LOCUS       NM_004210               4582 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens neuralized E3 ubiquitin protein ligase 1 (NEURL1),
            mRNA.
ACCESSION   NM_004210
VERSION     NM_004210.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4582)
  AUTHORS   Zhu,J., Li,Y., Zhong,C., Zhu,M., Zheng,Y., Xiong,A., Meng,P.,
            Shan,L., Li,Y. and Huang,J.
  TITLE     Neuritin affects the activity of neuralized-like 1 by promoting
            degradation and weakening its affinity for substrate
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 55 (10), 1650-1658 (2023)
   PUBMED   37249336
  REMARK    GeneRIF: Neuritin affects the activity of neuralized-like 1 by
            promoting degradation and weakening its affinity for substrate.
REFERENCE   2  (bases 1 to 4582)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   3  (bases 1 to 4582)
  AUTHORS   Szirak,K., Soltesz,B., Hajas,O., Urbancsek,R., Nagy-Balo,E.,
            Penyige,A., Csanadi,Z. and Nagy,B.
  TITLE     PITX2 and NEURL1 SNP polymorphisms in Hungarian atrial fibrillation
            patients determined by quantitative real-time PCR and melting curve
            analysis
  JOURNAL   J Biotechnol 299, 44-49 (2019)
   PUBMED   31039368
  REMARK    GeneRIF: Study found no association between NEURL1 rs6584555 and
            increased risk of atrial fibrillation.
REFERENCE   4  (bases 1 to 4582)
  AUTHORS   Taal,K., Tuvikene,J., Rullinkov,G., Piirsoo,M., Sepp,M., Neuman,T.,
            Tamme,R. and Timmusk,T.
  TITLE     Neuralized family member NEURL1 is a ubiquitin ligase for the
            cGMP-specific phosphodiesterase 9A
  JOURNAL   Sci Rep 9 (1), 7104 (2019)
   PUBMED   31068605
  REMARK    GeneRIF: Neuralized family member NEURL1 is a ubiquitin ligase for
            the cGMP-specific phosphodiesterase 9A.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4582)
  AUTHORS   Wang,P., Qin,W., Wang,P., Huang,Y., Liu,Y., Zhang,R., Li,S.,
            Yang,Q., Wang,X., Chen,F., Liu,J., Yang,B., Cheng,X., Liao,Y.,
            Wu,Y., Ke,T., Tu,X., Ren,X., Yang,Y., Xia,Y., Luo,X., Liu,M.,
            Li,H., Liu,J., Xiao,Y., Chen,Q., Xu,C. and Wang,Q.K.
  TITLE     Genomic Variants in NEURL, GJA1 and CUX2 Significantly Increase
            Genetic Susceptibility to Atrial Fibrillation
  JOURNAL   Sci Rep 8 (1), 3297 (2018)
   PUBMED   29459676
  REMARK    GeneRIF: Significant allelic and genotypic associations were
            identified between NEURL variant rs6584555 and GJA1 variant
            rs13216675 and Atrial fibrillation (AF). Significant genotypic
            association was found between CUX2 SNP rs6490029 and AF
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4582)
  AUTHORS   Timmusk,T., Palm,K., Belluardo,N., Mudo,G. and Neuman,T.
  TITLE     Dendritic localization of mammalian neuralized mRNA encoding a
            protein with transcription repression activities
  JOURNAL   Mol Cell Neurosci 20 (4), 649-668 (2002)
   PUBMED   12213446
REFERENCE   7  (bases 1 to 4582)
  AUTHORS   Kile,B.T., Schulman,B.A., Alexander,W.S., Nicola,N.A., Martin,H.M.
            and Hilton,D.J.
  TITLE     The SOCS box: a tale of destruction and degradation
  JOURNAL   Trends Biochem Sci 27 (5), 235-241 (2002)
   PUBMED   12076535
  REMARK    Review article
REFERENCE   8  (bases 1 to 4582)
  AUTHORS   Pavlopoulos,E., Kokkinaki,M., Koutelou,E., Mitsiadis,T.A.,
            Prinos,P., Delidakis,C., Kilpatrick,M.W., Tsipouras,P. and
            Moschonas,N.K.
  TITLE     Cloning, chromosomal organization and expression analysis of Neurl,
            the mouse homolog of Drosophila melanogaster neuralized gene
  JOURNAL   Biochim Biophys Acta 1574 (3), 375-382 (2002)
   PUBMED   11997106
REFERENCE   9  (bases 1 to 4582)
  AUTHORS   Vollrath,B., Pudney,J., Asa,S., Leder,P. and Fitzgerald,K.
  TITLE     Isolation of a murine homologue of the Drosophila neuralized gene,
            a gene required for axonemal integrity in spermatozoa and terminal
            maturation of the mammary gland
  JOURNAL   Mol Cell Biol 21 (21), 7481-7494 (2001)
   PUBMED   11585928
REFERENCE   10 (bases 1 to 4582)
  AUTHORS   Nakamura,H., Yoshida,M., Tsuiki,H., Ito,K., Ueno,M., Nakao,M.,
            Oka,K., Tada,M., Kochi,M., Kuratsu,J., Ushio,Y. and Saya,H.
  TITLE     Identification of a human homolog of the Drosophila neuralized gene
            within the 10q25.1 malignant astrocytoma deletion region
  JOURNAL   Oncogene 16 (8), 1009-1019 (1998)
   PUBMED   9519875
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL139339.22, U87864.1, AK299620.1 and AL121929.17.
            
            On Jun 2, 2019 this sequence version replaced NM_004210.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC026336.1, AF029729.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369780.9/ ENSP00000358795.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-629               AL139339.22        71166-71794
            630-2053            U87864.1           357-1780
            2054-2836           AK299620.1         300-1082
            2837-4582           AL121929.17        64536-66281
FEATURES             Location/Qualifiers
     source          1..4582
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.33"
     gene            1..4582
                     /gene="NEURL1"
                     /gene_synonym="bA416N2.1; neu; neu-1; NEUR1; NEURL; RNF67"
                     /note="neuralized E3 ubiquitin protein ligase 1"
                     /db_xref="GeneID:9148"
                     /db_xref="HGNC:HGNC:7761"
                     /db_xref="MIM:603804"
     exon            1..768
                     /gene="NEURL1"
                     /gene_synonym="bA416N2.1; neu; neu-1; NEUR1; NEURL; RNF67"
                     /inference="alignment:Splign:2.1.0"
     CDS             684..2408
                     /gene="NEURL1"
                     /gene_synonym="bA416N2.1; neu; neu-1; NEUR1; NEURL; RNF67"
                     /EC_number="2.3.2.27"
                     /note="neuralized-like protein 1A; h-neuralized 1; RING
                     finger protein 67; neuralized homolog; RING-type E3
                     ubiquitin transferase NEURL1"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase NEURL1"
                     /protein_id="NP_004201.3"
                     /db_xref="CCDS:CCDS7551.1"
                     /db_xref="GeneID:9148"
                     /db_xref="HGNC:HGNC:7761"
                     /db_xref="MIM:603804"
                     /translation="MGNNFSSIPSLPRGNPSRAPRGHPQNLKDSIGGPFPVTSHRCHH
                     KQKHCPAVLPSGGLPATPLLFHPHTKGSQILMDLSHKAVKRQASFCNAITFSNRPVLI
                     YEQVRLKITKKQCCWSGALRLGFTSKDPSRIHPDSLPKYACPDLVSQSGFWAKALPEE
                     FANEGNIIAFWVDKKGRVFHRINDSAVMLFFSGVRTADPLWALVDVYGLTRGVQLLDS
                     ELVLPDCLRPRSFTALRRPSLRREADDARLSVSLCDLNVPGADGDEAAPAAGCPIPQN
                     SLNSQHSRALPAQLDGDLRFHALRAGAHVRILDEQTVARVEHGRDERALVFTSRPVRV
                     AETIFVKVTRSGGARPGALSFGVTTCDPGTLRPADLPFSPEALVDRKEFWAVCRVPGP
                     LHSGDILGLVVNADGELHLSHNGAAAGMQLCVDASQPLWMLFGLHGTITQIRILGSTI
                     LAERGIPSLPCSPASTPTSPSALGSRLSDPLLSTCSSGPLGSSAGGTAPNSPVSLPES
                     PVTPGLGQWSDECTICYEHAVDTVIYTCGHMCLCYACGLRLKKALHACCPICRRPIKD
                     IIKTYRSS"
     exon            769..1010
                     /gene="NEURL1"
                     /gene_synonym="bA416N2.1; neu; neu-1; NEUR1; NEURL; RNF67"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1332
                     /gene="NEURL1"
                     /gene_synonym="bA416N2.1; neu; neu-1; NEUR1; NEURL; RNF67"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..2022
                     /gene="NEURL1"
                     /gene_synonym="bA416N2.1; neu; neu-1; NEUR1; NEURL; RNF67"
                     /inference="alignment:Splign:2.1.0"
     exon            2023..2169
                     /gene="NEURL1"
                     /gene_synonym="bA416N2.1; neu; neu-1; NEUR1; NEURL; RNF67"
                     /inference="alignment:Splign:2.1.0"
     exon            2170..4582
                     /gene="NEURL1"
                     /gene_synonym="bA416N2.1; neu; neu-1; NEUR1; NEURL; RNF67"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2525..2530
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NEURL1"
                     /gene_synonym="bA416N2.1; neu; neu-1; NEUR1; NEURL; RNF67"
                     /note="hexamer: ATTAAA"
     polyA_site      2544
                     /gene="NEURL1"
                     /gene_synonym="bA416N2.1; neu; neu-1; NEUR1; NEURL; RNF67"
                     /note="major polyA site"
     regulatory      4562..4567
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NEURL1"
                     /gene_synonym="bA416N2.1; neu; neu-1; NEUR1; NEURL; RNF67"
                     /note="hexamer: AATAAA"
     polyA_site      4582
                     /gene="NEURL1"
                     /gene_synonym="bA416N2.1; neu; neu-1; NEUR1; NEURL; RNF67"
                     /note="major polyA site"
ORIGIN      
        1 agacgctcat tcaccggcgc agctgtcacc ataacaaccg gagcgaggga atcctggaga
       61 ctgccggggc ggggggcggg ggcggcggtc gcaggaggga cccggcgcgg gcgggaccgc
      121 ggcggtcggg ggacaccagc tgcgtcggag cgcccagaac gccccgcgct ccgccgagcc
      181 ccgctccacg cagacccgcg ggcgggaggg agccacgcac atcgccgccg cggccgtctc
      241 cgcggggcgg taaccgagcc tgcctcggag ccgccgaacg cccacgccag cgaccctgac
      301 tctatggccc cgggggagcg cgccggagcc gccgcgccgc ccacccccag ccggaaccct
      361 agcgtcccgg ggagcaagcg gggagccccg ggcgtccccg gccccggccc agggccctgc
      421 ttgtggcccc cgctcccgcc acggggcatg ggaggcaggt agcccagcct gcgccaggac
      481 acccgtggcg ggcggaaccc gccaaggacc gcgaagtcca gagaaaggaa gctgaggagc
      541 tgcccgcccg cccccggctg cagccccagc agggccctcc cccggtggcg cgcacccgcg
      601 cgcgcacact cgcacaccgc acctcagcgc ctgcccggcc tcgcccccac ccgcgagcgc
      661 cgaacctcct ggggccggat gccatgggta acaacttctc cagtatcccc tcgctgcccc
      721 gaggaaaccc gagccgcgcg ccgcggggcc acccccagaa cctcaaagac tctatcgggg
      781 gccccttccc cgtcacttct caccgatgcc accacaagca gaagcactgt ccggcagtgc
      841 tgcccagcgg ggggctccca gccacgccgc tgctcttcca cccgcacacc aagggctccc
      901 agatcctcat ggacctcagc cacaaggctg tcaagaggca ggccagcttc tgcaacgcca
      961 tcaccttcag caaccgcccg gtcctcatct acgagcaagt caggctgaag atcaccaaga
     1021 agcagtgctg ctggagcggg gccctgcggc tgggcttcac cagcaaggac ccgtcccgca
     1081 tccaccctga ctcgctgccc aagtacgcct gccccgacct ggtgtcccag agtggcttct
     1141 gggccaaggc gctgcctgag gagtttgcca atgagggcaa catcatcgca ttctgggtgg
     1201 acaagaaggg ccgtgtcttc caccgcatca acgactcggc tgttatgctg ttcttcagcg
     1261 gggtccgcac ggccgacccg ctctgggccc tggtggacgt ctacggcctc acgcggggcg
     1321 tccagctgct tgatagcgag ctggtgctcc cggactgtct gcggccgcgc tccttcaccg
     1381 ccctgcggcg gccgtcgctg cggcgcgagg cggacgacgc gcgcctctcg gtgagcctat
     1441 gcgacctcaa cgtgccgggc gcggacggcg acgaggccgc gccggccgcc ggctgcccca
     1501 tcccgcagaa ctcactcaac tcgcagcaca gccgcgcgct gccggcgcag ctcgacggcg
     1561 acctgcgttt ccacgccctg cgcgccggcg cgcacgtccg catcctcgac gagcagacgg
     1621 tggcgcgcgt ggagcacggg cgcgacgagc gcgcgctcgt cttcaccagc cggcccgtgc
     1681 gcgtggccga gaccatcttc gtcaaggtca cgcgctcggg tggcgcgcgg cccggcgcgc
     1741 tgtcgttcgg cgtcaccacg tgcgaccccg gcacgctgcg gccggccgac ctgcctttca
     1801 gccctgaggc cctggtggac cgcaaggaat tctgggccgt gtgccgcgtg cccgggcccc
     1861 tgcacagcgg cgacatcctg ggcctggtgg tcaacgccga cggcgagctg cacctcagcc
     1921 acaatggcgc ggccgccggc atgcagctgt gcgtggacgc ctcgcagccg ctttggatgc
     1981 tcttcggcct gcacgggacc atcacgcaga tccgcatcct cggctccact atcctggccg
     2041 agcggggtat cccatcactc ccctgctccc ctgcctccac gccaacctcg cccagtgccc
     2101 tgggcagccg cctgtctgac cccttgctca gcacgtgcag ctctggccct ctgggtagct
     2161 ctgctggtgg gacagccccc aattcgccag tgagcctgcc cgagtcgcca gtgaccccag
     2221 gtctgggcca gtggagcgat gagtgcacca tttgctatga acacgcggtg gacacggtca
     2281 tctacacatg tggccacatg tgcctctgct acgcctgtgg cctgcgcctc aagaaggctc
     2341 tgcacgcctg ctgccccatc tgccgccgcc ccatcaagga catcatcaag acctaccgca
     2401 gctcctagcc cgttgcggtg gcccatcccg catacccatc ttctcgggct tcagcccagt
     2461 cccagctgag gaacaagcca gtggggcccc ttctcttcct cattttggaa acttttcctc
     2521 ctctattaaa catgggaaac tgaagccctt gaaggtttgg ggagaggggg gtatcaggca
     2581 gggagggggc agaggcaaat caccgggcag agggagggga ggagaggagg ccgcactctc
     2641 cctgtctctc ccgtctctgc acccagctcc tctctgcatg ctgagggcta aattgggatc
     2701 tcagcctgcc ctaatctttc cccatctgag gcaggtttct aggaggtgtc tgtagtccat
     2761 gtggcacctt tgtgagaatt agaaaacatg taccttcctc tgggcagctg cagccctgag
     2821 ccaggacatg tggcctggct agtgcagcat ggagtggatt ttaggctcat ttgccctctc
     2881 agccaactgc ccttgagcag tgtacagcct gctcaacaac cgccctgggc aggccgctcc
     2941 tgagctgctg tctccctctc tgacctatgc ctaccttctc tttcttcgtt ccctgcccac
     3001 tgggcatggc agctgggggt gagaggctgg tggttgcctc ccgtcctggg caggctgcag
     3061 cctcatgcca tgtctctctc ccactacctg atgggcacat ggacaggctg cagagggctc
     3121 caggttctgg gcccctggct gagaagggga ggatcctgtc ctggctgtag ccttcctgcc
     3181 ccaatcatct cgctggatgc cattgcccag gggtagccct tcggtatggg ctggggagaa
     3241 gggttggtct tctgccaggg tccctaagaa caggtttgca gctaccctct ctgacctttt
     3301 ccccatatct tgtgctgtcc agggcctagg ctgatagtca gagcctgtgg cacacctggg
     3361 atgggccagg gccctgggtg gggaggtgtg ggttccctgg gccaagacca gcctttttcc
     3421 tcagtttaat taatttattt atttggtttg tggttttggg ttttttttgt ttgtttgttt
     3481 gtaggtgagt tcccatcctc tgggccccta gaaatgctgc ctttgtgtgt ggggtacctg
     3541 ggaaagggtg tggctgaggc agtcataatg cagtatcttc ccctgactcc agccacaaag
     3601 ctcataccca gccctaccaa tcatgaactg gaactccata aggaggggcc aaattgggag
     3661 gccttttggc aaacagtgtc tattttacag agaggcaaac caagcctcct tagtgccctg
     3721 gggctgatgg tcacccagag ccatagagca cccttcctcc tgggccagag ctgggttatc
     3781 atggttggct taggtacctc aggtggccca ggaggtcccc cctccataag gacgtcaaac
     3841 ttccaggagg gccagtgttc ctagtgtggg ccaggaacag gacagggaga ccttgtgatg
     3901 gcggggcagg gagcctgttc gtagggaaga tgaggaggca agggctgcct ctcacacctc
     3961 caggttctct aagttctggg gagggagcgc cccacctgct gaggtcggtc ctctcagccc
     4021 tgcctgccct ggcctgggct ctcccagcct cccagccctc tgccccctca gatggctttt
     4081 tgtttttgtt tttttttgca tccatcagag actgcacctc tgtgtggcag gcagggcatg
     4141 ggttttagtc ctggccactg accagctgtg tggccctggc cgagtcgtag ccccctggag
     4201 cccagcttcc atttctataa aatggttgtt tcgggagaga ggggcaggct ttctgtgtga
     4261 ctcgggagtt cttccgtgag ggctgccagg gggtggtgtg ccaggacctc aggctgggcc
     4321 tttgtgctgg ccttgcagtg ggtgtgtggg gaagtcactg tcccactatg ggtctccact
     4381 acccagtcac tgaccctggg agaccccttc tgtgtgggag ggagcggggg ctggctagcg
     4441 ggccccccag ccagggatcc cagaggctga gggttgggga gaggaagcca tcatctcatt
     4501 acctctgtca gtgcaggggt ggctgctgct tcccttgtgc acttgggtcg ctgtgattgt
     4561 gaataaaagt gatttcgtac ca
//
