LOCUS       NM_022728               1959 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens neuronal differentiation 6 (NEUROD6), mRNA.
ACCESSION   NM_022728
VERSION     NM_022728.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1959)
  AUTHORS   Fowler,K.D., Funt,J.M., Artyomov,M.N., Zeskind,B., Kolitz,S.E. and
            Towfic,F.
  TITLE     Leveraging existing data sets to generate new insights into
            Alzheimer's disease biology in specific patient subsets
  JOURNAL   Sci Rep 5, 14324 (2015)
   PUBMED   26395074
  REMARK    GeneRIF: single nucleotide polymorphisms in either the region of
            NEUROD6 or SNAP25 were significantly associated with Alzheimer's
            Disease, in APOE4+ females and APOE4+ males, respectively.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1959)
  AUTHORS   Lemaitre,R.N., King,I.B., Kabagambe,E.K., Wu,J.H., McKnight,B.,
            Manichaikul,A., Guan,W., Sun,Q., Chasman,D.I., Foy,M., Wang,L.,
            Zhu,J., Siscovick,D.S., Tsai,M.Y., Arnett,D.K., Psaty,B.M.,
            Djousse,L., Chen,Y.D., Tang,W., Weng,L.C., Wu,H., Jensen,M.K.,
            Chu,A.Y., Jacobs,D.R. Jr., Rich,S.S., Mozaffarian,D., Steffen,L.,
            Rimm,E.B., Hu,F.B., Ridker,P.M., Fornage,M. and Friedlander,Y.
  TITLE     Genetic loci associated with circulating levels of very long-chain
            saturated fatty acids
  JOURNAL   J Lipid Res 56 (1), 176-184 (2015)
   PUBMED   25378659
REFERENCE   3  (bases 1 to 1959)
  AUTHORS   Satoh,J., Yamamoto,Y., Asahina,N., Kitano,S. and Kino,Y.
  TITLE     RNA-Seq data mining: downregulation of NeuroD6 serves as a possible
            biomarker for alzheimer's disease brains
  JOURNAL   Dis Markers 2014, 123165 (2014)
   PUBMED   25548427
  REMARK    GeneRIF: NeuroD6 serves as a possible biomarker for Alzheimer
            disease brains.
REFERENCE   4  (bases 1 to 1959)
  AUTHORS   Ribases,M., Bosch,R., Hervas,A., Ramos-Quiroga,J.A.,
            Sanchez-Mora,C., Bielsa,A., Gastaminza,X., Guijarro-Domingo,S.,
            Nogueira,M., Gomez-Barros,N., Kreiker,S., Gross-Lesch,S.,
            Jacob,C.P., Lesch,K.P., Reif,A., Johansson,S., Plessen,K.J.,
            Knappskog,P.M., Haavik,J., Estivill,X., Casas,M., Bayes,M. and
            Cormand,B.
  TITLE     Case-control study of six genes asymmetrically expressed in the two
            cerebral hemispheres: association of BAIAP2 with
            attention-deficit/hyperactivity disorder
  JOURNAL   Biol Psychiatry 66 (10), 926-934 (2009)
   PUBMED   19733838
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 1959)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   6  (bases 1 to 1959)
  AUTHORS   Satou,W., Suzuki,T., Noguchi,T., Ogino,H., Fujii,M. and Ayusawa,D.
  TITLE     AT-hook proteins stimulate induction of senescence markers
            triggered by 5-bromodeoxyuridine in mammalian cells
  JOURNAL   Exp Gerontol 39 (2), 173-179 (2004)
   PUBMED   15036409
REFERENCE   7  (bases 1 to 1959)
  AUTHORS   Guo,L., Jiang,M., Ma,Y., Cheng,H., Ni,X., Jin,Y., Xie,Y. and Mao,Y.
  TITLE     Cloning, chromosome localization and features of a novel human
            gene, MATH2
  JOURNAL   J Genet 81 (1), 13-17 (2002)
   PUBMED   12357074
  REMARK    GeneRIF: cloning and some features of a novel human gene, MATH2,
            which encodes a protein of 337 amino acid residues with a basic
            helix loop helix domain and exhibits 98% similarity to mouse Math2
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF248954.1.
            
            On Nov 23, 2018 this sequence version replaced NM_022728.3.
            
            Summary: This gene is a member of the NEUROD family of basic
            helix-loop-helix transcription factors. The encoded protein may be
            involved in the development and differentiation of the nervous
            system. [provided by RefSeq, Nov 2012].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC035048.2, AF248954.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000297142.4/ ENSP00000297142.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1959              AF248954.1         199-2157
FEATURES             Location/Qualifiers
     source          1..1959
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p14.3"
     gene            1..1959
                     /gene="NEUROD6"
                     /gene_synonym="Atoh2; bHLHa2; Math-2; MATH2; Nex1; NEX1M"
                     /note="neuronal differentiation 6"
                     /db_xref="GeneID:63974"
                     /db_xref="HGNC:HGNC:13804"
                     /db_xref="MIM:611513"
     exon            1..134
                     /gene="NEUROD6"
                     /gene_synonym="Atoh2; bHLHa2; Math-2; MATH2; Nex1; NEX1M"
                     /inference="alignment:Splign:2.1.0"
     exon            135..1959
                     /gene="NEUROD6"
                     /gene_synonym="Atoh2; bHLHa2; Math-2; MATH2; Nex1; NEX1M"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..1169
                     /gene="NEUROD6"
                     /gene_synonym="Atoh2; bHLHa2; Math-2; MATH2; Nex1; NEX1M"
                     /note="protein atonal homolog 2; class A basic
                     helix-loop-helix protein 2; brain my051 protein"
                     /codon_start=1
                     /product="neurogenic differentiation factor 6"
                     /protein_id="NP_073565.2"
                     /db_xref="CCDS:CCDS5434.1"
                     /db_xref="GeneID:63974"
                     /db_xref="HGNC:HGNC:13804"
                     /db_xref="MIM:611513"
                     /translation="MLTLPFDESVVMPESQMCRKFSRECEDQKQIKKPESFSKQIVLR
                     GKSIKRAPGEETEKEEEEEDREEEDENGLPRRRGLRKKKTTKLRLERVKFRRQEANAR
                     ERNRMHGLNDALDNLRKVVPCYSKTQKLSKIETLRLAKNYIWALSEILRIGKRPDLLT
                     FVQNLCKGLSQPTTNLVAGCLQLNARSFLMGQGGEAAHHTRSPYSTFYPPYHSPELTT
                     PPGHGTLDNSKSMKPYNYCSAYESFYESTSPECASPQFEGPLSPPPINYNGIFSLKQE
                     ETLDYGKNYNYGMHYCAVPPRGPLGQGAMFRLPTDSHFPYDLHLRSQSLTMQDELNAV
                     FHN"
     regulatory      1324..1329
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NEUROD6"
                     /gene_synonym="Atoh2; bHLHa2; Math-2; MATH2; Nex1; NEX1M"
                     /note="hexamer: AATAAA"
     polyA_site      1347
                     /gene="NEUROD6"
                     /gene_synonym="Atoh2; bHLHa2; Math-2; MATH2; Nex1; NEX1M"
                     /note="major polyA site"
     regulatory      1476..1481
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NEUROD6"
                     /gene_synonym="Atoh2; bHLHa2; Math-2; MATH2; Nex1; NEX1M"
                     /note="hexamer: AATAAA"
     polyA_site      1499
                     /gene="NEUROD6"
                     /gene_synonym="Atoh2; bHLHa2; Math-2; MATH2; Nex1; NEX1M"
                     /note="major polyA site"
     regulatory      1936..1941
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NEUROD6"
                     /gene_synonym="Atoh2; bHLHa2; Math-2; MATH2; Nex1; NEX1M"
                     /note="hexamer: AATATA"
     polyA_site      1959
                     /gene="NEUROD6"
                     /gene_synonym="Atoh2; bHLHa2; Math-2; MATH2; Nex1; NEX1M"
                     /note="major polyA site"
ORIGIN      
        1 actttttaga gatcaatgag atagtgcaga tatacacaga tctagagact ccaggagacg
       61 atgcgacact cagcctgaaa agatttggaa gacccaaaat gaaaactgat tattgaatga
      121 aattaaaacc taaggtaatt taagattaga gaaccatgtt aacactaccg tttgatgagt
      181 ctgttgtaat gccagaatcc cagatgtgca gaaagttttc tagagaatgc gaggaccaga
      241 agcaaattaa gaagccagaa agcttttcca aacagattgt ccttcgagga aagagcatca
      301 aaagggcccc tggagaagaa accgagaaag aagaagagga ggaagacagg gaagaggaag
      361 atgaaaatgg gttgcctaga aggaggggtc ttaggaaaaa aaagacaaca aagctgcgat
      421 tggaaagggt caagttcagg agacaggaag cgaacgcgcg cgagaggaac aggatgcacg
      481 gcctcaacga cgctctggac aacttaagaa aagtggtccc ctgttattct aaaacccaga
      541 aactgtccaa aatagagact ttacgactgg ccaaaaacta catctgggca ctttctgaaa
      601 ttctgagaat cggcaagaga ccagatctgc tcacattcgt ccaaaactta tgcaaaggtc
      661 tttcccagcc aactacaaac ttggtggcag gctgcttgca gctcaacgcc aggagtttcc
      721 tgatgggtca gggtggggag gctgcacacc acacaaggtc accctactct accttctacc
      781 caccctacca cagccctgag ctcaccactc ccccagggca tgggactctt gataattcca
      841 agtccatgaa accctacaat tattgcagtg cgtatgaatc cttctatgaa agtacttccc
      901 ctgagtgtgc cagccctcag tttgaaggtc ccttaagtcc tcccccaatt aactataatg
      961 ggatattttc cctgaagcaa gaagaaacct tggactatgg taaaaattac aattacggca
     1021 tgcattactg tgcagtgcca cccaggggtc cccttgggca gggtgccatg ttcaggttgc
     1081 ccaccgacag ccacttccct tacgacttac atctgcgcag ccaatctctc acaatgcaag
     1141 atgaattaaa tgcagttttt cataattaat gaggaaaatg aaaataaaca gtggtcattc
     1201 acctcccctg tctaattaag acaaagcaga tgcttgtggg ctgagtaatt ggcacaactc
     1261 tatctaaggt gtttactagt ttctgaagtg tgtttcaact attgtgagaa ttttctatgt
     1321 aataataaat ctcttttcgt atgagaactt cttttccttt ccttttgtct gtgaagcact
     1381 gtgattctgt ttctactgga aagatttttt tctttttaat tttcttttaa acttatttaa
     1441 tttgtttgaa caaggtgtct aagaatatac tgttgaataa agacatgcac acagcataat
     1501 tcaatgtcta ttttggttgt acagtaatta taaaatgcat gttattaaaa ccagatgagt
     1561 aaaatgatgt gtttataatt attaggaatt atatattatg tatcttttaa aaattgaaat
     1621 tttaaaatat ggagaatatc actaagctga caatgatatt gggagatgaa tttgcaacaa
     1681 tataaaaagc tatgcaattt tctttttatt aaggatgaat ctaaatgcat tcaattggta
     1741 actattcctc ttcaagtatt tgcagatggg gcaacatgat atttgggtag ctgatgtcat
     1801 aattcgggga caattatctc aatcatcaag aaaaaaattt cagcacttgt tttgtattat
     1861 tcagaaatta actgtacagg tttgttatca caatgtataa ttgtgttttt ccaccccaca
     1921 tttttaaggc aattaaatat agatatttcc actcgtaaa
//
