LOCUS       NM_006161               1683 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens neurogenin 1 (NEUROG1), mRNA.
ACCESSION   NM_006161
VERSION     NM_006161.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1683)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1683)
  AUTHORS   Dupont,J., Vieira,J.P., Tavares,A.L.T., Conceicao,C.R., Khan,S.,
            Bertoli-Avella,A.M. and Sousa,A.B.
  TITLE     Adding evidence to the role of NEUROG1 in congenital cranial
            dysinnervation disorders
  JOURNAL   Clin Genet 99 (4), 588-593 (2021)
   PUBMED   33439489
  REMARK    GeneRIF: Adding evidence to the role of NEUROG1 in congenital
            cranial dysinnervation disorders.
REFERENCE   3  (bases 1 to 1683)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 1683)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1683)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   6  (bases 1 to 1683)
  AUTHORS   Kim,S., Ghil,S.H., Kim,S.S., Myeong,H.H., Lee,Y.D. and Suh-Kim,H.
  TITLE     Overexpression of neurogenin1 induces neurite outgrowth in F11
            neuroblastoma cells
  JOURNAL   Exp Mol Med 34 (6), 469-475 (2002)
   PUBMED   12526089
  REMARK    GeneRIF: Overexpression of the full-length Ngn1 induced neurite
            outgrowth in F11 cells in the absence of cAMP
REFERENCE   7  (bases 1 to 1683)
  AUTHORS   Franklin,A., Kao,A., Tapscott,S. and Unis,A.
  TITLE     NeuroD homologue expression during cortical development in the
            human brain
  JOURNAL   J Child Neurol 16 (11), 849-853 (2001)
   PUBMED   11732772
REFERENCE   8  (bases 1 to 1683)
  AUTHORS   Sun,Y., Nadal-Vicens,M., Misono,S., Lin,M.Z., Zubiaga,A., Hua,X.,
            Fan,G. and Greenberg,M.E.
  TITLE     Neurogenin promotes neurogenesis and inhibits glial differentiation
            by independent mechanisms
  JOURNAL   Cell 104 (3), 365-376 (2001)
   PUBMED   11239394
REFERENCE   9  (bases 1 to 1683)
  AUTHORS   Tamimi,R.M., Steingrimsson,E., Montgomery-Dyer,K., Copeland,N.G.,
            Jenkins,N.A. and Tapscott,S.J.
  TITLE     NEUROD2 and NEUROD3 genes map to human chromosomes 17q12 and
            5q23-q31 and mouse chromosomes 11 and 13, respectively
  JOURNAL   Genomics 40 (2), 355-357 (1997)
   PUBMED   9119405
REFERENCE   10 (bases 1 to 1683)
  AUTHORS   McCormick,M.B., Tamimi,R.M., Snider,L., Asakura,A., Bergstrom,D.
            and Tapscott,S.J.
  TITLE     NeuroD2 and neuroD3: distinct expression patterns and
            transcriptional activation potentials within the neuroD gene family
  JOURNAL   Mol Cell Biol 16 (10), 5792-5800 (1996)
   PUBMED   8816493
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC005738.1 and BC028226.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006161.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC028226.1, AB593107.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000314744.6/ ENSP00000317580.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AC005738.1         75211-75225         c
            16-1683             BC028226.1         1-1668
FEATURES             Location/Qualifiers
     source          1..1683
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.1"
     gene            1..1683
                     /gene="NEUROG1"
                     /gene_synonym="AKA; bHLHa6; CCDDRD; Math4C; NEUROD3; ngn1"
                     /note="neurogenin 1"
                     /db_xref="GeneID:4762"
                     /db_xref="HGNC:HGNC:7764"
                     /db_xref="MIM:601726"
     exon            1..1683
                     /gene="NEUROG1"
                     /gene_synonym="AKA; bHLHa6; CCDDRD; Math4C; NEUROD3; ngn1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1666..1671
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NEUROG1"
                     /gene_synonym="AKA; bHLHa6; CCDDRD; Math4C; NEUROD3; ngn1"
                     /note="hexamer: AATAAA"
     polyA_site      1683
                     /gene="NEUROG1"
                     /gene_synonym="AKA; bHLHa6; CCDDRD; Math4C; NEUROD3; ngn1"
                     /note="major polyA site"
ORIGIN      
        1 gccacactcg gtgctcacac gagctgatct gatcgccggc gacatcactc aggagaccgg
       61 ccgggcgcgt ggcccctgca ggcgaggcga ggaggccagg ccaagttctc cgtgcgcccc
      121 tgcacccttc caggctctcg cacccgcaac tggcacagag taacaacccc aggctgttgg
      181 gaacgtaagt gcgccctggc ggctctgccc tcagtccggg ctgcagcgct ctgagcgcct
      241 ttctatctgt ccgtcggtcc tgcacagcgc aacgatgcca gcccgccttg agacctgcat
      301 ctccgacctc gactgcgcca gcagcagcgg cagtgaccta tccggcttcc tcaccgacga
      361 ggaagactgt gccagactcc aacaggcagc ctccgcttcg gggccgcccg cgccggcccg
      421 caggggcgcg cccaatatct cccgggcgtc tgaggttcca ggggcacagg acgacgagca
      481 ggagaggcgg cggcgccgcg gccggacgcg ggtccgctcc gaggcgctgc tgcactcgct
      541 gcgcaggagc cggcgcgtca aggccaacga tcgcgagcgc aaccgcatgc acaacttgaa
      601 cgcggccctg gacgcactgc gcagcgtgct gccctcgttc cccgacgaca ccaagctcac
      661 caaaatcgag acgctgcgct tcgcctacaa ctacatctgg gctctggccg agacactgcg
      721 cctggcggat caagggctgc ccggaggcgg tgcccgggag cgcctcctgc cgccgcagtg
      781 cgtcccctgc ctgcccggtc ccccaagccc cgccagcgac gcggagtcct ggggctcagg
      841 tgccgccgcc gcctccccgc tctctgaccc cagtagccca gccgcctccg aagacttcac
      901 ctaccgcccc ggcgaccctg ttttctcctt cccaagcctg cccaaagact tgctccacac
      961 aacgccctgt ttcattcctt accactaggc cctttgtaga cactgttact ttccccctcc
     1021 cctagtcagc aggcaataga tggggcccca gctgccgcct cgggaccccc tctccaggcg
     1081 gagggaggaa gcgggagctt taaagcagtc ggggatacct gagccgcttg ttaggtcgcc
     1141 gcaccctcgc ggcggatgtc tcttggtctg tttctccggc cctcagccca gcgcccctcc
     1201 tgcccgcccc tagacggcct ttccttttgc actttctgaa ctccacaaaa cctcctttgt
     1261 gactggctca gaactgaccc cagccaccac ttcagtgtga tttagaaaag ggacagatca
     1321 gcccctgaag acgaggtgaa aagtcaattt tacaatttgt agaactctaa tgaagaaaaa
     1381 cgagcatgaa aattcggttt gagccggctg acaatacaat gaaaaggctt aaaaagcaga
     1441 gacaaggagt gggcttcatg cattatggat cccgaccccc accactgcag actcgctcta
     1501 ggaagaactg gagactcttg cttagctatt caggcacagg gctggagagt actttaattt
     1561 attcaagatg cttcattcat atgaaaatgt atttttgtac ataaagagtt tattctatta
     1621 tgagctatca aagtttacat ttttgtactg cagacgcttc atgtaaataa aaactaaaaa
     1681 taa
//
