LOCUS       NM_024019               2295 bp    mRNA    linear   PRI 04-OCT-2024
DEFINITION  Homo sapiens neurogenin 2 (NEUROG2), mRNA.
ACCESSION   NM_024019
VERSION     NM_024019.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2295)
  AUTHORS   Ang,C.E., Olmos,V.H., Vodehnal,K., Zhou,B., Lee,Q.Y., Sinha,R.,
            Narayanaswamy,A., Mall,M., Chesnov,K., Dominicus,C.S., Sudhof,T.
            and Wernig,M.
  TITLE     Generation of human excitatory forebrain neurons by cooperative
            binding of proneural NGN2 and homeobox factor EMX1
  JOURNAL   Proc Natl Acad Sci U S A 121 (11), e2308401121 (2024)
   PUBMED   38446849
  REMARK    GeneRIF: Generation of human excitatory forebrain neurons by
            cooperative binding of proneural NGN2 and homeobox factor EMX1.
REFERENCE   2  (bases 1 to 2295)
  AUTHORS   Majeed,S., Aziz,A., Iftikhar,K. and Simjee,S.U.
  TITLE     Neurogenin-2 induced neuronal differentiation in co-cultured bone
            marrow stromal and neonatal cortical cells
  JOURNAL   J Pak Med Assoc 74 (1 (Supple-2)), S68-S73 (2024)
   PUBMED   38385475
  REMARK    GeneRIF: Neurogenin-2 induced neuronal differentiation in
            co-cultured bone marrow stromal and neonatal cortical cells.
REFERENCE   3  (bases 1 to 2295)
  AUTHORS   Aravantinou-Fatorou,K., Vejdani,S. and Thomaidou,D.
  TITLE     Cend1 and Neurog2 efficiently reprogram human cortical astrocytes
            to neural precursor cells and induced-neurons
  JOURNAL   Int J Dev Biol 66 (1-2-3), 199-209 (2022)
   PUBMED   34549796
  REMARK    GeneRIF: Cend1 and Neurog2 efficiently reprogram human cortical
            astrocytes to neural precursor cells and induced-neurons.
REFERENCE   4  (bases 1 to 2295)
  AUTHORS   Lin,H.C., He,Z., Ebert,S., Schornig,M., Santel,M., Nikolova,M.T.,
            Weigert,A., Hevers,W., Kasri,N.N., Taverna,E., Camp,J.G. and
            Treutlein,B.
  TITLE     NGN2 induces diverse neuron types from human pluripotency
  JOURNAL   Stem Cell Reports 16 (9), 2118-2127 (2021)
   PUBMED   34358451
  REMARK    GeneRIF: NGN2 induces diverse neuron types from human pluripotency.
REFERENCE   5  (bases 1 to 2295)
  AUTHORS   Pan,J.K., Lin,C.H., Kuo,Y.L., Ger,L.P., Cheng,H.C., Yao,Y.C.,
            Hsiao,M. and Lu,P.J.
  TITLE     MiR-211 determines brain metastasis specificity through SOX11/NGN2
            axis in triple-negative breast cancer
  JOURNAL   Oncogene 40 (9), 1737-1751 (2021)
   PUBMED   33536579
  REMARK    GeneRIF: MiR-211 determines brain metastasis specificity through
            SOX11/NGN2 axis in triple-negative breast cancer.
REFERENCE   6  (bases 1 to 2295)
  AUTHORS   Kumar,M., Bagchi,B., Gupta,S.K., Meena,A.S., Gressens,P. and
            Mani,S.
  TITLE     Neurospheres derived from human embryoid bodies treated with
            retinoic Acid show an increase in nestin and ngn2 expression that
            correlates with the proportion of tyrosine hydroxylase-positive
            cells
  JOURNAL   Stem Cells Dev 16 (4), 667-681 (2007)
   PUBMED   17784840
  REMARK    GeneRIF: expression of Ngn2 during the differentiation of neuronl
            human embryo stem cells.
REFERENCE   7  (bases 1 to 2295)
  AUTHORS   Yan,R.T., Ma,W.X. and Wang,S.Z.
  TITLE     neurogenin2 elicits the genesis of retinal neurons from cultures of
            nonneural cells
  JOURNAL   Proc Natl Acad Sci U S A 98 (26), 15014-15019 (2001)
   PUBMED   11752450
REFERENCE   8  (bases 1 to 2295)
  AUTHORS   Simmons,A.D., Horton,S., Abney,A.L. and Johnson,J.E.
  TITLE     Neurogenin2 expression in ventral and dorsal spinal neural tube
            progenitor cells is regulated by distinct enhancers
  JOURNAL   Dev Biol 229 (2), 327-339 (2001)
   PUBMED   11203697
REFERENCE   9  (bases 1 to 2295)
  AUTHORS   Fode,C., Gradwohl,G., Morin,X., Dierich,A., LeMeur,M., Goridis,C.
            and Guillemot,F.
  TITLE     The bHLH protein NEUROGENIN 2 is a determination factor for
            epibranchial placode-derived sensory neurons
  JOURNAL   Neuron 20 (3), 483-494 (1998)
   PUBMED   9539123
REFERENCE   10 (bases 1 to 2295)
  AUTHORS   Gradwohl,G., Fode,C. and Guillemot,F.
  TITLE     Restricted expression of a novel murine atonal-related bHLH protein
            in undifferentiated neural precursors
  JOURNAL   Dev Biol 180 (1), 227-241 (1996)
   PUBMED   8948587
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC023886.7 and BC036847.1.
            
            On Nov 22, 2018 this sequence version replaced NM_024019.3.
            
            Summary: This gene encodes a neural-specific basic helix-loop-helix
            (bHLH) transcription factor that can specify a neuronal fate on
            ectodermal cells and is expressed in neural progenitor cells within
            the developing central and peripheral nervous systems. The protein
            product of this gene also plays a role in the differentiation and
            survival of midbrain dopaminergic neurons. [provided by RefSeq, Apr
            2012].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC036847.1, AL540071.3 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000313341.4/ ENSP00000317333.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 AC023886.7         56960-56967         c
            9-922               BC036847.1         1-914
            923-923             AC023886.7         55675-55675         c
            924-2295            BC036847.1         916-2287
FEATURES             Location/Qualifiers
     source          1..2295
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q25"
     gene            1..2295
                     /gene="NEUROG2"
                     /gene_synonym="Atoh4; bHLHa8; Math4A; ngn-2; NGN2"
                     /note="neurogenin 2"
                     /db_xref="GeneID:63973"
                     /db_xref="HGNC:HGNC:13805"
                     /db_xref="MIM:606624"
     exon            1..334
                     /gene="NEUROG2"
                     /gene_synonym="Atoh4; bHLHa8; Math4A; ngn-2; NGN2"
                     /inference="alignment:Splign:2.1.0"
     exon            335..2295
                     /gene="NEUROG2"
                     /gene_synonym="Atoh4; bHLHa8; Math4A; ngn-2; NGN2"
                     /inference="alignment:Splign:2.1.0"
     CDS             336..1154
                     /gene="NEUROG2"
                     /gene_synonym="Atoh4; bHLHa8; Math4A; ngn-2; NGN2"
                     /note="protein atonal homolog 4; class A basic
                     helix-loop-helix protein 8"
                     /codon_start=1
                     /product="neurogenin-2"
                     /protein_id="NP_076924.1"
                     /db_xref="CCDS:CCDS3698.1"
                     /db_xref="GeneID:63973"
                     /db_xref="HGNC:HGNC:13805"
                     /db_xref="MIM:606624"
                     /translation="MFVKSETLELKEEEDVLVLLGSASPALAALTPLSSSADEEEEEE
                     PGASGGARRQRGAEAGQGARGGVAAGAEGCRPARLLGLVHDCKRRPSRARAVSRGAKT
                     AETVQRIKKTRRLKANNRERNRMHNLNAALDALREVLPTFPEDAKLTKIETLRFAHNY
                     IWALTETLRLADHCGGGGGGLPGALFSEAVLLSPGGASAALSSSGDSPSPASTWSCTN
                     SPAPSSSVSSNSTSPYSCTLSPASPAGSDMDYWQPPPPDKHRYAPHLPIARDCI"
     regulatory      2273..2278
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NEUROG2"
                     /gene_synonym="Atoh4; bHLHa8; Math4A; ngn-2; NGN2"
                     /note="hexamer: AATAAA"
     polyA_site      2295
                     /gene="NEUROG2"
                     /gene_synonym="Atoh4; bHLHa8; Math4A; ngn-2; NGN2"
                     /note="major polyA site"
ORIGIN      
        1 gccagacacg cagccactga accacaagca gcttcgcgtt aactggagtg cctgggagtc
       61 gcgtgccagg agccgcacgg ccagggactg actgacagac agacacgcac caccaccaca
      121 acacacgaga cccgggcggg ccgccgccgc cgccgccggg gctcttggca aactcgccgg
      181 tcgcagaggt cccccgcgga gctgcgccac agtagcgccg ggcttgcagc tttcacgccg
      241 ggcgaaggac ccggcgctgc gctcgcagct gcgcggagat tcccggcaca ggccaaagtc
      301 acagcaacgc tgaggcacag ttagagccaa ctaagatgtt cgtcaaatcc gagaccttgg
      361 agttgaagga ggaagaggac gtgttagtgc tgctcggatc ggcctccccc gccttggcgg
      421 ccctgacccc gctgtcatcc agcgccgacg aagaagagga ggaggagccg ggcgcgtcag
      481 gcggggcgcg tcggcagcgc ggggctgagg ccgggcaggg ggcgcggggc ggcgtggctg
      541 cgggtgcgga gggctgccgg cccgcacggc tgctgggtct ggtacacgat tgcaaacggc
      601 gcccttcccg ggcgcgggcc gtctcccgag gcgccaagac ggccgagacg gtgcagcgca
      661 tcaagaagac ccgtagactg aaggccaaca accgcgagcg aaaccgcatg cacaacctca
      721 acgcggcact ggacgcgctg cgcgaggtgc tccccacgtt ccccgaggac gccaagctca
      781 ccaagatcga gaccctgcgc ttcgcccaca actacatctg ggcactcacc gagaccctgc
      841 gcctggcgga tcactgcggg ggcggcggcg ggggcctgcc gggggcgctc ttctccgagg
      901 cagtgttgct gagcccggga ggagccagcg ccgccctgag cagcagcgga gacagcccct
      961 cgcccgcctc cacgtggagt tgcaccaaca gccccgcgcc gtcctcctcc gtgtcctcca
     1021 attccacctc cccctacagc tgcactttat cgcccgccag cccggccggg tcagacatgg
     1081 actattggca gcccccacct cccgacaagc accgctatgc acctcacctc cccatagcca
     1141 gggattgtat ctagagctgc catttctgct acccacgcca ggccttagtg ggttcccttt
     1201 cctgtcccca gtcgagccct cctcccttcc cctgcccctc ctttccacgc cctggaaacc
     1261 atctcacttc acagggcagg tgtagccttt ctgattcctc ggttgtttct tgcatttctt
     1321 ggctttgggt atccttcatt cagacgggct ctgatttact gaaggtgtga tggagcttat
     1381 tgtcaaagcc aagggtggcg ttttgggggc gcttcttgag acgaaaaaga ccctgggaag
     1441 agatgatggt ggcatatcta aagagtttgc agagcggact gacgctcctc ccctttctct
     1501 ttaacgccga aggacttggt gcagttcgtg tgaatctcac agggggaatg caactggttc
     1561 ctgtgatctc ttcacctttg cttctacata gagatgttaa tgtcgagtag aaagaaatgt
     1621 atcttagcat ctgaatgatt ttgctggtaa taatattatc cacagatttg caatggctgg
     1681 catctgcttt attcccattg ctgtctgcag gctgtgggaa tttcacctgt caaaccaaac
     1741 ttccctctct gatgtgcact ttgttctgtt tcccagattc gtcacaatgc ctattgtcct
     1801 gtccttctct ttcctttttc ttccccattt tgccatctgt ctcttatgat ttataagggg
     1861 aaaaaaactt gttttgttag aggggcaggt tagaagtcat tgtataattt gtaggctttg
     1921 taatgattga atgcaagcgt ggaaatttag gctgaactct ctatcaaaag gaaaaatgtg
     1981 gaggaaaagg gaaaaatcag gagggaggat tgcctcatgt attatttatt tcgacctttt
     2041 aggggagaag gaactccccc attctttcaa gagattaaaa ataaatcaac agtctgaaaa
     2101 cctaagcaga cacggagcat tatccggatc agccacacac gtgttccctt ctatttatta
     2161 taaagaaatt tttcatggga aaatatgtat tttttgtata ttctacagag tttattctag
     2221 tatgtattta catcttgaag aacaagaaag ttgttcttgt gattaaacta taaataaact
     2281 atctaatttt cataa
//
