LOCUS       NM_138966               6721 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens neuropilin and tolloid like 1 (NETO1), transcript
            variant 3, mRNA.
ACCESSION   NM_138966
VERSION     NM_138966.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6721)
  AUTHORS   Xu,Y., Wang,W., Chen,J., Mao,H., Liu,Y., Gu,S., Liu,Q., Xi,Q. and
            Shi,W.
  TITLE     High neuropilin and tolloid-like 1 expression associated with
            metastasis and poor survival in epithelial ovarian cancer via
            regulation of actin cytoskeleton
  JOURNAL   J Cell Mol Med 24 (16), 9114-9124 (2020)
   PUBMED   32638511
  REMARK    GeneRIF: High neuropilin and tolloid-like 1 expression associated
            with metastasis and poor survival in epithelial ovarian cancer via
            regulation of actin cytoskeleton.
REFERENCE   2  (bases 1 to 6721)
  AUTHORS   Orav,E., Atanasova,T., Shintyapina,A., Kesaf,S., Kokko,M.,
            Partanen,J., Taira,T. and Lauri,S.E.
  TITLE     NETO1 Guides Development of Glutamatergic Connectivity in the
            Hippocampus by Regulating Axonal Kainate Receptors
  JOURNAL   eNeuro 4 (3) (2017)
   PUBMED   28680963
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6721)
  AUTHORS   Sheng,N., Shi,Y.S. and Nicoll,R.A.
  TITLE     Amino-terminal domains of kainate receptors determine the
            differential dependence on Neto auxiliary subunits for trafficking
  JOURNAL   Proc Natl Acad Sci U S A 114 (5), 1159-1164 (2017)
   PUBMED   28100490
REFERENCE   4  (bases 1 to 6721)
  AUTHORS   Li,B., Rex,E., Wang,H., Qian,Y., Ogden,A.M., Bleakman,D. and
            Johnson,K.W.
  TITLE     Pharmacological Modulation of GluK1 and GluK2 by NETO1, NETO2, and
            PSD95
  JOURNAL   Assay Drug Dev Technol 14 (2), 131-143 (2016)
   PUBMED   26991362
REFERENCE   5  (bases 1 to 6721)
  AUTHORS   Fisher,J.L.
  TITLE     The auxiliary subunits Neto1 and Neto2 have distinct,
            subunit-dependent effects at recombinant GluK1- and
            GluK2-containing kainate receptors
  JOURNAL   Neuropharmacology 99, 471-480 (2015)
   PUBMED   26277340
  REMARK    GeneRIF: Results suggested that the extracellular N-terminal region
            including the two CUB domains was largely responsible for the
            distinct regulatory effects of Neto1 and Neto2 on the
            desensitization properties of GluK1 homomeric receptors
REFERENCE   6  (bases 1 to 6721)
  AUTHORS   Tang,M., Pelkey,K.A., Ng,D., Ivakine,E., McBain,C.J., Salter,M.W.
            and McInnes,R.R.
  TITLE     Neto1 is an auxiliary subunit of native synaptic kainate receptors
  JOURNAL   J Neurosci 31 (27), 10009-10018 (2011)
   PUBMED   21734292
REFERENCE   7  (bases 1 to 6721)
  AUTHORS   Straub,C., Hunt,D.L., Yamasaki,M., Kim,K.S., Watanabe,M.,
            Castillo,P.E. and Tomita,S.
  TITLE     Distinct functions of kainate receptors in the brain are determined
            by the auxiliary subunit Neto1
  JOURNAL   Nat Neurosci 14 (7), 866-873 (2011)
   PUBMED   21623363
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 6721)
  AUTHORS   O'Donnell,L., Soileau,B., Heard,P., Carter,E., Sebold,C.,
            Gelfond,J., Hale,D.E. and Cody,J.D.
  TITLE     Genetic determinants of autism in individuals with deletions of 18q
  JOURNAL   Hum Genet 128 (2), 155-164 (2010)
   PUBMED   20499253
REFERENCE   9  (bases 1 to 6721)
  AUTHORS   Ng,D., Pitcher,G.M., Szilard,R.K., Sertie,A., Kanisek,M.,
            Clapcote,S.J., Lipina,T., Kalia,L.V., Joo,D., McKerlie,C.,
            Cortez,M., Roder,J.C., Salter,M.W. and McInnes,R.R.
  TITLE     Neto1 is a novel CUB-domain NMDA receptor-interacting protein
            required for synaptic plasticity and learning
  JOURNAL   PLoS Biol 7 (2), e41 (2009)
   PUBMED   19243221
  REMARK    GeneRIF: Mouse neto1 plays a critical role in spatial learning and
            memory through the regulation of NMDAR subunit abundance at
            synapses.
REFERENCE   10 (bases 1 to 6721)
  AUTHORS   Stohr,H., Berger,C., Frohlich,S. and Weber,B.H.
  TITLE     A novel gene encoding a putative transmembrane protein with two
            extracellular CUB domains and a low-density lipoprotein class A
            module: isolation of alternatively spliced isoforms in retina and
            brain
  JOURNAL   Gene 286 (2), 223-231 (2002)
   PUBMED   11943477
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC091138.6 and AC023301.5.
            
            On Nov 23, 2018 this sequence version replaced NM_138966.4.
            
            Summary: This gene encodes a transmembrane protein containing two
            extracellular CUB domains followed by a low-density lipoprotein
            class A (LDLa) domain. This protein is thought to play a critical
            role in spatial learning and memory by regulating the function of
            synaptic N-methyl-D-aspartic acid receptor complexes in the
            hippocampus. Alternatively spliced transcript variants encoding
            multiple isoforms have been observed for this gene. [provided by
            RefSeq, Aug 2017].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.156901.1, AF448838.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000327305.11/ ENSP00000313088.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-724               AC091138.6         141663-142386       c
            725-778             AC091138.6         139587-139640       c
            779-916             AC091138.6         139207-139344       c
            917-1165            AC091138.6         133225-133473       c
            1166-1207           AC023301.5         38693-38734
            1208-1335           AC023301.5         38853-38980
            1336-1564           AC023301.5         49191-49419
            1565-1678           AC023301.5         76950-77063
            1679-2237           AC023301.5         82477-83035
            2238-2312           AC023301.5         84009-84083
            2313-6721           AC023301.5         84933-89341
FEATURES             Location/Qualifiers
     source          1..6721
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q22.3"
     gene            1..6721
                     /gene="NETO1"
                     /gene_synonym="BCTL1; BTCL1"
                     /note="neuropilin and tolloid like 1"
                     /db_xref="GeneID:81832"
                     /db_xref="HGNC:HGNC:13823"
                     /db_xref="MIM:607973"
     exon            1..724
                     /gene="NETO1"
                     /gene_synonym="BCTL1; BTCL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             697..2298
                     /gene="NETO1"
                     /gene_synonym="BCTL1; BTCL1"
                     /note="isoform 3 precursor is encoded by transcript
                     variant 3; neuropilin and tolloid-like protein 1;
                     brain-specific transmembrane protein containing 2 CUB and
                     1 LDL-receptor class A domains protein 1; neuropilin (NRP)
                     and tolloid (TLL)-like 1"
                     /codon_start=1
                     /product="neuropilin and tolloid-like protein 1 isoform 3
                     precursor"
                     /protein_id="NP_620416.2"
                     /db_xref="CCDS:CCDS12000.1"
                     /db_xref="GeneID:81832"
                     /db_xref="HGNC:HGNC:13823"
                     /db_xref="MIM:607973"
                     /translation="MIHGRSVLHIVASLIILHLSGATKKGTEKQTTSETQKSVQCGTW
                     TKHAEGGIFTSPNYPSKYPPDRECIYIIEAAPRQCIELYFDEKYSIEPSWECKFDHIE
                     VRDGPFGFSPIIGRFCGQQNPPVIKSSGRFLWIKFFADGELESMGFSARYNFTPDPDF
                     KDLGALKPLPACEFEMGGSEGIVESIQIMKEGKATASEAVDCKWYIRAPPRSKIYLRF
                     LDYEMQNSNECKRNFVAVYDGSSSVEDLKAKFCSTVANDVMLRTGLGVIRMWADEGSR
                     NSRFQMLFTSFQEPPCEGNTFFCHSNMCINNTLVCNGLQNCVYPWDENHCKEKRKTSL
                     LDQLTNTSGTVIGVTSCIVIILIIISVIVQIKQPRKKYVQRKSDFDQTVFQEVFEPPH
                     YELCTLRGTGATADFADVADDFENYHKLRRSSSKCIHDHHCGSQLSSTKGSRSNLSTR
                     DASILTEMPTQPGKPLIPPMNRRNILVMKHSYSQDAADACDIDEIEEVPTTSHRLSRH
                     DKAVQRFCLIGSLSKHESEYNTTRV"
     exon            725..778
                     /gene="NETO1"
                     /gene_synonym="BCTL1; BTCL1"
                     /inference="alignment:Splign:2.1.0"
     exon            779..916
                     /gene="NETO1"
                     /gene_synonym="BCTL1; BTCL1"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1165
                     /gene="NETO1"
                     /gene_synonym="BCTL1; BTCL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1207
                     /gene="NETO1"
                     /gene_synonym="BCTL1; BTCL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1335
                     /gene="NETO1"
                     /gene_synonym="BCTL1; BTCL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1564
                     /gene="NETO1"
                     /gene_synonym="BCTL1; BTCL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1678
                     /gene="NETO1"
                     /gene_synonym="BCTL1; BTCL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..2237
                     /gene="NETO1"
                     /gene_synonym="BCTL1; BTCL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2238..2312
                     /gene="NETO1"
                     /gene_synonym="BCTL1; BTCL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2313..6721
                     /gene="NETO1"
                     /gene_synonym="BCTL1; BTCL1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2701
                     /gene="NETO1"
                     /gene_synonym="BCTL1; BTCL1"
                     /note="major polyA site"
     regulatory      3600..3605
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NETO1"
                     /gene_synonym="BCTL1; BTCL1"
                     /note="hexamer: ATTATA"
     polyA_site      3620
                     /gene="NETO1"
                     /gene_synonym="BCTL1; BTCL1"
     regulatory      6244..6249
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NETO1"
                     /gene_synonym="BCTL1; BTCL1"
                     /note="hexamer: AATAAA"
     polyA_site      6267
                     /gene="NETO1"
                     /gene_synonym="BCTL1; BTCL1"
     regulatory      6403..6408
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NETO1"
                     /gene_synonym="BCTL1; BTCL1"
                     /note="hexamer: AATAAA"
     polyA_site      6424
                     /gene="NETO1"
                     /gene_synonym="BCTL1; BTCL1"
     regulatory      6694..6699
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NETO1"
                     /gene_synonym="BCTL1; BTCL1"
                     /note="hexamer: AATAAA"
     polyA_site      6721
                     /gene="NETO1"
                     /gene_synonym="BCTL1; BTCL1"
ORIGIN      
        1 cgcaagatag cagaggtggc gcgcagcccg gcgagccgat gacggacccc ttcttcctgc
       61 cttcaatgcc tcagcggaag atccccaagg gctggagcga ggagcgctgc cgctggacat
      121 cctcccgggg aggctgctcc gacctgctgc gcggcgcgtc tgagactggg gactgagcca
      181 ccccgccgcc gccggcgccg ccgccgccgc ccgctccgtc gctgccgtcg gtctggactg
      241 gcccccacct cgctgcgccc tctccccggc cccggccccg gctcggggcg tcccggggct
      301 cgccctgcga ccgccgcctc ccgcgcgccg cgtcctcccg accccgcggc ggcgacgatg
      361 cccgggagga gggtcctgac ggcggcggcg cggatggtgg cggccggcgc ccgggtgtga
      421 tgcgagcgtc acggtgggga tgctgctggc tgcgcggcgc tgagggccag cgagagcgag
      481 agcccgcccg gggcggagga cggactcatc cggatctggc tgcagcgtgg gctcggagct
      541 cccccttcct ctcggtctcc ctctcggccc ccctttattt ccttcttgct ttgcgtcttt
      601 aacacctctc gaccctgtcc tccccccgcc actggaagtc ttcccgtctc taaatggaat
      661 tagtggagcc cggagcctct ggtgtaacgc acagacatga tccatgggcg cagcgtgctt
      721 cacattgtag caagtttaat catcctccat ttgtctgggg caaccaagaa aggaacagaa
      781 aagcaaacca cctcagaaac acagaagtca gtgcagtgtg gaacttggac aaaacatgca
      841 gagggaggta tctttacctc tcccaactat cccagcaagt atccccctga ccgggaatgc
      901 atctacatca tagaagccgc tccaagacag tgcattgaac tttactttga tgaaaagtac
      961 tctattgaac cgtcttggga gtgcaaattt gatcatattg aagttcgaga tggacctttt
     1021 ggcttttctc caataattgg acgtttctgt ggacaacaaa atccacctgt cataaaatcc
     1081 agtggaagat ttctatggat taaatttttt gctgatggag agctggaatc tatgggattt
     1141 tcagctcgat acaatttcac acctgatcct gactttaagg accttggagc tttgaaacca
     1201 ttaccagcgt gtgagtttga gatgggcggt tccgaaggaa ttgtggagtc tatacaaatt
     1261 atgaaggaag gcaaagctac tgctagcgag gctgttgatt gcaagtggta catccgagca
     1321 cctccacggt ccaagattta cttacgattc ttggactatg agatgcagaa ttcaaatgag
     1381 tgcaagagga attttgtggc tgtgtatgat ggaagcagtt ccgtggagga tttgaaagct
     1441 aagttctgta gcactgtggc taatgatgtc atgctacgca cgggtcttgg ggtgatccgc
     1501 atgtgggcag atgagggcag tcgaaacagc cgatttcaga tgctcttcac atcctttcaa
     1561 gaacctcctt gtgaaggcaa cacattcttc tgccatagta acatgtgtat taataatact
     1621 ttggtctgca atggactcca gaactgtgtg tatccttggg atgaaaatca ctgtaaagag
     1681 aagaggaaaa ccagcctgct ggaccagctg accaacacca gtgggactgt cattggcgtg
     1741 acttcctgca tcgtgatcat cctcattatc atctctgtca tcgtacagat caaacagcct
     1801 cgtaaaaagt atgtccaaag gaaatcagac tttgaccaga cagttttcca ggaggtattt
     1861 gaacctcctc attatgagtt atgcactctc agagggacag gagctacagc tgactttgca
     1921 gatgtggcag atgactttga aaattaccat aaactgcgga ggtcatcttc caaatgcatt
     1981 catgaccatc actgtggatc acagctgtcc agcactaaag gcagccgcag taacctcagc
     2041 acaagagatg cttctatctt gacagagatg cccacacagc caggaaaacc cctcatccca
     2101 cccatgaaca gaagaaatat ccttgtcatg aaacacagct actcgcaaga tgctgcagat
     2161 gcctgtgaca tagatgaaat cgaagaggtg ccgaccacca gtcacaggct gtccagacac
     2221 gataaagccg tccagcggtt ctgcctcatt gggtctctaa gcaaacatga atctgaatac
     2281 aacacaacta gggtctagaa agaaaattca agagaagaac tatttataca aacatgggga
     2341 ctgtgaaaag aaaattctat agtgaattgt gaaaagtgga catatttcta aattcattcc
     2401 actgccttta tccaaactta agaattacag acatttgtta ttccttcggc aagacatccc
     2461 cgctgcacac tgatatgttc atttcgtaat ttggttgctg gccaccaagt gctccttagt
     2521 ttttaaatac attttgagat taactggaaa cttgaagaag aaattagttc ccgattaaga
     2581 ctatcccaac tttattttta ttgtcagttt cacttttgtt tctatgttgt tttatgtctt
     2641 tgttatataa ttgtacattg tgtgatatgt gaaaaaaaaa cacgaatttg gatgaacctt
     2701 gtgttacatg tacattgttt tcattatata gacagcttga gaatagtgcg ttcctgaatg
     2761 attttgaaca tgctacagtg aaaagtgaca gtgtggacca tggaatcacc agctagaggt
     2821 tatggactat acacacctat tattatattc tgattaaata caggaaaaag taacaagtaa
     2881 aattactaga ttgcaataaa aaaattcatt ttttggtctt tcctgtatac ccctgatttc
     2941 ctttttgttt tatatcaaag aaagtactga gtttcagaaa tcctttttga agtcaggtat
     3001 tttaccattc atactctaca gtagaaatgt ttttgattaa gcactcagca atatgaccaa
     3061 attgacagtt tgagaaaata ccctgcatgt cagtactgga tatttgagtt gggaaaatat
     3121 cctttttgtt agacacattg tgaaaagcat gcattgtcaa atactgttgt tactcttcca
     3181 tttctttatg tcatatgctt gctacttacg actttttata taaatatata taaaatgtat
     3241 aataatttcc taatttgagt taagagaaat gttttcttcc attagagtga ttaaaaaact
     3301 gactcacata aatacacatt ttatgtcaac tctttccacc ttttagggta caggatgtcc
     3361 ttcagtattg aggtttactt cccaaaatat ttggcttcta aaagtttagg ggaatatttt
     3421 cttcttttag aatagggaac tctttttaaa actgctttaa aatcacaagc ccttttatga
     3481 attaaaccac cattatgaat tattcttatt ctcaggtaca cataatacac ctgaaagctt
     3541 agtgattatg atgtgtttaa cataaagtaa aatcctaaaa tatattttac tgctattaaa
     3601 ttatatacac actctgtaaa gtttgatttg gtgagtggtt attttttaaa atattcaatg
     3661 tgtaatctta caaaataaat ttttaaaata agaattacta tcagtatata tgcttcccaa
     3721 cattttcaaa actactgaat tctccaggtt taaagaactc tgtccttcca ctaacagagc
     3781 agtctggtct actaaaattt ggactttgca attcaagcag gctttgcaaa ctagatgaat
     3841 tactgttata cttccctact aggaatacaa tgtcatatat gttaaaaaat aagcaaatag
     3901 aaaataaatt tttataatag aaaagtcaaa gagttatcat agccattata aacactctat
     3961 cttgaaaaaa tgtcaagcta cagaatcact tcaatgaatt tgataaacta gggaatcaga
     4021 aaaggttttg aacatgacaa agattatttt tcattgttat gctacatagt tttatacaca
     4081 ttgcttatga taaaatgtac ccttttttat ttggcttgac tggtttattt attaccatgg
     4141 ttcctttttt gccctttaat ttaaaattaa tacaccaaag atttttttaa aggattaatc
     4201 atatcttata ttgctttctc catttagaaa tcttcagagg actcctttcc ctttgaatga
     4261 taatctcaaa agtatgatat aactgtcaag attttttatt tgtaacagca ataaaaatag
     4321 tgaaataagt taggtgaaca ttttactatt aatttgttct ataactgtcc ggcatgtccg
     4381 tcccctccag tttctcctga atatacagaa tgctgattcc ctgcttaaaa ggtattttca
     4441 ccagaaatct accaatggga ctttaaaaaa aaacactaaa tgaagtataa taataagaat
     4501 gaatagctca catatattta acacacagca gcttcatggg aaaacaactg tattttaaat
     4561 gaagaacagg cctcctcagt gataactcta aaatttctca acaatgtaca gacacagact
     4621 aatcatgaaa gaagataatg acgatgctgg gcagtgtctg gaggtagcct tttctcctgg
     4681 cattcactct agatgctcaa acttgggagt gcagcgctct ggcagagttg ggagatgttc
     4741 tctggagggc tctggcggtg cttatttatc agccagtatt gaaatttgtc aatatatcaa
     4801 aaacgattta gtagctatat cagaccttat cacctgaatg cagcctttgg cccacattct
     4861 aaaggtggtg acacacatag ataaggaatg agatgtctca agacttataa gacatgttat
     4921 tttaataaat gattatattt tttgataaag tgaattcaaa tattaccaac ccaagtgctt
     4981 tattgattta acaagatgat ttcaaataat gcattaagtt agcctgctgt gttaatttca
     5041 taaagctatt ctttttcatt ttattttttc aagttttcat tcacttttca aaataatggt
     5101 agcatataat cacatgcaat gccaatgaat ccccatatta agcttcgtac ttctgtccaa
     5161 atgtattgta gttgcctaat ttcaaggttc taatttggaa atctgattta ttttgtatgt
     5221 ttttatatac ataccaattt taagcattat cttgcaaagt agacataggt ggtgtttgat
     5281 ttgccataat taacttgaat ttgattttgt aaccaaaatg tggctgtcca cataattgga
     5341 gatcagtgtc tttgggcttt taatggagaa caaatcacat tgtggtgttg ctggtttttc
     5401 tgtttcacat ttacttttgc tctagaagta tttccgtgag tctgatgact ccataagtta
     5461 tgatcctcag tgttaagtaa cttagacggt tggcattact ttaatattca cttaagcttc
     5521 tgtatcattt ttttctgtat ttttccctta ggaatttaat tcgggtcttc ctcaaatttt
     5581 acagctttaa aaaaattcca tgaatgggtt ttcctcaacc tcagaatatc ataataaatt
     5641 acaagatatg accccctggt tcctattacc ttgattaaag tggcggcaat taatttactg
     5701 atgttttgtc agtgaaataa ataatagcat cttatgaagt ttgtgtatct ctgatgaaaa
     5761 tgagtcatgt cagattccct ctctgaaggg aagttaaata aacaacattt ttaaaattct
     5821 ttgaattcta aataaatatg ctttgaaaag tgagttaggg ttttgtctaa ttgcactgag
     5881 gcgagctagc ttcggtgcca tttttctctg tgcccttttc cctccatgga ttcatttcta
     5941 tctattgcac tctagcgtaa aggacccagc caagaaattg taaaatagat tcaacaacaa
     6001 aataaacagg tcttgagtta attatcaatc tctatgcact taattaatat ttcccaagcc
     6061 catcttaaag gtgtaataag gtagaaaaat aaaagtacac tgttaaaata gccagaaatg
     6121 tttttataaa taatcctgct aaataaatct gaggcccttt gttaatttac aattatgatt
     6181 cattttatta ataaacttgt ttgaattgta ccacaaattt aactgaattg tatcatcaaa
     6241 ataaataaaa cagggtaata aaaataacaa ttagggtgac tgatgtcaga cactcatatc
     6301 aactcatcat tttcttgtag cctctgattc tgtactttct tgtgtattat taaagaggta
     6361 aatgctctct taaaatgcct ctagttcctc agaggtagga aaaataaact caacctgctt
     6421 tggacttgtg tatttacttg ggttggtttc cagaatctcc ttattcctga aacagtatga
     6481 tcatgtagtt aaactactcc tttatatctg taagtactgt gcagccaaca tgttcttttt
     6541 tgtccccaac ttctgccatc tttccaacct ctgaggcatg ctattttata gtggtttgct
     6601 ctttgaaaaa ttgtttttgt gccctctctt aatagtcaca gatactgaca caaaacttaa
     6661 aaatgaccag aaaacaatgt ataaattatt taaaataaaa cattcttttt atatcacatt
     6721 a
//
