LOCUS       NM_001201465            2769 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens neuropilin and tolloid like 1 (NETO1), transcript
            variant 4, mRNA.
ACCESSION   NM_001201465
VERSION     NM_001201465.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2769)
  AUTHORS   Xu,Y., Wang,W., Chen,J., Mao,H., Liu,Y., Gu,S., Liu,Q., Xi,Q. and
            Shi,W.
  TITLE     High neuropilin and tolloid-like 1 expression associated with
            metastasis and poor survival in epithelial ovarian cancer via
            regulation of actin cytoskeleton
  JOURNAL   J Cell Mol Med 24 (16), 9114-9124 (2020)
   PUBMED   32638511
  REMARK    GeneRIF: High neuropilin and tolloid-like 1 expression associated
            with metastasis and poor survival in epithelial ovarian cancer via
            regulation of actin cytoskeleton.
REFERENCE   2  (bases 1 to 2769)
  AUTHORS   Orav,E., Atanasova,T., Shintyapina,A., Kesaf,S., Kokko,M.,
            Partanen,J., Taira,T. and Lauri,S.E.
  TITLE     NETO1 Guides Development of Glutamatergic Connectivity in the
            Hippocampus by Regulating Axonal Kainate Receptors
  JOURNAL   eNeuro 4 (3) (2017)
   PUBMED   28680963
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2769)
  AUTHORS   Sheng,N., Shi,Y.S. and Nicoll,R.A.
  TITLE     Amino-terminal domains of kainate receptors determine the
            differential dependence on Neto auxiliary subunits for trafficking
  JOURNAL   Proc Natl Acad Sci U S A 114 (5), 1159-1164 (2017)
   PUBMED   28100490
REFERENCE   4  (bases 1 to 2769)
  AUTHORS   Li,B., Rex,E., Wang,H., Qian,Y., Ogden,A.M., Bleakman,D. and
            Johnson,K.W.
  TITLE     Pharmacological Modulation of GluK1 and GluK2 by NETO1, NETO2, and
            PSD95
  JOURNAL   Assay Drug Dev Technol 14 (2), 131-143 (2016)
   PUBMED   26991362
REFERENCE   5  (bases 1 to 2769)
  AUTHORS   Fisher,J.L.
  TITLE     The auxiliary subunits Neto1 and Neto2 have distinct,
            subunit-dependent effects at recombinant GluK1- and
            GluK2-containing kainate receptors
  JOURNAL   Neuropharmacology 99, 471-480 (2015)
   PUBMED   26277340
  REMARK    GeneRIF: Results suggested that the extracellular N-terminal region
            including the two CUB domains was largely responsible for the
            distinct regulatory effects of Neto1 and Neto2 on the
            desensitization properties of GluK1 homomeric receptors
REFERENCE   6  (bases 1 to 2769)
  AUTHORS   Tang,M., Pelkey,K.A., Ng,D., Ivakine,E., McBain,C.J., Salter,M.W.
            and McInnes,R.R.
  TITLE     Neto1 is an auxiliary subunit of native synaptic kainate receptors
  JOURNAL   J Neurosci 31 (27), 10009-10018 (2011)
   PUBMED   21734292
REFERENCE   7  (bases 1 to 2769)
  AUTHORS   Straub,C., Hunt,D.L., Yamasaki,M., Kim,K.S., Watanabe,M.,
            Castillo,P.E. and Tomita,S.
  TITLE     Distinct functions of kainate receptors in the brain are determined
            by the auxiliary subunit Neto1
  JOURNAL   Nat Neurosci 14 (7), 866-873 (2011)
   PUBMED   21623363
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2769)
  AUTHORS   O'Donnell,L., Soileau,B., Heard,P., Carter,E., Sebold,C.,
            Gelfond,J., Hale,D.E. and Cody,J.D.
  TITLE     Genetic determinants of autism in individuals with deletions of 18q
  JOURNAL   Hum Genet 128 (2), 155-164 (2010)
   PUBMED   20499253
REFERENCE   9  (bases 1 to 2769)
  AUTHORS   Ng,D., Pitcher,G.M., Szilard,R.K., Sertie,A., Kanisek,M.,
            Clapcote,S.J., Lipina,T., Kalia,L.V., Joo,D., McKerlie,C.,
            Cortez,M., Roder,J.C., Salter,M.W. and McInnes,R.R.
  TITLE     Neto1 is a novel CUB-domain NMDA receptor-interacting protein
            required for synaptic plasticity and learning
  JOURNAL   PLoS Biol 7 (2), e41 (2009)
   PUBMED   19243221
  REMARK    GeneRIF: Mouse neto1 plays a critical role in spatial learning and
            memory through the regulation of NMDAR subunit abundance at
            synapses.
REFERENCE   10 (bases 1 to 2769)
  AUTHORS   Stohr,H., Berger,C., Frohlich,S. and Weber,B.H.
  TITLE     A novel gene encoding a putative transmembrane protein with two
            extracellular CUB domains and a low-density lipoprotein class A
            module: isolation of alternatively spliced isoforms in retina and
            brain
  JOURNAL   Gene 286 (2), 223-231 (2002)
   PUBMED   11943477
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC091138.6 and AC023301.5.
            
            On May 31, 2019 this sequence version replaced NM_001201465.2.
            
            Summary: This gene encodes a transmembrane protein containing two
            extracellular CUB domains followed by a low-density lipoprotein
            class A (LDLa) domain. This protein is thought to play a critical
            role in spatial learning and memory by regulating the function of
            synaptic N-methyl-D-aspartic acid receptor complexes in the
            hippocampus. Alternatively spliced transcript variants encoding
            multiple isoforms have been observed for this gene. [provided by
            RefSeq, Aug 2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC050329.1, SRR1803613.277128.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-724               AC091138.6         141663-142386       c
            725-778             AC091138.6         139587-139640       c
            779-916             AC091138.6         139207-139344       c
            917-1165            AC091138.6         133225-133473       c
            1166-1207           AC023301.5         38693-38734
            1208-1335           AC023301.5         38853-38980
            1336-1564           AC023301.5         49191-49419
            1565-1678           AC023301.5         76950-77063
            1679-2237           AC023301.5         82477-83035
            2238-2312           AC023301.5         84009-84083
            2313-2769           AC023301.5         90327-90783
FEATURES             Location/Qualifiers
     source          1..2769
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q22.3"
     gene            1..2769
                     /gene="NETO1"
                     /gene_synonym="BCTL1; BTCL1"
                     /note="neuropilin and tolloid like 1"
                     /db_xref="GeneID:81832"
                     /db_xref="HGNC:HGNC:13823"
                     /db_xref="MIM:607973"
     exon            1..724
                     /gene="NETO1"
                     /gene_synonym="BCTL1; BTCL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             697..2298
                     /gene="NETO1"
                     /gene_synonym="BCTL1; BTCL1"
                     /note="isoform 3 precursor is encoded by transcript
                     variant 4; neuropilin and tolloid-like protein 1;
                     brain-specific transmembrane protein containing 2 CUB and
                     1 LDL-receptor class A domains protein 1; neuropilin (NRP)
                     and tolloid (TLL)-like 1"
                     /codon_start=1
                     /product="neuropilin and tolloid-like protein 1 isoform 3
                     precursor"
                     /protein_id="NP_001188394.2"
                     /db_xref="CCDS:CCDS12000.1"
                     /db_xref="GeneID:81832"
                     /db_xref="HGNC:HGNC:13823"
                     /db_xref="MIM:607973"
                     /translation="MIHGRSVLHIVASLIILHLSGATKKGTEKQTTSETQKSVQCGTW
                     TKHAEGGIFTSPNYPSKYPPDRECIYIIEAAPRQCIELYFDEKYSIEPSWECKFDHIE
                     VRDGPFGFSPIIGRFCGQQNPPVIKSSGRFLWIKFFADGELESMGFSARYNFTPDPDF
                     KDLGALKPLPACEFEMGGSEGIVESIQIMKEGKATASEAVDCKWYIRAPPRSKIYLRF
                     LDYEMQNSNECKRNFVAVYDGSSSVEDLKAKFCSTVANDVMLRTGLGVIRMWADEGSR
                     NSRFQMLFTSFQEPPCEGNTFFCHSNMCINNTLVCNGLQNCVYPWDENHCKEKRKTSL
                     LDQLTNTSGTVIGVTSCIVIILIIISVIVQIKQPRKKYVQRKSDFDQTVFQEVFEPPH
                     YELCTLRGTGATADFADVADDFENYHKLRRSSSKCIHDHHCGSQLSSTKGSRSNLSTR
                     DASILTEMPTQPGKPLIPPMNRRNILVMKHSYSQDAADACDIDEIEEVPTTSHRLSRH
                     DKAVQRFCLIGSLSKHESEYNTTRV"
     exon            725..778
                     /gene="NETO1"
                     /gene_synonym="BCTL1; BTCL1"
                     /inference="alignment:Splign:2.1.0"
     exon            779..916
                     /gene="NETO1"
                     /gene_synonym="BCTL1; BTCL1"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1165
                     /gene="NETO1"
                     /gene_synonym="BCTL1; BTCL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1207
                     /gene="NETO1"
                     /gene_synonym="BCTL1; BTCL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1335
                     /gene="NETO1"
                     /gene_synonym="BCTL1; BTCL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1564
                     /gene="NETO1"
                     /gene_synonym="BCTL1; BTCL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1678
                     /gene="NETO1"
                     /gene_synonym="BCTL1; BTCL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..2237
                     /gene="NETO1"
                     /gene_synonym="BCTL1; BTCL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2238..2312
                     /gene="NETO1"
                     /gene_synonym="BCTL1; BTCL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2313..2769
                     /gene="NETO1"
                     /gene_synonym="BCTL1; BTCL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2628..2633
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NETO1"
                     /gene_synonym="BCTL1; BTCL1"
                     /note="hexamer: AATAAA"
     polyA_site      2647
                     /gene="NETO1"
                     /gene_synonym="BCTL1; BTCL1"
                     /note="major polyA site"
     regulatory      2747..2752
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NETO1"
                     /gene_synonym="BCTL1; BTCL1"
                     /note="hexamer: AATATA"
     polyA_site      2769
                     /gene="NETO1"
                     /gene_synonym="BCTL1; BTCL1"
ORIGIN      
        1 cgcaagatag cagaggtggc gcgcagcccg gcgagccgat gacggacccc ttcttcctgc
       61 cttcaatgcc tcagcggaag atccccaagg gctggagcga ggagcgctgc cgctggacat
      121 cctcccgggg aggctgctcc gacctgctgc gcggcgcgtc tgagactggg gactgagcca
      181 ccccgccgcc gccggcgccg ccgccgccgc ccgctccgtc gctgccgtcg gtctggactg
      241 gcccccacct cgctgcgccc tctccccggc cccggccccg gctcggggcg tcccggggct
      301 cgccctgcga ccgccgcctc ccgcgcgccg cgtcctcccg accccgcggc ggcgacgatg
      361 cccgggagga gggtcctgac ggcggcggcg cggatggtgg cggccggcgc ccgggtgtga
      421 tgcgagcgtc acggtgggga tgctgctggc tgcgcggcgc tgagggccag cgagagcgag
      481 agcccgcccg gggcggagga cggactcatc cggatctggc tgcagcgtgg gctcggagct
      541 cccccttcct ctcggtctcc ctctcggccc ccctttattt ccttcttgct ttgcgtcttt
      601 aacacctctc gaccctgtcc tccccccgcc actggaagtc ttcccgtctc taaatggaat
      661 tagtggagcc cggagcctct ggtgtaacgc acagacatga tccatgggcg cagcgtgctt
      721 cacattgtag caagtttaat catcctccat ttgtctgggg caaccaagaa aggaacagaa
      781 aagcaaacca cctcagaaac acagaagtca gtgcagtgtg gaacttggac aaaacatgca
      841 gagggaggta tctttacctc tcccaactat cccagcaagt atccccctga ccgggaatgc
      901 atctacatca tagaagccgc tccaagacag tgcattgaac tttactttga tgaaaagtac
      961 tctattgaac cgtcttggga gtgcaaattt gatcatattg aagttcgaga tggacctttt
     1021 ggcttttctc caataattgg acgtttctgt ggacaacaaa atccacctgt cataaaatcc
     1081 agtggaagat ttctatggat taaatttttt gctgatggag agctggaatc tatgggattt
     1141 tcagctcgat acaatttcac acctgatcct gactttaagg accttggagc tttgaaacca
     1201 ttaccagcgt gtgagtttga gatgggcggt tccgaaggaa ttgtggagtc tatacaaatt
     1261 atgaaggaag gcaaagctac tgctagcgag gctgttgatt gcaagtggta catccgagca
     1321 cctccacggt ccaagattta cttacgattc ttggactatg agatgcagaa ttcaaatgag
     1381 tgcaagagga attttgtggc tgtgtatgat ggaagcagtt ccgtggagga tttgaaagct
     1441 aagttctgta gcactgtggc taatgatgtc atgctacgca cgggtcttgg ggtgatccgc
     1501 atgtgggcag atgagggcag tcgaaacagc cgatttcaga tgctcttcac atcctttcaa
     1561 gaacctcctt gtgaaggcaa cacattcttc tgccatagta acatgtgtat taataatact
     1621 ttggtctgca atggactcca gaactgtgtg tatccttggg atgaaaatca ctgtaaagag
     1681 aagaggaaaa ccagcctgct ggaccagctg accaacacca gtgggactgt cattggcgtg
     1741 acttcctgca tcgtgatcat cctcattatc atctctgtca tcgtacagat caaacagcct
     1801 cgtaaaaagt atgtccaaag gaaatcagac tttgaccaga cagttttcca ggaggtattt
     1861 gaacctcctc attatgagtt atgcactctc agagggacag gagctacagc tgactttgca
     1921 gatgtggcag atgactttga aaattaccat aaactgcgga ggtcatcttc caaatgcatt
     1981 catgaccatc actgtggatc acagctgtcc agcactaaag gcagccgcag taacctcagc
     2041 acaagagatg cttctatctt gacagagatg cccacacagc caggaaaacc cctcatccca
     2101 cccatgaaca gaagaaatat ccttgtcatg aaacacagct actcgcaaga tgctgcagat
     2161 gcctgtgaca tagatgaaat cgaagaggtg ccgaccacca gtcacaggct gtccagacac
     2221 gataaagccg tccagcggtt ctgcctcatt gggtctctaa gcaaacatga atctgaatac
     2281 aacacaacta gggtctagaa agaaaattca agatgaggaa actgaagagt tttagtaact
     2341 tttttaagat tacacaataa acaatgatga atcaagcttt gaagccaacc tcaccaacca
     2401 caagatcaac caacactctt caccaatgtg taatataacc acgttaatat tcaacatagt
     2461 acgtactgct gaaagaagtt gatacttatt catattaacc ccgtagtttt gtgtttcctc
     2521 atctgtaaaa gtatgtatta taacaccttc tctccacctt acagcgtgtg aggttcaaat
     2581 gaccattcat tggaagatat tttttatatc ctataatgca ttataaaaat aaatcatttt
     2641 tcctaaatca tgtgtagact tcattttatg atcgacatgg aacaaaagta tcatctataa
     2701 agagtaacaa tgtagagtaa cccccctcag aacttgtcca ccataaaata tatgactttc
     2761 caaatccaa
//
