LOCUS       NM_021191               3927 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens neuronal differentiation 4 (NEUROD4), mRNA.
ACCESSION   NM_021191
VERSION     NM_021191.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3927)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3927)
  AUTHORS   Gratacos,M., Costas,J., de Cid,R., Bayes,M., Gonzalez,J.R.,
            Baca-Garcia,E., de Diego,Y., Fernandez-Aranda,F.,
            Fernandez-Piqueras,J., Guitart,M., Martin-Santos,R., Martorell,L.,
            Menchon,J.M., Roca,M., Saiz-Ruiz,J., Sanjuan,J., Torrens,M.,
            Urretavizcaya,M., Valero,J., Vilella,E., Estivill,X. and
            Carracedo,A.
  CONSRTM   Psychiatric Genetics Network Group
  TITLE     Identification of new putative susceptibility genes for several
            psychiatric disorders by association analysis of regulatory and
            non-synonymous SNPs of 306 genes involved in neurotransmission and
            neurodevelopment
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 150B (6), 808-816 (2009)
   PUBMED   19086053
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 3927)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   4  (bases 1 to 3927)
  AUTHORS   Horikawa,Y., Horikawa,Y., Cox,N.J., Iwasaki,N., Ogata,M.,
            Iwamoto,Y., Schwitzgebel,V., German,M.S. and Bell,G.I.
  TITLE     beta-cell transcription factors and diabetes: no evidence for
            diabetes-associated mutations in the gene encoding the basic
            helix-loop-helix transcription factor neurogenic differentiation 4
            (NEUROD4) in Japanese patients with MODY
  JOURNAL   Diabetes 49 (11), 1955-1957 (2000)
   PUBMED   11078465
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA768001.1, DA417566.1, BC040961.1 and BM683125.1.
            
            On Nov 23, 2018 this sequence version replaced NM_021191.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA607396.1, SRR1803611.165175.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145544, SAMEA2146411
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000242994.4/ ENSP00000242994.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                DA768001.1         31-86
            57-481              DA417566.1         1-425
            482-3544            BC040961.1         1-3063
            3545-3927           BM683125.1         16-398              c
FEATURES             Location/Qualifiers
     source          1..3927
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.2"
     gene            1..3927
                     /gene="NEUROD4"
                     /gene_synonym="ATH-3; ATH3; Atoh3; bHLHa4; MATH-3; MATH3"
                     /note="neuronal differentiation 4"
                     /db_xref="GeneID:58158"
                     /db_xref="HGNC:HGNC:13802"
                     /db_xref="MIM:611635"
     exon            1..340
                     /gene="NEUROD4"
                     /gene_synonym="ATH-3; ATH3; Atoh3; bHLHa4; MATH-3; MATH3"
                     /inference="alignment:Splign:2.1.0"
     exon            341..3927
                     /gene="NEUROD4"
                     /gene_synonym="ATH-3; ATH3; Atoh3; bHLHa4; MATH-3; MATH3"
                     /inference="alignment:Splign:2.1.0"
     CDS             350..1345
                     /gene="NEUROD4"
                     /gene_synonym="ATH-3; ATH3; Atoh3; bHLHa4; MATH-3; MATH3"
                     /note="protein atonal homolog 3; class A basic
                     helix-loop-helix protein 4; neurogenic differentiation 4"
                     /codon_start=1
                     /product="neurogenic differentiation factor 4"
                     /protein_id="NP_067014.2"
                     /db_xref="CCDS:CCDS8886.1"
                     /db_xref="GeneID:58158"
                     /db_xref="HGNC:HGNC:13802"
                     /db_xref="MIM:611635"
                     /translation="MSKTFVKSKEMGELVNTPSWMDKGLGSQNEVKEEESRPGTYGML
                     SSLTEEHDSIEEEEEEEEDGEKPKRRGPKKKKMTKARLERFRARRVKANARERTRMHG
                     LNDALDNLRRVMPCYSKTQKLSKIETLRLARNYIWALSEVLETGQTPEGKGFVEMLCK
                     GLSQPTSNLVAGCLQLGPQSVLLEKHEDKSPICDSAISVHNFNYQSPGLPSPPYGHME
                     THLLHLKPQVFKSLGESSFGSHLPDCSTPPYEGPLTPPLSISGNFSLKQDGSPDLEKS
                     YSFMPHYPSSSLSSGHVHSTPFQAGTPRYDVPIDMSYDSYPHHGIGTQLNTVFTE"
     regulatory      3904..3909
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NEUROD4"
                     /gene_synonym="ATH-3; ATH3; Atoh3; bHLHa4; MATH-3; MATH3"
                     /note="hexamer: AATAAA"
     polyA_site      3927
                     /gene="NEUROD4"
                     /gene_synonym="ATH-3; ATH3; Atoh3; bHLHa4; MATH-3; MATH3"
                     /note="major polyA site"
ORIGIN      
        1 agagagcagg agctgcccag aggcttgtgg tcctgaaagc tcctctccgg ggagctaacc
       61 agggagagga ggtactgaag agcgactaaa ctggctgcag cggagagatc agcccgaagg
      121 cgtccttgag gagcatacgg aactccaagg aaggagtaga ataaggagca ggcagagaaa
      181 ccagacccgg tggaatctct aagaggtaac aaccgggttt gacatggatc gctgaaagcg
      241 tctcttctac catctggatg gtcagggaga cttggcttct ctgactgtcc tctaagacgc
      301 agattcacag agttcactcc aggaacggcc agtgaccgag agtctggaaa tgtcaaaaac
      361 ttttgtaaaa tccaaggaga tgggagagct agtcaacaca ccatcctgga tggataaagg
      421 tctgggctcc caaaatgagg tgaaggagga agagagcaga ccaggtactt atgggatgct
      481 cagcagctta actgaagagc atgacagtat tgaggaagaa gaagaagagg aagaagatgg
      541 ggagaaacct aagagaaggg gtcccaagaa aaagaagatg accaaagctc gccttgagag
      601 attcagggct cgaagagtca aggctaatgc cagagaacgg acccggatgc atggcctgaa
      661 tgacgccctg gataacctga ggcgagtcat gccatgctac tctaaaaccc aaaaactttc
      721 caagatagag actcttagac tggccaggaa ctatatttgg gctttatctg aagtcctgga
      781 gactggccag acacctgaag ggaaaggctt tgtggagatg ctgtgtaaag ggctctctca
      841 gcccacaagc aacctggtgg ctggatgtct ccaactgggc cctcagtctg tcctcctgga
      901 gaagcacgag gataaatctc ctatttgtga ctctgccatc tctgtccaca acttcaacta
      961 tcagtctccg gggcttccta gccctcctta tggtcatatg gaaacacatc tccttcatct
     1021 caagccccaa gtattcaaga gtttgggaga atcgtccttt gggagccatc tgcctgactg
     1081 cagtacaccc ccttatgagg gcccactcac tccacccctg agcatcagtg ggaacttctc
     1141 cttgaagcaa gatgggtctc ctgacctaga aaaatcctac agcttcatgc cacattaccc
     1201 ttcttcaagt ctaagctcag ggcatgtgca ttcaactcct tttcaggctg gtaccccccg
     1261 ttatgatgtt cctatagaca tgtcctatga ttcctacccc catcatggta ttgggaccca
     1321 actcaataca gtcttcactg agtgaggcag ttaagttcaa tgtttcagag aatgacgtgg
     1381 agacattttc cataattcaa gtggttgagc taaagattca atgaccttaa aggatcccta
     1441 tggatatata tcaaacaata gttcaagtcc atttaggctt tccttcacct atcacctctt
     1501 ttctcatcac cttctcacat tgcattgatt tctttataga gtcctcaagt gaaaatattt
     1561 gatgatttaa caaccatgtg aaaatagaac agaagacctg ggccctattc cagtggtgcc
     1621 aaaaactcat tgcataatct gtgccaatta attttccatt tctggccttt gtttatttac
     1681 tagcaattgt aaataaacaa attgtattta tatgaggcaa ctattctaag tccagatgat
     1741 ttctaaagtc cttcacagtt ctgaaatgct ataactgtgg tgatcactct tgacaatttc
     1801 ttgaaactga aagaatagag aaataatagg aaagggatgc tatgcataga atgatcaaat
     1861 tgaattatca gagggatcac aaggtacatg tctcttggct cacagaatgc aaagcttgtt
     1921 tggatttaat gataggacct ctttgtatct attgaaaaat agcttctgga agctaaaagt
     1981 ctaacatggc tgtcactgtg aagaacaaaa catgttcgtt aagagactaa ctctatttgt
     2041 tattagacta aaagttgaac atatcttcct tatgatttga agaaccataa tagagaacca
     2101 taatagaggc ctcatgccaa ctttattctt gataatattt caaaaccatt tttctcagta
     2161 ctagaggtag ggcaaacaag tcactgaagc ctcagactcc tataactaat gggacataga
     2221 gaagtctttt agaccatgac ctccataacc agagggctct ggaacttctg atgaagctca
     2281 ggtgctgctg ttagaatcag cacacaacac aggtttatat taaagagcaa taaaatagct
     2341 attggctata ataactacta tagttcaggg actctctcca gctcacagtt gcccatggga
     2401 aaaaccaatg gatttttttt taagcaagat gaatttcatt tggttaaacg tgattaaaac
     2461 catccacctc tgtccacacc aatatatttt ccagaagcac aagcaccaat caatttattg
     2521 atcaaggtta aatttttcca acatatatgt agttccttat ctctccccct acactaattg
     2581 ttacctcttc ctcacttcta agatagaata tgttattata tattgtaaat aacatttcag
     2641 gtgaccaaac ttaaggatgc agaaatgaaa tccaaggttg gtgaatattt ttaccaacta
     2701 tgtcttcatc acaggtttaa cccaatttgc agagtgttta tttttcttta tgtaactcct
     2761 ttttccttta tatcaatgct aacttcatca aatttgtatt ttttttcaga aaatgggacc
     2821 tgagaaattt tcctatcttg ttcaatcagc caggacagtt atttaagtca aaccagagcc
     2881 tgaatggctt atttgatagt agattaggtc ctgctcctgc cagaaaggat aagtttaaca
     2941 tgcagggtac atcaataggg ccaatttaaa aaatgataac acatattagt atgtcatttt
     3001 ctatagctca gctatcccct aaaatctgcc aactatatgt gtatcttgtc tgtttacctc
     3061 tcttatttat tatctccata cagtataagt tatttttttt ccattttgct ctcagcactt
     3121 accctgctgt attttgcacc cttggtttgt aaattcactt gaaagtagcc ttgcagagag
     3181 atcttaagcc ccatcagtca ccaaagtggt tcccttcatc acaatctgcc ctagaggaaa
     3241 taggcaagta aaatgatata taaagccata ctatgtgctt tctgagtata tactgcactt
     3301 acctttgtga gcggctgtag gagggtctat cctcgaagct agcattttct ggcatttaag
     3361 tttgtagata atcactgttg tttgagttat ttattagata ttatttattt aatttatttc
     3421 tctcttcctt tcacgaaaat tcctttagcc ccatagatgt gcttgcaaac ccttcctaaa
     3481 attttatttg gaaagtagct cataattttg ctaagaactg ctgagttttg gagtgagggg
     3541 aaaggaaaaa atagagaatt acctctgtga taatttttat aaaaagcagc aataattcga
     3601 atggctatgc aagttaatgt ttttagagtc ttttcttcag tctaaaatga gccagagtta
     3661 ttctttaata atctgctgtt tatgcctttg gggagtatgg tacccatgag ccaagcctcc
     3721 ctgaaattgt acagagggat tttataattg aattaaaatt taggaatgca atagcttgta
     3781 aagagcctgc tctccaacat agggtggtct cattcttctg gagacttttt tagataaagt
     3841 aaaataattg tttaaatatt ttgtttaaaa tatgactgtt tttcctccct ttttcctagc
     3901 agaaataaag ctgtaagtct tattaga
//
