LOCUS       NM_138713              13289 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens nuclear factor of activated T cells 5 (NFAT5),
            transcript variant 2, mRNA.
ACCESSION   NM_138713
VERSION     NM_138713.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 13289)
  AUTHORS   Deng,D., Begum,H., Liu,T., Zhang,J., Zhang,Q., Chu,T.Y., Li,H.,
            Lemenze,A., Hoque,M., Soteropoulos,P. and Hou,P.
  TITLE     NFAT5 governs cellular plasticity-driven resistance to
            KRAS-targeted therapy in pancreatic cancer
  JOURNAL   J Exp Med 221 (11) (2024)
   PUBMED   39432061
  REMARK    GeneRIF: NFAT5 governs cellular plasticity-driven resistance to
            KRAS-targeted therapy in pancreatic cancer.
REFERENCE   2  (bases 1 to 13289)
  AUTHORS   Li,J.Y., Feng,T.S., Gao,J., Yang,X.X., Li,X.C., Deng,Z.H., Xia,Y.X.
            and Wu,Z.S.
  TITLE     Differentiation and immunosuppressive function of CD19+CD24hiCD27+
            regulatory B cells are regulated through the miR-29a-3p/NFAT5
            pathway
  JOURNAL   Hepatobiliary Pancreat Dis Int 23 (5), 472-480 (2024)
   PUBMED   38724321
  REMARK    GeneRIF: Differentiation and immunosuppressive function of
            CD19[+]CD24[hi]CD27[+] regulatory B cells are regulated through the
            miR-29a-3p/NFAT5 pathway.
REFERENCE   3  (bases 1 to 13289)
  AUTHORS   Okumura,T., Raja Xavier,J.P., Pasternak,J., Yang,Z., Hang,C.,
            Nosirov,B., Singh,Y., Admard,J., Brucker,S.Y., Kommoss,S.,
            Takeda,S., Staebler,A., Lang,F. and Salker,M.S.
  TITLE     Rel Family Transcription Factor NFAT5 Upregulates COX2 via
            HIF-1alpha Activity in Ishikawa and HEC1a Cells
  JOURNAL   Int J Mol Sci 25 (7), 3666 (2024)
   PUBMED   38612478
  REMARK    GeneRIF: Rel Family Transcription Factor NFAT5 Upregulates COX2 via
            HIF-1alpha Activity in Ishikawa and HEC1a Cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 13289)
  AUTHORS   Song,H.J., Kim,Y.H., Choi,H.N., Kim,T., Kim,S.J., Kang,M.W. and
            Lee,S.D.
  TITLE     TonEBP/NFAT5 expression is associated with cisplatin resistance and
            migration in macrophage-induced A549 cells
  JOURNAL   BMC Mol Cell Biol 25 (1), 6 (2024)
   PUBMED   38438872
  REMARK    GeneRIF: TonEBP/NFAT5 expression is associated with cisplatin
            resistance and migration in macrophage-induced A549 cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 13289)
  AUTHORS   Zhou,G., Chen,C., Wu,H., Lin,J., Liu,H., Tao,Y. and Huang,B.
  TITLE     LncRNA AP000842.3 Triggers the Malignant Progression of Prostate
            Cancer by Regulating Cuproptosis Related Gene NFAT5
  JOURNAL   Technol Cancer Res Treat 23, 15330338241255585 (2024)
   PUBMED   38780486
  REMARK    GeneRIF: LncRNA AP000842.3 Triggers the Malignant Progression of
            Prostate Cancer by Regulating Cuproptosis Related Gene NFAT5.
REFERENCE   6  (bases 1 to 13289)
  AUTHORS   Trama,J., Lu,Q., Hawley,R.G. and Ho,S.N.
  TITLE     The NFAT-related protein NFATL1 (TonEBP/NFAT5) is induced upon T
            cell activation in a calcineurin-dependent manner
  JOURNAL   J Immunol 165 (9), 4884-4894 (2000)
   PUBMED   11046013
  REMARK    GeneRIF: Induced upon T cell activation in a calcineurin-dependent
            manner, which contrasts with the calcineurin-independent induction
            mediated by hyperosmotic stress.
REFERENCE   7  (bases 1 to 13289)
  AUTHORS   Ko,B.C., Turck,C.W., Lee,K.W., Yang,Y. and Chung,S.S.
  TITLE     Purification, identification, and characterization of an osmotic
            response element binding protein
  JOURNAL   Biochem Biophys Res Commun 270 (1), 52-61 (2000)
   PUBMED   10733904
REFERENCE   8  (bases 1 to 13289)
  AUTHORS   Lopez-Rodriguez,C., Aramburu,J., Rakeman,A.S. and Rao,A.
  TITLE     NFAT5, a constitutively nuclear NFAT protein that does not
            cooperate with Fos and Jun
  JOURNAL   Proc Natl Acad Sci U S A 96 (13), 7214-7219 (1999)
   PUBMED   10377394
REFERENCE   9  (bases 1 to 13289)
  AUTHORS   Miyakawa,H., Woo,S.K., Dahl,S.C., Handler,J.S. and Kwon,H.M.
  TITLE     Tonicity-responsive enhancer binding protein, a rel-like protein
            that stimulates transcription in response to hypertonicity
  JOURNAL   Proc Natl Acad Sci U S A 96 (5), 2538-2542 (1999)
   PUBMED   10051678
REFERENCE   10 (bases 1 to 13289)
  AUTHORS   Adams,M.D., Soares,M.B., Kerlavage,A.R., Fields,C. and Venter,J.C.
  TITLE     Rapid cDNA sequencing (expressed sequence tags) from a
            directionally cloned human infant brain cDNA library
  JOURNAL   Nat Genet 4 (4), 373-380 (1993)
   PUBMED   8401585
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC009032.8, AJ243299.1,
            BC131509.1, AC012321.8 and AA291524.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Dec 12, 2018 this sequence version replaced NM_138713.3.
            
            Summary: The product of this gene is a member of the nuclear
            factors of activated T cells family of transcription factors.
            Proteins belonging to this family play a central role in inducible
            gene transcription during the immune response. This protein
            regulates gene expression induced by osmotic stress in mammalian
            cells. Unlike monomeric members of this protein family, this
            protein exists as a homodimer and forms stable dimers with DNA
            elements. Multiple transcript variants encoding different isoforms
            have been found for this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) lacks an exon in the 5'
            region, compared to variant 1. This difference causes translation
            initiation at an upstream start codon and results in an isoform (b)
            with a longer N-terminus compared to isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ243299.1, SRR1803615.141797.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000349945.7/ ENSP00000338806.3
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-394               AC009032.8         67137-67530         c
            395-2222            AJ243299.1         154-1981
            2223-5157           BC131509.1         2124-5058
            5158-13007          AC012321.8         829-8678            c
            13008-13289         AA291524.1         19-300              c
FEATURES             Location/Qualifiers
     source          1..13289
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.1"
     gene            1..13289
                     /gene="NFAT5"
                     /gene_synonym="NF-AT5; NFATL1; NFATZ; OREBP; TONEBP"
                     /note="nuclear factor of activated T cells 5"
                     /db_xref="GeneID:10725"
                     /db_xref="HGNC:HGNC:7774"
                     /db_xref="MIM:604708"
     exon            1..409
                     /gene="NFAT5"
                     /gene_synonym="NF-AT5; NFATL1; NFATZ; OREBP; TONEBP"
                     /inference="alignment:Splign:2.1.0"
     CDS             337..4986
                     /gene="NFAT5"
                     /gene_synonym="NF-AT5; NFATL1; NFATZ; OREBP; TONEBP"
                     /note="isoform b is encoded by transcript variant 2;
                     osmotic response element-binding protein; glutamine rich
                     protein H65; NFAT-like protein 1; TonE-binding protein;
                     nuclear factor of activated T-cells 5,
                     tonicity-responsive; T-cell transcription factor NFAT5;
                     tonicity-responsive enhancer-binding protein"
                     /codon_start=1
                     /product="nuclear factor of activated T-cells 5 isoform b"
                     /protein_id="NP_619727.2"
                     /db_xref="CCDS:CCDS45518.1"
                     /db_xref="GeneID:10725"
                     /db_xref="HGNC:HGNC:7774"
                     /db_xref="MIM:604708"
                     /translation="MPSDFISLLSADLDLESPKSLYSRDSLKLHPSQNFHRAGLLEES
                     VYDLLPKELQLPPSRETSVASMSQTSGGEAGSPPPAVVAADASSAPSSSSMGGACSSF
                     TTSSSPTIYSTSVTDSKAMQVESCSSAVGVSNRGVSEKQLTSNTVQQHPSTPKRHTVL
                     YISPPPEDLLDNSRMSCQDEGCGLESEQSCSMWMEDSPSNFSNMSTSSYNDNTEVPRK
                     SRKRNPKQRPGVKRRDCEESNMDIFDADSAKAPHYVLSQLTTDNKGNSKAGNGTLENQ
                     KGTGVKKSPMLCGQYPVKSEGKELKIVVQPETQHRARYLTEGSRGSVKDRTQQGFPTV
                     KLEGHNEPVVLQVFVGNDSGRVKPHGFYQACRVTGRNTTPCKEVDIEGTTVIEVGLDP
                     SNNMTLAVDCVGILKLRNADVEARIGIAGSKKKSTRARLVFRVNIMRKDGSTLTLQTP
                     SSPILCTQPAGVPEILKKSLHSCSVKGEEEVFLIGKNFLKGTKVIFQENVSDENSWKS
                     EAEIDMELFHQNHLIVKVPPYHDQHITLPVSVGIYVVTNAGRSHDVQPFTYTPDPAAA
                     GALNVNVKKEISSPARPCSFEEAMKAMKTTGCNLDKVNIIPNALMTPLIPSSMIKSED
                     VTPMEVTAEKRSSTIFKTTKSVGSTQQTLENISNIAGNGSFSSPSSSHLPSENEKQQQ
                     IQPKAYNPETLTTIQTQDISQPGTFPAVSASSQLPNSDALLQQATQFQTRETQSREIL
                     QSDGTVVNLSQLTEASQQQQQSPLQEQAQTLQQQISSNIFPSPNSVSQLQNTIQQLQA
                     GSFTGSTASGSSGSVDLVQQVLEAQQQLSSVLFSAPDGNENVQEQLSADIFQQVSQIQ
                     SGVSPGMFSSTEPTVHTRPDNLLPGRAESVHPQSENTLSNQQQQQQQQQQVMESSAAM
                     VMEMQQSICQAAAQIQSELFPSTASANGNLQQSPVYQQTSHMMSALSTNEDMQMQCEL
                     FSSPPAVSGNETSTTTTQQVATPGTTMFQTSSSGDGEETGTQAKQIQNSVFQTMVQMQ
                     HSGDNQPQVNLFSSTKSMMSVQNSGTQQQGNGLFQQGNEMMSLQSGNFLQQSSHSQAQ
                     LFHPQNPIADAQNLSQETQGSLFHSPNPIVHSQTSTTSSEQMQPPMFHSQSTIAVLQG
                     SSVPQDQQSTNIFLSQSPMNNLQTNTVAQEAFFAAPNSISPLQSTSNSEQQAAFQQQA
                     PISHIQTPMLSQEQAQPPQQGLFQPQVALGSLPPNPMPQSQQGTMFQSQHSIVAMQSN
                     SPSQEQQQQQQQQQQQQQQQQQSILFSNQNTMATMASPKQPPPNMIFNPNQNPMANQE
                     QQNQSIFHQQSNMAPMNQEQQPMQFQSQSTVSSLQNPGPTQSESSQTPLFHSSPQIQL
                     VQGSPSSQEQQVTLFLSPASMSALQTSINQQDMQQSPLYSPQNNMPGIQGATSSPQPQ
                     ATLFHNTAGGTMNQLQNSPGSSQQTSGMFLFGIQNNCSQLLTSGPATLPDQLMAISQP
                     GQPQNEGQPPVTTLLSQQMPENSPLASSINTNQNIEKIDLLVSLQNQGNNLTGSF"
     exon            410..463
                     /gene="NFAT5"
                     /gene_synonym="NF-AT5; NFATL1; NFATZ; OREBP; TONEBP"
                     /inference="alignment:Splign:2.1.0"
     exon            464..589
                     /gene="NFAT5"
                     /gene_synonym="NF-AT5; NFATL1; NFATZ; OREBP; TONEBP"
                     /inference="alignment:Splign:2.1.0"
     exon            590..1148
                     /gene="NFAT5"
                     /gene_synonym="NF-AT5; NFATL1; NFATZ; OREBP; TONEBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1341
                     /gene="NFAT5"
                     /gene_synonym="NF-AT5; NFATL1; NFATZ; OREBP; TONEBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1532
                     /gene="NFAT5"
                     /gene_synonym="NF-AT5; NFATL1; NFATZ; OREBP; TONEBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..1705
                     /gene="NFAT5"
                     /gene_synonym="NF-AT5; NFATL1; NFATZ; OREBP; TONEBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..1840
                     /gene="NFAT5"
                     /gene_synonym="NF-AT5; NFATL1; NFATZ; OREBP; TONEBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..1893
                     /gene="NFAT5"
                     /gene_synonym="NF-AT5; NFATL1; NFATZ; OREBP; TONEBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1894..2026
                     /gene="NFAT5"
                     /gene_synonym="NF-AT5; NFATL1; NFATZ; OREBP; TONEBP"
                     /inference="alignment:Splign:2.1.0"
     exon            2027..2110
                     /gene="NFAT5"
                     /gene_synonym="NF-AT5; NFATL1; NFATZ; OREBP; TONEBP"
                     /inference="alignment:Splign:2.1.0"
     exon            2111..2259
                     /gene="NFAT5"
                     /gene_synonym="NF-AT5; NFATL1; NFATZ; OREBP; TONEBP"
                     /inference="alignment:Splign:2.1.0"
     exon            2260..4750
                     /gene="NFAT5"
                     /gene_synonym="NF-AT5; NFATL1; NFATZ; OREBP; TONEBP"
                     /inference="alignment:Splign:2.1.0"
     exon            4751..4994
                     /gene="NFAT5"
                     /gene_synonym="NF-AT5; NFATL1; NFATZ; OREBP; TONEBP"
                     /inference="alignment:Splign:2.1.0"
     exon            4995..13289
                     /gene="NFAT5"
                     /gene_synonym="NF-AT5; NFATL1; NFATZ; OREBP; TONEBP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      13268..13273
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NFAT5"
                     /gene_synonym="NF-AT5; NFATL1; NFATZ; OREBP; TONEBP"
                     /note="hexamer: AATAAA"
     polyA_site      13289
                     /gene="NFAT5"
                     /gene_synonym="NF-AT5; NFATL1; NFATZ; OREBP; TONEBP"
                     /note="major polyA site"
ORIGIN      
        1 agattcctgt cagcggcggc ggcggtggcg gcgaccgtca gttttcgctg aggagaaaca
       61 cgaaacggac cctttggctc tcccccttcc ccttccccgt cctgaacccc tctcctggtc
      121 accgagaatc agtccccgtg gagttccccc tccacctcgc catcgtttcc tcggtcctcg
      181 gcccagtgga agtcactacc ctcgaggagg aggcagcggc agccgccctc gcgtcgccgc
      241 ccccggttcg gtgcccgcgg tcccggagag gaggtgccgc cgccaccgcc gctccccccc
      301 tcccgctgcc ctcgggccgg gctgggtcga gctgcgatgc cctcggactt catctcattg
      361 ctcagcgcgg acctagacct ggaatcgccc aagtccctct actcgcgaga ttctctgaag
      421 ttacacccat cacagaattt tcatagagct ggactattgg aagaatctgt ctatgatctt
      481 ctcccaaagg agttacagtt acctccatct agagaaacat ctgtagcatc aatgagtcag
      541 acaagcggtg gtgaggcagg ctcgcctcct ccagctgttg ttgctgctga tgcttcttca
      601 gctccctcct cttcctccat gggcggtgct tgcagctcct ttaccacctc ttccagccct
      661 accatttatt ctacctcagt caccgacagc aaggctatgc aagtggagag ctgctcctca
      721 gccgtggggg taagtaacag aggggtaagt gaaaagcagt taaccagtaa cacagttcag
      781 cagcatccat caacaccgaa gaggcacaca gtcttgtaca tctcaccacc acctgaggac
      841 ttgctggata acagtcggat gtcctgccag gatgaggggt gtggattgga atctgagcag
      901 agctgcagta tgtggatgga ggattccccc tccaacttca gtaacatgag caccagttcc
      961 tacaatgata acactgaggt acctcgtaaa tcacgaaaac gaaatccaaa gcagaggccg
     1021 ggggtcaaac gacgagattg tgaagaatct aatatggata tatttgatgc cgacagtgcc
     1081 aaagcacctc actatgtgct ttctcagctt accacggaca acaaaggcaa ctcaaaagcg
     1141 ggaaatggaa cattggaaaa ccaaaaagga actggagtaa agaagagccc tatgttgtgt
     1201 ggacaatatc ctgttaaaag tgagggaaag gagctgaaga tagttgtaca acctgagaca
     1261 cagcaccgag ctcggtacct gactgagggc agccgtggct cagtgaaaga tagaacacag
     1321 caaggctttc ctacagtaaa gctggaaggc cataatgaac ctgtagtgtt gcaagtgttt
     1381 gtgggcaacg actctggacg agtgaaacca catggatttt atcaggcctg cagagtaact
     1441 ggacgaaata caactccttg caaagaagtg gacattgaag gcactactgt tatagaagtc
     1501 ggccttgatc ctagcaacaa catgacactg gcggtggact gcgtagggat attgaaattg
     1561 aggaatgctg atgtcgaagc cagaatagga attgctggtt ccaagaagaa aagcactcgt
     1621 gccagattgg tttttcgagt taatatcatg aggaaagatg gctccacttt gacactgcaa
     1681 acaccctctt ctccaatttt gtgtactcag ccagcaggag tgccagaaat cttaaagaaa
     1741 agcttgcata gctgttcagt gaaaggagaa gaagaagtgt ttttaatcgg caagaacttt
     1801 ctgaaaggaa ctaaagttat tttccaagaa aatgtttctg atgaaaactc ttggaagtca
     1861 gaagctgaaa ttgatatgga actatttcat cagaatcatc ttattgtgaa ggttcctccc
     1921 tatcatgacc aacatataac tttgcctgtg tcagtgggaa tatatgtagt gacaaatgct
     1981 ggaagatctc atgatgttca accattcact tacactccag acccagcagc agctggtgct
     2041 ttgaatgtaa atgtgaagaa ggaaatatct agtccagcaa gaccttgctc ttttgaagag
     2101 gccatgaaag caatgaaaac tactggatgt aatttagata aggtaaatat tatccctaat
     2161 gccctgatga ctccactcat accaagcagt atgattaaga gtgaagatgt tactccaatg
     2221 gaagtaacag cagaaaaaag atcttccact atttttaaga ctacaaagtc tgttggatca
     2281 actcagcaaa cattagaaaa catctcaaac atagcaggaa atggctcttt ttcatcacca
     2341 tcatcttccc acctaccttc tgaaaatgaa aaacagcagc agattcagcc caaggcatac
     2401 aacccagaga ccctgacaac tattcaaacc caggacatct cacagcctgg tacttttcca
     2461 gcagtttctg cttctagtca gctgcccaac agcgatgcac tattgcagca ggctacacag
     2521 tttcagacaa gagaaactca gtctagagag atattacagt cagatggtac agtggttaat
     2581 ttgtcacaac tgactgaggc atcacaacaa cagcagcagt caccactaca agaacaagca
     2641 cagactttac agcagcagat ttcatcaaat atttttccat caccaaatag tgtgagtcag
     2701 cttcagaata ctattcagca gctgcaagca gggagtttca caggcagtac tgctagtggc
     2761 agcagtggaa gtgttgactt ggtccaacaa gttttagagg cacagcagca gttatcttca
     2821 gttttatttt ctgctccaga tggtaatgag aatgttcaag agcagcttag tgcagatatt
     2881 tttcaacaag tcagtcaaat tcagagtggt gtaagccctg gaatgttttc ctcaacagag
     2941 ccaacagtcc ataccagacc agataattta ttacctggaa gagctgaaag tgttcatcca
     3001 cagtctgaaa acacgttatc taatcaacag cagcagcagc agcagcaaca gcaagtgatg
     3061 gaatcttcag ccgcaatggt gatggagatg caacagagta tctgccaggc agctgcccag
     3121 attcagtcag agttattccc ttcaactgct tcagcaaatg gaaaccttca gcaatcgcca
     3181 gtttaccagc agacttctca catgatgagt gcattgtcta ccaatgagga tatgcaaatg
     3241 cagtgtgaat tgttttcttc tcctcctgca gtttctggaa atgaaacttc tacaactacc
     3301 acacagcagg ttgcaacccc tggcactacc atgtttcaga catcaagttc aggagatgga
     3361 gaagaaactg gaacacaagc aaaacagatt cagaacagtg tctttcagac catggtccaa
     3421 atgcaacata gtggggacaa tcaacctcaa gttaaccttt tttcatccac aaaaagtatg
     3481 atgagtgttc agaatagtgg tacccaacaa caaggtaatg gtttattcca gcaagggaat
     3541 gagatgatgt cacttcaatc tggaaatttt ttgcagcagt cttctcattc acaggcccaa
     3601 ctttttcatc ctcaaaatcc tattgccgat gctcagaacc tttcccagga aactcaaggt
     3661 tctctctttc atagtccaaa tcctattgtc cacagtcaga cttctacaac ctcctctgaa
     3721 caaatgcagc ctccaatgtt tcactctcaa agtaccattg ctgtgttaca gggctcttca
     3781 gttcctcaag accagcagtc aaccaacata tttctttccc agagtcccat gaataatctt
     3841 cagactaaca cagtagccca agaagcattt tttgcagcac cgaactcaat ttctccactt
     3901 cagtcaacat caaacagtga acaacaagct gctttccaac agcaagctcc aatatcacac
     3961 atccagactc ctatgctttc ccaagaacag gcacaacccc cgcagcaggg tttatttcag
     4021 cctcaggtgg ccctgggctc ccttccacct aatccaatgc ctcaaagcca acaaggaacc
     4081 atgttccagt cacagcactc aatagttgcc atgcagagta actctccatc ccaggaacag
     4141 cagcagcagc agcaacagca gcagcaacag cagcagcaac aacaacagag cattttattc
     4201 agtaatcaga ataccatggc tacaatggcg tctccaaagc aaccaccacc aaacatgata
     4261 ttcaacccaa atcaaaatcc aatggctaat caggagcaac agaaccagtc aatttttcac
     4321 caacaaagta acatggcccc aatgaatcaa gagcaacagc ccatgcaatt tcagagtcag
     4381 tccacagttt cctcacttca gaacccaggt cctacccagt cggaatcatc acagaccccc
     4441 ttgttccata gctctcctca gattcagttg gtacaagggt cacctagttc tcaagagcag
     4501 caagtaactc tcttcttatc tccagcatcc atgtctgcct tgcagaccag tataaatcaa
     4561 caagatatgc aacagtctcc tctttattcc cctcagaaca acatgcctgg aattcaagga
     4621 gccacatctt cgcctcaacc acaggctact ttatttcaca acacagcagg aggcacaatg
     4681 aaccaactgc agaattctcc tggctcatct cagcagacat caggaatgtt cttatttggc
     4741 attcaaaata actgtagtca gcttttaacc tctggaccag ctacattgcc tgatcagttg
     4801 atggccataa gtcagccagg ccaaccacaa aacgagggcc agccacctgt gacaacactt
     4861 ctttctcagc aaatgccaga gaattctcca ctggcatcct ctataaacac caaccagaac
     4921 atcgaaaaga ttgatttgct tgtttcattg caaaaccaag ggaacaactt gactggctcc
     4981 ttttaactgg atataaattc cacgaagaaa atcctgattc caagatgtcc tgagatcttg
     5041 tggttccatg agaattatta ctttaaaaac aaaacaaaat ataaaaaact gtgtttgagt
     5101 aaactgatag attttactct gactgcaaaa gagcacacct atgctgcttg ttgcagtaac
     5161 taaccaccaa tgttaacatc ttcatatttt atattcctaa taacagtgat gactgagaat
     5221 ctatttgagt ttccagctgg cagaattaat tgttattatt ttcctaggcg caatttcctt
     5281 aaacgtacag tttaaattca aggctggacc actcagttat tattgctatt agaaaataat
     5341 atatcatgtt tacttttgtt cttcattatt ttctttcctg cattgtttta gtcaagtaat
     5401 ggcttttgaa aaagtaaagt tcaataataa ctaaggctgt gatttttttc aatataaaag
     5461 gcacagctgt tggccaaagt gaaggaatct tttttcagtt ttattggaga aactgaaggg
     5521 taacattcta acaagtaaac tgtatgtgca gataaaagta ctcttgattt aacacaaagg
     5581 cagatgatac acttataaaa ctgggaacag ctggaatgct tcttgatttt attttttcag
     5641 agagttgtta gttctctggg tttctactaa ggggtttagc cataactgtg catagaaaaa
     5701 taattatctg taaaaaatga aggggataat atatgataaa ttatgttctg atatcctcct
     5761 acagtagttt aaattgacag aaaaatttga atgttttctt cttaacccag tcttaggctg
     5821 gtattccctt tttatatata tctatattac ttttcacctc tttttcactt tactttagag
     5881 aactattaat atactactgg cttcatgacc ctgtagcatc tttggccact ttaatctagg
     5941 gtgacctagc aatcctgcag cacagggcag agagtactgt cttaggaatt attaggagtt
     6001 gattcctgag aaacaacaca tttttcccca tgaacggtgc tgttctgaag tcttcaaatt
     6061 tttccctcta ataggaaaca gtataaattt taattaaaaa aaaaaggcaa actaaaattt
     6121 cttgaaatat cacttctccc tgatctgcag tgagtataaa ttcacttgtc acctcagtgc
     6181 tttacagttt gaagtggtca cttacctgat ggttcccaca agccttaggc tttacagggt
     6241 tgtatcattg acttaaaatg aagaattaac ttgtgttaca tctataaaga gcaaaataac
     6301 acactccaga acttggcagt tgtagcatta gttatacagt tttgggtgtt cttgccaccc
     6361 gtgggatgcc tgcttctcac taccacctgt gtctggacac atgcttatgt ctcattttcc
     6421 ttttggcatg tggaaagctg tcaatgcagt gtaaggccaa cgtgtgtgtg gcttctatgt
     6481 gttgagataa tgttttggta tccttgtccg tttcatttat tttttaagtg tacaaaaaat
     6541 aacctgttaa ttgttgaagg ctacttttct gttctttttt tttttttttt tctatcctgt
     6601 acatttagtt gaactgtgcg gaattgtggt gttggttttg tttacacagc cagatttttc
     6661 cttctttttg ttttgtgatg atcttccttt gttctttgaa tgtgctcttt tgtctttttc
     6721 tcttttttct catgttttct tccctccacc tccacccctt tctttctttc tctctctgat
     6781 tgagaggcat tgaattacgt tttcagtagt acaggcttct tgccgatatg aagggaactt
     6841 ttcagaaaga gacctactct gggtcattta attttgaata cagttttcaa tcgttcaagt
     6901 tttggatggt ttatatctaa tgtgtgtttc atttttttgg aaagctatat tttgtattta
     6961 ggaaatggta tactattttg ctatttgtac tgagtgagta cattggcata aatatagaaa
     7021 tttatatata tacatatata taaactattc ttttttgcca cacatttttg tggtaaattt
     7081 gtgagtttgt ctgatgttct accacaacgt ggcgtctgat aacagtgagg gggggtgggg
     7141 tttgttatgt ctttattgag tatttaagta tcttttgaaa caaatgacct gttcatctgt
     7201 ggccattcca tcaggcagtt agttccttga tgtcagtagt gggctaaagg cagcttactg
     7261 tgtgtttgct ggagctttca ctcagccaag tgttagagtc aggaaaccca ttgaggcaat
     7321 ggcgtcaaat ggtgtttcac aagaatgagc cattcagtct ttgctcacta tatatttaat
     7381 attttattat tgttgttatt gttattatta attggctttc tgtattctat gccttttatt
     7441 tataaagaca ctaagaaaac ccatgtttgt aattttaata acatttttcc catcttgtaa
     7501 tatccagagc tactttataa attctctgaa ccaaaagtat tttcctcagt gtatctcttc
     7561 tcccccagcc cctattggga aaaattaccc agtatagttc aggttatgag gaggatcagc
     7621 cacacaatcc agtgcttcag tttgaaaatg taaaattcta accctaaagt agggttggtt
     7681 gaaatttcag acaaagcaaa cccagcaggt ataaaaagta gtataaatac aaatctgtaa
     7741 gttatttttg aattttctga acttttttct aagagattac ataggagact aaagaaatct
     7801 atctgttcaa gttctaatta ggatgattgt taatactgca ctgtggatga agtggcgact
     7861 ggcttgtgtg ctgacttctg tggtttagca agaggtttat tgttatcaaa tgctaattgg
     7921 caatgccaag tcactgggac caattttctg ttttataata tctaagttta gaacagaata
     7981 tatacctgaa ctgtagtggt ttgatcggat ggagacagaa aacccgattt ttattctcat
     8041 aaattttgtg gttatttata caagggctgt gctatgctac catattcttg ttcaataata
     8101 ataggtttgt tgtttttttt acattgttaa atgttcctta cccctaaagg tcaatgttaa
     8161 gtacaacatt ctgaaaatac aatttggcta cgaagagtat tcatcttctt tgaagctcag
     8221 tggttgatat ttgtgctaat aatgcaattt cctgattact gttacaagtt atagctacat
     8281 atgggagaga ctcagtgagc cagcaaaggc catagaaaca acaatttatt aaatgtattt
     8341 atggcagaag gacctaaata aactgtgagc caccttttct tctttatatt gttacattta
     8401 agtgttcttg ctttcagcaa ctcacattaa tgcttggagc ttatctcttt ctctctctct
     8461 ctctctctct ctgtgtgtgt gtgtgtatgt gtgtgtgtgt gtgtgtgtgt ttccttattg
     8521 tcattccatt atatatccac accaacatgg gtgacgataa ttcaaagtca tattttgcct
     8581 ctaagcttga tcatgttacc tttatgatta aagtatcatg ttatttagcc aatgcaaatc
     8641 tgttttaaaa caaatagttt aaaaaaagaa caagttttta agggctttat tatagaagaa
     8701 gtattaatga aggactttcc ttcctccctc cctttcctcc cctccctgcc tcccttcttc
     8761 ccttccatct ccccctcctc cctgccttct ttgtttctcc ttcccttatt cctccctccc
     8821 tcctttctcc cttccttcct ttcttccatt catccttcct tgccttttat ttttattttt
     8881 tgtaatatca catgtgctgt agtttggaat tttattctag tgcatttctt gctcatcaga
     8941 acctcagcta atctacctag gaaaaatagt atcaaaggaa atgagaaagt tgtatctgag
     9001 tccctccaga actaagataa ttctttttga ccatttaagc ctttataaat gcgttttgac
     9061 catttaagcc tttataaatg cttgttttag gaaagtgaat ctgttagatg catcaacaaa
     9121 taatgaccag gacaaaacga tttaataatt aaagtctcaa atcaccatgg ttatacattt
     9181 tcaccagaaa tagtaatctt acaatttttc atttttctga tgaagatttc tgttccaata
     9241 tctgtttcct aatagatttt ttaaattaat tagctttcct ctgctttatg accacaggtt
     9301 ttatccctaa ccgagacagc tgtcttatat ctgcatgcct tagactgtgt ggagggactc
     9361 catgaagaaa gaccataggt tagaaaaata actcatagta tataccctag taagtgggtt
     9421 agtagaatct cataacatgt attaaaaaga ggttttcttc tctgcttgtt tgtgtcacta
     9481 gagcaaaatt gtagagataa tgctcataat gcagtaaata tcagaataat atctacaata
     9541 tcatttgtgg atggtcccag gtcccagtgc tctagttact ttacttcttt tttttttttt
     9601 gagatggagt cttgctctgt ctctcaggct agagcagtgt gcgatctcag ctcactgcag
     9661 cctccacctc ccaggttcaa gcgattctcc tgcctcagcc tcccaagtag ccaggattac
     9721 aggcaccctc cactaggccc ggctaatttt ttttgtattt ttttagtaga gatggggttt
     9781 tgccatgttg gccaggctgg tttcgaactc ctaacctcca gtgatccacc tgcctcggcg
     9841 tcccaaagtg ctaggattac aggcatgagc caccacatcc ggcctaatta cttctttaat
     9901 ccccatttat ttttatgcca ttctagcctc atttattaat aaaattatgt ttttactttc
     9961 tctttcagga aattttttaa attaatattt tatatctaga tctaatgcta tggaaaagtg
    10021 cctttttatc atttataatt tcatttttca ctatttccaa aaacacataa acaaatagtt
    10081 tcagtaggtc ccagctttta ctttttccat ttaaaccttc ttttctccat ttcttccctt
    10141 tggcttaaga ataaaagaaa aggtacattg ctagaattgt ttctttggga gagggtaaaa
    10201 gattacagaa ttagactgtt cagcctttat ataaactaaa tttgtcttca tctcaaccag
    10261 ctaatggtag gtcttatctg aatactcatg agaattttag catctgtgaa actccatgca
    10321 ccagatgtgt gtaaatttca ggaagaaagt gttgaaagca ttttctctga tgttaattag
    10381 atggaaataa atcactaaaa catagtttag gtaaagcctg attatgccac ttttttttaa
    10441 ctagacaggg caaagttgtt tatgttagtg tacttcttgt ctatcctcag ttaatttacc
    10501 tagacaaaaa gtgtcaaagg aaatgagaaa aaggttatat ctgactccct ccagacctaa
    10561 gataattcct tttgatcaga tacagtcaga tggagtgcct tggtttttgt taattttgcc
    10621 tctattccag ctccttacca cagcggtggt gcttaaagaa aggatcatca gcaacaggtc
    10681 aggatagttc tacctttggg atagggctgc tttccccgtg ctagtatttc tgtgactgtt
    10741 agtggcactg aggactgcaa acttttatgc aatattctta ataccctatt gatattatgc
    10801 actttaatca ttccaaagaa gccaagaatg ctgtatagtg atgattcctt cctaatgaat
    10861 tcatcttaac tatttagaat gttatgtccc ttttcttttg gatagccaac ttggtataaa
    10921 tgttatatgg atttttctaa aatgactata taggacttaa gactttgaaa tgtaatttac
    10981 ttataagggg aaataattat gctttagcac atcattttag aaacgtcaca ttttagaaac
    11041 attcagcttg ctaacctaca tgtttgggaa ttcattaaaa ccagttgtct atatattttg
    11101 tgccatgtat ataagaacat tacaatatat ctttttctac atatgtagta tgtgcaacca
    11161 gtggttctca gagtatggtt ctcagcccac cagctagtat cagtatcacc tgggaactag
    11221 ttagaaatgt aaattctttg gccccatccc agacatactg agtcagaaac tctggaatag
    11281 ggcccccgca atctgttttc acaagccctc caggtgattc tgatgcacac tttaaagttt
    11341 aggaaccact gggctaagac tctgttgaga tatagagttt ttcttccact cagactgata
    11401 tagttataca ttgttcttca tgtaaattca gcttaacctg gttatctata atcttttatt
    11461 ggcaaaagtt aattctcagt actgcctata gagatacagt gtattttatg tacatacaca
    11521 attagtctaa ttcttgataa ttcagttaat ttagtttggc attttcctac cacttactaa
    11581 aaggtttaca ttaaatgact gatttaaata tataggtgca atgttctatg tttattttaa
    11641 ttgttatgac atttaagtag ctaatataat tgaccggtgc taaagtctcc tgtttatcca
    11701 taaaatgggt acattatggg cagtgtaata caagctttct tttcattgcc tagtacttta
    11761 ccagcagacc acagttttgc cctggctaga ccaaccctca gaacaaaatc atcattcctt
    11821 gtatttatat ttgtatctga gatagtaaac aagatggctg gccaggtcaa catggcacct
    11881 taacttattt ttttaatagg taaaacttct tcaaaagtag cttgctttgt ataagaacta
    11941 agctatcagt atagatatag ctatccttgg agcttatgtt tcagacaaga attatttact
    12001 aaaataaata ataaacaaga taatgcatta tacaatttgg gcatttctcg tttctcaagt
    12061 gtatgcatca tggtaaatat aaactaacca caagataggt agattgattc atttcatttt
    12121 aatctccttg tgtaattcag tacctccata attgttctaa tcttcttccc actgtttaca
    12181 aattaccagt taattaactc gtgaaagaaa aattcacata tcagaataaa aataaatgta
    12241 tactcacttt ataaaaatca ccactgctgt ctttccttaa tactagcagt ggaaatgtaa
    12301 gtggcttact ctacaaattt tggtgctggc aaatacatag gcaaactgtt gggagctgct
    12361 ctagttacat tcctcccttc ttattccctt tttctcttcc tcactttatt gcataacata
    12421 ttcctgtacc caaagcattc taccacagtt ctatttgact cccacttgta ataactcctt
    12481 taaaaaattc catgtttaac catatgaccc tgcttgctta ctcatattct ccctccctct
    12541 ccccttcctt tctctctctt ccagaagtca tttgcctggt ttgaaatatt ttgtagggat
    12601 tgcttattat attattttag ctgatgaacc tcaggacaac gtctacacac acacacatac
    12661 atacacgcac acaaaatctc agctgttgaa gagtgggctt ggaatcagac ttctgtgtcc
    12721 agtaaaaaac tcctgcactg aagtcattgt gacttgagta gttacagact gattccagtg
    12781 aacttgatct aatttctttt gatctaatga atgtgtctgc ttaccttgtt tccttttaat
    12841 tgataagctc caagtagttg ctaatttttt gacaacttta aatgagtttc attcacttct
    12901 tttacttaat gttttaagta tagtaccaat aatttcatta acctgttctc aagtggttta
    12961 gctaccattc tgccattttt aatttttatt taattttatt tgcttgagca cactgatcaa
    13021 ccactgaact gccttcttcc attgtcctgc aatgatataa gggttacatt tttgtgtata
    13081 tggctttcat agttgggatt tcagagcact gataccagat attttcagtt tgttctctgg
    13141 gggaatttca tttgcatcta tgtttttagc tatctgtgat aacttgttaa atattaaaaa
    13201 gatattttgc ttctattgga acatttgtat actcgcaact atatttctgt aaacagctgc
    13261 agtcaaaaat aaaacactga aagttttca
//
