LOCUS       NM_001142651            6427 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens neuralized E3 ubiquitin protein ligase 1B (NEURL1B),
            transcript variant 1, mRNA.
ACCESSION   NM_001142651 XM_001715114 XM_001715867 XM_001718086
VERSION     NM_001142651.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6427)
  AUTHORS   Scannell Bryan,M., Argos,M., Pierce,B., Tong,L., Rakibuz-Zaman,M.,
            Ahmed,A., Rahman,M., Islam,T., Yunus,M., Parvez,F., Roy,S.,
            Jasmine,F., Baron,J.A., Kibriya,M.G. and Ahsan,H.
  TITLE     Genome-wide association studies and heritability estimates of body
            mass index related phenotypes in Bangladeshi adults
  JOURNAL   PLoS One 9 (8), e105062 (2014)
   PUBMED   25133637
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6427)
  AUTHORS   Rullinkov,G., Tamme,R., Sarapuu,A., Lauren,J., Sepp,M., Palm,K. and
            Timmusk,T.
  TITLE     Neuralized-2: expression in human and rodents and interaction with
            Delta-like ligands
  JOURNAL   Biochem Biophys Res Commun 389 (3), 420-425 (2009)
   PUBMED   19723503
  REMARK    GeneRIF: Neur2, in contrast to Neur1, is highly expressed during
            embryonic development of the brain and several non-neural tissues
            and its mRNA levels subside postnatally.
REFERENCE   3  (bases 1 to 6427)
  AUTHORS   Song,R., Koo,B.K., Yoon,K.J., Yoon,M.J., Yoo,K.W., Kim,H.T.,
            Oh,H.J., Kim,Y.Y., Han,J.K., Kim,C.H. and Kong,Y.Y.
  TITLE     Neuralized-2 regulates a Notch ligand in cooperation with Mind
            bomb-1
  JOURNAL   J Biol Chem 281 (47), 36391-36400 (2006)
   PUBMED   17003037
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC027309.3, GQ414757.1, CN267889.1, HY104395.1, AK096661.1 and
            AK026748.1.
            
            On May 17, 2019 this sequence version replaced NM_001142651.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (hNEUR2).
            
            ##Evidence-Data-START##
            Transcript exon combination :: GQ414757.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369800.6/ ENSP00000358815.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AC027309.3         86806-86808
            4-1812              GQ414757.1         1-1809
            1813-2160           CN267889.1         163-510
            2161-2573           HY104395.1         2-414
            2574-4429           AK096661.1         157-2012
            4430-6415           AK096661.1         2014-3999
            6416-6427           AK026748.1         2206-2217
FEATURES             Location/Qualifiers
     source          1..6427
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.1"
     gene            1..6427
                     /gene="NEURL1B"
                     /gene_synonym="hNeur2; neur2; NEURL3; RNF67B"
                     /note="neuralized E3 ubiquitin protein ligase 1B"
                     /db_xref="GeneID:54492"
                     /db_xref="HGNC:HGNC:35422"
                     /db_xref="MIM:615893"
     exon            1..175
                     /gene="NEURL1B"
                     /gene_synonym="hNeur2; neur2; NEURL3; RNF67B"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..1812
                     /gene="NEURL1B"
                     /gene_synonym="hNeur2; neur2; NEURL3; RNF67B"
                     /EC_number="2.3.2.27"
                     /note="isoform hNEUR2 is encoded by transcript variant 1;
                     E3 ubiquitin-protein ligase NEURL1B; neuralized-2;
                     neuralized-like protein 3; E3 ubiquitin-protein ligase
                     NEURL3; neuralized 2 alternative protein; neuralized-like
                     protein 1B; neuralized homolog 1B; RING-type E3 ubiquitin
                     transferase NEURL1B"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase NEURL1B isoform
                     hNEUR2"
                     /protein_id="NP_001136123.1"
                     /db_xref="CCDS:CCDS47342.1"
                     /db_xref="GeneID:54492"
                     /db_xref="HGNC:HGNC:35422"
                     /db_xref="MIM:615893"
                     /translation="MGNTVHRTLPDPSPPARLLATRPCCGPGPERRPVLGEAPRFHAQ
                     AKGKNVRLDGHSRRATRRNSFCNGVTFTQRPIRLYEQVRLRLVAVRPGWSGALRFGFT
                     AHDPSLMSAQDIPKYACPDLVTRPGYWAKALPENLALRDTVLAYWADRHGRVFYSVND
                     GEPVLFHCGVAVGGPLWALIDVYGITDEVQLLESAFADTLTPARLSQARFSACLPPSS
                     HDAANFDNNELENNQVVAKLGHLALGRAPGPPPADAAAAAIPCGPRERPRPASSPALL
                     EADLRFHATRGPDVSLSADRKVACAPRPDGGRTLVFSERPLRPGESLFVEVGRPGLAA
                     PGALAFGITSCDPGVLRPNELPADPDALLDRKEYWVVARAGPVPSGGDALSFTLRPGG
                     DVLLGINGRPRGRLLCVDTTQALWAFFAVRGGVAGQLRLLGTLQSSPATTTPSGSLSG
                     SQDDSDSDMTFSVNQSSSASESSLVTAPSSPLSPPVSPVFSPPEPAGIKNGECTVCFD
                     GEVDTVIYTCGHMCLCHSCGLRLKRQARACCPICRRPIKDVIKIYRP"
     exon            176..721
                     /gene="NEURL1B"
                     /gene_synonym="hNeur2; neur2; NEURL3; RNF67B"
                     /inference="alignment:Splign:2.1.0"
     exon            722..1441
                     /gene="NEURL1B"
                     /gene_synonym="hNeur2; neur2; NEURL3; RNF67B"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1567
                     /gene="NEURL1B"
                     /gene_synonym="hNeur2; neur2; NEURL3; RNF67B"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..6427
                     /gene="NEURL1B"
                     /gene_synonym="hNeur2; neur2; NEURL3; RNF67B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2577..2582
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NEURL1B"
                     /gene_synonym="hNeur2; neur2; NEURL3; RNF67B"
                     /note="hexamer: AATACA"
     polyA_site      2596
                     /gene="NEURL1B"
                     /gene_synonym="hNeur2; neur2; NEURL3; RNF67B"
                     /note="major polyA site"
ORIGIN      
        1 cccgccccag ctgccgcccg ccggctcgcc cgtgcagctg cgatgccccg gagcgtcgac
       61 cccggtcctg gtccctggcc cgccgcgtaa ttagcctccg cgcgcccaga gcgcgccgcc
      121 gccaacgccg cgcccgacgc agcgatgggc aacacggtgc accggaccct gccagacccg
      181 agcccaccgg cgcgcctcct ggccacccgg ccgtgctgcg gccccggccc cgagcgacgc
      241 ccggtcctgg gcgaggcgcc gcgcttccac gcgcaggcca aaggcaagaa cgtgcggctg
      301 gacggccact cgcgccgggc cacacggcgc aacagcttct gcaatggcgt cacgttcacg
      361 cagcggccca tccggctgta cgagcaggtg cggctgcgcc tggtggccgt gcgccctggc
      421 tggagcggcg cgctgcgctt cggcttcacc gcgcacgatc cgtcgctcat gagcgcccag
      481 gacatcccca agtacgcctg cccggacctg gtcacgcggc cgggctactg ggccaaggca
      541 ctgcccgaga acctggcgct gcgcgacacg gtgctggcct actgggccga ccgccacggc
      601 cgcgtgttct acagcgtgaa cgacggcgag ccggtgctct tccactgcgg cgtggccgtg
      661 ggcggcccgc tctgggcgct cattgatgtc tacggcatca ccgacgaggt gcagcttctg
      721 gagagcgcct tcgctgacac gctgacgccc gcgcgcctca gccaggcccg cttcagcgcc
      781 tgcctgccgc ccagcagcca cgacgcggcc aacttcgaca acaacgagct cgagaacaac
      841 caggtggtgg ccaagctggg ccacctggcg ctgggccgcg ccccgggccc accgccagcc
      901 gacgccgcgg ccgccgccat tccgtgcggg ccccgtgagc gcccgcggcc cgcgtcgtcg
      961 ccggcgctac tggaggccga cctgcgcttc cacgcaacac gcgggcccga cgtgagcctg
     1021 tcggccgacc gcaaagtggc ctgcgcaccg cggcccgacg gcggccgcac gctggtcttc
     1081 tccgagcgcc cgctgcggcc cggcgagagc ctcttcgtgg aggtgggccg tccggggctg
     1141 gcggcgcccg gcgcgctggc cttcggcatc acgtcgtgcg acccgggcgt gctacggccc
     1201 aacgagctgc ccgccgaccc agacgcgctg ctcgaccgca aagagtactg ggtggtggcg
     1261 cgcgccgggc ccgtgccgag cggcggcgac gcgctcagct tcacgctgcg gcccggcggc
     1321 gacgtgctcc tgggcatcaa cgggcgtccg cgcggccgcc tgctgtgcgt cgacaccacg
     1381 caggcgctct gggccttctt cgccgtgcgc ggcggcgtcg cgggccagct gcgtctcctc
     1441 ggtaccctgc agtccagccc tgcgaccacg actccatcag ggtccctcag cggctcccag
     1501 gacgatagtg attcagatat gaccttcagt gtcaaccagt cctcctcggc atctgagtca
     1561 tccctggtga cggcccccag ctccccgctg agccccccgg tgtcccccgt gttctcccca
     1621 ccggagccgg caggcatcaa gaatggcgag tgcacggtgt gcttcgatgg cgaggtggac
     1681 acggtcatct acacgtgtgg acacatgtgc ctgtgccaca gctgcggcct gcggctcaag
     1741 cgacaggccc gggcctgctg ccccatctgc cggcggccca tcaaggacgt cattaagatc
     1801 tacaggccat agcctagcct gcccacgggc cttggccggt gcaaggtcac ctttctgaag
     1861 gccccctggg ctgggcaacc acatggctgc cagggagtcc acgggcagcg gccatctctc
     1921 cagtggtggg caaggtgtga cagtcgtgga gcgaggccca cagggcctca gcccaggcag
     1981 gggttgcttc tggctccaaa gtgctttgcc cccaaaaggc cgtcccaaga gcaagctcag
     2041 gaactgcctg gcagatcacc ctgtcccttg gtgacctttc aactgggaaa cagcgtcctc
     2101 tgtctgtgca atgcttcttg ctggggttgg gttgagtgtg agagaagggg aggggaggga
     2161 gggagaacag agagaatgtg tgtgtgagag agagagagag agaatgaacg tgtagcgatt
     2221 ttaccagggg tcccggctcc gggaggagac gtgcaatccg gagccccgac attggcatga
     2281 ctagaagttg ttcactttct ggggatggga cataagctgg ttttgaatgt atgaagctga
     2341 ccctcacaga actccctggg gtggtgtaga aaagagatgc tcagattttc taaggggagg
     2401 caaaaataac tcattgttta cagctccaaa gcatgaactc cttgagggga aggtgggtga
     2461 agaacaattc acttcttcat ttcttactgg gtcttagagc tgggtgtgat gggcaccgag
     2521 gccaacccct ctggattgtg tcatcttttc accccttcac ccccagactg tctaataata
     2581 cacacatcat accttgtctc cgtctctgga ggcaagtctc tgtaatgccc ttccctatct
     2641 ccaaggagaa gaccagcagt aagttctgtt tttctgtggg agagaaagaa tcctagaggc
     2701 aggtgaccca cctggagctg gaaagcccac tccacgatgc agacagctct ctaccttcct
     2761 gtggtggccc ctgggcctgg cattcccagg ggacctgctg gcaggaggag gaacgagggc
     2821 tttataactt tggttataac ttttggtctt tgttctgatt ctcagtgtat cttcctccgc
     2881 tggttactaa agtgttcact gataagtatg ttaactaatg atcgagacag taacgaaaaa
     2941 tgctggcact gggattctct cccttcccag acctacctgc tggtatttcc tgggaccttg
     3001 accctgcccc accccctcag ccgtgcccat ctctgcagac tcccagatca catctgggct
     3061 gatgggctgg cccaggcctg tccctccctt cttgccccca gttctgggct ccacctctgc
     3121 cctcttctgt gctgtcccat tagggaagtc ccttggcctg tctatttttc agttcccaat
     3181 tagaagtcta gaacctgaca actccaggag ttcttgggag gaccagtaca acgttctaaa
     3241 aagcctgaga cgccttacaa aaagcaagta tcatttggag tacaattcct aatctgttca
     3301 tgtcctgctg aaggagggaa ggagggagag gaaggcaggg gagttgatgc attcatataa
     3361 caaacactgc tgggtgtctg ggtgcccaga gcaaagctgg gccaggcctt caccagatca
     3421 agccccacag accagctggt gcccatgcgc tgctggtggt ttggggcctc ctgttcctcc
     3481 tctagctggg agtaatcaca gttgtctgac ctgattccaa cttaaggtcc ccactctctt
     3541 gccccatcaa gaatccctga ttatttactt ttccctagaa aatctgggga aattcccaca
     3601 ttttaatttt gcagcagaat cttttgagca gcttttggaa ccacagtgtt tgccaagata
     3661 agagtttgag aatccagcag ccctgggtgc ctggctgaat ttggtttcct gcatgtgctg
     3721 ggtgtgggcg gggccacgca caggccctgc atgggaggac tcctcacccc aggcctgtgg
     3781 tgctgcagac aaccgtctcc tgtctacact gcgacccagc cacaagctgt ggggtctcag
     3841 tggcctgggg gaaagcagct ccactctcct gcccttcctg gctgcccctt tgggttccag
     3901 ccggggtcac gtccagcctc cactgggaaa ccagtgactg aggcctggac ccagaggtgg
     3961 accaggcatc tcctggccac ctgtgacctg ggaagaagcg agtcagtggc ccgttcaacc
     4021 tgctctgcag ctgctataaa tagcctccct gtttccaaga ggaggtaagg aagtgtttat
     4081 cttctaaaaa ccagacgttt cctgatgctc tgagcgttac tcagtgctac agaggagatg
     4141 cacacgtccc cactatgttc tgtcttgaga aggggacaag agaaagagga aaaggagcca
     4201 ctgtacttta ttttgcacct acagcgtgcc ttggcactgg gctagagagg caccttcctg
     4261 cgtgaatcct gtgcggcagg tcttattgcc ataataagtc acatcaaaga cactgctggt
     4321 cataaaacac tgttttacat accataggga aaaacgctgc caatcttaac taagatgcta
     4381 caactgtaca gttccttcca atcagagatg ttcacgtgtg aaaaaaaaac tgtgctactt
     4441 acaatctatg aaagctggtg ttatcccact tggcaggtaa ggaaactgag gtcctgtgag
     4501 tgaagtgacc tcatgatcac acaacaggag atggcagggc tgggattcaa acccgggagt
     4561 gtctgctgcc acatcccaca ctcccactgc ctggctccaa gtcccaggaa gctcgagact
     4621 gtgagttttc tcccttgaaa ctcacctgga gagagtccgg gcacctgtgc ctatgtggag
     4681 ggttccagcc ccagccaggc ccctccgctg cccacaccct gggaggagaa gcggcctccc
     4741 ttccaggctc atctgctcac tgcccgcatt ctcctggcag agctgaggtc tgagagatct
     4801 ggactccaac ccaagggccc tctcttgtta ttcaggggtg tccacagtta ggaagggacc
     4861 tggggccttg tcccaccacc ttcctaggcc ccgtgatcac caccccctca agcggggccc
     4921 cagccccctg agcaccccct cacgtgaccc agccctcggc tgttccaggc tcactgccca
     4981 tggtgtgctc ttctgggcca cagcagccag ggctccaggg cgaggacagg ggacacctga
     5041 aaacaccccg ttgttcatgg tcttgtgccc attcattcgg agactcctga aaaactgggc
     5101 tgtttgcaaa gcaaatccag ctccttgtcc tagcaggttc tcagaacggg gagtcccctg
     5161 ggatggagct gctcccctca cggcagcacc acgtttccag tccctcgatg ccactaatca
     5221 gcatggactg tgttcaggac acagggtgaa cttttctctg acccccggtg ctggtcctgt
     5281 gccagcacgt agtagttact cagtagaggt ttgctgagta aaccagaaat cagattatga
     5341 gtgttcaggg gtttgataaa acagcaccac ataacgcaca caaagatact ccagaaacat
     5401 ttgctgagta cctagtacgt gtgaggtgct gtgaggatag agcagagagg actgtgcccc
     5461 agctgtgatg ctggcagagg tgacactaag agggaaatga gatatttggg gcagaatcca
     5521 ctgggctctc ttggccatcc gctgccttgg gtctgttgag gtgggtgccc aaaggctgcc
     5581 ttcttgacca gaacctgctg tgcgcttcac agaacctcct cttcattgga aatgctgggc
     5641 acattgcagt cagtgagctg ctgccaaaac ggcgttaagt agaaccccca gaggccccgc
     5701 cggttggtga tcaccctcag gtcctgccag ggagacacag tgaggaggtt ggctaattgc
     5761 tgctttcagg ccctggaaat cagtcgccaa ggcccaggag aaccccggtg agtccgtcca
     5821 gttgaggcag aggcaataac ctcccattgc tcggccctgc gcctgcccca gtcctggcag
     5881 ggggcaccgg ctcaggaaca tgcggcctcc tggcatttct cggtatttaa ctgtctcgct
     5941 gtcttatccg agtccctaat gaaacgactt gtgtgacaat ctgtctgtgc cttacgaaag
     6001 tgtctgtgca ctttttatcc tttttaaaag caacttttaa aagtggatgg ggaggggggc
     6061 tagcatacgt ggtagggttc tagaaatctg tggtcatcgc tgaaatcctt tttgcatcat
     6121 gttttttgat gttggagtga tgaagtgtac atcccccacc ccacacacca ctacctgtgt
     6181 acagaccttt taaaacatgt cttctttttc tgattcaata ctgtgacctc tccgatacag
     6241 tctaatcctt ggggatctgt aatcaaggtt ttaaaacctg ggaagtgggt tgggaagggt
     6301 ttgcactggt cttgagtgtt gtgcttttct gtgttgtgtg ttttgatttt tgtcttttta
     6361 tctgttttat attgacataa ttttcctgtt taaaaaaata caactttggc ttgttaaaaa
     6421 aaaaaaa
//
