LOCUS       NM_018092               7429 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens neuropilin and tolloid like 2 (NETO2), transcript
            variant 1, mRNA.
ACCESSION   NM_018092
VERSION     NM_018092.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7429)
  AUTHORS   Zhu,S., Zhang,X., Guo,Y., Tang,L., Zhou,Z., Chen,X. and Peng,C.
  TITLE     NETO2 promotes melanoma progression via activation of the
            Ca2+/CaMKII signaling pathway
  JOURNAL   Front Med 17 (2), 263-274 (2023)
   PUBMED   36738427
  REMARK    GeneRIF: NETO2 promotes melanoma progression via activation of the
            Ca[2+]/CaMKII signaling pathway.
REFERENCE   2  (bases 1 to 7429)
  AUTHORS   Li,Y., Wang,W., Hou,X., Huang,W., Zhang,P., He,Y., Wang,B.,
            Duan,Q., Mao,F. and Guo,D.
  TITLE     Glioma-derived LRIG3 interacts with NETO2 in tumor-associated
            macrophages to modulate microenvironment and suppress tumor growth
  JOURNAL   Cell Death Dis 14 (1), 28 (2023)
   PUBMED   36639372
  REMARK    GeneRIF: Glioma-derived LRIG3 interacts with NETO2 in
            tumor-associated macrophages to modulate microenvironment and
            suppress tumor growth.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7429)
  AUTHORS   He,L., Sun,J., Gao,Y., Li,B., Wang,Y., Dong,Y., An,W., Li,H.,
            Yang,B., Ge,Y., Zhang,X.C., Shi,Y.S. and Zhao,Y.
  TITLE     Kainate receptor modulation by NETO2
  JOURNAL   Nature 599 (7884), 325-329 (2021)
   PUBMED   34552241
  REMARK    GeneRIF: Kainate receptor modulation by NETO2.
REFERENCE   4  (bases 1 to 7429)
  AUTHORS   Xu,J.C., Chen,T.Y., Liao,L.T., Chen,T., Li,Q.L., Xu,J.X., Hu,J.W.,
            Zhou,P.H. and Zhang,Y.Q.
  TITLE     NETO2 promotes esophageal cancer progression by inducing
            proliferation and metastasis via PI3K/AKT and ERK pathway
  JOURNAL   Int J Biol Sci 17 (1), 259-270 (2021)
   PUBMED   33390848
  REMARK    GeneRIF: NETO2 promotes esophageal cancer progression by inducing
            proliferation and metastasis via PI3K/AKT and ERK pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7429)
  AUTHORS   Calicchio,M.L., Collins,T. and Kozakewich,H.P.
  TITLE     Identification of signaling systems in proliferating and involuting
            phase infantile hemangiomas by genome-wide transcriptional
            profiling
  JOURNAL   Am J Pathol 174 (5), 1638-1649 (2009)
   PUBMED   19349369
REFERENCE   6  (bases 1 to 7429)
  AUTHORS   Zhang,W., St-Gelais,F., Grabner,C.P., Trinidad,J.C., Sumioka,A.,
            Morimoto-Tomita,M., Kim,K.S., Straub,C., Burlingame,A.L., Howe,J.R.
            and Tomita,S.
  TITLE     A transmembrane accessory subunit that modulates kainate-type
            glutamate receptors
  JOURNAL   Neuron 61 (3), 385-396 (2009)
   PUBMED   19217376
  REMARK    GeneRIF: Rat neto2 plays a role in glutamate signaling in the brain
            by modulating the function of kainate receptors.
REFERENCE   7  (bases 1 to 7429)
  AUTHORS   Sanford,J.R., Coutinho,P., Hackett,J.A., Wang,X., Ranahan,W. and
            Caceres,J.F.
  TITLE     Identification of nuclear and cytoplasmic mRNA targets for the
            shuttling protein SF2/ASF
  JOURNAL   PLoS One 3 (10), e3369 (2008)
   PUBMED   18841201
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 7429)
  AUTHORS   Horak,C.E., Lee,J.H., Elkahloun,A.G., Boissan,M., Dumont,S.,
            Maga,T.K., Arnaud-Dabernat,S., Palmieri,D., Stetler-Stevenson,W.G.,
            Lacombe,M.L., Meltzer,P.S. and Steeg,P.S.
  TITLE     Nm23-H1 suppresses tumor cell motility by down-regulating the
            lysophosphatidic acid receptor EDG2
  JOURNAL   Cancer Res 67 (15), 7238-7246 (2007)
   PUBMED   17671192
REFERENCE   9  (bases 1 to 7429)
  AUTHORS   Zhang,Z. and Henzel,W.J.
  TITLE     Signal peptide prediction based on analysis of experimentally
            verified cleavage sites
  JOURNAL   Protein Sci 13 (10), 2819-2824 (2004)
   PUBMED   15340161
  REMARK    GeneRIF: Determination of the neuropilin and tolloid-like protein 2
            signal peptide cleavage site by N-terminal sequencing.
REFERENCE   10 (bases 1 to 7429)
  AUTHORS   Stohr,H., Berger,C., Frohlich,S. and Weber,B.H.
  TITLE     A novel gene encoding a putative transmembrane protein with two
            extracellular CUB domains and a low-density lipoprotein class A
            module: isolation of alternatively spliced isoforms in retina and
            brain
  JOURNAL   Gene 286 (2), 223-231 (2002)
   PUBMED   11943477
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK074937.1 and AC007338.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_018092.4.
            
            Summary: This gene encodes a predicted transmembrane protein
            containing two extracellular CUB domains followed by a low-density
            lipoprotein class A (LDLa) domain. A similar gene in rats encodes a
            protein that modulates glutamate signaling in the brain by
            regulating kainate receptor function. Expression of this gene may
            be a biomarker for proliferating infantile hemangiomas. A
            pseudogene of this gene is located on the long arm of chromosome 8.
            Alternatively spliced transcript variants encoding multiple
            isoforms have been observed for this gene. [provided by RefSeq, Jan
            2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358718.1, BC098380.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000562435.6/ ENSP00000455169.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1997              AK074937.1         53-2049
            1998-7429           AC007338.6         13567-18998
FEATURES             Location/Qualifiers
     source          1..7429
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q12.1"
     gene            1..7429
                     /gene="NETO2"
                     /gene_synonym="BTCL2; NEOT2"
                     /note="neuropilin and tolloid like 2"
                     /db_xref="GeneID:81831"
                     /db_xref="HGNC:HGNC:14644"
                     /db_xref="MIM:607974"
     exon            1..367
                     /gene="NETO2"
                     /gene_synonym="BTCL2; NEOT2"
                     /inference="alignment:Splign:2.1.0"
     CDS             334..1911
                     /gene="NETO2"
                     /gene_synonym="BTCL2; NEOT2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; brain-specific transmembrane protein containing
                     2 CUB and 1 LDL-receptor class A domains protein 2;
                     neuropilin (NRP) and tolloid (TLL)-like 2"
                     /codon_start=1
                     /product="neuropilin and tolloid-like protein 2 isoform 1
                     precursor"
                     /protein_id="NP_060562.3"
                     /db_xref="CCDS:CCDS10727.1"
                     /db_xref="GeneID:81831"
                     /db_xref="HGNC:HGNC:14644"
                     /db_xref="MIM:607974"
                     /translation="MALERLCSVLKVLLITVLVVEGIAVAQKTQDGQNIGIKHIPATQ
                     CGIWVRTSNGGHFASPNYPDSYPPNKECIYILEAAPRQRIELTFDEHYYIEPSFECRF
                     DHLEVRDGPFGFSPLIDRYCGVKSPPLIRSTGRFMWIKFSSDEELEGLGFRAKYSFIP
                     DPDFTYLGGILNPIPDCQFELSGADGIVRSSQVEQEEKTKPGQAVDCIWTIKATPKAK
                     IYLRFLDYQMEHSNECKRNFVAVYDGSSSIENLKAKFCSTVANDVMLKTGIGVIRMWA
                     DEGSRLSRFRMLFTSFVEPPCTSSTFFCHSNMCINNSLVCNGVQNCAYPWDENHCKEK
                     KKAGVFEQITKTHGTIIGITSGIVLVLLIISILVQVKQPRKKVMACKTAFNKTGFQEV
                     FDPPHYELFSLRDKEISADLADLSEELDNYQKMRRSSTASRCIHDHHCGSQASSVKQS
                     RTNLSSMELPFRNDFAQPQPMKTFNSTFKKSSYTFKQGHECPEQALEDRVMEEIPCEI
                     YVRGREDSAQASISIDF"
     exon            368..424
                     /gene="NETO2"
                     /gene_synonym="BTCL2; NEOT2"
                     /inference="alignment:Splign:2.1.0"
     exon            425..565
                     /gene="NETO2"
                     /gene_synonym="BTCL2; NEOT2"
                     /inference="alignment:Splign:2.1.0"
     exon            566..814
                     /gene="NETO2"
                     /gene_synonym="BTCL2; NEOT2"
                     /inference="alignment:Splign:2.1.0"
     exon            815..859
                     /gene="NETO2"
                     /gene_synonym="BTCL2; NEOT2"
                     /inference="alignment:Splign:2.1.0"
     exon            860..987
                     /gene="NETO2"
                     /gene_synonym="BTCL2; NEOT2"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1216
                     /gene="NETO2"
                     /gene_synonym="BTCL2; NEOT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1330
                     /gene="NETO2"
                     /gene_synonym="BTCL2; NEOT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..7429
                     /gene="NETO2"
                     /gene_synonym="BTCL2; NEOT2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2283..2288
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NETO2"
                     /gene_synonym="BTCL2; NEOT2"
                     /note="hexamer: AATAAA"
     polyA_site      2303
                     /gene="NETO2"
                     /gene_synonym="BTCL2; NEOT2"
                     /note="major polyA site"
     regulatory      3317..3322
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NETO2"
                     /gene_synonym="BTCL2; NEOT2"
                     /note="hexamer: ATTAAA"
     polyA_site      3339
                     /gene="NETO2"
                     /gene_synonym="BTCL2; NEOT2"
                     /note="major polyA site"
     regulatory      3475..3480
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NETO2"
                     /gene_synonym="BTCL2; NEOT2"
                     /note="hexamer: AGTAAA"
     polyA_site      3495
                     /gene="NETO2"
                     /gene_synonym="BTCL2; NEOT2"
                     /note="major polyA site"
     regulatory      6430..6435
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NETO2"
                     /gene_synonym="BTCL2; NEOT2"
                     /note="hexamer: ATTAAA"
     polyA_site      6450
                     /gene="NETO2"
                     /gene_synonym="BTCL2; NEOT2"
     regulatory      6802..6807
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NETO2"
                     /gene_synonym="BTCL2; NEOT2"
                     /note="hexamer: ATTAAA"
     polyA_site      6823
                     /gene="NETO2"
                     /gene_synonym="BTCL2; NEOT2"
ORIGIN      
        1 acttcagtgg atcccgcgcc ggggccgcgg gcggagctgc ctgccggtcc cgcgccgcgc
       61 gtccgcactc ctcggccctc gggcggtcga tgggacgggg cgccgcggag caggaggcgg
      121 cgcccgtcgg ggtgctcggg ccgcgcggga gcccactgtg gggctcgggc atggcgggcc
      181 gcaggacctg agctctcctc aggggagcgg ggaggcagct gctggccggc gatggggacg
      241 gagtggggcc gtcgccgccg cgccgagccg tgagcgccga gccaccgccg ccgctacctc
      301 agcccttcgc gaagcgccgg gcagctcggg aacatggccc tggagcggct ctgctcggtc
      361 ctcaaagtgt tgttaataac agtactggta gtggaaggga ttgccgtggc ccaaaaaacc
      421 caagatggac aaaatattgg aatcaagcat attcctgcaa cccagtgtgg catttgggtt
      481 cgaaccagca atggaggtca ttttgcttcg ccaaattatc ctgactcata tccaccaaac
      541 aaggagtgta tctacatttt ggaagctgct ccacgtcaaa gaatagagtt gacctttgat
      601 gaacattatt atatagaacc atcatttgag tgtcggtttg atcacttgga agttcgagat
      661 gggccatttg gtttctctcc tcttatagat cgttactgtg gcgtgaaaag ccctccatta
      721 attagatcaa cagggagatt catgtggatt aagtttagtt ctgatgaaga gcttgaagga
      781 ctgggatttc gagcaaaata ttcatttatt ccagatccag actttactta cctaggaggt
      841 attttaaatc ccattccaga ttgtcagttc gagctctcgg gagctgatgg aatagtgcgc
      901 tctagtcagg tagaacaaga ggagaaaaca aaaccaggcc aagccgttga ttgcatctgg
      961 accattaaag ccactccaaa agctaagatt tatttgaggt tcctagatta tcaaatggag
     1021 cactcaaatg aatgcaagag aaacttcgtt gcagtctatg atggaagcag ttctattgaa
     1081 aacctgaagg ccaagttttg cagcactgtg gccaatgatg taatgcttaa aacaggaatt
     1141 ggagtgattc gaatgtgggc agatgaaggt agtcggctta gcaggtttcg aatgctcttt
     1201 acttcctttg tggagcctcc ctgcacaagc agcactttct tttgccatag caacatgtgc
     1261 atcaataatt ctttagtctg taatggtgtc caaaattgtg catacccttg ggatgaaaat
     1321 cattgtaaag aaaagaaaaa agcaggagta tttgaacaaa tcactaagac tcatggaaca
     1381 attattggca ttacttcagg gattgtcttg gtccttctca ttatttctat tttagtacaa
     1441 gtgaaacagc ctcgaaaaaa ggtcatggct tgcaaaaccg cttttaataa aaccgggttc
     1501 caagaagtgt ttgatcctcc tcattatgaa ctgttttcac taagggacaa agagatttct
     1561 gcagacctgg cagacttgtc ggaagaattg gacaactacc agaagatgcg gcgctcctcc
     1621 accgcctccc gctgcatcca cgaccaccac tgtgggtcgc aggcctccag cgtcaaacaa
     1681 agcaggacca acctcagttc catggaactt cctttccgaa atgactttgc acaaccacag
     1741 ccaatgaaaa catttaatag caccttcaag aaaagtagtt acactttcaa acagggacat
     1801 gagtgccctg agcaggccct ggaagaccga gtaatggagg agattccctg tgaaatttat
     1861 gtcagggggc gagaagattc tgcacaagca tccatatcca ttgacttcta atcttctgct
     1921 aatggtgatg tgaattctta gggtgtgtac gtacgcagcc tccagggcac catactgttt
     1981 ccagcagcca acccttttct cccatcacaa ctacgaagac cttgatttac cgttaaccta
     2041 ttgtatggtg atgtttttat tctctcaggc agtctatata tgttaaacca atcaaggaac
     2101 ttactctatt cagtggaaac aataatcatc tctattgctt ggtgtcattt ataggaagca
     2161 ctgccagtta aagagcatta gaagaggtgg ttggatggag ccaggctcag gctgcctctt
     2221 cgttttagca acaagaagac tgctcttgac tgataacagc tctgtcaata ttttgatgcc
     2281 acaataaact tgatttttct ttacattcct tttatttttc ctttctctaa atttaatttg
     2341 ttttataagc ctatcgtttt accatttcat tttcttacat aagtacaagt ggttaatgta
     2401 ccacatactt cagtataggc atttgttctt gagtgtgtca aaatacagct agttactgtg
     2461 ccaattaaga cccagttgta tttcacccat ctgtttcttc ttggctaatc tctgtacttc
     2521 tgccttttaa ttactgggcc cttattcctt attttctgtg agaaataata gatgatatga
     2581 tttattacct ttcaattata tttttctcag ttatactaga aaatttcata atcctgggat
     2641 atatgtacca ttgtcagcta tgactaaaaa tttgaaaaag ataaaaattt ctagcaagcc
     2701 tttgaagttt accaagtata gtcacattca gtgacagccc attcattcca gtaaagaatc
     2761 atttcattca ctttgggaga ggcctataat tacatttatt tgcaatgttt ctcttcgcta
     2821 gattgttaca tagctcccat tctgttggtt ttgcttacag catatggtaa ccaaggttag
     2881 atgccagtta aaattcctta gaaattggat gagccttgag attgcttctt aactgggaca
     2941 tgacattttt ctagctctta tcaagaataa caacttccac ttttttttaa actgcacttt
     3001 tgactttttt tatggtataa aaacaataat ttataaacat aaaagctcat tgtgtttttt
     3061 agacttttga tattatttga tactgtacaa actttattaa atcaagatga aagacctaca
     3121 ggacagattc ctttcagtgt tcacatcagt ggctttgtat gcaaatatgc tgtgttggac
     3181 ctggacgcta taacttattg taaagacctt ggaaatgtgg acataagctc tttctttcct
     3241 tttgttactg tatttagttt gtgataaatt tttcactgtg tgatatttat gctctaaatc
     3301 actacacaaa tcccatatta aaatatacat tgtacctgac cctttaatca tgttatttat
     3361 gccaccaagg ttgtggatct taaggtatgt atggaaagga actcatttat caaattgtaa
     3421 gtaatacaga catgccattt aaaagaggta aattcttgtt ttctatattt tgttagtaaa
     3481 ttctcaatga aataagttga agtttcactg gatttcatta acttttaaat attacatata
     3541 tgtgttttct cagattagtg aaaattgtga ccttaaattt aatacacata tactgcctca
     3601 gagtgctttc ttgtatcaaa atttttgttt tttaaaaaag tagataatat ttaggagaca
     3661 gaaaaaccta tacataatgt attcatgatt taaatttttt taagtcagcc tagtttcttg
     3721 ttttaaaaat ataacgtgga aacatgaaaa gacttgatgc atataatatt caatgaacta
     3781 ataccagaga cagctaagtt ttttcagtag ttatgctgaa taagcatttt agtaggtaac
     3841 ttacaccagc taacatttga acagcataat aaatacttaa tataacaaca actatgatct
     3901 tatgatgata aaagggaagt tagcatattt tctatgtaaa attattcatt ttttaaaata
     3961 gctgttaaac ctatatttaa tctttagatt ataatagcaa ataatacagt atgctaaact
     4021 atagtcactt gtaactacat ttttgttttt gaaatttgat ttctatttat aaggtcttga
     4081 agaggcctac aaaatacaga gcctttaaag aagacataac agtaaaatag aagtacacag
     4141 ttttatacga gtcaatgtag caagtaacat ttagacagta agtttggttc tgaattttct
     4201 ggctgctaaa acactttttg cttttcacag taaaaaaact tatgtgcaga ggctaatttc
     4261 ctcttgaact acagcatgag ggtctgtata taggaacatt tcttcagaat gtaaaaaaga
     4321 tgcaaaatgg agacagaggt tataatggtg cttcttaacc cagtgaaggc acaacttaat
     4381 gtcgtctagg aacattggtt tagggtcagt ctgtattttc agggatagaa ctaaagaacc
     4441 agatgatcaa tagctaagcc agccttagcc tgtcacatgt tatacacctt cattgaatca
     4501 tagatgggca ttagatctca tttatttatt aaacttctct atgcttttgg aagaggtaag
     4561 aatggaacta ataaatctta ggcattattg ccagaataat gctaattgct gtatatacag
     4621 cctttaatct ttgagatcag tgagaaaact ttataaattg cttactaaaa tgaaagccat
     4681 aaaatttaat aacagaagac atgaaattta gcaatcttgt ggaattcatt acacagtatt
     4741 aactgtcacg cagggtaccc cacacagtgt cccagtgttg aacacaaaat gcaaatctgg
     4801 aagggataaa tatcttcaat tcagaaacag cattaagtat acctgtataa tactgtcacc
     4861 attatcttcc atctgcaatt caccgcatca tcccccaaat gcccacagat ctattgcagg
     4921 aaacctacta atcccaacat ctaaagcatg taggaataag atgtgatatt ccttttgtgt
     4981 gtggggagag tgtcaatcta aacgtttaac aaaaggcaaa gaatgttcac atttcacatc
     5041 acaaaagaga tttcaaagac tcctttaacc cgacagcgct tatgtcagtg tctttgtcat
     5101 gtttcataga attgttagac tttaaaagaa cctcctgaaa gtctgcctct gaacatttgt
     5161 atggttctgc caatgtctga tgagaagaat gcttccctgt ttgaggagtg tgttcactga
     5221 tgagagggga cgggagaagc ctggttgtga tttcaggaat aattctcaaa ggagattata
     5281 ctcttattgc aaaatggggt ctgctatata ttgttcatgt cactttattg caagtgacat
     5341 gaattatatg acattaaaaa taatatgcct tgaatcacac tgattagacc cagaaggatc
     5401 attgagtttt tggtggtttt aaagatccaa gaaagaccta tctagcccaa gtgtatgaat
     5461 gagaagactg aagcccacag aagtgaactc agcaccagtg tctcaagaac cccagtactc
     5521 tggttttttt cttttttgag acggagtctc gctctgtcgc ccaggctgga gtgcagtggc
     5581 gcgatctcgg ctcactgcaa gctccgcctc ccgggttcac gctattctcc tgcctcagtc
     5641 tcccaagtag ctgggactac aggcgcccga caccatgccc ggctaatttc ttgtattttt
     5701 agtagagacg gggtttcacc gtgttagcca ggatagtctc aatctcctga cctcgtgatc
     5761 cacccgcctc ggcctcccaa agtgctggga ttacaggcgt gagccaccgc gcctggcctt
     5821 ctgtttttgt ttttctgttt ttttgttttt tgagacagag tctcgctctg tcacccaggc
     5881 tagagtgcag tggcgtgatc tcggctcact gcaagctccg cctcccgggt tcatgccatt
     5941 ctcctgtctc agcctctcga gtagctggga ctacaggcgc ccgccaccat gcccggctaa
     6001 ttttttgtat ttttagtaga gacggggttt caccatgtta gccaggatgg tctcgatctc
     6061 ctgacctcgt gatccgcccg cctcggcctc ccaaagtgct gggattacag gagtgagcca
     6121 aggcgcccag cccagctgta cgttttaaaa gtcaagcact tctgtttagc agcccatgta
     6181 agcttgtcaa tcattctgaa ttgaaatgta atttattctg taatttcttc aatgcattat
     6241 atttcccctt ttctttaaat gtatgtaaca ttgtgttcta cagttttgct gccatgattc
     6301 cttggcaccg tgaattctta ctaagcaatg tttgttaaca gtatacaggc tcgatactag
     6361 gcaggaagag ctcctgtgtt cttgcttttt tgatcttttt taaatctaaa ggagacgtgt
     6421 attctagaaa ttaaatattt gtgtgccata tctcttgagt tttggagaat gattggagtt
     6481 tgagttactg taaataacaa gattatcttg gatattttag ttttctgcaa aatcacttat
     6541 gttttatata cctctgctaa taattcaaaa ctctgaattt gctttacttt aactttttaa
     6601 aaatgtattt ttgcaattgg tttaatgact accaaagcct aaaaagctaa tgactagggt
     6661 gcatgtttag tatgcactgt ctagtgtaag ctttttaaaa gcagtagatt tttattagag
     6721 atgaacttcc aggccatatg agaatatgct taatcctaga tttggcattt tatagaaaag
     6781 aattttgact cttgaactag aattaaaaac ttgttctgat ttccttgctt gcctcaattt
     6841 ctaaagtcta gaagtggcaa ataatttaga tcacttatac caacagaatc tgtatttcct
     6901 tccggggcaa agttggcatt tcctatccac tagcttccaa aatacaataa tcctagttat
     6961 gataagggca actttatttt attacactta gaaccatttt atgttttcaa attcattaat
     7021 cttcaagtga agatgaacta aagaaaaaaa tgcgttttgt cccaggttgc ctgcaggttg
     7081 cagtctgctg catccggtca ctgaagaggc agtgaggact gtcacagagt gggctggaga
     7141 gccaagctgt tctttcgggg tgcacagtgc accagccata acacagctta gaaacatgga
     7201 tgagtatacc tcaagacagg tgaacacgga gtggggagca aaagaaggca gaaactcctc
     7261 tgagtttcac aagcatcagg cacagatcag ggcacagagg aagaagaaag aaggtttacc
     7321 actggtctgt ctctgtaaat tgttacagag caattttact ttgtgttatt taggatcaag
     7381 aaacaagtgt tatttaaaag ttctcttacc ctccaacctt tgtcatact
//
