LOCUS       NM_145912               5613 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens NFAT activating protein with ITAM motif 1 (NFAM1),
            transcript variant 1, mRNA.
ACCESSION   NM_145912
VERSION     NM_145912.8
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5613)
  AUTHORS   Zhu,J., Chen,Z., Peng,X., Zheng,Z., Le,A., Guo,J., Ma,L., Shi,H.,
            Yao,K., Zhang,S., Ge,J., Zheng,Z. and Wang,Q.
  TITLE     Extracellular Vesicle-Derived circITGB1 Regulates Dendritic Cell
            Maturation and Cardiac Inflammation via miR-342-3p/NFAM1
  JOURNAL   Oxid Med Cell Longev 2022, 8392313 (2022)
   PUBMED   35615580
  REMARK    GeneRIF: Extracellular Vesicle-Derived circITGB1 Regulates
            Dendritic Cell Maturation and Cardiac Inflammation via
            miR-342-3p/NFAM1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5613)
  AUTHORS   Juchem,K.W., Gounder,A.P., Gao,J.P., Seccareccia,E., Yeddula,N.,
            Huffmaster,N.J., Cote-Martin,A., Fogal,S.E., Souza,D., Wang,S.S.,
            Glynn,E.R.A., Yung,I., Ritchie,J., Li,L., Zheng,J., Mbow,M.L.,
            Li,J. and Chanda,S.K.
  TITLE     NFAM1 Promotes Pro-Inflammatory Cytokine Production in Mouse and
            Human Monocytes
  JOURNAL   Front Immunol 12, 773445 (2022)
   PUBMED   35095847
  REMARK    GeneRIF: NFAM1 Promotes Pro-Inflammatory Cytokine Production in
            Mouse and Human Monocytes.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5613)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 5613)
  AUTHORS   Long,J., Chen,J., Wang,Q., Gao,F., Lian,M., Zhang,P., Yang,Y. and
            Zhu,H.
  TITLE     NFAT activating protein with ITAM motif 1 (NFAM1) is upregulated on
            circulating monocytes in coronary artery disease and potentially
            correlated with monocyte chemotaxis
  JOURNAL   Atherosclerosis 307, 39-51 (2020)
   PUBMED   32711213
  REMARK    GeneRIF: NFAT activating protein with ITAM motif 1 (NFAM1) is
            upregulated on circulating monocytes in coronary artery disease and
            potentially correlated with monocyte chemotaxis.
REFERENCE   5  (bases 1 to 5613)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 5613)
  AUTHORS   Nilsson,L.M., Sun,Z.W., Nilsson,J., Nordstrom,I., Chen,Y.W.,
            Molkentin,J.D., Wide-Swensson,D., Hellstrand,P., Lydrup,M.L. and
            Gomez,M.F.
  TITLE     Novel blocker of NFAT activation inhibits IL-6 production in human
            myometrial arteries and reduces vascular smooth muscle cell
            proliferation
  JOURNAL   Am J Physiol Cell Physiol 292 (3), C1167-C1178 (2007)
   PUBMED   17079331
  REMARK    GeneRIF: Our results demonstrate NFAT expression and activation in
            native human vessels and point out A-285222 as a powerful
            pharmacological blocker of NFAT signaling in the vasculature.
REFERENCE   7  (bases 1 to 5613)
  AUTHORS   Ohtsuka,M., Arase,H., Takeuchi,A., Yamasaki,S., Shiina,R.,
            Suenaga,T., Sakurai,D., Yokosuka,T., Arase,N., Iwashima,M.,
            Kitamura,T., Moriya,H. and Saito,T.
  TITLE     NFAM1, an immunoreceptor tyrosine-based activation motif-bearing
            molecule that regulates B cell development and signaling
  JOURNAL   Proc Natl Acad Sci U S A 101 (21), 8126-8131 (2004)
   PUBMED   15143214
REFERENCE   8  (bases 1 to 5613)
  AUTHORS   Collins,J.E., Wright,C.L., Edwards,C.A., Davis,M.P., Grinham,J.A.,
            Cole,C.G., Goward,M.E., Aguado,B., Mallya,M., Mokrab,Y.,
            Huckle,E.J., Beare,D.M. and Dunham,I.
  TITLE     A genome annotation-driven approach to cloning the human ORFeome
  JOURNAL   Genome Biol 5 (10), R84 (2004)
   PUBMED   15461802
REFERENCE   9  (bases 1 to 5613)
  AUTHORS   Yang,J., Hu,G., Wang,S.W., Li,Y., Martin,R., Li,K. and Yao,Z.
  TITLE     Calcineurin/nuclear factors of activated T cells (NFAT)-activating
            and immunoreceptor tyrosine-based activation motif
            (ITAM)-containing protein (CNAIP), a novel ITAM-containing protein
            that activates the calcineurin/NFAT-signaling pathway
  JOURNAL   J Biol Chem 278 (19), 16797-16801 (2003)
   PUBMED   12615919
  REMARK    GeneRIF: CNAIP is a ITAM-containing protein that activates the
            calcineurin/NFAT-signaling pathway and the downstream cytokine gene
            promoters
REFERENCE   10 (bases 1 to 5613)
  AUTHORS   Jikuya,H., Takano,J., Kikuno,R., Hirosawa,M., Nagase,T., Nomura,N.
            and Ohara,O.
  TITLE     Characterization of long cDNA clones from human adult spleen. II.
            The complete sequences of 81 cDNA clones
  JOURNAL   DNA Res 10 (1), 49-57 (2003)
   PUBMED   12693554
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL022316.2, AY121370.1, BC038241.1 and CA426933.1.
            
            On Jul 17, 2019 this sequence version replaced NM_145912.7.
            
            Summary: The protein encoded by this gene is a type I membrane
            receptor that activates cytokine gene promoters such as the IL-13
            and TNF-alpha promoters. The encoded protein contains an
            immunoreceptor tyrosine-based activation motif (ITAM) and is
            thought to regulate the signaling and development of B-cells.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC038241.1, SRR14038191.205606.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2149004 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000329021.10/ ENSP00000333680.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 AL022316.2         61202-61209         c
            9-917               AY121370.1         1-909
            918-1694            BC038241.1         905-1681
            1695-5438           AL022316.2         9388-13131          c
            5439-5613           CA426933.1         16-190              c
FEATURES             Location/Qualifiers
     source          1..5613
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.2"
     gene            1..5613
                     /gene="NFAM1"
                     /gene_synonym="CNAIP"
                     /note="NFAT activating protein with ITAM motif 1"
                     /db_xref="GeneID:150372"
                     /db_xref="HGNC:HGNC:29872"
                     /db_xref="MIM:608740"
     exon            1..167
                     /gene="NFAM1"
                     /gene_synonym="CNAIP"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..859
                     /gene="NFAM1"
                     /gene_synonym="CNAIP"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; NFAT activation molecule 1;
                     calcineurin/NFAT-activating ITAM-containing protein"
                     /codon_start=1
                     /product="NFAT activation molecule 1 isoform 1 precursor"
                     /protein_id="NP_666017.1"
                     /db_xref="CCDS:CCDS14034.1"
                     /db_xref="GeneID:150372"
                     /db_xref="HGNC:HGNC:29872"
                     /db_xref="MIM:608740"
                     /translation="MENQPVRWRALPGLPRPPGLPAAPWLLLGVLLLPGTLRLAGGQS
                     VTHTGLPIMASLANTAISFSCRITYPYTPQFKVFTVSYFHEDLQGQRSPKKPTNCHPG
                     LGTENQSHTLDCQVTLVLPGASATGTYYCSVHWPHSTVRGSGTFILVRDAGYREPPQS
                     PQKLLLFGFTGLLSVLSVVGTALLLWNKKRMRGPGKDPTRKCPDPRSASSPKQHPSES
                     VYTALQRRETEVYACIENEDGSSPTAKQSPLSQERPHRFEDDGELNLVYENL"
     exon            168..497
                     /gene="NFAM1"
                     /gene_synonym="CNAIP"
                     /inference="alignment:Splign:2.1.0"
     exon            498..610
                     /gene="NFAM1"
                     /gene_synonym="CNAIP"
                     /inference="alignment:Splign:2.1.0"
     exon            611..709
                     /gene="NFAM1"
                     /gene_synonym="CNAIP"
                     /inference="alignment:Splign:2.1.0"
     exon            710..799
                     /gene="NFAM1"
                     /gene_synonym="CNAIP"
                     /inference="alignment:Splign:2.1.0"
     exon            800..5613
                     /gene="NFAM1"
                     /gene_synonym="CNAIP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3035..3040
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NFAM1"
                     /gene_synonym="CNAIP"
                     /note="hexamer: AATAAA"
     polyA_site      3053
                     /gene="NFAM1"
                     /gene_synonym="CNAIP"
                     /note="major polyA site"
     regulatory      5591..5596
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NFAM1"
                     /gene_synonym="CNAIP"
                     /note="hexamer: ATTAAA"
     polyA_site      5613
                     /gene="NFAM1"
                     /gene_synonym="CNAIP"
                     /note="major polyA site"
ORIGIN      
        1 cccctcctgt gaactaaaga gtcgccgcag acaagcaggc ccccagatgg agaaccagcc
       61 tgtgaggtgg cgggccctgc caggcctccc acgccctcct gggctccccg cagccccctg
      121 gctcctcctt ggcgtgctgc tgctgcccgg gaccctgcga ctggcaggag gacagtcagt
      181 gacccacacc ggcctgccca tcatggcctc cctggccaac acagctatct ccttcagctg
      241 caggatcacc tatccataca ctccccaatt caaggttttc acagtcagct actttcatga
      301 agatctccag ggacagagga gccctaagaa gccaacaaac tgccaccctg gactgggcac
      361 agagaaccag agccacaccc tggactgcca ggtcaccctt gtgctgccgg gagcatcggc
      421 cactggcacc tactactgct ctgtccactg gccacactcc acggtgagag gcagcggcac
      481 cttcatcctg gtcagagacg cagggtaccg agagcccccg cagagtccac agaagctcct
      541 gctctttggc ttcaccggcc tcctgagtgt cctgagtgta gtgggcacgg ccctgctgct
      601 ctggaacaag aagcggatgc ggggtccagg gaaggacccc accaggaagt gcccagatcc
      661 aagatctgcc agcagcccca agcagcatcc ttcagaatct gtctacacag ctctgcagcg
      721 ccgcgagacc gaggtctatg cctgcatcga gaatgaggat ggcagctcac ccaccgccaa
      781 gcagagcccc ctctcccagg agagaccgca tagattcgaa gatgatggcg aacttaacct
      841 ggtctatgaa aatctctagg atgggctcca ccgctcatag agcttgccct gggtcagagg
      901 accggggcag cccctgccac caaaggactt gatctgagtt gggagtaagg cccccaggga
      961 caccccatca tttcaccctc acattcaagg cccttcctgt cttggccggc cccactgccc
     1021 ccccattcta tgccccaacc accaaggctt tcccatcttg gggcctttgc ccaggctgtt
     1081 ccttctgcca ggcaggccct tcctcccttg gcccaaccag caaagcgccc ctcagtcttc
     1141 aagggctttc ctggatgcca cccttgccca gagccctgct cactgcctca tgctgacaga
     1201 gcagcatgct ctcttggcac cagcctgcac ctcagccagt agggcagcct ctgagctgag
     1261 ggaggaccct gcaggggcgc ctagcagtgc tgtgtgggga gccgaggtat ggaggagctg
     1321 gggagcagct atgcaaatcc ctacctaccc agctgggcca gaggcacgag gcagccaggc
     1381 agggtgggag caggggctgg cgtgggaggt ctgggggaca gacaaggatg atggacccct
     1441 cagaggcaag actaggatca gggacagatc tggaggccca ggacatggct gagaggtggt
     1501 cagcaggctg ggggcatgga gcagagaggg cttgggtaca agctggagag gaaggagatt
     1561 ctggcatgtt ggggtgaggg cagagggaca gatgagggga ggagggtgct ggctaaacag
     1621 gaactgaatg aatggcctga agctccctct cccaagggtt cccactccca ttggcctggc
     1681 cctgtacgtg cactctgtca tctccttggt caccctctgc tccaggcctt ctccaccaca
     1741 ggacctcagc tgtccctcct tctacccaag gtggagtccc ccaaagtccc ttctgtctgg
     1801 cctatcctgt gcccaccacc tgtggcttca tccagccctc ctcctctatc tttatctgcc
     1861 ataggccgca gccctggccc cctgtggatt gaggtcccaa gtggtccagc tgtggggttt
     1921 ggtgctggga ccctcaatgg cagccggaag gtccctctga ggcagaagct caagccccat
     1981 ggggacagtg gctccccagt gcctggccct gagccatttc tgctgtttca ggtgcccaca
     2041 tcaccctcat ttcctcctcg cagtagccct gcaccgtggc cagaaaccca tccacaggca
     2101 ggcagtggct ggggtccggg tgccccgggc tgttgggctc tgcttcctcc ctctgctccc
     2161 ccatgtctcc ctgagttctc ccacctttgc tcatttgtaa aatgggcagg tcaatcttcc
     2221 caccccaccg tgtgggctgc cccaacccca aatgtgccca gggagggggg ggaacccaag
     2281 gcacaggccc cgcccctgcc cccaagcagc actgggctac tggctcacag aagcaccttt
     2341 ggttctgcag gtcatgcccc tccctgcagg gaagggaaag ctggtggtag aggctgggca
     2401 cagactgacg tccagaagaa gtcccttggc cctgctaggg tggcaccaga cttctctggt
     2461 cccacaggac agccagtggc ctcccaactt ggttctgggc ccccgcctgc aagcacacat
     2521 ggcaaggagg gctttagcag gctcacataa ccgagtggca aggcccctgc tcccagaggc
     2581 tggatttgaa tgaactccgg gcctgtttgg ggaggtgaag ctgccaggtg tgcacagggg
     2641 cctcccaggc tcctggctcc accagccaag gaggtggggg caagggtcag ggcaatgggg
     2701 gacaatgccg ctcagggtgc agtgagctcc cctgggaaaa ccgaagccag caagaccagg
     2761 agagggccac ctcactgggc ctgcctcccc cacctcctgg gcctctctga cctcagctcc
     2821 tagaccctgg acccttggct gggactcagc attttccagt ctttttcagg ggtagacagg
     2881 ggagcctggg ttaaacttta ccactgtgcc ctggcccagg catcaccaac acggcctccc
     2941 tgcagctgcc ctgccaccga cagaccccga ttaaacccac acctggcctt ggcctcccct
     3001 gctctatacc ttgcatggtt tttgcctcac ttggaataaa attccaactc ctccctgtgg
     3061 cgtaggaggt tcttgggggc tgacccatca cccctctggt ggacagagac attgccagcg
     3121 tggtggtcgt ctgtgcttgg ttcagggcaa ggctgggagg cagtgggtgc tgaggtcttc
     3181 agtgagcaag gagagaggca gggaggagga ggaggaggag gagagcacag catgaaagga
     3241 cgggacccta aagggctttg gcccaaggga gggtggggca agaatgttct gagacttctg
     3301 tgggcagcaa agaggactga gcacctgttc tccagccccc aggactgaga gcctgcagag
     3361 acaagctggc acagggcgag gggtggcagg gaacttcagg gtgggaggtg catggggcag
     3421 gcgggaggag gaagaacaga gaggggacag agagggtatg aatgggagct cctggggtgc
     3481 aggcttgctt tccactatga atgggtggag gagggaagag aagaaaattg cttttgagac
     3541 ccacccaggc tgggtggcct cagggcctcc cttgaatccc tgctccacct cccacagcct
     3601 tgtggacttg ggcaagtcac tggccacctg agcctcagtt tgcagtgaca gtcaagacag
     3661 ctcaggccag gcgtagtggc ttatgcctgt aatcccagca tgttgggagg ccgaggcggg
     3721 tggatcactt gaggccagga gtttgagacc agcctggcca acgtggtgaa accccgtctc
     3781 tactaaaaat acaaaaatta gcctggtgtg gtggcacgca cctgtagtcc cagctactcg
     3841 agaggctaag gcaggagaat ctcttgaacc tgggagacag aggttgcagt gagccgaagt
     3901 ggcaccactg cacaccagcc tgggctacag agcacgctct gtccaaataa acaaacaaac
     3961 aaacactact cagtgtctca gaaaggacag aaggggactc cctggctcag gcagaagctc
     4021 agtgggtgtg catttccttc aagactcgtc cttcagaagg aataggcttc tggggcagta
     4081 cagaggagtc taagtgagag gcaggcctcc ctgggagctg ggcccaggct ctctgcagcc
     4141 atgcctttaa ggagtgccta cggggtagca cgatcagatg gacaggccag ggctgcccag
     4201 agctgggggt gggagcaagg taagcagaga ggtgagggaa ggagggtgct ggcttagcag
     4261 gagctgaatg aatgggcctg gaggggaaaa gctaaggggg atggggtggc ttgagtggag
     4321 taggtgaggc ctaggtgaag gggagctgtg gaccttccag gacggacgga tgtgagcagt
     4381 cctgagtggg gactggagtt agggtgggga agggaagccc caggcagccc ctgcaggccc
     4441 ctgcccctgg gccctaccgc agcagggcag ccctgtctct gggtctcagc tgatgcttcc
     4501 ctctgcccac tggcccctga cctggtggga tttcccacca tctctcccgg cccagcctgc
     4561 cctgccctcc taggtcttcc caacctcccc tctgcagaaa catctcagcc acgtctggca
     4621 cccccaggca tccctgcctg cctctaggaa gttgacccct tcaatgggtt tcagcctcca
     4681 accccacccc cgcttgactc ctgctctgtc agcacttgct tgagaaaatc atcctgggaa
     4741 accagcttct gggagcaggg gccttgccac tcggttctgc gagcctgctg aagccctcct
     4801 tgccacgtgt gcttgcaggc gggggcccag aactaagcta ggaggccact ggctgtcctg
     4861 tgggaccagg gaagtctggt gccaccctag cagagggccc atggacttct tctggaggtc
     4921 agtctgtgcc cagcctctac caccagtcca gaacttgcag tgggtgcggt aaacggtggc
     4981 ccctcctcag caaacatttc caggggattc tggcagcaga gtttccatgg gaacatgtgc
     5041 tggttctgcg ctgaacccgg tgtggctggg gttcccttca cagccaatat tgcaggaact
     5101 gagcctggtg gcctcggcca gggtaggcag tgctctttgg ccacccagtg tcacaaacct
     5161 gaactcaagt tacaggcaaa acctgctttt cctttttctt tctctctctc tctctttttt
     5221 tttttgttaa agcacattct aatgtaaagt ccatgctcca ttctaaagat gcctctggga
     5281 tttcagggat ggatttttat gtagttcaat agttttcttg gcagacagct tatgcaggag
     5341 aggtgggccg ttggctcagt ccagccaggc tgagtggcgt cactccattc cttgcaatgc
     5401 caggggatgt catttgtcca cctgaggggg cttccccagt ctcccttccc tgacctgtgg
     5461 tcagaatgat ggcctcagcc ttgactgagc gcgggtcagg ccagactctc tgaacttggt
     5521 gttggcgtgt gttttgtgtg tgtctggagg tgacatatgt gggtgacaga agcatatgtt
     5581 acagtgaaac attaaaacta cagcaaagtg aaa
//
