LOCUS       NM_032442               5207 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens neuralized E3 ubiquitin protein ligase 4 (NEURL4),
            transcript variant 1, mRNA.
ACCESSION   NM_032442
VERSION     NM_032442.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5207)
  AUTHORS   Cardamone,M.D., Gao,Y., Kwan,J., Hayashi,V., Sheeran,M., Xu,J.,
            English,J., Orofino,J., Emili,A. and Perissi,V.
  TITLE     Neuralized-like protein 4 (NEURL4) mediates ADP-ribosylation of
            mitochondrial proteins
  JOURNAL   J Cell Biol 221 (3) (2022)
   PUBMED   35157000
  REMARK    GeneRIF: Neuralized-like protein 4 (NEURL4) mediates
            ADP-ribosylation of mitochondrial proteins.
REFERENCE   2  (bases 1 to 5207)
  AUTHORS   Loukil,A., Tormanen,K. and Sutterlin,C.
  TITLE     The daughter centriole controls ciliogenesis by regulating Neurl-4
            localization at the centrosome
  JOURNAL   J Cell Biol 216 (5), 1287-1300 (2017)
   PUBMED   28385950
  REMARK    GeneRIF: The data support a model in which the daughter centriole
            promotes ciliogenesis through Neurl-4-dependent regulation of CP110
            levels at the mother centriole.
REFERENCE   3  (bases 1 to 5207)
  AUTHORS   Li,J., Kim,S., Kobayashi,T., Liang,F.X., Korzeniewski,N.,
            Duensing,S. and Dynlacht,B.D.
  TITLE     Neurl4, a novel daughter centriole protein, prevents formation of
            ectopic microtubule organizing centres
  JOURNAL   EMBO Rep 13 (6), 547-553 (2012)
   PUBMED   22441691
  REMARK    GeneRIF: Neurl4 counteracts accumulation of CP110, thereby
            maintaining normal centriolar homeostasis and preventing formation
            of ectopic microtubular organizing centres
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5207)
  AUTHORS   Al-Hakim,A.K., Bashkurov,M., Gingras,A.C., Durocher,D. and
            Pelletier,L.
  TITLE     Interaction proteomics identify NEURL4 and the HECT E3 ligase HERC2
            as novel modulators of centrosome architecture
  JOURNAL   Mol Cell Proteomics 11 (6), M111.014233 (2012)
   PUBMED   22261722
  REMARK    GeneRIF: the NEURL4-HERC2 complex participates in the
            ubiquitin-dependent regulation of centrosome architecture
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC026954.14, AB058690.1 and AL136870.1.
            
            On Nov 22, 2018 this sequence version replaced NM_032442.2.
            
            Summary: The protein encoded by this gene is predicted and it
            includes two isoforms resulting from two alternatively spliced
            transcript variants. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB058690.1, SRR1803613.12439.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000399464.7/ ENSP00000382390.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                AC026954.14        50806-50821         c
            17-5201             AB058690.1         1-5185
            5202-5203           AL136870.1         5036-5037
            5204-5207           AC026954.14        37114-37117         c
FEATURES             Location/Qualifiers
     source          1..5207
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..5207
                     /gene="NEURL4"
                     /note="neuralized E3 ubiquitin protein ligase 4"
                     /db_xref="GeneID:84461"
                     /db_xref="HGNC:HGNC:34410"
                     /db_xref="MIM:615865"
     exon            1..305
                     /gene="NEURL4"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..4712
                     /gene="NEURL4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     neuralized-like protein 4; neuralized homolog 4"
                     /codon_start=1
                     /product="neuralized-like protein 4 isoform 1"
                     /protein_id="NP_115818.2"
                     /db_xref="CCDS:CCDS42251.1"
                     /db_xref="GeneID:84461"
                     /db_xref="HGNC:HGNC:34410"
                     /db_xref="MIM:615865"
                     /translation="MAAGSGGSGGSGGGPGPGPGGGGGPSGSGSGPGSNGGLGSGGEL
                     HPRTGRLVSLSACGRTARRQQPGQEFNHGLVLSREPLRDGRVFTVRIDRKVNSWSGSI
                     EIGVTALDPSVLDFPSSATGLKGGSWVVSGCSVLRDGRSVLEEYGQDLDQLGEGDRVG
                     VERTVAGELRLWVNGRDCGVAATGLPPRVWAVVDLYGKCTQITVLPPEPGFSPPTPIP
                     TPPLEPLAPTEDSALAEQGTSADEAFMVSPAQARPETFPNSLESHNDFANMELSEVVS
                     NTILSAYNGGLLNVNLSSPPAGEGLGSSGAATSPILTSNDALLFHEKCGTLIKLSNNN
                     KTAERRRPLDEFNNGVVMTNRPLRDNEMFEIRIDKLVDKWSGSIEIGVTTHNPNSLEY
                     PATMTNLQSGTIMMSGCGILTNGKGTRREYCEFSLDELQEGDHIGLTRKSNSALHFFI
                     NGIDQGVATPLTPPVVYGVVDLYGMAVKVTIVHNNNHSDRLRRNNAILRALSPEGALR
                     RAAPAAQAEPERLLFHPNCGQKAAITHEGRTALRPHATDDFNHGVVLSSRALRDGEVF
                     QVRIDKMVDKWAGSIEIGVTTHNPAYLQLPSTMTNLRSGTWMMTGNGVMHNGTTILDE
                     YGHNLDRLKAGDTVGVVRREDGTLHFFVNGMTQGPAAWNVPPGVYAVVDLYGQAAQAT
                     IVDDVEVAPVPEPLPEGNNQVSPSSPSSGAGGSDLRFHQLHGSNAVITNGGRTALRHN
                     CRSEFNDAIVISNRALRDGELFEIVIQKMVDRWSGSIEAGVTAIRPEDLEFPNTMTDI
                     DYDTWMLSGTAIMQDGNTMRNNYGCDLDALGTGARIGMMRTAKGDLHYFINGQDQGAA
                     CSGLPPGKEVYAVVDLYGQCVQVSITNATGPMDNSLATSNTATEKSFPLHSPVAGVAH
                     RFHSTCGKNVTLEEDGTRAVRAAGYAHGLVFSTKELRAEEVFEVKVEELDEKWAGSLR
                     LGLTTLAPGEMGPGAGGGGPGLPPSLPELRTKTTWMVSSCEVRRDGQLQRMNYGRNLE
                     RLGVGSRVGVRRGADDTMHILVDGEDMGPAATGIAKNVWAVLDLYGPVRGVSIVSSTR
                     LEESEGTQPPSPSSDTGSEGEEDDEGEEHGLGGQNEVGIIPTTLEFLENHGKNILLSN
                     GNRTATRVASYNQGIVVINQPLVPQLLVQVRIDFLNRQWTSSLVLGVITCAPERLNFP
                     ASACALKRAAWLLRGRGVFHNGLKICEKFGPNLDTCPEGTILGLRLDSSGGLHLHVNG
                     VDQGVAVPDVPQPCHALVDLYGQCEQVTIVNPEPGAASGKSAGTQGDMEKADMVDGIK
                     ESVCWGPPPAASPLKSCEYHALCSRFQELLLLPEDYFMPPPKRSLCYCESCRKLRGDE
                     AHRRRGEPPREYALPFGWCRFNLRVNPRLEAGTLTKKWHMAYHGSNVAAVRRVLDRGE
                     LGAGTASILSCRPLKGEPGVGFEEPGENCAPPREEQPPPVLLSPSLQYAGAETLASKV
                     QFRDPKSQRTHQAQVAFQVCVRPGSYTPGPPSAALGEPPDPHFSPAELEWVTKEKGAT
                     LLCALLVRVE"
     exon            306..750
                     /gene="NEURL4"
                     /inference="alignment:Splign:2.1.0"
     exon            751..816
                     /gene="NEURL4"
                     /inference="alignment:Splign:2.1.0"
     exon            817..1115
                     /gene="NEURL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1227
                     /gene="NEURL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1316
                     /gene="NEURL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1389
                     /gene="NEURL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1654
                     /gene="NEURL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..1836
                     /gene="NEURL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1837..1922
                     /gene="NEURL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1923..2085
                     /gene="NEURL4"
                     /inference="alignment:Splign:2.1.0"
     exon            2086..2284
                     /gene="NEURL4"
                     /inference="alignment:Splign:2.1.0"
     exon            2285..2361
                     /gene="NEURL4"
                     /inference="alignment:Splign:2.1.0"
     exon            2362..2440
                     /gene="NEURL4"
                     /inference="alignment:Splign:2.1.0"
     exon            2441..2616
                     /gene="NEURL4"
                     /inference="alignment:Splign:2.1.0"
     exon            2617..2748
                     /gene="NEURL4"
                     /inference="alignment:Splign:2.1.0"
     exon            2749..2894
                     /gene="NEURL4"
                     /inference="alignment:Splign:2.1.0"
     exon            2895..3122
                     /gene="NEURL4"
                     /inference="alignment:Splign:2.1.0"
     exon            3123..3221
                     /gene="NEURL4"
                     /inference="alignment:Splign:2.1.0"
     exon            3222..3383
                     /gene="NEURL4"
                     /inference="alignment:Splign:2.1.0"
     exon            3384..3548
                     /gene="NEURL4"
                     /inference="alignment:Splign:2.1.0"
     exon            3549..3707
                     /gene="NEURL4"
                     /inference="alignment:Splign:2.1.0"
     exon            3708..3887
                     /gene="NEURL4"
                     /inference="alignment:Splign:2.1.0"
     exon            3888..3975
                     /gene="NEURL4"
                     /inference="alignment:Splign:2.1.0"
     exon            3976..4083
                     /gene="NEURL4"
                     /inference="alignment:Splign:2.1.0"
     exon            4084..4228
                     /gene="NEURL4"
                     /inference="alignment:Splign:2.1.0"
     exon            4229..4341
                     /gene="NEURL4"
                     /inference="alignment:Splign:2.1.0"
     exon            4342..4507
                     /gene="NEURL4"
                     /inference="alignment:Splign:2.1.0"
     exon            4508..5207
                     /gene="NEURL4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5185..5190
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NEURL4"
                     /note="hexamer: AATAAA"
     polyA_site      5207
                     /gene="NEURL4"
                     /note="major polyA site"
ORIGIN      
        1 gcgctgcccc ggtgtcagcg gagatggcgg cagggtcggg tgggagtggg ggctctgggg
       61 gaggccctgg accggggccg ggcgggggtg ggggccccag cgggagcggc tcaggaccgg
      121 ggtccaacgg gggtctgggc agcggcgggg aactgcaccc gcgcactggg cgcttggtga
      181 gcctgtcggc ctgtgggcgt acggcgcggc ggcagcagcc gggccaggag tttaaccacg
      241 ggctggtgtt gagccgagaa cccttgcgcg atggacgcgt cttcaccgtc cgcatcgacc
      301 gcaaggtcaa ctcctggagc ggctccattg agattggggt gacagcgctg gaccccagtg
      361 tgctggactt tccaagcagt gccacgggcc tgaagggggg ctcgtgggta gtgtcgggct
      421 gctctgtgct gagagatgga cgctctgtgt tggaggagta tggtcaggac ctggaccagc
      481 ttggtgaagg ggaccgcgtg ggcgtggagc gcacagttgc tggggagctt cggctctggg
      541 tgaatgggcg ggattgcggt gtggctgcca caggcctgcc ccctcgtgtc tgggccgtcg
      601 tggaccttta tggcaagtgc acccagatca ccgtgctacc ccctgagcca ggcttcagcc
      661 cccctactcc catccccaca cctcccctcg agcccttggc ccccactgaa gactctgcct
      721 tggctgaaca ggggacctct gcagatgaag ccttcatggt gtccccagcg caggcccggc
      781 cggagacgtt tcctaacagc cttgagtcgc ataatgactt tgccaacatg gagctgtctg
      841 aggtggtgag caacaccatc ctgtctgcct acaatggagg gctcctgaat gtgaacctga
      901 gctccccacc ggcaggggaa ggcctgggat ctagcggtgc tgccacctcg cccattctca
      961 cttccaacga tgccctgctc tttcatgaaa agtgcgggac cctcatcaaa ctcagcaaca
     1021 ataataagac ggctgagcgc cggcggcccc tggatgaatt caacaatggg gttgtcatga
     1081 ccaatcgccc ccttcgggac aatgagatgt ttgagatccg tatcgacaag cttgttgata
     1141 agtggtcagg ctccattgag attggggtca ccacccacaa ccccaacagt ttggagtacc
     1201 cagccaccat gaccaacctc cagtcaggca ccatcatgat gagcggctgt ggaatcctga
     1261 ccaatggcaa gggcacccgc cgggagtact gcgaattcag tctggatgag ttgcaggagg
     1321 gtgaccacat tggcctcaca aggaagtcca actctgccct acacttcttc attaatggta
     1381 tcgatcaggg agtggcaacc cccttgacgc ccccagtggt gtatggtgtg gtggacttgt
     1441 acgggatggc agtgaaggtg accatcgtcc acaataacaa ccacagtgac cgtctccgcc
     1501 gaaacaacgc catcctgcgg gcgctgtccc ccgagggtgc tctccgccgt gctgcccctg
     1561 ccgcccaggc agaacctgag cgcctgctct tccaccccaa ctgtgggcag aaggcagcca
     1621 tcacccacga gggacgcact gccctgaggc cccatgccac cgatgacttc aatcacggcg
     1681 tggtgctgag cagcagagcc ctgcgggatg gagaggtgtt ccaggtgcgc atcgacaaga
     1741 tggtggacaa atgggctggc tccattgaaa ttggtgtcac cacccacaac cctgcctacc
     1801 tccagttgcc ctccaccatg accaacttgc gctctgggac ctggatgatg actgggaatg
     1861 gggtgatgca caatgggacg accatcctgg atgaatacgg gcacaatctg gaccgcctca
     1921 aggcagggga cacggtgggc gtggtacggc gggaggacgg gactctccac ttctttgtca
     1981 atgggatgac tcagggccct gctgcctgga acgtgccccc gggcgtctat gctgtcgtcg
     2041 atctctatgg ccaggcggcc caggccacca ttgtggacga cgtggaggtg gctccagttc
     2101 ctgaaccact ccctgagggg aacaaccagg tgtctccaag ctctccgtcc tcaggggccg
     2161 ggggctctga cctgcgcttc catcagctgc acggcagtaa cgcagtcatc actaacgggg
     2221 gccgcaccgc cctccgccac aactgtcgca gcgagtttaa tgacgccatc gtcatctcca
     2281 accgggccct gcgggatgga gagctgtttg aaattgtcat tcagaagatg gtggaccgct
     2341 ggtcaggctc cattgaggct ggagtgactg ctattcggcc tgaagacctg gaattcccca
     2401 acaccatgac agacattgac tatgacacat ggatgctgag tggtacagcc atcatgcaag
     2461 acggtaacac gatgcgcaac aattatgggt gtgacctgga tgcgctgggc acaggtgcac
     2521 gcattggcat gatgcgaact gccaagggcg acctgcacta cttcatcaac ggccaggacc
     2581 aaggcgctgc ctgctcgggc ctgcctccgg gtaaagaggt gtatgcggta gtcgatctct
     2641 atggccagtg tgtccaagtg tccatcacca atgccaccgg ccccatggac aacagcctgg
     2701 cgaccagcaa cactgccacc gagaagtcct tcccactgca ctccccagtg gctggcgtgg
     2761 ctcaccgatt ccacagtact tgcggcaaga acgtcactct agaggaggat ggcacgaggg
     2821 cagtgcgtgc cgctggctat gctcatggcc ttgtcttcag taccaaggag ctgagggctg
     2881 aggaagtctt tgaggtgaaa gtggaagagc tagatgagaa gtgggcaggt tccctgcggc
     2941 tggggctgac cacactagca ccgggggaga tgggacccgg ggcaggcggt ggtggcccag
     3001 ggctgcctcc ttccctgcca gagctccgga cgaagaccac ttggatggta tccagctgtg
     3061 aagtgaggcg tgatgggcag ctccagagga tgaactatgg ccggaaccta gagaggctgg
     3121 gggtggggag ccgtgtgggt gttcgtcggg gggcagatga cacgatgcac atcctggtgg
     3181 atggagagga tatggggcct gcagccactg gcattgccaa gaacgtgtgg gctgtgttgg
     3241 atctctacgg gccagtccgc ggtgtgtcaa ttgtcagttc cacgagactg gaggagtcag
     3301 aaggcaccca gcctccttcc cccagttcag acaccggcag tgagggcgag gaggatgacg
     3361 agggcgagga gcatggcctg ggaggccaga atgaagtggg tattataccc accaccctcg
     3421 agttcctgga gaaccatggg aagaatatcc ttttgtctaa tgggaaccgt acggccacac
     3481 gggtggccag ctacaatcag ggcatcgttg tcatcaacca acctctggtg ccccagctgc
     3541 tggtgcaggt gcggatagat ttcctaaacc gacagtggac atcttccctt gtcctgggag
     3601 tcatcacctg cgcgcctgag aggctcaact tccctgcttc tgcctgtgcc ctcaaacggg
     3661 cagcctggct gctgcggggc cgtggggtct tccacaacgg tctcaagatc tgcgagaagt
     3721 ttgggcccaa tctggacacg tgccctgaag gcaccatcct gggactgcgg ctggacagct
     3781 ctggggggct gcatcttcat gttaatgggg tggaccaggg ggtagctgtg ccagatgtgc
     3841 cccagccctg ccatgcgctt gtggacctct atgggcagtg tgagcaggtg acaatcgtga
     3901 accctgagcc aggggctgcc agtgggaaaa gtgctggaac ccaaggggac atggagaaag
     3961 cagacatggt ggacggtatc aaagagagtg tgtgctgggg tccaccacct gccgctagtc
     4021 ctctaaagag ctgcgagtac catgcccttt gctctcgctt ccaagaactc ctgctgcttc
     4081 ccgaagatta tttcatgcct ccgccaaagc gaagcctgtg ctactgtgag tcttgccgga
     4141 agctgcgagg agacgaggcc cacaggcgca gaggggagcc tccccgggaa tatgcactgc
     4201 cctttggctg gtgcaggttc aacctcagag tgaatccccg cctggaggct gggacactaa
     4261 ccaagaagtg gcacatggca tatcacggga gcaatgttgc cgctgtacgg agagtgctgg
     4321 accgagggga gctgggagca ggtactgcct ccatcctgag ctgccgtcct ttgaagggag
     4381 aacctggggt agggttcgag gagcctggcg agaactgtgc acctcctcgg gaggagcagc
     4441 cccctcctgt gctgctttcc ccctcccttc aatatgctgg ggcggagacc ctggcctcca
     4501 aagtgcaatt ccgggacccc aaatcccagc ggacgcacca ggctcaggtg gcgttccagg
     4561 tgtgtgtgcg ccctggctcc tacaccccgg gacccccttc cgctgccctt ggagaacctc
     4621 ctgaccctca cttcagtcca gccgaacttg agtgggtcac taaggagaag ggggccacac
     4681 tcctctgtgc cctgctggta cgggtggaat gaggggtgag acaccactac tacaagcaca
     4741 gtcgggccgc gggcccatgg actctgagtg gcgactgcct ccacctcatt cccgtgactc
     4801 gtggcatgcg caggtgctgg agcttggcag ccgcgcagga gcatgtaggc aggctctcag
     4861 atgtaggtgg caagtggcac agctccatgt ccggaggccc agcactccgt ctgatgggag
     4921 gagtcgtggg agcccagctc caggccctgg tacccctctt catgcactga tttggggaac
     4981 atgactccct tttactcccc taccccacat cacttaattt atttccgttt ttgtttctgg
     5041 ttactgtgaa tcccagagga gtctctccct gtgcccacat gaagctgctt tttccggggc
     5101 caccgggcgg gagtggggaa gggtgggcgc acggaagatg ggggcctctg tacagttgtt
     5161 actgactctg atttctaagg agccaataaa caccgtctca gagcctc
//
