LOCUS       NM_020999               1560 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens neurogenin 3 (NEUROG3), mRNA.
ACCESSION   NM_020999
VERSION     NM_020999.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1560)
  AUTHORS   Manea,T., Nelson,J.K., Garrone,C.M., Hansson,K., Evans,I.,
            Behrens,A. and Sancho,R.
  TITLE     USP7 controls NGN3 stability and pancreatic endocrine lineage
            development
  JOURNAL   Nat Commun 14 (1), 2457 (2023)
   PUBMED   37117185
  REMARK    GeneRIF: USP7 controls NGN3 stability and pancreatic endocrine
            lineage development.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1560)
  AUTHORS   Wejaphikul,K., Srilanchakon,K., Kamolvisit,W., Jantasuwan,S.,
            Santawong,K., Tongkobpetch,S., Theerapanon,T., Damrongmanee,A.,
            Hongsawong,N., Ukarapol,N., Dejkhamron,P., Supornsilchai,V.,
            Porntaveetus,T. and Shotelersuk,V.
  TITLE     Novel Variants and Phenotypes in NEUROG3-Associated Syndrome
  JOURNAL   J Clin Endocrinol Metab 108 (1), 52-58 (2022)
   PUBMED   36149814
  REMARK    GeneRIF: Novel Variants and Phenotypes in NEUROG3-Associated
            Syndrome.
REFERENCE   3  (bases 1 to 1560)
  AUTHORS   Narayan,G., Agrawal,A., Joshi,N., Gogoi,R., Nagotu,S. and
            Thummer,R.P.
  TITLE     Protein Production and Purification of a Codon-Optimized Human NGN3
            Transcription Factor from E. coli
  JOURNAL   Protein J 40 (6), 891-906 (2021)
   PUBMED   34550497
  REMARK    GeneRIF: Protein Production and Purification of a Codon-Optimized
            Human NGN3 Transcription Factor from E. coli.
REFERENCE   4  (bases 1 to 1560)
  AUTHORS   Schreiber,V., Mercier,R., Jimenez,S., Ye,T., Garcia-Sanchez,E.,
            Klein,A., Meunier,A., Ghimire,S., Birck,C., Jost,B., de
            Lichtenberg,K.H., Honore,C., Serup,P. and Gradwohl,G.
  TITLE     Extensive NEUROG3 occupancy in the human pancreatic endocrine gene
            regulatory network
  JOURNAL   Mol Metab 53, 101313 (2021)
   PUBMED   34352411
  REMARK    GeneRIF: Extensive NEUROG3 occupancy in the human pancreatic
            endocrine gene regulatory network.
REFERENCE   5  (bases 1 to 1560)
  AUTHORS   Yong,H.J., Xie,G., Liu,C., Wang,W., Naji,A., Irianto,J. and
            Wang,Y.J.
  TITLE     Gene Signatures of NEUROGENIN3+ Endocrine Progenitor Cells in the
            Human Pancreas
  JOURNAL   Front Endocrinol (Lausanne) 12, 736286 (2021)
   PUBMED   34566896
  REMARK    GeneRIF: Gene Signatures of NEUROGENIN3+ Endocrine Progenitor Cells
            in the Human Pancreas.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1560)
  AUTHORS   del Bosque-Plata,L., Lin,J., Horikawa,Y., Schwarz,P.E., Cox,N.J.,
            Iwasaki,N., Ogata,M., Iwamoto,Y., German,M.S. and Bell,G.I.
  TITLE     Mutations in the coding region of the neurogenin 3 gene (NEUROG3)
            are not a common cause of maturity-onset diabetes of the young in
            Japanese subjects
  JOURNAL   Diabetes 50 (3), 694-696 (2001)
   PUBMED   11246894
REFERENCE   7  (bases 1 to 1560)
  AUTHORS   Okada,T., Tobe,K., Hara,K., Yasuda,K., Kawaguchi,Y., Ikegami,H.,
            Ito,C. and Kadowaki,T.
  TITLE     Variants of neurogenin 3 gene are not associated with Type II
            diabetes in Japanese subjects
  JOURNAL   Diabetologia 44 (2), 241-244 (2001)
   PUBMED   11270683
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 1560)
  AUTHORS   Jensen,J.N., Hansen,L., Ekstrom,C.T., Pociot,F., Nerup,J.,
            Hansen,T. and Pedersen,O.
  TITLE     Polymorphisms in the neurogenin 3 gene (NEUROG) and their relation
            to altered insulin secretion and diabetes in the Danish Caucasian
            population
  JOURNAL   Diabetologia 44 (1), 123-126 (2001)
   PUBMED   11206403
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 1560)
  AUTHORS   Gradwohl,G., Dierich,A., LeMeur,M. and Guillemot,F.
  TITLE     neurogenin3 is required for the development of the four endocrine
            cell lineages of the pancreas
  JOURNAL   Proc Natl Acad Sci U S A 97 (4), 1607-1611 (2000)
   PUBMED   10677506
REFERENCE   10 (bases 1 to 1560)
  AUTHORS   Sommer,L., Ma,Q. and Anderson,D.J.
  TITLE     neurogenins, a novel family of atonal-related bHLH transcription
            factors, are putative mammalian neuronal determination genes that
            reveal progenitor cell heterogeneity in the developing CNS and PNS
  JOURNAL   Mol Cell Neurosci 8 (4), 221-241 (1996)
   PUBMED   9000438
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK313952.1, BC069098.1 and
            AL450311.11.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_020999.3.
            
            Summary: The protein encoded by this gene is a basic
            helix-loop-helix (bHLH) transcription factor involved in
            neurogenesis. The encoded protein likely acts as a heterodimer with
            another bHLH protein. Defects in this gene are a cause of
            congenital malabsorptive diarrhea 4 (DIAR4).[provided by RefSeq,
            May 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC069098.1, AK313952.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348, SAMEA2144120
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000242462.5/ ENSP00000242462.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                AK313952.1         34-89
            57-243              BC069098.1         1-187
            244-859             AK313952.1         279-894
            860-1223            BC069098.1         804-1167
            1224-1560           AL450311.11        28980-29316         c
FEATURES             Location/Qualifiers
     source          1..1560
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q22.1"
     gene            1..1560
                     /gene="NEUROG3"
                     /gene_synonym="Atoh5; bHLHa7; Math4B; NGN-3; ngn3"
                     /note="neurogenin 3"
                     /db_xref="GeneID:50674"
                     /db_xref="HGNC:HGNC:13806"
                     /db_xref="MIM:604882"
     exon            1..213
                     /gene="NEUROG3"
                     /gene_synonym="Atoh5; bHLHa7; Math4B; NGN-3; ngn3"
                     /inference="alignment:Splign:2.1.0"
     exon            214..1560
                     /gene="NEUROG3"
                     /gene_synonym="Atoh5; bHLHa7; Math4B; NGN-3; ngn3"
                     /inference="alignment:Splign:2.1.0"
     CDS             215..859
                     /gene="NEUROG3"
                     /gene_synonym="Atoh5; bHLHa7; Math4B; NGN-3; ngn3"
                     /note="protein atonal homolog 5; class A basic
                     helix-loop-helix protein 7"
                     /codon_start=1
                     /product="neurogenin-3"
                     /protein_id="NP_066279.2"
                     /db_xref="CCDS:CCDS31212.1"
                     /db_xref="GeneID:50674"
                     /db_xref="HGNC:HGNC:13806"
                     /db_xref="MIM:604882"
                     /translation="MTPQPSGAPTVQVTRETERSFPRASEDEVTCPTSAPPSPTRTRG
                     NCAEAEEGGCRGAPRKLRARRGGRSRPKSELALSKQRRSRRKKANDRERNRMHNLNSA
                     LDALRGVLPTFPDDAKLTKIETLRFAHNYIWALTQTLRIADHSLYALEPPAPHCGELG
                     SPGGSPGDWGSLYSPVSQAGSLSPAASLEERPGLLGATFSACLSPGSLAFSDFL"
ORIGIN      
        1 gctcaggaaa tccctgcggt ctcaccgccg cgcctcgaga gagagcgtga cagaggcctc
       61 ggaccccatt ctctcttctt ttctcctttg gggctggggc aactcccagg cgggggcgcc
      121 tgcagctcag ctgaacttgg cgaccagaag cccgctgagc tccccacggc cctcgctgct
      181 catcgctctc tattcttttg cgccggtaga aaggatgacg cctcaaccct cgggtgcgcc
      241 cactgtccaa gtgacccgtg agacggagcg gtccttcccc agagcctcgg aagacgaagt
      301 gacctgcccc acgtccgccc cgcccagccc cactcgcaca cgggggaact gcgcagaggc
      361 ggaagaggga ggctgccgag gggccccgag gaagctccgg gcacggcgcg ggggacgcag
      421 ccggcctaag agcgagttgg cactgagcaa gcagcgacgg agtcggcgaa agaaggccaa
      481 cgaccgcgag cgcaatcgaa tgcacaacct caactcggca ctggacgccc tgcgcggtgt
      541 cctgcccacc ttcccagacg acgcgaagct caccaagatc gagacgctgc gcttcgccca
      601 caactacatc tgggcgctga ctcaaacgct gcgcatagcg gaccacagct tgtacgcgct
      661 ggagccgccg gcgccgcact gcggggagct gggcagccca ggcggttccc ccggggactg
      721 ggggtccctc tactccccag tctcccaggc tggcagcctg agtcccgccg cgtcgctgga
      781 ggagcgaccc gggctgctgg gggccacctt ttccgcctgc ttgagcccag gcagtctggc
      841 tttctcagat tttctgtgaa aggacctgtc tgtcgctggg ctgtgggtgc taagggtaag
      901 ggagagggag ggagccggga gccgtagagg gtggccgacg gcggcggccc tcaaaagcac
      961 ttgttccttc tgcttctccc tggctgaccc ctggccggcc caggcctcca cgggggcggc
     1021 aggctgggtt cattccccgg ccctccgagc cgcgccaacg cacgcaaccc ttgctgctgc
     1081 ccgcgcgaag tgggcattgc aaagtgcgct cattttaggc ctcctctctg ccaccacccc
     1141 ataatctcat tcaaagaata ctagaatggt agcactaccc ggccggagcc gcccaccgtc
     1201 ttgggtcgcc ctaccctcac tcaagtctgt ctgcctctca gtctcttacc acccctcctc
     1261 caatgtgatt caatccaatg tttggtctct cagcgcttac tccccttgcc ttgctccaaa
     1321 gacgctgccg atctgctcta ctcccaatca ggtccgggat ttcagggcgc ctcactctgc
     1381 cttaaagcca cgaaggcgac cctctgcctt ctcctcgtgc acttttcgga gccattgccc
     1441 tcccggggcg gaagaccagg ctgtgaactg ggaaagcgct agcccggcca gggagcatct
     1501 ccccagcctc cctgcgaact gcgcctgaaa cgtgagctgc gctgcaggtg cctggagcac
//
