LOCUS       NM_001042492           12373 bp    mRNA    linear   PRI 08-FEB-2025
DEFINITION  Homo sapiens neurofibromin 1 (NF1), transcript variant 1, mRNA.
ACCESSION   NM_001042492
VERSION     NM_001042492.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 12373)
  AUTHORS   Savad,S., Modarressi,M.H., Younesi,S., Seifi-Alan,M., Samadaian,N.,
            Masoomy,M., Dianatpour,M., Norouzi,S., Amidi,S., Boroumand,A.,
            Ashrafi,M.R., Ronagh,A., Eslami,M., Hashemnejad,M., Nourian,S.,
            Mohammadi,S., Taheri Amin,M.M., Heidari,M., Seifi-Alan,M.,
            Shojaaldini Ardakani,H., Aghamahdi,F., Khalilian,S. and
            Ghafouri-Fard,S.
  TITLE     A Comprehensive Overview of NF1 Mutations in Iranian Patients
  JOURNAL   Neuromolecular Med 26 (1), 28 (2024)
   PUBMED   38954284
  REMARK    GeneRIF: A Comprehensive Overview of NF1 Mutations in Iranian
            Patients.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 12373)
  AUTHORS   Chen,S., Cheng,H. and Zhao,G.
  TITLE     The genetic spectrum of NF1 variants in 10 unrelated Chinese
            families with neurofibromatosis type 1
  JOURNAL   Neurosciences (Riyadh) 29 (3), 177-183 (2024)
   PUBMED   38981629
  REMARK    GeneRIF: The genetic spectrum of NF1 variants in 10 unrelated
            Chinese families with neurofibromatosis type 1.
REFERENCE   3  (bases 1 to 12373)
  AUTHORS   Perrin,S., Protic,S., Bretegnier,V., Laurendeau,I., de
            Lageneste,O.D., Panara,N., Ruckebusch,O., Luka,M., Masson,C.,
            Maillard,T., Coulpier,F., Pannier,S., Wicart,P., Hadj-Rabia,S.,
            Radomska,K.J., Zarhrate,M., Menager,M., Vidaud,D., Topilko,P.,
            Parfait,B. and Colnot,C.
  TITLE     MEK-SHP2 inhibition prevents tibial pseudarthrosis caused by NF1
            loss in Schwann cells and skeletal stem/progenitor cells
  JOURNAL   Sci Transl Med 16 (753), eadj1597 (2024)
   PUBMED   38924432
  REMARK    GeneRIF: MEK-SHP2 inhibition prevents tibial pseudarthrosis caused
            by NF1 loss in Schwann cells and skeletal stem/progenitor cells.
            Erratum:[Sci Transl Med. 2024 Aug 28;16(762):eads3171. doi:
            10.1126/scitranslmed.ads3171.. PMID: 39196963]
REFERENCE   4  (bases 1 to 12373)
  AUTHORS   Mukhopadhyay,D., Anant,S., Lee,R.M., Kennedy,S., Viskochil,D. and
            Davidson,N.O.
  TITLE     C-->U editing of neurofibromatosis 1 mRNA occurs in tumors that
            express both the type II transcript and apobec-1, the catalytic
            subunit of the apolipoprotein B mRNA-editing enzyme
  JOURNAL   Am J Hum Genet 70 (1), 38-50 (2002)
   PUBMED   11727199
  REMARK    GeneRIF: C-->U editing of neurofibromatosis 1 mRNA occurs in tumors
            that express both the type II transcript and apobec-1, the
            catalytic subunit of the apolipoprotein B mRNA-editing enzyme
REFERENCE   5  (bases 1 to 12373)
  AUTHORS   Skuse,G.R., Cappione,A.J., Sowden,M., Metheny,L.J. and Smith,H.C.
  TITLE     The neurofibromatosis type I messenger RNA undergoes
            base-modification RNA editing
  JOURNAL   Nucleic Acids Res 24 (3), 478-485 (1996)
   PUBMED   8602361
REFERENCE   6  (bases 1 to 12373)
  AUTHORS   Parisi,M.A.
  TITLE     Hirschsprung Disease Overview - RETIRED CHAPTER, FOR HISTORICAL
            REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301612
REFERENCE   7  (bases 1 to 12373)
  AUTHORS   Turner,J.T., Brzezinski,J. and Dome,J.S.
  TITLE     Wilms Tumor Predisposition
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301471
REFERENCE   8  (bases 1 to 12373)
  AUTHORS   Friedman,J.M.
  TITLE     Neurofibromatosis 1
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301288
REFERENCE   9  (bases 1 to 12373)
  AUTHORS   Upadhyaya,M., Shen,M., Cherryson,A., Farnham,J., Maynard,J.,
            Huson,S.M. and Harper,P.S.
  TITLE     Analysis of mutations at the neurofibromatosis 1 (NF1) locus
  JOURNAL   Hum Mol Genet 1 (9), 735-740 (1992)
   PUBMED   1302608
REFERENCE   10 (bases 1 to 12373)
  AUTHORS   Suzuki,H., Takahashi,K., Kubota,Y. and Shibahara,S.
  TITLE     Molecular cloning of a cDNA coding for neurofibromatosis type 1
            protein isoform lacking the domain related to ras GTPase-activating
            protein
  JOURNAL   Biochem Biophys Res Commun 187 (2), 984-990 (1992)
   PUBMED   1339276
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from D12625.1, M89914.1, BX391799.2,
            BP271334.1, AC135724.9 and AK026658.1.
            
            On Aug 31, 2019 this sequence version replaced NM_001042492.2.
            
            Summary: This gene product appears to function as a negative
            regulator of the ras signal transduction pathway. Mutations in this
            gene have been linked to neurofibromatosis type 1, juvenile
            myelomonocytic leukemia and Watson syndrome. The mRNA for this gene
            is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in
            premature translation termination. Alternatively spliced transcript
            variants encoding different isoforms have also been described for
            this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1), with an additional in-frame
            coding exon, represents the longest transcript and encodes the
            longest isoform (1). Studies suggest preferential C->U RNA editing
            of transcripts containing this exon.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.230565.1, M89914.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358273.9/ ENSP00000351015.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            undergoes RNA editing  :: PMID: 8602361, 11727199
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-160               D12625.1           51-210
            161-1034            M89914.1           25-898
            1035-1035           BX391799.2         367-367             c
            1036-5594           M89914.1           900-5458
            5595-5836           BP271334.1         341-582
            5837-9054           M89914.1           5701-8918
            9055-12221          AC135724.9         82157-85323         c
            12222-12373         AK026658.1         2215-2366
FEATURES             Location/Qualifiers
     source          1..12373
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q11.2"
     gene            1..12373
                     /gene="NF1"
                     /gene_synonym="NFNS; VRNF; WSS"
                     /note="neurofibromin 1"
                     /db_xref="GeneID:4763"
                     /db_xref="HGNC:HGNC:7765"
                     /db_xref="MIM:613113"
     exon            1..393
                     /gene="NF1"
                     /gene_synonym="NFNS; VRNF; WSS"
                     /inference="alignment:Splign:2.1.0"
     CDS             334..8853
                     /gene="NF1"
                     /gene_synonym="NFNS; VRNF; WSS"
                     /note="isoform 1 is encoded by transcript variant 1;
                     neurofibromatosis-related protein NF-1; neurofibromatosis
                     1"
                     /codon_start=1
                     /product="neurofibromin isoform 1"
                     /protein_id="NP_001035957.1"
                     /db_xref="CCDS:CCDS42292.1"
                     /db_xref="GeneID:4763"
                     /db_xref="HGNC:HGNC:7765"
                     /db_xref="MIM:613113"
                     /translation="MAAHRPVEWVQAVVSRFDEQLPIKTGQQNTHTKVSTEHNKECLI
                     NISKYKFSLVISGLTTILKNVNNMRIFGEAAEKNLYLSQLIILDTLEKCLAGQPKDTM
                     RLDETMLVKQLLPEICHFLHTCREGNQHAAELRNSASGVLFSLSCNNFNAVFSRISTR
                     LQELTVCSEDNVDVHDIELLQYINVDCAKLKRLLKETAFKFKALKKVAQLAVINSLEK
                     AFWNWVENYPDEFTKLYQIPQTDMAECAEKLFDLVDGFAESTKRKAAVWPLQIILLIL
                     CPEIIQDISKDVVDENNMNKKLFLDSLRKALAGHGGSRQLTESAAIACVKLCKASTYI
                     NWEDNSVIFLLVQSMVVDLKNLLFNPSKPFSRGSQPADVDLMIDCLVSCFRISPHNNQ
                     HFKICLAQNSPSTFHYVLVNSLHRIITNSALDWWPKIDAVYCHSVELRNMFGETLHKA
                     VQGCGAHPAIRMAPSLTFKEKVTSLKFKEKPTDLETRSYKYLLLSMVKLIHADPKLLL
                     CNPRKQGPETQGSTAELITGLVQLVPQSHMPEIAQEAMEALLVLHQLDSIDLWNPDAP
                     VETFWEISSQMLFYICKKLTSHQMLSSTEILKWLREILICRNKFLLKNKQADRSSCHF
                     LLFYGVGCDIPSSGNTSQMSMDHEELLRTPGASLRKGKGNSSMDSAAGCSGTPPICRQ
                     AQTKLEVALYMFLWNPDTEAVLVAMSCFRHLCEEADIRCGVDEVSVHNLLPNYNTFME
                     FASVSNMMSTGRAALQKRVMALLRRIEHPTAGNTEAWEDTHAKWEQATKLILNYPKAK
                     MEDGQAAESLHKTIVKRRMSHVSGGGSIDLSDTDSLQEWINMTGFLCALGGVCLQQRS
                     NSGLATYSPPMGPVSERKGSMISVMSSEGNADTPVSKFMDRLLSLMVCNHEKVGLQIR
                     TNVKDLVGLELSPALYPMLFNKLKNTISKFFDSQGQVLLTDTNTQFVEQTIAIMKNLL
                     DNHTEGSSEHLGQASIETMMLNLVRYVRVLGNMVHAIQIKTKLCQLVEVMMARRDDLS
                     FCQEMKFRNKMVEYLTDWVMGTSNQAADDDVKCLTRDLDQASMEAVVSLLAGLPLQPE
                     EGDGVELMEAKSQLFLKYFTLFMNLLNDCSEVEDESAQTGGRKRGMSRRLASLRHCTV
                     LAMSNLLNANVDSGLMHSIGLGYHKDLQTRATFMEVLTKILQQGTEFDTLAETVLADR
                     FERLVELVTMMGDQGELPIAMALANVVPCSQWDELARVLVTLFDSRHLLYQLLWNMFS
                     KEVELADSMQTLFRGNSLASKIMTFCFKVYGATYLQKLLDPLLRIVITSSDWQHVSFE
                     VDPTRLEPSESLEENQRNLLQMTEKFFHAIISSSSEFPPQLRSVCHCLYQATCHSLLN
                     KATVKEKKENKKSVVSQRFPQNSIGAVGSAMFLRFINPAIVSPYEAGILDKKPPPRIE
                     RGLKLMSKILQSIANHVLFTKEEHMRPFNDFVKSNFDAARRFFLDIASDCPTSDAVNH
                     SLSFISDGNVLALHRLLWNNQEKIGQYLSSNRDHKAVGRRPFDKMATLLAYLGPPEHK
                     PVADTHWSSLNLTSSKFEEFMTRHQVHEKEEFKALKTLSIFYQAGTSKAGNPIFYYVA
                     RRFKTGQINGDLLIYHVLLTLKPYYAKPYEIVVDLTHTGPSNRFKTDFLSKWFVVFPG
                     FAYDNVSAVYIYNCNSWVREYTKYHERLLTGLKGSKRLVFIDCPGKLAEHIEHEQQKL
                     PAATLALEEDLKVFHNALKLAHKDTKVSIKVGSTAVQVTSAERTKVLGQSVFLNDIYY
                     ASEIEEICLVDENQFTLTIANQGTPLTFMHQECEAIVQSIIHIRTRWELSQPDSIPQH
                     TKIRPKDVPGTLLNIALLNLGSSDPSLRSAAYNLLCALTCTFNLKIEGQLLETSGLCI
                     PANNTLFIVSISKTLAANEPHLTLEFLEECISGFSKSSIELKHLCLEYMTPWLSNLVR
                     FCKHNDDAKRQRVTAILDKLITMTINEKQMYPSIQAKIWGSLGQITDLLDVVLDSFIK
                     TSATGGLGSIKAEVMADTAVALASGNVKLVSSKVIGRMCKIIDKTCLSPTPTLEQHLM
                     WDDIAILARYMLMLSFNNSLDVAAHLPYLFHVVTFLVATGPLSLRASTHGLVINIIHS
                     LCTCSQLHFSEETKQVLRLSLTEFSLPKFYLLFGISKVKSAAVIAFRSSYRDRSFSPG
                     SYERETFALTSLETVTEALLEIMEACMRDIPTCKWLDQWTELAQRFAFQYNPSLQPRA
                     LVVFGCISKRVSHGQIKQIIRILSKALESCLKGPDTYNSQVLIEATVIALTKLQPLLN
                     KDSPLHKALFWVAVAVLQLDEVNLYSAGTALLEQNLHTLDSLRIFNDKSPEEVFMAIR
                     NPLEWHCKQMDHFVGLNFNSNFNFALVGHLLKGYRHPSPAIVARTVRILHTLLTLVNK
                     HRNCDKFEVNTQSVAYLAALLTVSEEVRSRCSLKHRKSLLLTDISMENVPMDTYPIHH
                     GDPSYRTLKETQPWSSPKGSEGYLAATYPTVGQTSPRARKSMSLDMGQPSQANTKKLL
                     GTRKSFDHLISDTKAPKRQEMESGITTPPKMRRVAETDYEMETQRISSSQQHPHLRKV
                     SVSESNVLLDEEVLTDPKIQALLLTVLATLVKYTTDEFDQRILYEYLAEASVVFPKVF
                     PVVHNLLDSKINTLLSLCQDPNLLNPIHGIVQSVVYHEESPPQYQTSYLQSFGFNGLW
                     RFAGPFSKQTQIPDYAELIVKFLDALIDTYLPGIDEETSEESLLTPTSPYPPALQSQL
                     SITANLNLSNSMTSLATSQHSPGIDKENVELSPTTGHCNSGRTRHGSASQVQKQRSAG
                     SFKRNSIKKIV"
     exon            394..537
                     /gene="NF1"
                     /gene_synonym="NFNS; VRNF; WSS"
                     /inference="alignment:Splign:2.1.0"
     exon            538..621
                     /gene="NF1"
                     /gene_synonym="NFNS; VRNF; WSS"
                     /inference="alignment:Splign:2.1.0"
     exon            622..812
                     /gene="NF1"
                     /gene_synonym="NFNS; VRNF; WSS"
                     /inference="alignment:Splign:2.1.0"
     exon            813..919
                     /gene="NF1"
                     /gene_synonym="NFNS; VRNF; WSS"
                     /inference="alignment:Splign:2.1.0"
     exon            920..987
                     /gene="NF1"
                     /gene_synonym="NFNS; VRNF; WSS"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1063
                     /gene="NF1"
                     /gene_synonym="NFNS; VRNF; WSS"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1221
                     /gene="NF1"
                     /gene_synonym="NFNS; VRNF; WSS"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1395
                     /gene="NF1"
                     /gene_synonym="NFNS; VRNF; WSS"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1518
                     /gene="NF1"
                     /gene_synonym="NFNS; VRNF; WSS"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..1593
                     /gene="NF1"
                     /gene_synonym="NFNS; VRNF; WSS"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1725
                     /gene="NF1"
                     /gene_synonym="NFNS; VRNF; WSS"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..1860
                     /gene="NF1"
                     /gene_synonym="NFNS; VRNF; WSS"
                     /inference="alignment:Splign:2.1.0"
     exon            1861..1974
                     /gene="NF1"
                     /gene_synonym="NFNS; VRNF; WSS"
                     /inference="alignment:Splign:2.1.0"
     exon            1975..2054
                     /gene="NF1"
                     /gene_synonym="NFNS; VRNF; WSS"
                     /inference="alignment:Splign:2.1.0"
     exon            2055..2178
                     /gene="NF1"
                     /gene_synonym="NFNS; VRNF; WSS"
                     /inference="alignment:Splign:2.1.0"
     exon            2179..2334
                     /gene="NF1"
                     /gene_synonym="NFNS; VRNF; WSS"
                     /inference="alignment:Splign:2.1.0"
     exon            2335..2584
                     /gene="NF1"
                     /gene_synonym="NFNS; VRNF; WSS"
                     /inference="alignment:Splign:2.1.0"
     exon            2585..2658
                     /gene="NF1"
                     /gene_synonym="NFNS; VRNF; WSS"
                     /inference="alignment:Splign:2.1.0"
     exon            2659..2742
                     /gene="NF1"
                     /gene_synonym="NFNS; VRNF; WSS"
                     /inference="alignment:Splign:2.1.0"
     exon            2743..3183
                     /gene="NF1"
                     /gene_synonym="NFNS; VRNF; WSS"
                     /inference="alignment:Splign:2.1.0"
     exon            3184..3323
                     /gene="NF1"
                     /gene_synonym="NFNS; VRNF; WSS"
                     /inference="alignment:Splign:2.1.0"
     exon            3324..3446
                     /gene="NF1"
                     /gene_synonym="NFNS; VRNF; WSS"
                     /inference="alignment:Splign:2.1.0"
     exon            3447..3530
                     /gene="NF1"
                     /gene_synonym="NFNS; VRNF; WSS"
                     /inference="alignment:Splign:2.1.0"
     exon            3531..3647
                     /gene="NF1"
                     /gene_synonym="NFNS; VRNF; WSS"
                     /inference="alignment:Splign:2.1.0"
     exon            3648..3829
                     /gene="NF1"
                     /gene_synonym="NFNS; VRNF; WSS"
                     /inference="alignment:Splign:2.1.0"
     exon            3830..4041
                     /gene="NF1"
                     /gene_synonym="NFNS; VRNF; WSS"
                     /inference="alignment:Splign:2.1.0"
     exon            4042..4203
                     /gene="NF1"
                     /gene_synonym="NFNS; VRNF; WSS"
                     /inference="alignment:Splign:2.1.0"
     exon            4204..4307
                     /gene="NF1"
                     /gene_synonym="NFNS; VRNF; WSS"
                     /inference="alignment:Splign:2.1.0"
     exon            4308..4443
                     /gene="NF1"
                     /gene_synonym="NFNS; VRNF; WSS"
                     /inference="alignment:Splign:2.1.0"
     exon            4444..4506
                     /gene="NF1"
                     /gene_synonym="NFNS; VRNF; WSS"
                     /inference="alignment:Splign:2.1.0"
     exon            4507..4665
                     /gene="NF1"
                     /gene_synonym="NFNS; VRNF; WSS"
                     /inference="alignment:Splign:2.1.0"
     exon            4666..4763
                     /gene="NF1"
                     /gene_synonym="NFNS; VRNF; WSS"
                     /inference="alignment:Splign:2.1.0"
     exon            4764..4910
                     /gene="NF1"
                     /gene_synonym="NFNS; VRNF; WSS"
                     /inference="alignment:Splign:2.1.0"
     exon            4911..5057
                     /gene="NF1"
                     /gene_synonym="NFNS; VRNF; WSS"
                     /inference="alignment:Splign:2.1.0"
     exon            5058..5168
                     /gene="NF1"
                     /gene_synonym="NFNS; VRNF; WSS"
                     /inference="alignment:Splign:2.1.0"
     exon            5169..5601
                     /gene="NF1"
                     /gene_synonym="NFNS; VRNF; WSS"
                     /inference="alignment:Splign:2.1.0"
     exon            5602..5942
                     /gene="NF1"
                     /gene_synonym="NFNS; VRNF; WSS"
                     /inference="alignment:Splign:2.1.0"
     exon            5943..6145
                     /gene="NF1"
                     /gene_synonym="NFNS; VRNF; WSS"
                     /inference="alignment:Splign:2.1.0"
     exon            6146..6339
                     /gene="NF1"
                     /gene_synonym="NFNS; VRNF; WSS"
                     /inference="alignment:Splign:2.1.0"
     exon            6340..6480
                     /gene="NF1"
                     /gene_synonym="NFNS; VRNF; WSS"
                     /inference="alignment:Splign:2.1.0"
     exon            6481..6760
                     /gene="NF1"
                     /gene_synonym="NFNS; VRNF; WSS"
                     /inference="alignment:Splign:2.1.0"
     exon            6761..6975
                     /gene="NF1"
                     /gene_synonym="NFNS; VRNF; WSS"
                     /inference="alignment:Splign:2.1.0"
     exon            6976..7037
                     /gene="NF1"
                     /gene_synonym="NFNS; VRNF; WSS"
                     /inference="alignment:Splign:2.1.0"
     exon            7038..7152
                     /gene="NF1"
                     /gene_synonym="NFNS; VRNF; WSS"
                     /inference="alignment:Splign:2.1.0"
     exon            7153..7254
                     /gene="NF1"
                     /gene_synonym="NFNS; VRNF; WSS"
                     /inference="alignment:Splign:2.1.0"
     exon            7255..7395
                     /gene="NF1"
                     /gene_synonym="NFNS; VRNF; WSS"
                     /inference="alignment:Splign:2.1.0"
     exon            7396..7522
                     /gene="NF1"
                     /gene_synonym="NFNS; VRNF; WSS"
                     /inference="alignment:Splign:2.1.0"
     exon            7523..7654
                     /gene="NF1"
                     /gene_synonym="NFNS; VRNF; WSS"
                     /inference="alignment:Splign:2.1.0"
     exon            7655..7790
                     /gene="NF1"
                     /gene_synonym="NFNS; VRNF; WSS"
                     /inference="alignment:Splign:2.1.0"
     exon            7791..7948
                     /gene="NF1"
                     /gene_synonym="NFNS; VRNF; WSS"
                     /inference="alignment:Splign:2.1.0"
     exon            7949..8071
                     /gene="NF1"
                     /gene_synonym="NFNS; VRNF; WSS"
                     /inference="alignment:Splign:2.1.0"
     exon            8072..8202
                     /gene="NF1"
                     /gene_synonym="NFNS; VRNF; WSS"
                     /inference="alignment:Splign:2.1.0"
     exon            8203..8303
                     /gene="NF1"
                     /gene_synonym="NFNS; VRNF; WSS"
                     /inference="alignment:Splign:2.1.0"
     exon            8304..8446
                     /gene="NF1"
                     /gene_synonym="NFNS; VRNF; WSS"
                     /inference="alignment:Splign:2.1.0"
     exon            8447..8493
                     /gene="NF1"
                     /gene_synonym="NFNS; VRNF; WSS"
                     /inference="alignment:Splign:2.1.0"
     exon            8494..8710
                     /gene="NF1"
                     /gene_synonym="NFNS; VRNF; WSS"
                     /inference="alignment:Splign:2.1.0"
     exon            8711..12373
                     /gene="NF1"
                     /gene_synonym="NFNS; VRNF; WSS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10503..10508
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NF1"
                     /gene_synonym="NFNS; VRNF; WSS"
                     /note="hexamer: AATAAA"
     polyA_site      10529
                     /gene="NF1"
                     /gene_synonym="NFNS; VRNF; WSS"
                     /note="major polyA site"
     regulatory      12346..12351
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NF1"
                     /gene_synonym="NFNS; VRNF; WSS"
                     /note="hexamer: AGTAAA"
     polyA_site      12373
                     /gene="NF1"
                     /gene_synonym="NFNS; VRNF; WSS"
                     /note="major polyA site"
ORIGIN      
        1 acttccggtg gggtgtcatg gcggcgtctc ggactgtgat ggctgtgggg agacggcgct
       61 agtggggaga gcgaccaaga ggccccctcc cctccccggg tccccttccc ctatccccct
      121 ccccccagcc tccttgccaa cgcccccttt ccctctcccc ctcccgctcg gcgctgaccc
      181 cccatcccca cccccgtggg aacactggga gcctgcactc cacagaccct ctccttgcct
      241 cttccctcac ctcagcctcc gctccccgcc ctcttcccgg cccagggcgc cggcccaccc
      301 ttccctccgc cgccccccgg ccgcggggag gacatggccg cgcacaggcc ggtggaatgg
      361 gtccaggccg tggtcagccg cttcgacgag cagcttccaa taaaaacagg acagcagaac
      421 acacatacca aagtcagtac tgagcacaac aaggaatgtc taatcaatat ttccaaatac
      481 aagttttctt tggttataag cggcctcact actattttaa agaatgttaa caatatgaga
      541 atatttggag aagctgctga aaaaaattta tatctctctc agttgattat attggataca
      601 ctggaaaaat gtcttgctgg gcaaccaaag gacacaatga gattagatga aacgatgctg
      661 gtcaaacagt tgctgccaga aatctgccat tttcttcaca cctgtcgtga aggaaaccag
      721 catgcagctg aacttcggaa ttctgcctct ggggttttat tttctctcag ctgcaacaac
      781 ttcaatgcag tctttagtcg catttctacc aggttacagg aattaactgt ttgttcagaa
      841 gacaatgttg atgttcatga tatagaattg ttacagtata tcaatgtgga ttgtgcaaaa
      901 ttaaaacgac tcctgaagga aacagcattt aaatttaaag ccctaaagaa ggttgcgcag
      961 ttagcagtta taaatagcct ggaaaaggca ttttggaact gggtagaaaa ttatccagat
     1021 gaatttacaa aactgtacca gatcccacag actgatatgg ctgaatgtgc agaaaagcta
     1081 tttgacttgg tggatggttt tgctgaaagc accaaacgta aagcagcagt ttggccacta
     1141 caaatcattc tccttatctt gtgtccagaa ataatccagg atatatccaa agacgtggtt
     1201 gatgaaaaca acatgaataa gaagttattt ctggacagtc tacgaaaagc tcttgctggc
     1261 catggaggaa gtaggcagct gacagaaagt gctgcaattg cctgtgtcaa actgtgtaaa
     1321 gcaagtactt acatcaattg ggaagataac tctgtcattt tcctacttgt tcagtccatg
     1381 gtggttgatc ttaagaacct gctttttaat ccaagtaagc cattctcaag aggcagtcag
     1441 cctgcagatg tggatctaat gattgactgc cttgtttctt gctttcgtat aagccctcac
     1501 aacaaccaac actttaagat ctgcctggct cagaattcac cttctacatt tcactatgtg
     1561 ctggtaaatt cactccatcg aatcatcacc aattccgcat tggattggtg gcctaagatt
     1621 gatgctgtgt attgtcactc ggttgaactt cgaaatatgt ttggtgaaac acttcataaa
     1681 gcagtgcaag gttgtggagc acacccagca atacgaatgg caccgagtct tacatttaaa
     1741 gaaaaagtaa caagccttaa atttaaagaa aaacctacag acctggagac aagaagctat
     1801 aagtatcttc tcttgtccat ggtgaaacta attcatgcag atccaaagct cttgctttgt
     1861 aatccaagaa aacaggggcc cgaaacccaa ggcagtacag cagaattaat tacagggctc
     1921 gtccaactgg tccctcagtc acacatgcca gagattgctc aggaagcaat ggaggctctg
     1981 ctggttcttc atcagttaga tagcattgat ttgtggaatc ctgatgctcc tgtagaaaca
     2041 ttttgggaga ttagctcaca aatgcttttt tacatctgca agaaattaac tagtcatcaa
     2101 atgcttagta gcacagaaat tctcaagtgg ttgcgggaaa tattgatctg caggaataaa
     2161 tttcttctta aaaataagca ggcagataga agttcctgtc actttctcct tttttacggg
     2221 gtaggatgtg atattccttc tagtggaaat accagtcaaa tgtccatgga tcatgaagaa
     2281 ttactacgta ctcctggagc ctctctccgg aagggaaaag ggaactcctc tatggatagt
     2341 gcagcaggat gcagcggaac ccccccgatt tgccgacaag cccagaccaa actagaagtg
     2401 gccctgtaca tgtttctgtg gaaccctgac actgaagctg ttctggttgc catgtcctgt
     2461 ttccgccacc tctgtgagga agcagatatc cggtgtgggg tggatgaagt gtcagtgcat
     2521 aacctcttgc ccaactataa cacattcatg gagtttgcct ctgtcagcaa tatgatgtca
     2581 acaggaagag cagcacttca gaaaagagtg atggcactgc tgaggcgcat tgagcatccc
     2641 actgcaggaa acactgaggc ttgggaagat acacatgcaa aatgggaaca agcaacaaag
     2701 ctaatcctta actatccaaa agccaaaatg gaagatggcc aggctgctga aagccttcac
     2761 aagaccattg ttaagaggcg aatgtcccat gtgagtggag gaggatccat agatttgtct
     2821 gacacagact ccctacagga atggatcaac atgactggct tcctttgtgc ccttggggga
     2881 gtgtgcctcc agcagagaag caattctggc ctggcaacct atagcccacc catgggtcca
     2941 gtcagtgaac gtaagggttc tatgatttca gtgatgtctt cagagggaaa cgcagataca
     3001 cctgtcagca aatttatgga tcggctgttg tccttaatgg tgtgtaacca tgagaaagtg
     3061 ggacttcaaa tacggaccaa tgttaaggat ctggtgggtc tagaattgag tcctgctctg
     3121 tatccaatgc tatttaacaa attgaagaat accatcagca agttttttga ctcccaagga
     3181 caggttttat tgactgatac caatactcaa tttgtagaac aaaccatagc tataatgaag
     3241 aacttgctag ataatcatac tgaaggcagc tctgaacatc tagggcaagc tagcattgaa
     3301 acaatgatgt taaatctggt caggtatgtt cgtgtgcttg ggaatatggt ccatgcaatt
     3361 caaataaaaa cgaaactgtg tcaattagtt gaagtaatga tggcaaggag agatgacctc
     3421 tcattttgcc aagagatgaa atttaggaat aagatggtag aatacctgac agactgggtt
     3481 atgggaacat caaaccaagc agcagatgat gatgtaaaat gtcttacaag agatttggac
     3541 caggcaagca tggaagcagt agtttcactt ctagctggtc tccctctgca gcctgaagaa
     3601 ggagatggtg tggaattgat ggaagccaaa tcacagttat ttcttaaata cttcacatta
     3661 tttatgaacc ttttgaatga ctgcagtgaa gttgaagatg aaagtgcgca aacaggtggc
     3721 aggaaacgtg gcatgtctcg gaggctggca tcactgaggc actgtacggt ccttgcaatg
     3781 tcaaacttac tcaatgccaa cgtagacagt ggtctcatgc actccatagg cttaggttac
     3841 cacaaggatc tccagacaag agctacattt atggaagttc tgacaaaaat ccttcaacaa
     3901 ggcacagaat ttgacacact tgcagaaaca gtattggctg atcggtttga gagattggtg
     3961 gaactggtca caatgatggg tgatcaagga gaactcccta tagcgatggc tctggccaat
     4021 gtggttcctt gttctcagtg ggatgaacta gctcgagttc tggttactct gtttgattct
     4081 cggcatttac tctaccaact gctctggaac atgttttcta aagaagtaga attggcagac
     4141 tccatgcaga ctctcttccg aggcaacagc ttggccagta aaataatgac attctgtttc
     4201 aaggtatatg gtgctaccta tctacaaaaa ctcctggatc ctttattacg aattgtgatc
     4261 acatcctctg attggcaaca tgttagcttt gaagtggatc ctaccaggtt agaaccatca
     4321 gagagccttg aggaaaacca gcggaacctc cttcagatga ctgaaaagtt cttccatgcc
     4381 atcatcagtt cctcctcaga attcccccct caacttcgaa gtgtgtgcca ctgtttatac
     4441 caggcaactt gccactccct actgaataaa gctacagtaa aagaaaaaaa ggaaaacaaa
     4501 aaatcagtgg ttagccagcg tttccctcag aacagcatcg gtgcagtagg aagtgccatg
     4561 ttcctcagat ttatcaatcc tgccattgtc tcaccgtatg aagcagggat tttagataaa
     4621 aagccaccac ctagaatcga aaggggcttg aagttaatgt caaagatact tcagagtatt
     4681 gccaatcatg ttctcttcac aaaagaagaa catatgcggc ctttcaatga ttttgtgaaa
     4741 agcaactttg atgcagcacg caggtttttc cttgatatag catctgattg tcctacaagt
     4801 gatgcagtaa atcatagtct ttccttcata agtgacggca atgtgcttgc tttacatcgt
     4861 ctactctgga acaatcagga gaaaattggg cagtatcttt ccagcaacag ggatcataaa
     4921 gctgttggaa gacgaccttt tgataagatg gcaacacttc ttgcatacct gggtcctcca
     4981 gagcacaaac ctgtggcaga tacacactgg tccagcctta accttaccag ttcaaagttt
     5041 gaggaattta tgactaggca tcaggtacat gaaaaagaag aattcaaggc tttgaaaacg
     5101 ttaagtattt tctaccaagc tgggacttcc aaagctggga atcctatttt ttattatgtt
     5161 gcacggaggt tcaaaactgg tcaaatcaat ggtgatttgc tgatatacca tgtcttactg
     5221 actttaaagc catattatgc aaagccatat gaaattgtag tggaccttac ccataccggg
     5281 cctagcaatc gctttaaaac agactttctc tctaagtggt ttgttgtttt tcctggcttt
     5341 gcttacgaca acgtctccgc agtctatatc tataactgta actcctgggt cagggagtac
     5401 accaagtatc atgagcggct gctgactggc ctcaaaggta gcaaaaggct tgttttcata
     5461 gactgtcctg ggaaactggc tgagcacata gagcatgaac aacagaaact acctgctgcc
     5521 accttggctt tagaagagga cctgaaggta ttccacaatg ctctcaagct agctcacaaa
     5581 gacaccaaag tttctattaa agttggttct actgctgtcc aagtaacttc agcagagcga
     5641 acaaaagtcc tagggcaatc agtctttcta aatgacattt attatgcttc ggaaattgaa
     5701 gaaatctgcc tagtagatga gaaccagttc accttaacca ttgcaaacca gggcacgccg
     5761 ctcaccttca tgcaccagga gtgtgaagcc attgtccagt ctatcattca tatccggacc
     5821 cgctgggaac tgtcacagcc cgactctatc ccccaacaca ccaagattcg gccaaaagat
     5881 gtccctggga cactgctcaa tatcgcatta cttaatttag gcagttctga cccgagttta
     5941 cggtcagctg cctataatct tctgtgtgcc ttaacttgta cctttaattt aaaaatcgag
     6001 ggccagttac tagagacatc aggtttatgt atccctgcca acaacaccct ctttattgtc
     6061 tctattagta agacactggc agccaatgag ccacacctca cgttagaatt tttggaagag
     6121 tgtatttctg gatttagcaa atctagtatt gaattgaaac acctttgttt ggaatacatg
     6181 actccatggc tgtcaaatct agttcgtttt tgcaagcata atgatgatgc caaacgacaa
     6241 agagttactg ctattcttga caagctgata acaatgacca tcaatgaaaa acagatgtac
     6301 ccatctattc aagcaaaaat atggggaagc cttgggcaga ttacagatct gcttgatgtt
     6361 gtactagaca gtttcatcaa aaccagtgca acaggtggct tgggatcaat aaaagctgag
     6421 gtgatggcag atactgctgt agctttggct tctggaaatg tgaaattggt ttcaagcaag
     6481 gttattggaa ggatgtgcaa aataattgac aagacatgct tatctccaac tcctacttta
     6541 gaacaacatc ttatgtggga tgatattgct attttagcac gctacatgct gatgctgtcc
     6601 ttcaacaatt cccttgatgt ggcagctcat cttccctacc tcttccacgt tgttactttc
     6661 ttagtagcca caggtccgct ctcccttaga gcttccacac atggactggt cattaatatc
     6721 attcactctc tgtgtacttg ttcacagctt cattttagtg aagagaccaa gcaagttttg
     6781 agactcagtc tgacagagtt ctcattaccc aaattttact tgctgtttgg cattagcaaa
     6841 gtcaagtcag ctgctgtcat tgccttccgt tccagttacc gggacaggtc attctctcct
     6901 ggctcctatg agagagagac ttttgctttg acatccttgg aaacagtcac agaagctttg
     6961 ttggagatca tggaggcatg catgagagat attccaacgt gcaagtggct ggaccagtgg
     7021 acagaactag ctcaaagatt tgcattccaa tataatccat ccctgcaacc aagagctctt
     7081 gttgtctttg ggtgtattag caaacgagtg tctcatgggc agataaagca gataatccgt
     7141 attcttagca aggcacttga gagttgctta aaaggacctg acacttacaa cagtcaagtt
     7201 ctgatagaag ctacagtaat agcactaacc aaattacagc cacttcttaa taaggactcg
     7261 cctctgcaca aagccctctt ttgggtagct gtggctgtgc tgcagcttga tgaggtcaac
     7321 ttgtattcag caggtaccgc acttcttgaa caaaacctgc atactttaga tagtctccgt
     7381 atattcaatg acaagagtcc agaggaagta tttatggcaa tccggaatcc tctggagtgg
     7441 cactgcaagc aaatggatca ttttgttgga ctcaatttca actctaactt taactttgca
     7501 ttggttggac accttttaaa agggtacagg catccttcac ctgctattgt tgcaagaaca
     7561 gtcagaattt tacatacact actaactctg gttaacaaac acagaaattg tgacaaattt
     7621 gaagtgaata cacagagcgt ggcctactta gcagctttac ttacagtgtc tgaagaagtt
     7681 cgaagtcgct gcagcctaaa acatagaaag tcacttcttc ttactgatat ttcaatggaa
     7741 aatgttccta tggatacata tcccattcat catggtgacc cttcctatag gacactaaag
     7801 gagactcagc catggtcctc tcccaaaggt tctgaaggat accttgcagc cacctatcca
     7861 actgtcggcc agaccagtcc ccgagccagg aaatccatga gcctggacat ggggcaacct
     7921 tctcaggcca acactaagaa gttgcttgga acaaggaaaa gttttgatca cttgatatca
     7981 gacacaaagg ctcctaaaag gcaagaaatg gaatcaggga tcacaacacc ccccaaaatg
     8041 aggagagtag cagaaactga ttatgaaatg gaaactcaga ggatttcctc atcacaacag
     8101 cacccacatt tacgtaaagt ttcagtgtct gaatcaaatg ttctcttgga tgaagaagta
     8161 cttactgatc cgaagatcca ggcgctgctt cttactgttc tagctacact ggtaaaatat
     8221 accacagatg agtttgatca acgaattctt tatgaatact tagcagaggc cagtgttgtg
     8281 tttcccaaag tctttcctgt tgtgcataat ttgttggact ctaagatcaa caccctgtta
     8341 tcattgtgcc aagatccaaa tttgttaaat ccaatccatg gaattgtgca gagtgtggtg
     8401 taccatgaag aatccccacc acaataccaa acatcttacc tgcaaagttt tggttttaat
     8461 ggcttgtggc ggtttgcagg accgttttca aagcaaacac aaattccaga ctatgctgag
     8521 cttattgtta agtttcttga tgccttgatt gacacgtacc tgcctggaat tgatgaagaa
     8581 accagtgaag aatccctcct gactcccaca tctccttacc ctcctgcact gcagagccag
     8641 cttagtatca ctgccaacct taacctttct aattccatga cctcacttgc aacttcccag
     8701 cattccccag gaatcgacaa ggagaacgtt gaactctccc ctaccactgg ccactgtaac
     8761 agtggacgaa ctcgccacgg atccgcaagc caagtgcaga agcaaagaag cgctggcagt
     8821 ttcaaacgta atagcattaa gaagatcgtg tgaagcttgc ttgctttctt ttttaaaatc
     8881 aacttaacat gggctcttca ctagtgaccc cttccctgtc cttgcccttt ccccccatgt
     8941 tgtaatgctg cacttcctgt tttataatga acccatccgg tttgccatgt tgccagatga
     9001 tcaactcttc gaagccttgc ctaaatttaa tgctgccttt tctttaactt tttttcttct
     9061 acttttggcg tgtatctggt atatgtaagt gttcagaaca actgcaaaga aagtgggagg
     9121 tcaggaaact tttaactgag aaatctcaat tgtaagagag gatgaattct tgaatactgc
     9181 tactactggc cagtgatgaa agccatttgc acagagctct gccttctgtg gttttccctt
     9241 cttcatccta cagagtaaag tgttagtcct atttatacat ttttcaagat acaagtttat
     9301 gagagaaata gtattataac cccagtatgt ttaatctttt agctgtggac ttttttttta
     9361 accgtacaaa actgaaagaa ccatagaggt caagcctcag tgacttgaca ccataaagcc
     9421 acagacaagg tacttggggg ggagggcagg gaaatttcat attttatagt ggattcttaa
     9481 gaaatactaa cacttgagta ttagcaataa ttacaggaaa ataagtgcga ccacatatat
     9541 cttaacatta ctgaattaaa actatggctt ctaagtcctt atccaaactc agtcatccaa
     9601 actagtttat ttttttctcc agttgattat cttttaattt ttaattttgc taaaggtggt
     9661 ttttttgtgt tttgtttttt gtaaaccaaa actatactaa gtatagtaat tatatatata
     9721 tatatatttt ttcccctccc cctcttcttt cctaactaat tctgagcagg gtaatcagtg
     9781 aacaaagtgt tgaaaattgt tcccagaagg taattttcat agatgtttgc attagctcca
     9841 tagcaaaatg gaatggtacg tgacatttag ggtagctgat atttttattt tgttaaataa
     9901 tttccaagaa tagagtatgg tgtatattat aaatttcttt gataagatgt attttgaatg
     9961 tcttttaatc ttcctcctcc tctccaaaaa aatcagaaac ctctttaaga aaacatgtag
    10021 gttatatatg ctagaattgc atttaatcac tgtgaaaaga ctggtcagcc tgcattagta
    10081 tgacagtagg ggggctgtta gaattgctgc tatactggtg gtatggatta tcatggcatt
    10141 ggaattttca tagtaatgca gatccaattt ctttgtggta cctgcagttt acaaaataat
    10201 ttgacttcag tgagcatatt ggtatctgga tgttccaatt tagaactaaa ccatatttat
    10261 tacaaaaaga tattaatccc tctactccca ggttcccttt atatgttaag atataatggc
    10321 tttgaggggg gaaaaaataa acctagggga gaggggagtt tcctgtagtg ctgtttcatt
    10381 agaggatttc agtaaattaa attccacagc taattcaata aataatggta catttaagtg
    10441 ttctgatttt aataatatat ttcacattta tccacacagt aacaatgtaa tatgttaatg
    10501 taaataaaat tggttttgat actcagaaat aacaagaatt taatttttta aatttgttta
    10561 cagtcctggg aaaagtaaga attatttgcc aaaataagag gaaagaaaac cttagtatta
    10621 ttaatgagtt taccatagaa ttgttggaaa tactgaagac aggtgcaatt tactaaactt
    10681 ttgtttttaa actattgtag aggctgcatt agaagaaaat gtttataatg acagagcaac
    10741 tatgactata taaaaaagct gaaattagaa ctgtgtttag aaatagatca gtaacccagt
    10801 gccaaggatg ccaagctgcc accatggtct tggctctccc acaacccagt gtttctgggg
    10861 taagtttcac agtttctagg ccctggaata gcaggcagtg taagcctttg ataactttag
    10921 ttcgatgttt ttcttgtttt tgtttgttgg tttggtgcat atgatagtgg gtgttatgct
    10981 attttgctct tcccatcaaa ataaagaaac ttccagaggt ttactgttaa aaatactgat
    11041 atttccataa acgggtttac caagggtgta gtatttcata ccgcctgaaa tgatcagcat
    11101 tggcacaaat caaaattcag ccgcctttga aatgcaaaaa tacctttgac tagtaagtac
    11161 atcctaggag tttgaaaact taactaaggt ttaaaattta ccttgtttaa agaacttctg
    11221 acttttgagg aaaatctagc tttccaagta actaaaatgt acatgagata aacctctcac
    11281 cactatgtgt cccttgagaa atgcaacact tttttagtct tcatacttgt aatctataaa
    11341 agaaattctg aagtttagac caagttgccc atttctgcgt aattgacata agttctgtta
    11401 aaaatattat aagtaattcg tttcggtttg tagatgtttc ccctgacttg ttaaagagga
    11461 aaccaggaac tcagtcatgt ttttgtcctg gataatctac ctgttatgcc agtactccca
    11521 tccgaggggc atgcccttag ttgcccagat ggagatgcag ttcagtagat ttggggcaaa
    11581 gtggctacag ctctgtcttc cattcactca acacctgttc atgactgagc caggtgccca
    11641 ggacacatcc taaacagtca gcttctatcc tgtgtcctag ttggggagac agagtgccag
    11701 ccagcaaccc tcccaggttt gtaggtttta ggggttttca gttttgtttg ggttttttgt
    11761 tttttgtttt tgtttctaca tccttccccg actcccaggc ataatgaggc atgtcttact
    11821 caatgttatg caatggattt aggcaaaaat tcattcttag tgtcagccac acaatttttt
    11881 ttaatgcagt atattcacct gtaaatagtt tgtgtaaaat ttgacaaaaa aagtatattt
    11941 actatactgt aaatatatgt gatgatatat tgtattattt tgcttttttg taaagcagtt
    12001 agttgctgca catggataac aacaaaaatt tgattattct cgtgttagta ttgttaactt
    12061 ctttttgcga ctgcgttaca tcatttaaag aaaatgctgt gtattgtaaa cttaaattgt
    12121 atatgataac ttactgtcct ttccatccgg gcctaaactt tggcagttcc tttgtctaca
    12181 accttgttaa tactgtaaac agttgtacgc cagcaggaaa aatactgccc aacagacaaa
    12241 atcgatcatt gtaggggaaa atcatagaaa tccatttcag atctttattg ttcctcaccc
    12301 cattttcctc cttgtgtatg tacttccccc accccccttt ttttaagtaa aatgtaaatt
    12361 caatctgctc taa
//
