcatttat ttttccctga caatgaacga cctttccctc
     4861 acccacccta agctcaaaga gtttagcaaa attctctttt aaataaacag aatgccagta
     4921 agaggttgac ccctaccatg gaacttctgg gatgctaaat acttcctcat gaacaaaata
     4981 agttccttat tataagttcc ttatactagc agcttcacct aaagaatttt ctctccagca
     5041 atattgactt cactggggaa aagccaagag tgtgtggtga gtgatttgtt ctcactcgac
     5101 ctggctagga ctggctagga gctgtttttt gtacatgagg gaatttgggc tttcctcagt
     5161 tatctgaatg ttttacccaa gtgccttcct gctattgtag caaagtagct cagcttcctt
     5221 gtccacaggg tgaaaaagga ctaatgcatt ttccatcagt tttctaacta tgttagcaaa
     5281 aacggcctcc tggtagctca acctcctgta cgcgtgtgtg tgtgtaatac acacacaaat
     5341 aaacccctct gtttttctaa gacatcttag ctggatatta taggaagcac tttcataaac
     5401 aactgtaaca aatcgcaaag gaaagagaaa caaaagcatt agatttgaga cataaacagg
     5461 caagagaaag tgtattagga actgacagct atcaaggaag ttttgtcagt tacaaatgct
     5521 aggaggaaat tttgccaaga aggatggctc atgaaatatt tccagtacgg gaagaggcaa
     5581 taagatcctc taagagaatg agaaagtagg ggtgtctaaa tggtaaagat gggtgtgttg
     5641 cacgtgtgtt agaaggatct cagttgagtg aaggtttgca ctgctacatc taagttaatg
     5701 taaatatgta gcactctgac aggtctaccg tgttgctgaa tgtagtatat ttccaaagtt
     5761 tgcaagtctt cctgtattgt acaaagatgc tgctgcttga taatatgtat agcaatccag
     5821 attagtatgt tattaaattt tattttctta cctgtatttt tatgcttttt acctgtcctc
     5881 aaaatattac acccctgttg gaattagatt tatatttata aatggtcaga aatcttttta
     5941 agtgtctctt tttacacata ggttgatttt tttttcttaa gagaaatgat gtattcttga
     6001 aacatttgtt actcattcca ggaaacaaaa acccatataa taaaaccccc actcagagcc
     6061 tgttagtcac ctctctagaa gatggcatct caggagaagg aatggctttg tggaagaagg
     6121 aatcaccttt ttcttgctca agaattatgc tgacttcagc cctgagcctg gatctggtca
     6181 ctgagaatca tcaagtgtct agatcctccc cccaaaataa ctaatttagt aggtgatttt
     6241 gattttaaaa aattgacacc aaaaccctgc ctgcattgta atggaattcg aaaagaattc
     6301 atgttcacag aactcaacgt tcaggctaat atttacagaa gggaccaaat ctaaatcctg
     6361 gtagataact cctgtatgct ttatccaaag gacacccaca gttttccagc atagatataa
     6421 ccaaggatga attgattcct tcaaagaact gggaggcacg gatattgcat tttttgttta
     6481 catccagtag ccaagacgcc tcagtgagcc agtcttgggc agaggctgtc acatttaggc
     6541 agattggaag ttggtatgtt ctaattctca ctctggacta cagtgaggct gaatttatca
     6601 tgtcaaaaaa aaaaaaaaaa aaagaccttt ccaagtgctt tctattgctc agaattgaaa
     6661 gaatgttttc atttcaagtt tacaagaggc atggatggag ttgtgacgtt cttgacaagc
     6721 tgggctaacc tttcccgaac ttgtttcccg gaggcaaggt gctcggtgac ccagcgcatc
     6781 ttaaccttgg gtctcctagg ctcgaggcta gggcattacg tttcgtggaa ccaaagcagc
     6841 caattgcata gcaagtattt tcctgcattc caattaaatg cttaagaaaa agcagcatcc
     6901 tataaaattg tgatcataaa catccatttc cctcagcttt tgtgagtgcc ttgacttaca
     6961 gccaacatca ctgtttaact cagtctgttt aaaaacaaac ttttctggtg gttgataaca
     7021 gagagttgct ccctgagcca tcagggtcct gggagctgga agtgaaaggg ttattaacat
     7081 tctaccttta tgcagctgtt ggctgaccag aataaactcc ctgctgagtt caagctttga
     7141 atggaatgga tgcaaatgat gttgtttcca ttagagcagg tgctcacagc attctgattg
     7201 gcctgagcag accgaggcta tggctgttgg gacaagctta gcatcctgga catcttgtca
     7261 aagaacctca ctcacccctc tggcctctac agccctcaga ggagagaaaa ccaattctcc
     7321 aacaaacagg tctctccaac atggtggtgc tggcaggctt aggtttagaa aatcctgact
     7381 gttaaaggcg tttgaataca tcacattcct atgcaaatgt ttttaatctc cagtttaatg
     7441 tagtttattt ttcctatatg taaagtattt ttatacggct tgtatcatga tagtttagca
     7501 ataaaacagt tggaagcaa
//
