LOCUS       NM_001354022            2182 bp    mRNA    linear   PRI 10-JUN-2024
DEFINITION  Homo sapiens neuropilin and tolloid like 1 (NETO1), transcript
            variant 11, mRNA.
ACCESSION   NM_001354022
VERSION     NM_001354022.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2182)
  AUTHORS   Xu,Y., Wang,W., Chen,J., Mao,H., Liu,Y., Gu,S., Liu,Q., Xi,Q. and
            Shi,W.
  TITLE     High neuropilin and tolloid-like 1 expression associated with
            metastasis and poor survival in epithelial ovarian cancer via
            regulation of actin cytoskeleton
  JOURNAL   J Cell Mol Med 24 (16), 9114-9124 (2020)
   PUBMED   32638511
  REMARK    GeneRIF: High neuropilin and tolloid-like 1 expression associated
            with metastasis and poor survival in epithelial ovarian cancer via
            regulation of actin cytoskeleton.
REFERENCE   2  (bases 1 to 2182)
  AUTHORS   Orav,E., Atanasova,T., Shintyapina,A., Kesaf,S., Kokko,M.,
            Partanen,J., Taira,T. and Lauri,S.E.
  TITLE     NETO1 Guides Development of Glutamatergic Connectivity in the
            Hippocampus by Regulating Axonal Kainate Receptors
  JOURNAL   eNeuro 4 (3) (2017)
   PUBMED   28680963
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2182)
  AUTHORS   Sheng,N., Shi,Y.S. and Nicoll,R.A.
  TITLE     Amino-terminal domains of kainate receptors determine the
            differential dependence on Neto auxiliary subunits for trafficking
  JOURNAL   Proc Natl Acad Sci U S A 114 (5), 1159-1164 (2017)
   PUBMED   28100490
REFERENCE   4  (bases 1 to 2182)
  AUTHORS   Li,B., Rex,E., Wang,H., Qian,Y., Ogden,A.M., Bleakman,D. and
            Johnson,K.W.
  TITLE     Pharmacological Modulation of GluK1 and GluK2 by NETO1, NETO2, and
            PSD95
  JOURNAL   Assay Drug Dev Technol 14 (2), 131-143 (2016)
   PUBMED   26991362
REFERENCE   5  (bases 1 to 2182)
  AUTHORS   Fisher,J.L.
  TITLE     The auxiliary subunits Neto1 and Neto2 have distinct,
            subunit-dependent effects at recombinant GluK1- and
            GluK2-containing kainate receptors
  JOURNAL   Neuropharmacology 99, 471-480 (2015)
   PUBMED   26277340
  REMARK    GeneRIF: Results suggested that the extracellular N-terminal region
            including the two CUB domains was largely responsible for the
            distinct regulatory effects of Neto1 and Neto2 on the
            desensitization properties of GluK1 homomeric receptors
REFERENCE   6  (bases 1 to 2182)
  AUTHORS   Tang,M., Pelkey,K.A., Ng,D., Ivakine,E., McBain,C.J., Salter,M.W.
            and McInnes,R.R.
  TITLE     Neto1 is an auxiliary subunit of native synaptic kainate receptors
  JOURNAL   J Neurosci 31 (27), 10009-10018 (2011)
   PUBMED   21734292
REFERENCE   7  (bases 1 to 2182)
  AUTHORS   Straub,C., Hunt,D.L., Yamasaki,M., Kim,K.S., Watanabe,M.,
            Castillo,P.E. and Tomita,S.
  TITLE     Distinct functions of kainate receptors in the brain are determined
            by the auxiliary subunit Neto1
  JOURNAL   Nat Neurosci 14 (7), 866-873 (2011)
   PUBMED   21623363
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2182)
  AUTHORS   O'Donnell,L., Soileau,B., Heard,P., Carter,E., Sebold,C.,
            Gelfond,J., Hale,D.E. and Cody,J.D.
  TITLE     Genetic determinants of autism in individuals with deletions of 18q
  JOURNAL   Hum Genet 128 (2), 155-164 (2010)
   PUBMED   20499253
REFERENCE   9  (bases 1 to 2182)
  AUTHORS   Ng,D., Pitcher,G.M., Szilard,R.K., Sertie,A., Kanisek,M.,
            Clapcote,S.J., Lipina,T., Kalia,L.V., Joo,D., McKerlie,C.,
            Cortez,M., Roder,J.C., Salter,M.W. and McInnes,R.R.
  TITLE     Neto1 is a novel CUB-domain NMDA receptor-interacting protein
            required for synaptic plasticity and learning
  JOURNAL   PLoS Biol 7 (2), e41 (2009)
   PUBMED   19243221
  REMARK    GeneRIF: Mouse neto1 plays a critical role in spatial learning and
            memory through the regulation of NMDAR subunit abundance at
            synapses.
REFERENCE   10 (bases 1 to 2182)
  AUTHORS   Stohr,H., Berger,C., Frohlich,S. and Weber,B.H.
  TITLE     A novel gene encoding a putative transmembrane protein with two
            extracellular CUB domains and a low-density lipoprotein class A
            module: isolation of alternatively spliced isoforms in retina and
            brain
  JOURNAL   Gene 286 (2), 223-231 (2002)
   PUBMED   11943477
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC091138.6.
            
            On Aug 13, 2020 this sequence version replaced NM_001354022.1.
            
            Summary: This gene encodes a transmembrane protein containing two
            extracellular CUB domains followed by a low-density lipoprotein
            class A (LDLa) domain. This protein is thought to play a critical
            role in spatial learning and memory by regulating the function of
            synaptic N-methyl-D-aspartic acid receptor complexes in the
            hippocampus. Alternatively spliced transcript variants encoding
            multiple isoforms have been observed for this gene. [provided by
            RefSeq, Aug 2017].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.446235.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968968,
                                           SAMEA2144120 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-454               AC091138.6         141145-141598       c
            455-508             AC091138.6         139587-139640       c
            509-646             AC091138.6         139207-139344       c
            647-895             AC091138.6         133225-133473       c
            896-2182            AC091138.6         108432-109718       c
FEATURES             Location/Qualifiers
     source          1..2182
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q22.3"
     gene            1..2182
                     /gene="NETO1"
                     /gene_synonym="BCTL1; BTCL1"
                     /note="neuropilin and tolloid like 1"
                     /db_xref="GeneID:81832"
                     /db_xref="HGNC:HGNC:13823"
                     /db_xref="MIM:607973"
     exon            1..454
                     /gene="NETO1"
                     /gene_synonym="BCTL1; BTCL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             451..900
                     /gene="NETO1"
                     /gene_synonym="BCTL1; BTCL1"
                     /note="isoform 7 is encoded by transcript variant 11;
                     neuropilin and tolloid-like protein 1; brain-specific
                     transmembrane protein containing 2 CUB and 1 LDL-receptor
                     class A domains protein 1; neuropilin (NRP) and tolloid
                     (TLL)-like 1"
                     /codon_start=1
                     /product="neuropilin and tolloid-like protein 1 isoform 7"
                     /protein_id="NP_001340951.1"
                     /db_xref="GeneID:81832"
                     /db_xref="HGNC:HGNC:13823"
                     /db_xref="MIM:607973"
                     /translation="MVVASLIILHLSGATKKGTEKQTTSETQKSVQCGTWTKHAEGGI
                     FTSPNYPSKYPPDRECIYIIEAAPRQCIELYFDEKYSIEPSWECKFDHIEVRDGPFGF
                     SPIIGRFCGQQNPPVIKSSGRFLWIKFFADGELESMGFSARYNFTPE"
     exon            455..508
                     /gene="NETO1"
                     /gene_synonym="BCTL1; BTCL1"
                     /inference="alignment:Splign:2.1.0"
     exon            509..646
                     /gene="NETO1"
                     /gene_synonym="BCTL1; BTCL1"
                     /inference="alignment:Splign:2.1.0"
     exon            647..895
                     /gene="NETO1"
                     /gene_synonym="BCTL1; BTCL1"
                     /inference="alignment:Splign:2.1.0"
     exon            896..2182
                     /gene="NETO1"
                     /gene_synonym="BCTL1; BTCL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1818..1823
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NETO1"
                     /gene_synonym="BCTL1; BTCL1"
                     /note="hexamer: ATTAAA"
     polyA_site      1853
                     /gene="NETO1"
                     /gene_synonym="BCTL1; BTCL1"
                     /note="major polyA site"
     regulatory      2045..2050
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NETO1"
                     /gene_synonym="BCTL1; BTCL1"
                     /note="hexamer: ATTAAA"
     polyA_site      2068
                     /gene="NETO1"
                     /gene_synonym="BCTL1; BTCL1"
                     /note="major polyA site"
     regulatory      2158..2163
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NETO1"
                     /gene_synonym="BCTL1; BTCL1"
                     /note="hexamer: AATAAA"
     polyA_site      2182
                     /gene="NETO1"
                     /gene_synonym="BCTL1; BTCL1"
                     /note="major polyA site"
ORIGIN      
        1 ccgaacgcgc aggaaaagcc tctgcgccgc gctccggcgg accctgcagt cccgcgcggg
       61 tcggggccga cgtaaacttt ctgtattgca gcatcgtgga accgggcgtg ggggcggcgc
      121 gcggtcagcc gtcgccggat cccaaaacct gccggagaac ggtctttcag tgcgcaggaa
      181 ccccccgggg gtggaggata gcgtgcagtt cagggatgga cacgtgcggc agagattggc
      241 ccaagcgagg gcgcaggtgg aaagcgggag agcgcggatg atacctagtg gggccagagg
      301 agtcttcctc ttctaggggc tcccggagct cggcgggccc ctgttcgcag tacaggaggt
      361 agcagaaggc acacctgaag ccagcgctgg agggaagggc gagggtcagc ttccacccct
      421 ttccgccctg gagaccgctg atgtcgcttt atggttgtag caagtttaat catcctccat
      481 ttgtctgggg caaccaagaa aggaacagaa aagcaaacca cctcagaaac acagaagtca
      541 gtgcagtgtg gaacttggac aaaacatgca gagggaggta tctttacctc tcccaactat
      601 cccagcaagt atccccctga ccgggaatgc atctacatca tagaagccgc tccaagacag
      661 tgcattgaac tttactttga tgaaaagtac tctattgaac cgtcttggga gtgcaaattt
      721 gatcatattg aagttcgaga tggacctttt ggcttttctc caataattgg acgtttctgt
      781 ggacaacaaa atccacctgt cataaaatcc agtggaagat ttctatggat taaatttttt
      841 gctgatggag agctggaatc tatgggattt tcagctcgat acaatttcac acctgaataa
      901 aaggcaaact ccttagcagg atctacagag tgtttcgtga tctctccttc tccatcatct
      961 catctctgga tgctgtggtg cccagaacgt tgatctaaca ccatcttgaa gcacacatgc
     1021 tgatctccag gtgcaccacg atttgtgccc ttgaaaatgc tgtttgctca atctttctgg
     1081 agaaagtttg ccacatattc ggacttagta aattagaact cctaccttga aacccagatg
     1141 aaggttcaat tttccccagg attcctttcc tcaccattct cctatgtgag ggacttcttg
     1201 tattataatc ttttaatata atattatatt ttatgtaata ttgtgttaaa ttatattgtt
     1261 ttatgtaata tattatttta aatgttattt tatatatgat attaaaagat tataattata
     1321 taatcttttt cgataattta ttcttgtatt acaatctttt tattataata gtctccactc
     1381 tccccaaaat attgtgaatt cttcagctga ggagttttgc tttagtttct tatcgccatg
     1441 gactgggaat taacatgtat ttaacacatt ttgctcaaac aatcaaacag taaaagctga
     1501 agagagcgta ttattattcg cccattccga gagaaagttg aagatgactg aagaactaaa
     1561 aatacataaa tgaattaagt aattataaac ataaatttcc tgtagctcca acatgacttt
     1621 gatctgagta atagtgttgt gaaatagatt actacatgat tttcattgct tttatattat
     1681 atatagtaat taatattcag aatagttgat taactttctt aagtgtcaca taatttaaaa
     1741 atgaaattgc tgtttgcccc agatatgttt ttctgtgttc tttttaaatt tcagtgaaat
     1801 tttcttatac tcccttcatt aaatctatta tctggtttct aaacctttac ctatttaatg
     1861 tctcttttcc tttctttcta aaaagtaact ggttaaacta cagttttgtc atttatgaaa
     1921 ttttttctgt tattattgta gggatagtca atattatcat tttaaggata gttaaaactt
     1981 attttgcaat taatacgtat tttacagtac actaatatgc atatatgttg tattttatta
     2041 aaatattaaa atgtttttta aacaaaaata ttgtccgaag ctctaaatac cagagtattg
     2101 attttaaagt ctgccaagac aataatacaa gtaacacaac taagcctttc tttaaataat
     2161 aaaacgagta tctaaatgaa aa
//
