LOCUS       NM_001008537           11717 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens neurite extension and migration factor (NEXMIF), mRNA.
ACCESSION   NM_001008537 XM_291326
VERSION     NM_001008537.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 11717)
  AUTHORS   Celik,G., Gunay,M., Vural,A., Kizilay,O., Demirkol,Y.K. and
            Erol,M.K.
  TITLE     Clinical evaluation of torpedo maculopathy in an infant population
            with additional genetic testing for NEXMIF mutation
  JOURNAL   Eye (Lond) 36 (8), 1639-1644 (2022)
   PUBMED   34326501
  REMARK    GeneRIF: Clinical evaluation of torpedo maculopathy in an infant
            population with additional genetic testing for NEXMIF mutation.
REFERENCE   2  (bases 1 to 11717)
  AUTHORS   Langley,E., Farach,L.S., Koenig,M.K., Northrup,H.,
            Rodriguez-Buritica,D.F. and Mowrey,K.
  TITLE     NEXMIF pathogenic variants in individuals of Korean, Vietnamese,
            and Mexican descent
  JOURNAL   Am J Med Genet A 188 (6), 1688-1692 (2022)
   PUBMED   35146903
  REMARK    GeneRIF: NEXMIF pathogenic variants in individuals of Korean,
            Vietnamese, and Mexican descent.
REFERENCE   3  (bases 1 to 11717)
  AUTHORS   Chen,S., Deng,X., Xiong,J., Chen,B., He,F., Yang,L., Yang,L.,
            Peng,J. and Yin,F.
  TITLE     NEXMIF mutations in intellectual disability and epilepsy: A report
            of 2 cases and literature review
  JOURNAL   Zhong Nan Da Xue Xue Bao Yi Xue Ban 47 (2), 265-270 (2022)
   PUBMED   35545418
  REMARK    GeneRIF: NEXMIF mutations in intellectual disability and epilepsy:
            A report of 2 cases and literature review.', trans 'NEXMIF2.
REFERENCE   4  (bases 1 to 11717)
  AUTHORS   Gamirova,R.G., Barkov,A.I., Shaimuchametova,V.A., Liukshina,N.G.,
            Volkov,I.V., Tomenko,T.R., Rachmanina,O.A., Shestakova,O.I. and
            Gorobets,E.A.
  TITLE     [Epilepsy and other phenotypic features of X-linked intellectual
            disability caused by the mutations in the KIAA2022 gene]
  JOURNAL   Zh Nevrol Psikhiatr Im S S Korsakova 122 (9. Vyp. 2), 14-20 (2022)
   PUBMED   36170093
  REMARK    GeneRIF: [Epilepsy and other phenotypic features of X-linked
            intellectual disability caused by the mutations in the KIAA2022
            gene].', trans 'Epilepsiya i drugie fenotipicheskie osobennosti
            X-stseplennoi intellektual'noi nedostatochnosti, obuslovlennoi
            mutatsiyami gena KIAA2022.
REFERENCE   5  (bases 1 to 11717)
  AUTHORS   Stamberger,H., Hammer,T.B., Gardella,E., Vlaskamp,D.R.M.,
            Bertelsen,B., Mandelstam,S., de Lange,I., Zhang,J., Myers,C.T.,
            Fenger,C., Afawi,Z., Almanza Fuerte,E.P., Andrade,D.M., Balcik,Y.,
            Ben Zeev,B., Bennett,M.F., Berkovic,S.F., Isidor,B., Bouman,A.,
            Brilstra,E., Busk,O.L., Cairns,A., Caumes,R., Chatron,N.,
            Dale,R.C., de Geus,C., Edery,P., Gill,D., Granild-Jensen,J.B.,
            Gunderson,L., Gunning,B., Heimer,G., Helle,J.R., Hildebrand,M.S.,
            Hollingsworth,G., Kharytonov,V., Klee,E.W., Koeleman,B.P.C.,
            Koolen,D.A., Korff,C., Kury,S., Lesca,G., Lev,D., Leventer,R.J.,
            Mackay,M.T., Macke,E.L., McEntagart,M., Mohammad,S.S., Monin,P.,
            Montomoli,M., Morava,E., Moutton,S., Muir,A.M., Parrini,E.,
            Procopis,P., Ranza,E., Reed,L., Reif,P.S., Rosenow,F., Rossi,M.,
            Sadleir,L.G., Sadoway,T., Schelhaas,H.J., Schneider,A.L., Shah,K.,
            Shalev,R., Sisodiya,S.M., Smol,T., Stumpel,C.T.R.M., Stuurman,K.,
            Symonds,J.D., Mau-Them,F.T., Verbeek,N., Verhoeven,J.S.,
            Wallace,G., Yosovich,K., Zarate,Y.A., Zerem,A., Zuberi,S.M.,
            Guerrini,R., Mefford,H.C., Patel,C., Zhang,Y.H., Moller,R.S. and
            Scheffer,I.E.
  TITLE     NEXMIF encephalopathy: an X-linked disorder with male and female
            phenotypic patterns
  JOURNAL   Genet Med 23 (2), 363-373 (2021)
   PUBMED   33144681
  REMARK    GeneRIF: NEXMIF encephalopathy: an X-linked disorder with male and
            female phenotypic patterns.
REFERENCE   6  (bases 1 to 11717)
  AUTHORS   Charzewska,A., Rzonca,S., Janeczko,M., Nawara,M., Smyk,M., Bal,J.
            and Hoffman-Zacharska,D.
  TITLE     A duplication of the whole KIAA2022 gene validates the gene role in
            the pathogenesis of intellectual disability and autism
  JOURNAL   Clin Genet 88 (3), 297-299 (2015)
   PUBMED   25394356
REFERENCE   7  (bases 1 to 11717)
  AUTHORS   Magome,T., Hattori,T., Taniguchi,M., Ishikawa,T., Miyata,S.,
            Yamada,K., Takamura,H., Matsuzaki,S., Ito,A., Tohyama,M. and
            Katayama,T.
  TITLE     XLMR protein related to neurite extension (Xpn/KIAA2022) regulates
            cell-cell and cell-matrix adhesion and migration
  JOURNAL   Neurochem Int 63 (6), 561-569 (2013)
   PUBMED   24071057
  REMARK    GeneRIF: Xpn regulates cell-cell and cell-matrix adhesion and
            cellular migration by regulating the expression of adhesion
            molecules
REFERENCE   8  (bases 1 to 11717)
  AUTHORS   Van Maldergem,L., Hou,Q., Kalscheuer,V.M., Rio,M., Doco-Fenzy,M.,
            Medeira,A., de Brouwer,A.P., Cabrol,C., Haas,S.A., Cacciagli,P.,
            Moutton,S., Landais,E., Motte,J., Colleaux,L., Bonnet,C.,
            Villard,L., Dupont,J. and Man,H.Y.
  TITLE     Loss of function of KIAA2022 causes mild to severe intellectual
            disability with an autism spectrum disorder and impairs neurite
            outgrowth
  JOURNAL   Hum Mol Genet 22 (16), 3306-3314 (2013)
   PUBMED   23615299
  REMARK    GeneRIF: study describes 3 new families with likely pathogenic
            mutations of KIAA2022 and further defined clinical and genetic
            phenotypes; role of KIAA2022 in neuronal development, together with
            the clinical features of patients observed, provides evidence that
            KIAA2022 is essential for proper brain development
REFERENCE   9  (bases 1 to 11717)
  AUTHORS   Ishikawa,T., Miyata,S., Koyama,Y., Yoshikawa,K., Hattori,T.,
            Kumamoto,N., Shingaki,K., Katayama,T. and Tohyama,M.
  TITLE     Transient expression of Xpn, an XLMR protein related to neurite
            extension, during brain development and participation in neurite
            outgrowth
  JOURNAL   Neuroscience 214, 181-191 (2012)
   PUBMED   22531377
REFERENCE   10 (bases 1 to 11717)
  AUTHORS   Cantagrel,V., Lossi,A.M., Boulanger,S., Depetris,D., Mattei,M.G.,
            Gecz,J., Schwartz,C.E., Van Maldergem,L. and Villard,L.
  TITLE     Disruption of a new X linked gene highly expressed in brain in a
            family with two mentally retarded males
  JOURNAL   J Med Genet 41 (10), 736-742 (2004)
   PUBMED   15466006
  REMARK    GeneRIF: disrupted in X-linked mental retardation
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA776009.1, AY563507.1, AL139395.7 and AI167637.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001008537.2.
            
            Summary: An inversion on the X chromosome which disrupts this gene
            and a G-protein coupled purinergic receptor gene located in the
            pseudoautosomal region of the X chromosome has been linked to X
            linked cognitive disability.[provided by RefSeq, Mar 2009].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY563507.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2152798, SAMEA2155984
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000055682.12/ ENSP00000055682.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-303               DA776009.1         1-303
            304-10996           AY563507.1         1-10693
            10997-11286         AL139395.7         82383-82672
            11287-11717         AI167637.1         19-449              c
FEATURES             Location/Qualifiers
     source          1..11717
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq13.3"
     gene            1..11717
                     /gene="NEXMIF"
                     /gene_synonym="KIAA2022; KIDLIA; MRX98; XLID98; XPN"
                     /note="neurite extension and migration factor"
                     /db_xref="GeneID:340533"
                     /db_xref="HGNC:HGNC:29433"
                     /db_xref="MIM:300524"
     exon            1..570
                     /gene="NEXMIF"
                     /gene_synonym="KIAA2022; KIDLIA; MRX98; XLID98; XPN"
                     /inference="alignment:Splign:2.1.0"
     exon            571..696
                     /gene="NEXMIF"
                     /gene_synonym="KIAA2022; KIDLIA; MRX98; XLID98; XPN"
                     /inference="alignment:Splign:2.1.0"
     CDS             618..5168
                     /gene="NEXMIF"
                     /gene_synonym="KIAA2022; KIDLIA; MRX98; XLID98; XPN"
                     /note="XLMR protein related to neurite extension;
                     XLMR-related protein, neurite extension"
                     /codon_start=1
                     /product="neurite extension and migration factor"
                     /protein_id="NP_001008537.1"
                     /db_xref="CCDS:CCDS35337.1"
                     /db_xref="GeneID:340533"
                     /db_xref="HGNC:HGNC:29433"
                     /db_xref="MIM:300524"
                     /translation="MDNQQDKAIVASANGENTLINGVKENDSEDQDVAMKSFAALEAA
                     APIQPTPVAQKETLMYPRGLLPLPSKKPCMQSPPSPLGLIEAPEHAANSASVNAISLT
                     SGIAKGLNTWSLPNECEKAPFAIMEPAGMSALNGDCLMQPSRTCLGCFMESKDAVDPE
                     PGISLKVGDLNRDYETCAVSDIGIQCINAGENMKYGEQLLSDQLLGFPLHKSRAGDRR
                     ETEKPDIDLEDPAQKSYYEALLLDKCNTEEALLANSNQDWGYFETFISESKIELLDLC
                     SKNELSVNLFSEEDVDNYMFDDDESTLGSDVCSLKIRYESFQDNVRDKTTLLMQEDAQ
                     FNFFPSVFTTCPKRESKSGALKQSSDFSQFKVPDVSIIWGEEDKNLDKKKGKEEGQED
                     KGVEKKDGKDNGEKPALNKPCSGTEVEQLKNPKQGHLANSLETSGSFSDDSSFIEISY
                     DAMGEIKDCSRYMARDTNSGSSSSQQNYGLRAKRKVRYSEDYLYDVDSLEGEKVNERK
                     EWLPVGSKEEDDDEWCPKKRRKVTRKEPPVIIKYIIINRFKGEKNMLVKLGKVDASET
                     TVNLSENQLNKYAKLAPLKGFWQKKKKQRNTNTDSIKTPFSQKQSFEPGSFEVSFLPP
                     ARKRKSKLGNRHRIQRIPSIEISASSKQISLCNDQRHASNHKEDGGLKGTLKSAPLGA
                     PSCANGSHLNDITGPDSVKVKAQDTEFKGPERKVLNKIKFKSEARLKSKKVKAAGQES
                     KPIVQMSPLLENQSSKANLKNEVIPGTSNSSRLSEFHEAKAAKSSTFLPTTCSSEMPL
                     SSANVTTNIPVIPGGYLQTLLDASDLSNNTSISYFSHHSPEQNEGSLTQTEKSFVPLQ
                     PTQDCVLTSSSDSELQQSSHNFKMESSNYRNVWPNKATSGTQEFMAEVSREIAPTQSS
                     EFGASQVVSMENNLTPTTYNPICLNSGGSNCNKVLYDSMQDTQLPSDDSYQLCHFNNG
                     EICFPFQQGPVNMDDGRLFSFDSMAPLSVSSSNYCSLSLKSCEKDGDDDITDDFLAHC
                     SPKLVIQQSIDEIAPLKESTDLLDISNFTPDKFRHSSLSEMSPPDTPSLSPQITRCES
                     MKTLGTLKGFQEGVPGPLDSVEKIKWDCSTLSRQVQMEDGFTLNNHQFQFHMFNDEDS
                     VSLLQKNPCLSTFNDPSGQISTNNKVSKSRKKSSPSKSGAMNQSSSQKNTRKKSLKGN
                     NKGIEKPPGKNSRQVPKSTKKGKYMAAINGEKMQIGIGRGGSQTNTISSTGKTLAECI
                     QHGGPMASMKMPSQKGLSGDWALGKESSPGWSDMSMGTNTNSLLDDDQREFQEPSYIL
                     SNIASGMADVQRFMMASIEPLWEPMEHHGDPNIFYSPESNSLKLKTLKILAGTPQESK
                     KKINSGSQGATKNHRSIKGVSKSNGKTAIGDPGRANMPGYNEDSRSTFFDKKYSNMST
                     LGNNGPTHKKLYRHKSSSKALRDEKCKGKHMEREQVHKDESGTASFEKLRDSDYNLLK
                     AETTFWVLPVFEEETRIFQKDI"
     exon            697..5074
                     /gene="NEXMIF"
                     /gene_synonym="KIAA2022; KIDLIA; MRX98; XLID98; XPN"
                     /inference="alignment:Splign:2.1.0"
     exon            5075..11717
                     /gene="NEXMIF"
                     /gene_synonym="KIAA2022; KIDLIA; MRX98; XLID98; XPN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      11695..11700
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NEXMIF"
                     /gene_synonym="KIAA2022; KIDLIA; MRX98; XLID98; XPN"
                     /note="hexamer: AATAAA"
     polyA_site      11717
                     /gene="NEXMIF"
                     /gene_synonym="KIAA2022; KIDLIA; MRX98; XLID98; XPN"
                     /note="major polyA site"
ORIGIN      
        1 aaaaccagta gcatcagcag cagcagcagc agccgccgcc gccaccaccg ccgccacagc
       61 agtagcatta gcggcagtag cagcatttag caatagcttt aacagctata gcgacagtag
      121 cagccgccct cctctctccc tctcgcggac ggccgcagcc accgcacaga gcgggctcca
      181 ggcgccgagc gcgcagcccg ctcgctaggt agctccagcc ggggcgagcg acagtgtaag
      241 cgaagcacgg acccttggag cagccgggca gccgcggagg ctctgagttt cagggccaga
      301 gcccgacagc tctgactcca tctagcgcgg cggcggcgga gcctgaggga gcgagcgagg
      361 agagaggcgc gtccacctgg cgggcccagc gtatggagct gaggcagagg cggcggcggc
      421 ggcggcagca gtagcagcgg cggtggcggc taaggcagct cgaacagctg cggcgacggc
      481 gacagcccag ccttgactgc gaccgcgcta gctacagcgc ctgctgcctg agcccgccag
      541 cgacgtgcgc ctcgggagtc ggcctgtgag gttggacagc atttggactt ggaatgaaac
      601 aataagaggt tatattcatg gataaccaac aagataaggc tattgttgcc tcagccaacg
      661 gagaaaacac tctgattaat ggggtcaaag aaaatgactc agaggaccag gatgtggcaa
      721 tgaagtcatt tgcagctcta gaagctgctg cacctatcca gcctacaccg gtggcacaaa
      781 aagagaccct gatgtatccc agaggtctcc tgcctctacc ctctaagaag ccctgtatgc
      841 agagcccgcc ctctcctttg ggcctgattg aagcacccga acatgctgct aatagtgctt
      901 ctgtgaatgc catctccctc acatctggca ttgcaaaagg cctgaacaca tggtcacttc
      961 ccaatgaatg tgagaaagct ccatttgcca taatggagcc tgcaggcatg tcagctctga
     1021 atggggactg tctcatgcag ccaagtcgga cttgcttagg ctgcttcatg gaatccaagg
     1081 atgcagtaga tcctgagcca gggatcagtc tgaaagttgg tgatctaaat agggattatg
     1141 aaacgtgtgc agtctctgat atagggattc agtgtattaa tgctggagaa aatatgaaat
     1201 atggagagca gctgctctca gaccagctcc taggcttccc cctgcataag tcaagggcag
     1261 gagacagacg agaaactgag aaacctgaca ttgacttgga ggatccggct cagaaaagct
     1321 attatgaggc attactgtta gacaagtgca atacagaaga agctttgctt gcaaattcca
     1381 atcaggattg gggttacttc gagactttta ttagtgaaag taagattgaa ctgcttgacc
     1441 tctgttccaa aaatgagctg tctgtcaacc tattctctga agaagatgtg gataactaca
     1501 tgtttgatga tgatgaatca acactaggca gtgatgtctg ctccctgaaa attcgatatg
     1561 aatcctttca ggacaatgtt cgagacaaga ctactctttt gatgcaggaa gatgcccaat
     1621 tcaacttttt tcccagcgtc tttactacct gccccaagcg agagtctaag agtggggccc
     1681 tgaagcagag cagtgatttt tcccaattca aggtccctga tgtgagcatc atctgggggg
     1741 aggaagataa aaacttggac aagaagaaag gcaaagagga aggacaggaa gacaaaggtg
     1801 tagagaagaa agatggaaag gataatggag aaaagcctgc cttaaataaa ccatgcagtg
     1861 ggactgaagt agagcaactt aagaatccaa agcagggcca tcttgctaat tccctggaga
     1921 catcagggag tttcagtgat gatagttcct tcattgagat ctcatatgat gctatgggtg
     1981 agatcaagga ctgtagtcgc tatatggctc gggacactaa ttctggcagc tcctcctccc
     2041 aacagaacta tgggctgcga gccaagagaa aagtcagata cagtgaagat tatctatatg
     2101 atgttgactc actagagggt gaaaaagtaa atgagaggaa ggaatggctg ccagttggtt
     2161 ccaaagagga agatgatgat gaatggtgtc ccaaaaagag aagaaaagta acccgtaagg
     2221 agccccctgt tattatcaaa tatatcatca ttaatcgctt taaaggtgag aagaacatgc
     2281 tggtgaagtt gggtaaggtg gatgccagtg agacaacagt gaatttgagt gagaatcagc
     2341 tcaacaaata tgccaagctg gcacccttga aaggcttctg gcaaaagaag aagaagcaga
     2401 gaaacaccaa cacggactcc atcaagacac ctttttccca aaagcaaagc tttgaaccag
     2461 gtagctttga ggtgtcattt ctgccacctg ctcgcaaacg aaaatctaaa cttggcaaca
     2521 ggcacaggat tcaaagaatc ccatccattg aaatttcagc aagtagtaaa cagatttcat
     2581 tatgtaatga tcagaggcac gctagtaatc ataaagaaga tggaggccta aaaggtacac
     2641 tgaagtcagc acctctgggt gctcctagct gtgcaaatgg atcacattta aatgacatca
     2701 caggccctga ctcagtgaaa gtcaaagccc aagacacaga gtttaagggg ccagagagga
     2761 aagtgctcaa taaaatcaaa tttaaaagtg aagctaggtt aaaatctaag aaagtcaaag
     2821 ctgctgggca agaaagcaag ccaattgttc aaatgagccc tctcttggaa aaccaatcct
     2881 caaaggctaa tttaaagaat gaagttattc ctgggacatc aaacagttcc cgtctatctg
     2941 aatttcatga ggcaaaggct gctaagagtt ccacttttct accaacgaca tgctcttctg
     3001 aaatgccttt atcatctgct aatgttacca ctaatatacc tgttatcccg ggagggtatc
     3061 tgcagacatt gttagatgct tctgacttgt caaataacac tagtatctca tacttcagcc
     3121 accattctcc agagcaaaat gaaggcagcc tcactcaaac cgaaaaatca tttgtacccc
     3181 tccagcctac ccaggactgt gtgctcacct catcctctga ctctgagctg cagcagtcat
     3241 ctcataactt caaaatggaa tcaagcaact atagaaatgt gtggcccaac aaggctactt
     3301 ctggcaccca ggaattcatg gctgaagtct caagggagat agccccaacc caatccagtg
     3361 aatttggagc ctcccaagta gtctccatgg aaaataacct cacacctaca acatacaatc
     3421 caatctgtct caatagtggt ggcagtaatt gcaacaaggt cctgtatgac tccatgcaag
     3481 atacccaact cccatctgat gactcttacc aattatgtca ctttaataat ggagagatct
     3541 gctttccttt ccagcagggg ccagtcaata tggatgatgg tcggctcttt agctttgatt
     3601 caatggcccc actctctgtc agctcaagta attattgctc cttaagcttg aagtcctgtg
     3661 aaaaggatgg cgatgatgat atcactgatg acttcctggc ccattgcagc cctaagctgg
     3721 tgatccagca aagcattgat gagatagcac cactaaagga gtccactgac ctcctggata
     3781 tatccaactt cacccctgac aaattccgcc actcttccct ttcagagatg tccccaccgg
     3841 acacccctag tctttcccct caaattacca gatgtgagag tatgaagaca ctaggaacac
     3901 taaaggggtt ccaagagggt gtcccaggac cattggacag tgtggaaaaa atcaagtggg
     3961 actgcagtac cctttcacgg caggtccaaa tggaggatgg atttacttta aataatcacc
     4021 agtttcagtt ccatatgttc aatgatgagg attctgtcag cctgctccaa aaaaaccctt
     4081 gcctgtcaac atttaatgat ccatctggtc aaattagtac caacaacaaa gtgtcaaaat
     4141 caagaaagaa aagttcaccc agcaagagtg gggctatgaa ccaaagctct tctcagaaaa
     4201 acaccaggaa aaaatccctc aaaggtaaca acaaggggat tgaaaaacca cctggcaaaa
     4261 actcccgcca ggtccctaag tccacaaaga aagggaaata catggctgcc atcaatggag
     4321 agaaaatgca aattggcatt ggccgtgggg gaagccaaac caacaccata tcctccactg
     4381 ggaagacatt ggctgaatgt atccaacatg gtggccctat ggcctctatg aagatgccaa
     4441 gtcaaaaggg actttctgga gattgggcct tggggaagga gagcagccca ggctggagtg
     4501 atatgagcat gggcaccaac accaacagcc ttctggatga tgaccaacgg gaatttcagg
     4561 agccttccta tatcttgtcc aacattgcct ctggtatggc agatgtgcag agattcatga
     4621 tggcctccat agagcccctt tgggaaccca tggagcacca tggggatccc aacatattct
     4681 actcccctga gtccaatagt ctaaaattaa aaaccctcaa aatattggct gggacaccac
     4741 aggagtctaa gaaaaagatc aacagtgggt cccaaggagc cactaagaat cacaggtcaa
     4801 tcaagggtgt gagcaaaagc aatgggaaaa cagcaatagg tgatcctggt cgtgcaaaca
     4861 tgcctggtta taacgaggac tctcgctcta ccttctttga taaaaagtat agtaacatga
     4921 gcactttagg caataacgga ccgacacaca aaaagttgta tcgtcacaaa tccagctcca
     4981 aggccctgag agatgagaaa tgtaagggaa agcacatgga gcgagaacag gtccacaagg
     5041 atgagtctgg gacagcttct tttgaaaaac tgagggattc cgactacaat ctcctaaaag
     5101 cagaaacaac cttttgggtt ttacctgtgt ttgaagaaga gactcgcatt ttccagaaag
     5161 acatttgatg tttgtgtttt atttctttca aaatatgcct tgtggtatgt atgttgacat
     5221 gtaagtgctt aaagaaaaga attttaaatt gtgggaatac gtctttggag caaactttaa
     5281 tctcatgttc tatgtaaaag acttaaaaag tcatacagtt gcacaagtag tttatgcact
     5341 atttacccac aaggaaaaaa ttgaaaacat tgtgccaaac tacaaacaag tgactgtact
     5401 gtatatattt ttacttctat atcaacattt ggttgtattt ggggaagttg tccctgttaa
     5461 tttactagaa acattccagt gattcttgct attaaccacc cccacttatg tggatagcac
     5521 ctgtagatca tggtggaaaa atatgttgtg ttacacaatt taccaaaatt aaaggatact
     5581 gtttgaaatg tgccaaattt tcttacctca tctcacagat tcacccacag tttaaagctc
     5641 attaattatt tttaaatgga tatatacaca cccaaacata tatatgtata tgtttgtgtg
     5701 tgtgtgtgtg tgtgtatata tatgtatata tatatataca cacacacacg ttcttttaaa
     5761 gttttagact ctactgtcct gtgtggaaac atgaacagct aaacaaggca aaataaagat
     5821 tttcttgttc cattgtgtaa gggttaaaat tttggaaaag tctgaaggcc acaacagcta
     5881 agtccatcag ggacccaagt atatgcattt acagaacgtt ttacaaggaa acaaaacagc
     5941 tgctttcaaa gtttgttttc taaaagcaaa atctgtagct gaaaattatt taaagtgcaa
     6001 agttatattg ctgatacttt atatctcagt tttatatatt ttataatagt ctgggataaa
     6061 ttataaaaat agctataaaa tcaacactaa tgataaatga agtatataga atgcttttat
     6121 ttaaatagtt tcctaaatgt tttattccag ttttgtcaaa agtgcactca tatcatggct
     6181 ttagtgttct ttcagtgttt aatcttgcaa tgccaatgtc atttaaagaa aatgttaagg
     6241 catcccagtt caaccaaatt tttcttctta tgagtaaagt acatttacta tcagataaga
     6301 tgaacaattt gtggcaacaa ctgatttggg ccatataccc ttagtctgag gataaccaat
     6361 atttgatgcc acacactaaa cttaaatctc aattttaagt acaaattttt aaatcacatt
     6421 ttttattcag tactccccct actttttaaa aaaaatttca cagccccaac attcctcact
     6481 actacttttt cttccctttt attcaccact tgacttctaa catttgatct cttttctttg
     6541 cacaattgaa ggcctgtgca tctgatgact gatgcattat ggcacagatg agataatgga
     6601 tgtgagagcg ctttgtagat cataaagtgc tatacagata taggggatta atattattaa
     6661 tattgttagt tgttgtcgtt gttactattc ttattaatat tgttactaac ctattaactt
     6721 gtgaatatat aggctggggt gggagggtgg agaataagtg ggaagggaaa aaggggattt
     6781 aacaaaaaaa gggaagatgt ttcaaaagga aaattttaag caaaatatga acctacctag
     6841 tcaatgccac ctaaatgtat tcacaaacag agaagcaaca tttgaaagta gtcagagaga
     6901 aatggaagga agcctgtcat gtatataagt atatacactt cccggtccat gattcctttc
     6961 accagcctgc tctattcctt acagctgggt cgtaaaatga acaagcctgt gttcttgatc
     7021 atgtgtgttc ccagcgtcag tctcttgtgt ctgtggggat gagtgggtga ggagcattct
     7081 gtgaggctgg tacaggccca ttcctaggct ttaatgctct gtttgcagtg agccctggaa
     7141 aattacttag tggaaaggca ccagatgaaa catgtctcct gccccatagc taccattcaa
     7201 aagggaaaat aaccaaactg gaaaaccttc ttctatttct ctattctgat agctagctgt
     7261 actaaatgct atggccagtc cctagaaact ggtctttgtt ttgtttttgt ttttgttttt
     7321 gatttttctg ttttgcagct gaattttggc ttggaatcac caactctgcc tgtattgtga
     7381 tccccaagac tccagacctc agagtcacct gctggcttag aggagtggag tgctttctat
     7441 gtaatgaaaa ggtggcaatt aatgaaaaaa taaagaaaat gttccattaa tacaatgtgt
     7501 ttttataaaa gtaaatatgg gagcagttgt cccagttttt tttcggtatc agttcagctt
     7561 tggagaatgg ggtgtgagtg gggtaggaca gcctgaaact gttggaaaca atttccttgt
     7621 gagaacttgc tatcataagt cctttggaat ggatattctt tcagttgctc ctatggagcc
     7681 cattaagggc caattctagg gcatagttca tccctttctc caaagagaat tgttatttta
     7741 aagtaccttt ttaattggcc tgcagtgtat tatatgtttt taatatataa attagtgacg
     7801 cataaccagt cactttgtac tgaaacataa aaagaaacag agtttgagaa atgagcaata
     7861 ggccgaggca gaagatgttt attctcttaa ttgcatttaa tattcctctc agtacattgt
     7921 gttctgagat gttcatcatt tagcattttg ttggtcctgt ctctgctctc acagttcttt
     7981 ttcttcctgt cataaccagc tgccttagta gagtataaaa atagtgtttt gccctatcac
     8041 tggtatctca agtcagaaat atatattatc cttggtctga aattcctgat taccgctccc
     8101 ttctaacctt ccccctctga gaagctgttt cctattaatg cctccctaac agagtcccat
     8161 ttaatcttta ctttcctgga aatggtaacc tcccttattc ttcttactta atctcagacc
     8221 ttggtcttag aatttttctt ttatggtctc atatcccacc tgcccaaatt gtcagggctc
     8281 aacaatctta ggctgctttc ttctggaagt tcagaaggaa accttcccat tcttaattgc
     8341 ctttaattgc tttggctatt ttcaaatcta attttttaat taaatttttt ttaattttta
     8401 tagagtaggg gtacaaggac agttgtgtta catggatata ttgcttagtg ttgaaatctg
     8461 ggcttttagt gtacccatca ccgaaatagt gtacattgta cccaataggt ggtatttcat
     8521 ccctcaaata taattttaaa cacacactcg tgcccacatg gacaaattat atcacatgac
     8581 tgaggaaact tagaaattcc ttttccctga agatctgtta agaataggtc tcatctcctg
     8641 ccctggttag gtgctatatt atatggagaa gggtattgag actttggggg tcatgtttgg
     8701 gctgtgataa ctggcttgaa ccagtgacca tcctttctgc ctcgccaagg tctcttatac
     8761 cagcttcttc acatatgctg cttcctccca gctttccctt ctgacttctt gttactctgc
     8821 aactatgtgt caaggcctta ccttttcctg atgttttcaa acctcctgca ttactttgat
     8881 catcacttct tcagccatct cactgaagtc cttggtgcta gctgggcttt tgtgacaact
     8941 ttcaccttct ctgaactttt tccttgctgg gaagcatctg cgtgtgtgag ggggctacgg
     9001 agggaagtgt gtgtgtgtgt aagagagagg caaaaggatg cttcaaaagc tataaacaac
     9061 tctagcaagc atcctaagtc ctatgtgagg ttttgcagtt ctagtgaatt tctgttttag
     9121 taggtttcaa ttagcattta ctgcctaaag gagaaaaacc atatccaagg accttttagc
     9181 catgcttgct attaccaagc tggaccagtg tgatgtagat ccaacatgtc ttcagcttac
     9241 agatgctctc agaacagttc caagaattga agagagctaa gtttttatgc tgaagaggag
     9301 aatggagcac tagctagtcc taactattgc tagaaataga aatgtttatt ttctccttta
     9361 ttattgagaa attatctaat ttaaggagta accattttca tttagggatt tttttaatga
     9421 ctgcccatca ctacagaaat atgttctttt tataaaataa aactaatgtg aggttggttt
     9481 gttttctaat cataaaattc actaagccta tagttacatt tagaagattt agtaccaaaa
     9541 tcaaactttt agtaacaaac aggaatcttg tcaacacaat gtaggccagg gattttgtaa
     9601 aggtttctca aagacccaaa taagggagaa aaaaatttta gttgggctgt ttaacttggg
     9661 aaacactgtc atcagcttga gggtcctcag ccagcatgtg attattttga tgacaggact
     9721 caggctaccc tttaaggcac attttttact cagcattaaa cactagctac agtcgtgaag
     9781 cagagctccc attgcagcta catacttgag atgtactctt ggtttcagaa tcgtaactaa
     9841 gaggtaaggc attggagaag gacaatgtaa aagacagagg tttagaacaa agtttatggt
     9901 gtgaatgagg ctttcaaaat cagtatctgg gtaaattgat actaaagaca ctgaagaaac
     9961 actcatccac ataagatgga aaggatgtct gtccatctaa caagctcagg ggtttctgag
    10021 tctcagaatg acatcccatt tcaaaaagaa gaaaagagat attgaaatca ttctgcctgt
    10081 ttgagagatg actggttatt tacagcacaa aaaaaggctt agaatgaaaa ctagaagagg
    10141 ccttttgttt ttcactccca gtgaggagag tagaaatctt aagatgctct actgggctac
    10201 ctgtagcact gactggagtt tgctgcctac agagttttga atgtactagt ccttagtttc
    10261 catagaactg aatgcacctc tttagtaagt tgctgattta tggtgctaaa gaaaatgatt
    10321 attcccattt ttttcttctt ccccaagccc cttaagcatt taagaaaatt taaaataaaa
    10381 gcgttagagg ccctttttat gaatgtaacc taagtttctg tttgacatat gacactgcaa
    10441 cttaaaaatg ttaggaaatt atttgccttt ttttttcttt tagagttaag ctttataaat
    10501 aatctgtaga atcaattgaa gtttaaagct taaggatcac tcttaagacg tctacaaaat
    10561 cttgtatatt tttaagtgtg ccaatttgta acatattttg taagtgtata tttttcttag
    10621 aaaagtgctg tgaagtgtct gtatgtgaga gttttccttt ttctgcacca ctaggtgcta
    10681 ataaaaggat atttacttca aagtttctgg ttttagaaac cacaatacaa agaaaaaaaa
    10741 tacacttttg ttggaaattt tgtaacacaa aacatgttgt gaaagagtgt agtgatcttg
    10801 tgcaaaaaaa atgaacattt gtgagcttct tgctgtttta tagattttct tgtaaattat
    10861 tcttgtaaca cttctggttt tgttgttctt gttgcgaagg tttcaaatat ttgtgactga
    10921 atgtacggtg aaactgtcat aatgttacct agctgagttt tgttattgtt tatgaaataa
    10981 ataaaaagaa aagtttaaaa tactgcttta gaatcatatg tattagaaat caaaccattt
    11041 ctaattaaat ctatgtccca aataaaacgt tctttatcat ctagagcagt gtttctcaaa
    11101 ctatctgtgg tgagggacca atagtttttg caatccatca cagaccaata ctattataaa
    11161 acacaacaaa aatgaatttc taagaaagtt aaatggaaaa aagatatgca aaataaaagc
    11221 ccaaatgtat tagatttaac atgtaaaatt acatttcgag ataaacataa cataagggga
    11281 aagaaacgaa ttgcaaaaag ttggtaccct gtttgagaca agtccactca tcaatgtcaa
    11341 attgccatag aaggttctaa tcatactttg aataatactt tgactagacc agcagcattg
    11401 ccatcatctg ggaacttgtt aggaatgcga aattccaagc cctacaccaa ttctgctgaa
    11461 tgagaatctg aattttaaca agatccctag gtgttttgtg tgcatgttaa agtttgagaa
    11521 gcactgggct agagttttgt gtaggggatt cttttgcccc tcaaattgag gaatcatctt
    11581 ctagtgtgtc cagtcttcaa agaccttaaa acaaattgtg tctttgtttt gtgatccaga
    11641 tggaatctgc agagatgcag tcctctcaaa gtgttaaagc tgtttattga aagtaataaa
    11701 tgctgatttg cctggta
//
