LOCUS       NM_001285485            1458 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens neuralized E3 ubiquitin protein ligase 3 (NEURL3),
            transcript variant 1, mRNA.
ACCESSION   NM_001285485
VERSION     NM_001285485.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1458)
  AUTHORS   Yokosawa,T., Miyagawa,S., Suzuki,W., Nada,Y., Hirata,Y., Noguchi,T.
            and Matsuzawa,A.
  TITLE     The E3 Ubiquitin Protein Ligase LINCR Amplifies the TLR-Mediated
            Signals through Direct Degradation of MKP1
  JOURNAL   Cells 13 (8), 687 (2024)
   PUBMED   38667302
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1458)
  AUTHORS   Zhou,S.Q., Feng,P., Ye,M.L., Huang,S.Y., He,S.W., Zhu,X.H.,
            Chen,J., Zhang,Q. and Li,Y.Q.
  TITLE     The E3 ligase NEURL3 suppresses epithelial-mesenchymal transition
            and metastasis in nasopharyngeal carcinoma by promoting vimentin
            degradation
  JOURNAL   J Exp Clin Cancer Res 43 (1), 14 (2024)
   PUBMED   38191501
  REMARK    GeneRIF: The E3 ligase NEURL3 suppresses epithelial-mesenchymal
            transition and metastasis in nasopharyngeal carcinoma by promoting
            vimentin degradation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1458)
  AUTHORS   Zhao,Y., Cao,X., Guo,M., Wang,X., Yu,T., Ye,L., Han,L., Hei,L.,
            Tao,W., Tong,Y., Xu,Y. and Zhong,J.
  TITLE     Neuralized E3 Ubiquitin Protein Ligase 3 Is an Inducible Antiviral
            Effector That Inhibits Hepatitis C Virus Assembly by Targeting
            Viral E1 Glycoprotein
  JOURNAL   J Virol 92 (21), e01123-18 (2018)
   PUBMED   30111563
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1458)
  AUTHORS   Hu,Y., Nguyen,T.T., Bui,K.C., Demello,D.E. and Smith,J.B.
  TITLE     A novel inflammation-induced ubiquitin E3 ligase in alveolar type
            II cells
  JOURNAL   Biochem Biophys Res Commun 333 (1), 253-263 (2005)
   PUBMED   15936721
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC406186.1, AC013270.6, HY288910.1 and CA311039.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001285485.1.
            
            Transcript Variant: This variant (1) represents the shortest
            transcript and encodes the longer isoform (a).
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1968540, SAMEA1968832
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000451794.6/ ENSP00000478591.1
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                DC406186.1         30-55
            27-27               AC013270.6         3464-3464           c
            28-473              DC406186.1         57-502
            474-795             HY288910.1         81-402
            796-1458            CA311039.1         21-683              c
FEATURES             Location/Qualifiers
     source          1..1458
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q11.2"
     gene            1..1458
                     /gene="NEURL3"
                     /gene_synonym="LINCR; RNF132"
                     /note="neuralized E3 ubiquitin protein ligase 3"
                     /db_xref="GeneID:93082"
                     /db_xref="HGNC:HGNC:25162"
                     /db_xref="MIM:617206"
     exon            1..99
                     /gene="NEURL3"
                     /gene_synonym="LINCR; RNF132"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..860
                     /gene="NEURL3"
                     /gene_synonym="LINCR; RNF132"
                     /EC_number="2.3.2.27"
                     /note="isoform a is encoded by transcript variant 1;
                     neuralized-like protein 3; lung-inducible
                     neuralized-related C3CH4 RING domain protein; E3
                     ubiquitin-protein ligase NEURL3; neuralized homolog 3
                     pseudogene; RING-type E3 ubiquitin transferase NEURL3"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase NEURL3 isoform a"
                     /protein_id="NP_001272414.1"
                     /db_xref="CCDS:CCDS74542.1"
                     /db_xref="GeneID:93082"
                     /db_xref="HGNC:HGNC:25162"
                     /db_xref="MIM:617206"
                     /translation="MGAQLCFEANAKAPREALRFHAEAKGAQVRLDTRGCIAHRRTTF
                     HDGIVFSQRPVRLGERVALRVLREESGWCGGLRVGFTRLDPACVSVPSLPPFLCPDLE
                     EQSPTWAAVLPEGCALTGDLVRFWVDRRGCLFAKVNAGCRLLLREGVPVGAPLWAVMD
                     VYGTTKAIELLDPTASRLPTPMPWDLSNKAVPEPKATPGEECAICFYHAANTRLVPCG
                     HTYFCRYCAWRVFSDTAKCPVCRWQIEAVAPAQGPPALRVEEGS"
     exon            100..585
                     /gene="NEURL3"
                     /gene_synonym="LINCR; RNF132"
                     /inference="alignment:Splign:2.1.0"
     exon            586..657
                     /gene="NEURL3"
                     /gene_synonym="LINCR; RNF132"
                     /inference="alignment:Splign:2.1.0"
     exon            658..1458
                     /gene="NEURL3"
                     /gene_synonym="LINCR; RNF132"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1437..1442
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NEURL3"
                     /gene_synonym="LINCR; RNF132"
                     /note="hexamer: AATAAA"
     polyA_site      1458
                     /gene="NEURL3"
                     /gene_synonym="LINCR; RNF132"
                     /note="major polyA site"
ORIGIN      
        1 aacctgtcca ctggccttct ccaggcagtt ccttctagac ctggggacct gtgcccgagg
       61 accttagact gatgggtgcc cagctctgct tcgaggccaa cgccaaggcg ccccgagagg
      121 cacttcgctt ccatgccgag gccaagggcg cacaggtgcg tctggacacg cgtggctgca
      181 tcgcgcacag gcgcaccacg ttccacgacg gcatcgtgtt cagccagcgg ccggtgcgcc
      241 tgggcgagcg tgtggcgctg cgagtgctgc gggaggagag cggctggtgc ggcggcctcc
      301 gcgtgggctt cacgcgcctg gaccccgcgt gcgtgtccgt gcccagcctg ccgcccttcc
      361 tgtgccccga cctggaggag cagagcccga cgtgggcggc cgtgctgcct gagggctgcg
      421 cgctcactgg ggacttggtc cgcttctggg tggaccgccg cggctgcctc ttcgccaagg
      481 tcaacgccgg ctgccggctc ctgctgcgtg agggcgtgcc cgtcggcgcc ccgctctggg
      541 ccgtgatgga cgtgtatggg accactaagg ccatcgagct gctggatccc acagccagcc
      601 ggctcccaac acccatgcca tgggacctca gcaacaaggc tgtgcctgag cccaaagcca
      661 caccaggaga ggagtgtgcc atctgcttct atcacgctgc caacacccgc cttgtgccct
      721 gcggccacac atacttctgc agatactgtg cctggcgggt cttcagcgat acggccaagt
      781 gccctgtgtg ccgctggcag atagaggcgg tagcccctgc gcagggccct cctgctctga
      841 gggttgagga aggctcatga aaggaggctt cccagtatga gtggcagccc gggcctagat
      901 ctgagtctgg cccctgcaga gaggaaggag gcgcagccct accttctttc tggggaagag
      961 tcagaaaggc tgattagcaa gaggtgcggc agagagagga aggcagggag gtgctgtctg
     1021 ctgcctccac ctgttcccca acaggatagc aaggaaaaac ccctctttct gtccatgcca
     1081 gaactatcct tctgatgggg tgctttgttt agagatgggg tggcccaatc cccaatcagt
     1141 tttacatctg agggagttca ggtatctgtt gtgactggtg aagccctgta cctcctgggt
     1201 attgaagaac ctggacttga agcaggaggt atctgcaagg aatgtataaa gttccacatg
     1261 gaagctgggt tgcctcccac aagtccccag tagagtggat ctgtagttac ccgccctgcc
     1321 tccctttcag ggtggtcatg aggtcccaga gagaccatgc atctgaagat gatttaaaac
     1381 atgaaagtgt attgttgtca ctgtggtaat ttccttgcca gtttctgaga tatcaaaata
     1441 aagtttgtgt ttcctgaa
//
