LOCUS       NM_006656               5929 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens neuraminidase 3 (NEU3), transcript variant 1, mRNA.
ACCESSION   NM_006656
VERSION     NM_006656.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5929)
  AUTHORS   Wu,G., Cao,B., Zhai,H., Liu,B., Huang,Y., Chen,X., Ling,H.,
            Ling,S., Jin,S., Yang,X. and Wang,J.
  TITLE     EPO promotes the progression of rheumatoid arthritis by inducing
            desialylation via increasing the expression of neuraminidase 3
  JOURNAL   Ann Rheum Dis 83 (5), 564-575 (2024)
   PUBMED   38272667
  REMARK    GeneRIF: EPO promotes the progression of rheumatoid arthritis by
            inducing desialylation via increasing the expression of
            neuraminidase 3.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5929)
  AUTHORS   Kirolos,S.A., Pilling,D. and Gomer,R.H.
  TITLE     The extracellular sialidase NEU3 primes neutrophils
  JOURNAL   J Leukoc Biol 112 (6), 1399-1411 (2022)
   PUBMED   35899930
  REMARK    GeneRIF: The extracellular sialidase NEU3 primes neutrophils.
            Erratum:[J Leukoc Biol. 2024 Feb 23;115(3):583. doi:
            10.1093/jleuko/qiad154.. PMID: 38206829]
REFERENCE   3  (bases 1 to 5929)
  AUTHORS   Miyagi,T. and Yamamoto,K.
  TITLE     Sialidase NEU3 and its pathological significance
  JOURNAL   Glycoconj J 39 (5), 677-683 (2022)
   PUBMED   35675020
  REMARK    GeneRIF: Sialidase NEU3 and its pathological significance.
            Review article
            Erratum:[Glycoconj J. 2022 Aug;39(4):543. doi:
            10.1007/s10719-022-10075-7.. PMID: 35834088]
REFERENCE   4  (bases 1 to 5929)
  AUTHORS   Bovio,F., Epistolio,S., Mozzi,A., Monti,E., Fusi,P., Forcella,M.
            and Frattini,M.
  TITLE     Role of NEU3 Overexpression in the Prediction of Efficacy of
            EGFR-Targeted Therapies in Colon Cancer Cell Lines
  JOURNAL   Int J Mol Sci 21 (22), 8805 (2020)
   PUBMED   33233823
  REMARK    GeneRIF: Role of NEU3 Overexpression in the Prediction of Efficacy
            of EGFR-Targeted Therapies in Colon Cancer Cell Lines.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5929)
  AUTHORS   Ghiroldi,A., Piccoli,M., Creo,P., Cirillo,F., Rota,P.,
            D'Imperio,S., Ciconte,G., Monasky,M.M., Micaglio,E., Garatti,A.,
            Aureli,M., Carsana,E.V., Menicanti,L., Pappone,C. and Anastasia,L.
  TITLE     Role of sialidase Neu3 and ganglioside GM3 in cardiac fibroblasts
            activation
  JOURNAL   Biochem J 477 (17), 3401-3415 (2020)
   PUBMED   32869836
  REMARK    GeneRIF: Role of sialidase Neu3 and ganglioside GM3 in cardiac
            fibroblasts activation.
REFERENCE   6  (bases 1 to 5929)
  AUTHORS   Kakugawa,Y., Wada,T., Yamaguchi,K., Yamanami,H., Ouchi,K., Sato,I.
            and Miyagi,T.
  TITLE     Up-regulation of plasma membrane-associated ganglioside sialidase
            (Neu3) in human colon cancer and its involvement in apoptosis
            suppression
  JOURNAL   Proc Natl Acad Sci U S A 99 (16), 10718-10723 (2002)
   PUBMED   12149448
  REMARK    GeneRIF: up-regulation of plasma membrane-associated ganglioside
            sialidase (Neu3) in human colon cancer and its involvement in
            apoptosis suppression
REFERENCE   7  (bases 1 to 5929)
  AUTHORS   Wang,Y., Yamaguchi,K., Wada,T., Hata,K., Zhao,X., Fujimoto,T. and
            Miyagi,T.
  TITLE     A close association of the ganglioside-specific sialidase Neu3 with
            caveolin in membrane microdomains
  JOURNAL   J Biol Chem 277 (29), 26252-26259 (2002)
   PUBMED   12011038
  REMARK    GeneRIF: Neu3 functions as a caveolin-related signaling molecule
            within caveolin-rich microdomains
REFERENCE   8  (bases 1 to 5929)
  AUTHORS   Wang,Y., Yamaguchi,K., Shimada,Y., Zhao,X. and Miyagi,T.
  TITLE     Site-directed mutagenesis of human membrane-associated ganglioside
            sialidase: identification of amino-acid residues contributing to
            substrate specificity
  JOURNAL   Eur J Biochem 268 (8), 2201-2208 (2001)
   PUBMED   11298736
REFERENCE   9  (bases 1 to 5929)
  AUTHORS   Monti,E., Bassi,M.T., Papini,N., Riboni,M., Manzoni,M.,
            Venerando,B., Croci,G., Preti,A., Ballabio,A., Tettamanti,G. and
            Borsani,G.
  TITLE     Identification and expression of NEU3, a novel human sialidase
            associated to the plasma membrane
  JOURNAL   Biochem J 349 (Pt 1), 343-351 (2000)
   PUBMED   10861246
REFERENCE   10 (bases 1 to 5929)
  AUTHORS   Wada,T., Yoshikawa,Y., Tokuyama,S., Kuwabara,M., Akita,H. and
            Miyagi,T.
  TITLE     Cloning, expression, and chromosomal mapping of a human ganglioside
            sialidase
  JOURNAL   Biochem Biophys Res Commun 261 (1), 21-27 (1999)
   PUBMED   10405317
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB240271.1, CN429425.1 and
            AP001992.4.
            
            On Nov 22, 2018 this sequence version replaced NM_006656.5.
            
            Summary: This gene product belongs to a family of glycohydrolytic
            enzymes which remove sialic acid residues from glycoproteins and
            glycolipids. It is localized in the plasma membrane, and its
            activity is specific for gangliosides. It may play a role in
            modulating the ganglioside content of the lipid bilayer. [provided
            by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a). Variants 1 and 2 both encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y18563.1, ERR279857.766.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000294064.9/ ENSP00000294064.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-222               DB240271.1         29-250
            223-434             CN429425.1         161-372
            435-2720            AP001992.4         153724-156009
            2721-5929           AP001992.4         156010-159218
FEATURES             Location/Qualifiers
     source          1..5929
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.4"
     gene            1..5929
                     /gene="NEU3"
                     /gene_synonym="SIAL3"
                     /note="neuraminidase 3"
                     /db_xref="GeneID:10825"
                     /db_xref="HGNC:HGNC:7760"
                     /db_xref="MIM:604617"
     exon            1..222
                     /gene="NEU3"
                     /gene_synonym="SIAL3"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..1514
                     /gene="NEU3"
                     /gene_synonym="SIAL3"
                     /EC_number="3.2.1.18"
                     /note="isoform a is encoded by transcript variant 1;
                     ganglioside sialidase; N-acetyl-alpha-neuraminidase 3;
                     sialidase-3; membrane sialidase; sialidase 3 (membrane
                     sialidase); ganglioside sialidasedis"
                     /codon_start=1
                     /product="sialidase-3 isoform a"
                     /protein_id="NP_006647.3"
                     /db_xref="CCDS:CCDS44682.1"
                     /db_xref="GeneID:10825"
                     /db_xref="HGNC:HGNC:7760"
                     /db_xref="MIM:604617"
                     /translation="MRPADLPPRPMEESPASSSAPTETEEPGSSAEVMEEVTTCSFNS
                     PLFRQEDDRGITYRIPALLYIPPTHTFLAFAEKRSTRRDEDALHLVLRRGLRIGQLVQ
                     WGPLKPLMEATLPGHRTMNPCPVWEQKSGCVFLFFICVRGHVTERQQIVSGRNAARLC
                     FIYSQDAGCSWSEVRDLTEEVIGSELKHWATFAVGPGHGIQLQSGRLVIPAYTYYIPS
                     WFFCFQLPCKTRPHSLMIYSDDLGVTWHHGRLIRPMVTVECEVAEVTGRAGHPVLYCS
                     ARTPNRCRAEALSTDHGEGFQRLALSRQLCEPPHGCQGSVVSFRPLEIPHRCQDSSSK
                     DAPTIQQSSPGSSLRLEEEAGTPSESWLLYSHPTSRKQRVDLGIYLNQTPLEAACWSR
                     PWILHCGPCGYSDLAALEEEGLFGCLFECGTKQECEQIAFRLFTHREILSHLQGDCTS
                     PGRNPSQFKSN"
     exon            223..434
                     /gene="NEU3"
                     /gene_synonym="SIAL3"
                     /inference="alignment:Splign:2.1.0"
     exon            435..5929
                     /gene="NEU3"
                     /gene_synonym="SIAL3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5907..5912
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NEU3"
                     /gene_synonym="SIAL3"
                     /note="hexamer: AATAAA"
     polyA_site      5929
                     /gene="NEU3"
                     /gene_synonym="SIAL3"
                     /note="major polyA site"
ORIGIN      
        1 agtcgacacg ctcttcgctt ctcggggctt gtctccgtgt cctccgtctc agttgtttct
       61 ccctctctat cctcctctgt ctcagtctcc ccagccttgg ggccggtgcc tcttccgggc
      121 ttcggcgaat gagacctgcg gacctgcccc cgcgccccat ggaagaatcc ccggcgtcca
      181 gctctgcccc gacagagacg gaggagccgg ggtccagtgc agaggtcatg gaagaagtga
      241 caacatgctc cttcaacagc cctctgttcc ggcaggaaga tgacagaggg attacctacc
      301 ggatcccagc cctgctctac atacccccca cccacacctt cctggccttt gcagagaagc
      361 gttctacgag gagagatgag gatgctctcc acctggtgct gaggcgaggg ttgaggattg
      421 ggcagttggt acagtggggg cccctgaagc cactgatgga agccacacta ccggggcatc
      481 ggaccatgaa cccctgtcct gtatgggagc agaagagtgg ttgtgtgttc ctgttcttca
      541 tctgtgtgcg gggccatgtc acagagcgtc aacagattgt gtcaggcagg aatgctgccc
      601 gcctttgctt catctacagt caggatgctg gatgttcatg gagtgaggtg agggacttga
      661 ctgaggaggt cattggctca gagctgaagc actgggccac atttgctgtg ggcccaggtc
      721 atggcatcca gctgcagtca gggagactgg tcatccctgc gtatacctac tacatccctt
      781 cctggttctt ttgcttccag ctaccatgta aaaccaggcc tcattctctg atgatctaca
      841 gtgatgacct aggggtcaca tggcaccatg gtagactcat taggcccatg gttacagtag
      901 aatgtgaagt ggcagaggtg actgggaggg ctggccaccc tgtgctatat tgcagtgccc
      961 ggacaccaaa caggtgccgg gcagaggcgc tcagcactga ccatggtgaa ggctttcaga
     1021 gactggccct gagtcgacag ctctgtgagc ccccacatgg ttgccaaggg agtgtggtaa
     1081 gtttccggcc cctggagatc ccacataggt gccaggactc tagcagcaaa gatgcaccca
     1141 ccattcagca gagctctcca ggcagttcac tgaggctgga ggaggaagct ggaacaccgt
     1201 cagaatcatg gctcttgtac tcacacccaa ccagtaggaa acagagggtt gacctaggta
     1261 tctatctcaa ccagaccccc ttggaggctg cctgctggtc ccgcccctgg atcttgcact
     1321 gtgggccctg tggctactct gatctggctg ctctggagga ggagggcttg tttgggtgtt
     1381 tgtttgaatg tgggaccaag caagagtgtg agcagattgc cttccgcctg tttacacacc
     1441 gggagatcct gagtcacctg cagggggact gcaccagccc tggtaggaac ccaagccaat
     1501 tcaaaagcaa ttaattggct taggacccaa tttccataga tgcaaatggc agttacagac
     1561 aggttaacag aagctactga agtctacaga taatcaaaaa acttaatatt ctgttcccta
     1621 ccttttttca cttttcctcc tccaaagagc aaaatgaaaa ttttgcctta gctactgcag
     1681 tggaaagagc actgaactag gagttggaag acaaggatgt ggtcctggct ctgccactgg
     1741 cttgcttttg gaccttggat gtgtcacctg aactctctgg acctcaggtt tccatctgta
     1801 aaatgagagt attggttcta agatttctca tcttctcatc cctaggacaa gcatagtgcc
     1861 tgcatgcttc atgatcagta agtcctggct gcataaagga ctctgatgtc aaaatggaaa
     1921 ccaggggact taccttttca catgacttac ccctcatccg agtgtgaggt tacaagcagg
     1981 tgtcatggca ggaaggaaga ccagatctgt atgatttgtt ccatttttaa taacaaaaat
     2041 atccacaccc ttttaataat gctcagttct gtaggctctc tatcctagag gaattgagca
     2101 aaacagaaga atcatgaagt ctcctacctt ctacagcctt gtagttctgc ttaccttctc
     2161 ttcctcatcc agaaagcatc attttctagg gagaacaatg agaatctcaa tgccagtagt
     2221 actggataat agtgcgtatt gcttctggtg gcattaccct gatgatgggc tgaagttcat
     2281 ttattagggt ggttcctgat gggaaaagga catggattag gactttaaaa cactggacag
     2341 aatttcccac agtctttgcc ctcaaggagt tcaccagttt atggggctag aagagcgaga
     2401 aaattcaaga aaataaatgt agctggtggg agactttgta gatgttgggc tatatgttgg
     2461 ggtgatggta gctcctgatg taattttctt agttgcatct tcaatatgcc tggagtcgtc
     2521 tgtccaaggc ttgtccaggc ttctgggttt ctctcaagtt tgtttttctc aggatattgt
     2581 cctggcccag ctactccttt acctgtgaga agatcttcac cattaggaag atctctagac
     2641 ccccagatct cagaatcagg cctatttgtg taggcccatg gaaatcacta cttgtgaagt
     2701 agagatgcct ttttgtctaa tggttttcgt gctgaactta gttcatgctg agtctctcag
     2761 atgataccac gttggttgtt cctatcttag attgtttctc ccatagcctg ttattgcaac
     2821 agaaattcta tcatgagaga tttatttttt tgtccctatt ttaggagtct aatgcttaaa
     2881 ctggtatcaa ctaaatatat ttggtgttgt acaatgacca cagagaacaa gtcttagtca
     2941 tgaaatatag cctaggagac taggggttac agttgcacta gttgggtaga gagagtccta
     3001 caggataaaa gtggagatta actttaccta ctttagcaga ttgcttaagc catggcttag
     3061 agtggctttt aaaaatcccc ttagcctctc ctacatttgc caaggtaatc ttcccaatac
     3121 acaattattc actcatgtat acatttatct aaatatttct tgagtgccta atacaaggta
     3181 ctttctactg ccattccttg gctctaaatc atttgtggtt ctccattgcc tattataatg
     3241 taaagatgtt tacatttagc ctggcatgta ggaccttcca gctgttgggt gaaataatgc
     3301 acactttcct ctacttcctt atatgaggcc cactgtcagg gaaaacctct gtcaagttgg
     3361 caggtggagg gtggtggagg tctagggatg ggcaggattg gtgcagggag gaattgggga
     3421 aggggagagg attaaaaggg cagccccctc ctgagtggta gaaactcctt gtttagcaaa
     3481 gctttcctga acactgtact gcaagtggat aggaataggg aggatggcca agtcgtacaa
     3541 ccagggctaa aggatgaaaa gaatgagaat atcaacttct tttttttttt ttttgagaca
     3601 gaatctcact ctgtcgccca ggctggagta cagtggcaca atctcagctc actgcagtct
     3661 ccgcctcctg ggttcaagca attctcctgc ctcagcctcc caagtagctg ggattacagg
     3721 tgcctgccac tacgcccagc taattttttg tatttttagt agagacgggg tttcaccatg
     3781 ttggccaggc ttgtctcgaa ctcctagcct tgtgattcgc ctgcctcggc ctcccaaagt
     3841 gctgggaata caggcatgag ctactgcgcc cagccgagaa tatcaacttc tttaggacta
     3901 ctcaagaagg gagtcaaggc agggaccttg gtctgtgcca ctgtgacgca gagatgtata
     3961 ataccagtac tcataagagg tccatctcta aattgccctc ctcttacttc ttccccctgc
     4021 ctcatgtttt ttctctttaa tgactagcat cgaaactctt taaatggggc aggcctgtgt
     4081 tcttatctca ggaatagtaa gaaaaggggg ttgggaacag gggaaatcca gaataaagac
     4141 ttgagaaagg aacagagtgg gtgatggcag ctatgaagaa aaaacagatc agaagaagag
     4201 tcctggcacc ttaggaagag aaagtgtcac agacacgagg cctaggctag agagatggtg
     4261 taggtggtag ctgctgtgaa gaagaaatga caacaggctg gagctgttcc ctgaaacctg
     4321 tgggaaggaa gagagacctg cacaggccgg cacttagctt gtggagaagg tcctaactca
     4381 acactgcaac tttaagctgg cttaacttgt ccaagttcca gatgaccaac aaagacagct
     4441 atagacactc taactctgtg ccaattaccc aaggccttca gggccctggg acctattcca
     4501 tgatagtggt accctaactg aacccatttc agccactcag attgatagga tggaaaagac
     4561 agggcaggtg gtagcagctg tgaagaaaag aggaaagcag aagggtggcc tataatctac
     4621 aggcatgtag agaggactac ataggcctct gttctttgcc ctcaggagcc cccttcctgt
     4681 cccttggact cagaatggat ccttccagca cacatggccc aacactgaga gtgcaggaag
     4741 catgggtagg ggcctcctgc tgctggtatg tacccaggcc agcctcctgc cgacacagcc
     4801 tactggctgg gttcatgttc ttactattca cctcaggcca ttgtctgggt gcttaatttg
     4861 acttgtttcc cctggtcacc agtctcccct ccgatattca caggacatca agcagcttca
     4921 gccacgggta agaggctttt caccctgcct gttgggtagc ccagaggacc cacaaaggtc
     4981 aacctgagtc tccacagcct cctccccagg gcagtaggaa ttgatatctc acttttgcca
     5041 gattaggctt ctcactcttc ttgagtaggc cataatccac ctcttcagta ggccatgcat
     5101 cttgtctctg cagtgccaga attcacagtc tgggcctccc tttggtcctt accataggct
     5161 gccatgtatt attgtctatg ttgtgccctg taggcctctg ctaggctgtg aactccttga
     5221 ctgactcctc actgtgtcct ttttaccttg aatcacagtg gcttatctaa aaatataagc
     5281 ttttttctgt catattctga attccctgaa ggtaaggact atgtctgatt cctctctttg
     5341 tcctctgcac ccagcgtagg gcctgaaaca gagtagctag cagtaaagat acactgaatg
     5401 aatgaatgag tcaaccatcc ttggcctctg gagctaattg agaaggctag ggggagttcc
     5461 gctgtaggga gaaggatgtt gcatcccttt gtagattgtg tagcattcaa aacctgctga
     5521 acactcaccc tcaatgtata ttctctgttc tggcctgctt caaggtcagt tacactactt
     5581 cctgggatgg gcctttctct ggcttaagct tggttgtccc tggctttccc aaggatcaca
     5641 gcccaaaagg cacagtgggg aaaatttatg gcctattcca gaagagtgag cagcctaatc
     5701 aagccaagcc ttgatttggg gttctcactt cactggtatt ttccctctgt ccctaattgg
     5761 gttttctata gttactagtt ttccaggcct ccaagggaga ttctgaggct tgatgtgttc
     5821 tgactgtgtc ttggctttgt gatgctgagt gccagaaata ctctgtacta taaaaactac
     5881 catcgttctt tgaaacaaca aagaggaata aagaacttaa ttctggtga
//
