LOCUS       NM_001047160            3989 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens neuroepithelial cell transforming 1 (NET1), transcript
            variant 1, mRNA.
ACCESSION   NM_001047160
VERSION     NM_001047160.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3989)
  AUTHORS   Liu,D., Shen,M., Liu,Z., Chen,D., Pan,Y., Zhang,L. and Xu,X.
  TITLE     SP1-induced circ_0017552 modulates colon cancer cell proliferation
            and apoptosis via up-regulation of NET1
  JOURNAL   Cancer Genet 286-287, 1-10 (2024)
   PUBMED   38810361
  REMARK    GeneRIF: SP1-induced circ_0017552 modulates colon cancer cell
            proliferation and apoptosis via up-regulation of NET1.
REFERENCE   2  (bases 1 to 3989)
  AUTHORS   Luo,S., Hu,Y., Li,S., Wang,L. and Huang,Y.
  TITLE     Association between NET-1 Level in Placenta from Preeclampsia
            Pregnancies and Trophoblast Proliferation and Apoptosis: A
            Correlation Analysis
  JOURNAL   Altern Ther Health Med 29 (5), 353-357 (2023)
   PUBMED   37171948
  REMARK    GeneRIF: Association between NET-1 Level in Placenta from
            Preeclampsia Pregnancies and Trophoblast Proliferation and
            Apoptosis: A Correlation Analysis.
REFERENCE   3  (bases 1 to 3989)
  AUTHORS   Yang,X., Li,Y., Zhang,Y. and Liu,J.
  TITLE     Circ_0000745 promotes acute lymphoblastic leukemia progression
            through mediating miR-494-3p/NET1 axis
  JOURNAL   Hematology 27 (1), 11-22 (2022)
   PUBMED   34957935
  REMARK    GeneRIF: Circ_0000745 promotes acute lymphoblastic leukemia
            progression through mediating miR-494-3p/NET1 axis.
REFERENCE   4  (bases 1 to 3989)
  AUTHORS   Chen,Z.H., Ni,Q.Z., Zhang,X.P., Ma,N., Feng,J.K., Wang,K., Li,J.J.,
            Xie,D., Ma,X.Y. and Cheng,S.Q.
  TITLE     NET1 promotes HCC growth and metastasis in vitro and in vivo via
            activating the Akt signaling pathway
  JOURNAL   Aging (Albany NY) 13 (7), 10672-10687 (2021)
   PUBMED   33839702
  REMARK    GeneRIF: NET1 promotes HCC growth and metastasis in vitro and in
            vivo via activating the Akt signaling pathway.
REFERENCE   5  (bases 1 to 3989)
  AUTHORS   Leyden,J., Murray,D., Moss,A., Arumuguma,M., Doyle,E., McEntee,G.,
            O'Keane,C., Doran,P. and MacMathuna,P.
  TITLE     Net1 and Myeov: computationally identified mediators of gastric
            cancer
  JOURNAL   Br J Cancer 94 (8), 1204-1212 (2006)
   PUBMED   16552434
  REMARK    GeneRIF: The putative role for NET1 genes may provide important
            targets for intervention in Gastric adenocarcinoma, evidenced by
            their role in promoting invasion and proliferation, key phenotypic
            hallmarks of cancer cells.
REFERENCE   6  (bases 1 to 3989)
  AUTHORS   Ozyildirim,A.M., Wistow,G.J., Gao,J., Wang,J., Dickinson,D.P.,
            Frierson,H.F. Jr. and Laurie,G.W.
  TITLE     The lacrimal gland transcriptome is an unusually rich source of
            rare and poorly characterized gene transcripts
  JOURNAL   Invest Ophthalmol Vis Sci 46 (5), 1572-1580 (2005)
   PUBMED   15851553
REFERENCE   7  (bases 1 to 3989)
  AUTHORS   Alberts,A.S., Qin,H., Carr,H.S. and Frost,J.A.
  TITLE     PAK1 negatively regulates the activity of the Rho exchange factor
            NET1
  JOURNAL   J Biol Chem 280 (13), 12152-12161 (2005)
   PUBMED   15684429
  REMARK    GeneRIF: PAK1 negatively regulates the activity of NET1
REFERENCE   8  (bases 1 to 3989)
  AUTHORS   Qin,H., Carr,H.S., Wu,X., Muallem,D., Tran,N.H. and Frost,J.A.
  TITLE     Characterization of the biochemical and transforming properties of
            the neuroepithelial transforming protein 1
  JOURNAL   J Biol Chem 280 (9), 7603-7613 (2005)
   PUBMED   15611121
  REMARK    GeneRIF: NET1 has roles in stimulating cytoskeletal reorganization
            and in transforming cells
REFERENCE   9  (bases 1 to 3989)
  AUTHORS   Shen,X., Li,J., Hu,P.P., Waddell,D., Zhang,J. and Wang,X.F.
  TITLE     The activity of guanine exchange factor NET1 is essential for
            transforming growth factor-beta-mediated stress fiber formation
  JOURNAL   J Biol Chem 276 (18), 15362-15368 (2001)
   PUBMED   11278519
REFERENCE   10 (bases 1 to 3989)
  AUTHORS   Chan,A.M., Takai,S., Yamada,K. and Miki,T.
  TITLE     Isolation of a novel oncogene, NET1, from neuroepithelioma cells by
            expression cDNA cloning
  JOURNAL   Oncogene 12 (6), 1259-1266 (1996)
   PUBMED   8649828
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL732437.12.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001047160.2.
            
            Summary: This gene is part of the family of Rho guanine nucleotide
            exchange factors. Members of this family activate Rho proteins by
            catalyzing the exchange of GDP for GTP. The protein encoded by this
            gene interacts with RhoA within the cell nucleus and may play a
            role in repairing DNA damage after ionizing radiation. Pseudogenes
            of this gene are located on the long arms of chromosomes 1, 7 and
            18. Alternative splicing results in multiple transcript variants
            that encode different protein isoforms. [provided by RefSeq, Jul
            2012].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.16542.1,
                                           SRR1803617.217470.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000355029.9/ ENSP00000347134.4
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-264               AL732437.12        176903-177166       c
            265-331             AL732437.12        163002-163068       c
            332-391             AL732437.12        160494-160553       c
            392-499             AL732437.12        137786-137893       c
            500-667             AL732437.12        137198-137365       c
            668-730             AL732437.12        136803-136865       c
            731-827             AL732437.12        136377-136473       c
            828-904             AL732437.12        136163-136239       c
            905-1162            AL732437.12        135201-135458       c
            1163-1333           AL732437.12        134605-134775       c
            1334-1520           AL732437.12        133450-133636       c
            1521-3989           AL732437.12        130667-133135       c
FEATURES             Location/Qualifiers
     source          1..3989
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p15.1"
     gene            1..3989
                     /gene="NET1"
                     /gene_synonym="ARHGEF8; NET1A"
                     /note="neuroepithelial cell transforming 1"
                     /db_xref="GeneID:10276"
                     /db_xref="HGNC:HGNC:14592"
                     /db_xref="MIM:606450"
     exon            1..264
                     /gene="NET1"
                     /gene_synonym="ARHGEF8; NET1A"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..1927
                     /gene="NET1"
                     /gene_synonym="ARHGEF8; NET1A"
                     /note="isoform 1 is encoded by transcript variant 1;
                     guanine nucleotide regulatory protein (oncogene); Rho
                     guanine nucleotide exchange factor (GEF) 8;
                     neuroepithelial cell-transforming gene 1 protein; p65 Net1
                     proto-oncogene protein; neuroepithelioma transforming gene
                     1; small GTP-binding protein regulator; epididymis
                     secretory sperm binding protein"
                     /codon_start=1
                     /product="neuroepithelial cell-transforming gene 1 protein
                     isoform 1"
                     /protein_id="NP_001040625.1"
                     /db_xref="CCDS:CCDS41483.1"
                     /db_xref="GeneID:10276"
                     /db_xref="HGNC:HGNC:14592"
                     /db_xref="MIM:606450"
                     /translation="MEPELAAQKQPRPRRRSRRASGLSTEGATGPSADTSGSELDGRC
                     SLRRGSSFTFLTPGPNWDFTLKRKRREKDDDVVSLSSLDLKEPSNKRVRPLARVTSLA
                     NLISPVRNGAVRRFGQTIQSFTLRGDHRSPASAQKFSSRSTVPTPAKRRSSALWSEML
                     DITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEELTHI
                     FGDLDSYIPLHEDLLTRIGEATKPDGTVEQIGHILVSWLPRLNAYRGYCSNQLAAKAL
                     LDQKKQDPRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKEILKHTPKEHP
                     DVQLLEDAILIIQGVLSDINLKKGESECQYYIDKLEYLDEKQRDPRIEASKVLLCHGE
                     LRSKSGHKLYIFLFQDILVLTRPVTRNERHSYQVYRQPIPVQELVLEDLQDGDVRMGG
                     SFRGAFSNSEKAKNIFRIRFHDPSPAQSHTLQANDVFHKQQWFNCIRAAIAPFQSAGS
                     PPELQGLPELHEECEGNHPSARKLTAQRRASTVSSVTQVEVDENAYRCGSGMQMAEDS
                     KSLKTHQTQPGIRRARDKALSGGKRKETLV"
     exon            265..331
                     /gene="NET1"
                     /gene_synonym="ARHGEF8; NET1A"
                     /inference="alignment:Splign:2.1.0"
     exon            332..391
                     /gene="NET1"
                     /gene_synonym="ARHGEF8; NET1A"
                     /inference="alignment:Splign:2.1.0"
     exon            392..499
                     /gene="NET1"
                     /gene_synonym="ARHGEF8; NET1A"
                     /inference="alignment:Splign:2.1.0"
     exon            500..667
                     /gene="NET1"
                     /gene_synonym="ARHGEF8; NET1A"
                     /inference="alignment:Splign:2.1.0"
     exon            668..730
                     /gene="NET1"
                     /gene_synonym="ARHGEF8; NET1A"
                     /inference="alignment:Splign:2.1.0"
     exon            731..827
                     /gene="NET1"
                     /gene_synonym="ARHGEF8; NET1A"
                     /inference="alignment:Splign:2.1.0"
     exon            828..904
                     /gene="NET1"
                     /gene_synonym="ARHGEF8; NET1A"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1162
                     /gene="NET1"
                     /gene_synonym="ARHGEF8; NET1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1333
                     /gene="NET1"
                     /gene_synonym="ARHGEF8; NET1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1520
                     /gene="NET1"
                     /gene_synonym="ARHGEF8; NET1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..3989
                     /gene="NET1"
                     /gene_synonym="ARHGEF8; NET1A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2628..2633
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NET1"
                     /gene_synonym="ARHGEF8; NET1A"
                     /note="hexamer: ATTAAA"
     polyA_site      2645
                     /gene="NET1"
                     /gene_synonym="ARHGEF8; NET1A"
                     /note="major polyA site"
     regulatory      3066..3071
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NET1"
                     /gene_synonym="ARHGEF8; NET1A"
                     /note="hexamer: AATAAT"
     polyA_site      3082
                     /gene="NET1"
                     /gene_synonym="ARHGEF8; NET1A"
     regulatory      3119..3124
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NET1"
                     /gene_synonym="ARHGEF8; NET1A"
                     /note="hexamer: GATAAA"
     polyA_site      3155
                     /gene="NET1"
                     /gene_synonym="ARHGEF8; NET1A"
     regulatory      3239..3244
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NET1"
                     /gene_synonym="ARHGEF8; NET1A"
                     /note="hexamer: ATTATA"
     polyA_site      3260
                     /gene="NET1"
                     /gene_synonym="ARHGEF8; NET1A"
     regulatory      3283..3288
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NET1"
                     /gene_synonym="ARHGEF8; NET1A"
                     /note="hexamer: AATATA"
     polyA_site      3317
                     /gene="NET1"
                     /gene_synonym="ARHGEF8; NET1A"
     regulatory      3969..3974
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NET1"
                     /gene_synonym="ARHGEF8; NET1A"
                     /note="hexamer: AATGAA"
     polyA_site      3989
                     /gene="NET1"
                     /gene_synonym="ARHGEF8; NET1A"
ORIGIN      
        1 aaatccccgg atgacggcgg tggcggctgc agtccgctga caggcgcttt ctgcctggca
       61 gaggctggcg ggcatcgtgc ccgtccctgc cggtctcccg ggcacccggc caccgcccca
      121 ccccctcctc cgtgccatgg agcccgagct ggcggctcag aagcagcctc gaccgcggag
      181 gcgaagccgc cgggcctctg ggctcagcac ggagggagcg acggggcctt cggccgacac
      241 ctccgggtcg gagctggacg ggagatgttc ccttcggaga ggcagctcct tcacattctt
      301 aacacctggc cccaactggg acttcacttt gaaaagaaaa cgcagagaga aagatgatga
      361 tgttgtaagc cttagcagcc ttgatctgaa ggagccaagc aataaaagag ttcgacctct
      421 ggctcgtgtc acgtccttgg caaatttaat ctctcctgta agaaatggag ctgtcagacg
      481 ttttggtcaa acaatacagt catttaccct tcgtggtgac cacagatccc cagcctctgc
      541 ccagaagttt tctagcaggt caacagtccc aacacccgcc aagagaagga gcagtgcact
      601 gtggtcagag atgctggaca tcaccatgaa ggagtctctc accaccaggg agatcagacg
      661 gcaggaggca atatatgaaa tgtcccgagg tgaacaggat ttaattgagg atctcaaact
      721 tgcaagaaag gcctatcatg accccatgtt aaagttgtcc atcatgtcag aagaggaact
      781 cacacatata tttggtgatc tggactctta catacctctg catgaagatt tgttgacaag
      841 aataggagaa gcaaccaagc ctgatggaac agtggagcag attggtcaca ttctcgtgag
      901 ctggttaccg cgcttgaatg cctacagagg ttactgtagt aaccagctgg cagccaaagc
      961 tcttcttgat caaaagaaac aggatccaag agtccaagac ttcctccagc gatgtctcga
     1021 gtctcccttc agtcgaaaac tagatctttg gagtttccta gatatccctc gaagtcgcct
     1081 agtcaaatac cctttactgt taaaagaaat tcttaaacac actccaaaag agcaccctga
     1141 tgttcagctt ctggaggatg ctatattgat aatacaggga gtcctctctg atatcaactt
     1201 gaagaaaggt gaatccgagt gccagtatta catcgacaag ctggagtacc tggatgaaaa
     1261 gcagagggac cccagaatcg aagcgagcaa agtgctgctg tgccatgggg agctgcggag
     1321 caagagtgga cataaacttt acattttcct gtttcaagac atcttggttc tgactcggcc
     1381 cgtcacacgg aacgaacggc actcttacca ggtttaccgg cagccaatcc cagtccaaga
     1441 gctagtccta gaagacctgc aggatggaga tgtgagaatg ggaggctcct ttcgaggagc
     1501 tttcagtaac tcagagaaag ctaaaaatat ctttagaatt cgcttccatg acccctctcc
     1561 agcccagtct cacactctgc aagccaatga cgtgttccac aagcagcagt ggttcaactg
     1621 tattcgagcg gccattgccc ccttccagtc ggcaggcagt ccacctgagc tgcagggcct
     1681 gccggagctg cacgaagagt gtgaggggaa ccacccctct gcgaggaaac tcacagccca
     1741 gaggagggca tccacagttt ccagtgttac tcaggtagaa gttgatgaaa acgcttacag
     1801 atgtggctct ggcatgcaga tggcagagga cagcaagagc ttaaagacac accagacaca
     1861 gcccggcatc cgaagagcga gggacaaagc cctttctggt ggcaaacgga aagagacttt
     1921 ggtgtagaga aggctctgtg tgttaactga tgggagagac tgtttgttta taaatgtgta
     1981 cagttttgtt ttctcgtaag gggagcatca tagggttact ttataccagt tgtaacattt
     2041 tcattgtttt tggttgttct tttttctttt tttaatggca gctaaagata tacagattac
     2101 tgttaaattg cagtcctttt ttttttaaag atattttctt gaattattta gaacatggta
     2161 agcctggtat tttttaatca aacaaaatat ttatgaaatg ggttttctct taattctgga
     2221 ttcatcatgg ctttctaata ccaattgtaa tatttacaat attcaccaaa acttagaatt
     2281 ttgcaaatgc tggaattctg ccagtgtttc tttgctaagc cttgcatgca aaatttgaaa
     2341 ttttaacatt ggcacccaaa acctacatgg aatgtatgtc tggagtattt caaactttac
     2401 attgaaacat aatttccttg gaaaacaaac cataagcctg aggaggtttt tatcaactgg
     2461 aatgctttat attagtttgt ttttcactgt acattcctca ttttacattc atttaacctg
     2521 ccgattattt aattttttta ttgtaaagta gtttttagca tttgctttta tttttttact
     2581 ttgatgcctt ttcaaattgg catgtcttta aagtattttt cttcctgatt aaaaatgtgt
     2641 gtgtatgtgt gtgtgtgtgt gtatatatat atatattttt aaatcacatt aattttacca
     2701 agtgaaacca agccatactg tttttgagcc aattaagaaa attgccattt ttaaagtgta
     2761 gcatttcagg gtaaagaccc atgaaatggc ttgatgtatt ctagactact gaaagaaaac
     2821 cacttcaaag attttgttga aagttttagt gttgtctgaa atgcaagagg gaaggtgatt
     2881 ggtagtgagt taaaagaaaa agagaggaaa agagagtagt tttgtcttca agtaaaatgt
     2941 ctggttgtgc cagacatttc acaagtgtga aaggagatag gagaagctca acttgagggc
     3001 gtgtagtaag ttgtagaagg ctcgagggga cgtggactta tttgccttgg tttgcaatac
     3061 ctgcaaataa tgagtttgaa aagaaacaat gaaatgtgtt aaaaatttga ccatattaga
     3121 taaattttcg tggatttagt cataagatgg aaaaagactg gtgaatcttt tattacaaaa
     3181 tgtttctgtt aaaatgggat catcatcttt gaaagggggg aggaggagta aaagcccgat
     3241 tataatggtg atcaattcaa gtcagtgttg actattctgt gaaatatatt tggccagtgg
     3301 aaatgataat cagaaaagac tgtaaataga tccatccaaa tgatttctct gtacaaatga
     3361 atgatactat taaaaaaaaa aaaagcacac acataatcac cctgaaggtt tcttgcctgg
     3421 tggctatgtt gggggcattt ggcaaaatat gctggtgtgg caaaggaggt agtggtaagc
     3481 ctcataaaag ttagtaaaaa ttgtagttca acctttgaaa tcattgatga atcagcgaaa
     3541 ggtaggtaag tcttgtgtta ggaaatcttt taagaacatg gtgtaatcag acacagcaat
     3601 tgtattgaaa ataactgaac acctgttact ttctggatag gatagtaagg gtagtagtgg
     3661 caaaggatcc tgattaattt cagattttaa tgtaagtacc tcaggttctt gtctttggaa
     3721 attcacattc ataagtgtat attacaccaa tgattgtgat ctgcaacacc agaaagcaag
     3781 atttctaatc atttccagag gtgttgtata gaatagttat tccagagtta ccttgatcag
     3841 cttctgaagt ttaagaagca agtaatagtt caagtgttgt taatggaatt atgttttatt
     3901 taaaaccgta tcttcttttg gttccctcaa aggtaaaaat aagacccaga atctgagtaa
     3961 atctattaaa tgaatgttct tcagaaata
//
