LOCUS       NM_006617               5568 bp    mRNA    linear   PRI 01-JUL-2024
DEFINITION  Homo sapiens nestin (NES), mRNA.
ACCESSION   NM_006617
VERSION     NM_006617.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5568)
  AUTHORS   Murugesan,A., Bharath,C., Balakrishnan,S., Kandasamy,S.,
            Priyadharshini,I. and Ravi,S.
  TITLE     Expression of HIF-1alpha and Nestin in oral squamous cell carcinoma
            and its association with vasculogenic mimicry
  JOURNAL   J Cancer Res Ther 20 (1), 176-180 (2024)
   PUBMED   38554317
  REMARK    GeneRIF: Expression of HIF-1alpha and Nestin in oral squamous cell
            carcinoma and its association with vasculogenic mimicry.
REFERENCE   2  (bases 1 to 5568)
  AUTHORS   Sasaki,M., Sato,Y. and Nakanuma,Y.
  TITLE     Nestin may be a candidate marker for differential diagnosis between
            small duct type and large duct type intrahepatic
            cholangiocarcinomas
  JOURNAL   Pathol Res Pract 253, 155061 (2024)
   PUBMED   38154357
  REMARK    GeneRIF: Nestin may be a candidate marker for differential
            diagnosis between small duct type and large duct type intrahepatic
            cholangiocarcinomas.
REFERENCE   3  (bases 1 to 5568)
  AUTHORS   Koerber,R.M., Schneider,R.K., Pritchard,J.E., Teichmann,L.L.,
            Schumacher,U., Brossart,P. and Gutgemann,I.
  TITLE     Nestin expression in osteocytes following myeloablation and during
            bone marrow metastasis
  JOURNAL   Br J Haematol 200 (5), 643-651 (2023)
   PUBMED   36382360
  REMARK    GeneRIF: Nestin expression in osteocytes following myeloablation
            and during bone marrow metastasis.
REFERENCE   4  (bases 1 to 5568)
  AUTHORS   Dominguez-Castro,M., Dominguez-Galicia,A., Perez-Perez,O.,
            Hernandez-Pineda,J., Mancilla-Herrera,I., Bazan-Tejeda,M.L.,
            Rodriguez-Cruz,L., Gonzalez-Torres,M.C., Montoya-Estrada,A.,
            Reyes-Munoz,E. and Romo-Yanez,J.
  TITLE     Hyperglycemia affects neuronal differentiation and Nestin, FOXO1,
            and LMO3 mRNA expression of human Wharton's jelly mesenchymal stem
            cells of children from diabetic mothers
  JOURNAL   Biochem Biophys Res Commun 637, 300-307 (2022)
   PUBMED   36413852
  REMARK    GeneRIF: Hyperglycemia affects neuronal differentiation and Nestin,
            FOXO1, and LMO3 mRNA expression of human Wharton's jelly
            mesenchymal stem cells of children from diabetic mothers.
REFERENCE   5  (bases 1 to 5568)
  AUTHORS   Zarina,K.Z. and Pilmane,M.
  TITLE     Expression of Markers Ki-67, Nestin, VEGF, CD34 and Apoptosis in
            Relatively Healthy Lung Tissue with Non-Changed and Metaplastic
            Bronchial Epithelium
  JOURNAL   Med Sci (Basel) 11 (1), 7 (2022)
   PUBMED   36649044
  REMARK    GeneRIF: Expression of Markers Ki-67, Nestin, VEGF, CD34 and
            Apoptosis in Relatively Healthy Lung Tissue with Non-Changed and
            Metaplastic Bronchial Epithelium.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5568)
  AUTHORS   Messam,C.A., Hou,J. and Major,E.O.
  TITLE     Coexpression of nestin in neural and glial cells in the developing
            human CNS defined by a human-specific anti-nestin antibody
  JOURNAL   Exp Neurol 161 (2), 585-596 (2000)
   PUBMED   10686078
REFERENCE   7  (bases 1 to 5568)
  AUTHORS   Cassiman,D., van Pelt,J., De Vos,R., Van Lommel,F., Desmet,V.,
            Yap,S.H. and Roskams,T.
  TITLE     Synaptophysin: A novel marker for human and rat hepatic stellate
            cells
  JOURNAL   Am J Pathol 155 (6), 1831-1839 (1999)
   PUBMED   10595912
REFERENCE   8  (bases 1 to 5568)
  AUTHORS   Yaworsky,P.J. and Kappen,C.
  TITLE     Heterogeneity of neural progenitor cells revealed by enhancers in
            the nestin gene
  JOURNAL   Dev Biol 205 (2), 309-321 (1999)
   PUBMED   9917366
REFERENCE   9  (bases 1 to 5568)
  AUTHORS   Lothian,C. and Lendahl,U.
  TITLE     An evolutionarily conserved region in the second intron of the
            human nestin gene directs gene expression to CNS progenitor cells
            and to early neural crest cells
  JOURNAL   Eur J Neurosci 9 (3), 452-462 (1997)
   PUBMED   9104587
REFERENCE   10 (bases 1 to 5568)
  AUTHORS   Dahlstrand,J., Zimmerman,L.B., McKay,R.D. and Lendahl,U.
  TITLE     Characterization of the human nestin gene reveals a close
            evolutionary relationship to neurofilaments
  JOURNAL   J Cell Sci 103 (Pt 2), 589-597 (1992)
   PUBMED   1478958
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL590666.8, BC051373.1 and
            AK025494.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_006617.1.
            
            Summary: This gene encodes a member of the intermediate filament
            protein family and is expressed primarily in nerve cells. [provided
            by RefSeq, Sep 2011].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.1738944.1,
                                           SRR14038191.2762046.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368223.4/ ENSP00000357206.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AL590666.8         26023-26032         c
            11-531              BC051373.1         1-521
            532-532             AL590666.8         25501-25501         c
            533-1910            BC051373.1         523-1900
            1911-5123           AL590666.8         17833-21045         c
            5124-5568           AK025494.1         1850-2294
FEATURES             Location/Qualifiers
     source          1..5568
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.1"
     gene            1..5568
                     /gene="NES"
                     /gene_synonym="Nbla00170"
                     /note="nestin"
                     /db_xref="GeneID:10763"
                     /db_xref="HGNC:HGNC:7756"
                     /db_xref="MIM:600915"
     exon            1..926
                     /gene="NES"
                     /gene_synonym="Nbla00170"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..5009
                     /gene="NES"
                     /gene_synonym="Nbla00170"
                     /codon_start=1
                     /product="nestin"
                     /protein_id="NP_006608.1"
                     /db_xref="CCDS:CCDS1151.1"
                     /db_xref="GeneID:10763"
                     /db_xref="HGNC:HGNC:7756"
                     /db_xref="MIM:600915"
                     /translation="MEGCMGEESFQMWELNRRLEAYLARVKALEEQNELLSAELGGLR
                     AQSADTSWRAHADDELAALRALVDQRWREKHAAEVARDNLAEELEGVAGRCQQLRLAR
                     ERTTEEVARNRRAVEAEKCARAWLSSQVAELERELEALRVAHEEERVGLNAQAACAPR
                     CPAPPRGPPAPAPEVEELARRLGEAWRGAVRGYQERVAHMETSLGQARERLGRAVQGA
                     REGRLELQQLQAERGGLLERRAALEQRLEGRWQERLRATEKFQLAVEALEQEKQGLQS
                     QIAQVLEGRQQLAHLKMSLSLEVATYRTLLEAENSRLQTPGGGSKTSLSFQDPKLELQ
                     FPRTPEGRRLGSLLPVLSPTSLPSPLPATLETPVPAFLKNQEFLQARTPTLASTPIPP
                     TPQAPSPAVDAEIRAQDAPLSLLQTQGGRKQAPEPLRAEARVAIPASVLPGPEEPGGQ
                     RQEASTGQSPEDHASLAPPLSPDHSSLEAKDGESGGSRVFSICRGEGEGQIWGLVEKE
                     TAIEGKVVSSLQQEIWEEEDLNRKEIQDSQVPLEKETLKSLGEEIQESLKTLENQSHE
                     TLERENQECPRSLEEDLETLKSLEKENKELLKDVEVVRPLEKEAVGQLKPTGKEDTQT
                     LQSLQKENQELMKSLEGNLETFLFPGTENQELVSSLQENLESLTALEKENQEPLRSPE
                     VGDEEALRPLTKENQEPLRSLEDENKEAFRSLEKENQEPLKTLEEEDQSIVRPLETEN
                     HKSLRSLEEQDQETLRTLEKETQQRRRSLGEQDQMTLRPPEKVDLEPLKSLDQEIARP
                     LENENQEFLKSLKEESVEAVKSLETEILESLKSAGQENLETLKSPETQAPLWTPEEIN
                     QGAMNPLEKEIQEPLESVEVNQETFRLLEEENQESLRSLGAWNLENLRSPEEVDKESQ
                     RNLEEEENLGKGEYQESLRSLEEEGQELPQSADVQRWEDTVEKDQELAQESPPGMAGV
                     ENEDEAELNLREQDGFTGKEEVVEQGELNATEEVWIPGEGHPESPEPKEQRGLVEGAS
                     VKGGAEGLQDPEGQSQQVGAPGLQAPQGLPEAIEPLVEDDVAPGGDQASPEVMLGSEP
                     AMGESAAGAEPGPGQGVGGLGDPGHLTREEVMEPPLEEESLEAKRVQGLEGPRKDLEE
                     AGGLGTEFSELPGKSRDPWEPPREGREESEAEAPRGAEEAFPAETLGHTGSDAPSPWP
                     LGSEEAEEDVPPVLVSPSPTYTPILEDAPGPQPQAEGSQEASWGVQGRAEALGKVESE
                     QEELGSGEIPEGPQEEGEESREESEEDELGETLPDSTPLGFYLRSPTSPRWDPTGEQR
                     PPPQGETGKEGWDPAVLASEGLEAPPSEKEEGEEGEEECGRDSDLSEEFEDLGTEAPF
                     LPGVPGEVAEPLGQVPQLLLDPAAWDRDGESDGFADEEESGEEGEEDQEEGREPGAGR
                     WGPGSSVGSLQALSSSQRGEFLESDSVSVSVPWDDSLRGAVAGAPKTALETESQDSAE
                     PSGSEEESDPVSLEREDKVPGPLEIPSGMEDAGPGADIIGVNGQGPNLEGKSQHVNGG
                     VMNGLEQSEEVGQGMPLVSEGDRGSPFQEEEGSALKTSWAGAPVHLGQGQFLKFTQRE
                     GDRESWSSGED"
     exon            927..1051
                     /gene="NES"
                     /gene_synonym="Nbla00170"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1125
                     /gene="NES"
                     /gene_synonym="Nbla00170"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..5568
                     /gene="NES"
                     /gene_synonym="Nbla00170"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5544..5549
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NES"
                     /gene_synonym="Nbla00170"
                     /note="hexamer: AATAAA"
     polyA_site      5568
                     /gene="NES"
                     /gene_synonym="Nbla00170"
                     /note="major polyA site"
ORIGIN      
        1 agtcgctcag gctactccca ccccgccccg ccccgtcatt gtccccgtcg gtctcttttc
       61 tcttccgtcc taaaagctct gcgagccgct cccttctccc ggtgccccgc gtctgtccat
      121 cctcagtggg tcagacgagc aggatggagg gctgcatggg ggaggagtcg tttcagatgt
      181 gggagctcaa tcggcgcctg gaggcctacc tggcccgggt caaggcgctg gaggagcaga
      241 atgagctgct cagcgcggag ctcggggggc tccgggcaca atccgcggac acctcctggc
      301 gggcgcatgc cgacgacgag ctggcggccc tgcgggccct cgttgaccaa cgctggcggg
      361 agaagcacgc ggccgaggtg gcgcgcgaca acctggctga agagctggag ggcgtggcag
      421 gccgatgcca gcagctgcgg ctggcccggg agcggacgac ggaggaggta gcccgcaacc
      481 ggcgcgccgt cgaggcagag aaatgcgccc gggcctggct gagtagccag gtggcagagc
      541 tggagcgcga gctagaggct ctacgcgtgg cgcacgagga ggagcgcgtc ggcctgaacg
      601 cgcaggctgc ctgtgccccc cgctgccccg cgccgccccg cgggcctccc gcgccggccc
      661 cggaggtaga ggagctggca aggcgactgg gcgaggcgtg gcgcggggca gtgcgcggct
      721 accaggagcg cgtggcacac atggagacgt cgctgggcca ggcccgcgag cggctgggcc
      781 gggcggtgca gggtgcccgc gagggccgcc tggagctgca gcagctccag gctgagcgcg
      841 gaggcctcct ggagcgcagg gcagcgttgg aacagaggtt ggagggccgc tggcaggagc
      901 ggctgcgggc tactgaaaag ttccagctgg ctgtggaggc cctggagcag gagaaacagg
      961 gcctacagag ccagatcgct caggtcctgg aaggtcggca gcagctggcg cacctcaaga
     1021 tgtccctcag cctggaggtg gccacgtaca ggaccctcct ggaggctgag aactcccggc
     1081 tgcaaacacc tggcggtggc tccaagactt ccctcagctt tcaggacccc aagctggagc
     1141 tgcaattccc taggacccca gagggccggc gtcttggatc tttgctccca gtcctgagcc
     1201 caacttccct cccctcaccc ttgcctgcta cccttgagac acctgtgcca gcctttctta
     1261 agaaccaaga attcctccag gcccgtaccc ctaccttggc cagcaccccc atccccccca
     1321 cacctcaggc accctctcct gctgtagatg cagagatcag agcccaggat gctcctctct
     1381 ctctgctcca gacacagggt gggaggaaac aggctccaga gcccctgcgg gctgaagcca
     1441 gggtggccat tcctgccagc gtcctgcctg gaccagagga gcctgggggc cagcggcaag
     1501 aggccagtac aggccagtcc ccagaggacc atgcctcctt ggcaccaccc ctcagccctg
     1561 accactccag tttagaggct aaggatggag aatccggtgg gtctagagtg ttcagcatat
     1621 gccgagggga aggtgaaggg caaatctggg ggttggtaga gaaagaaaca gccatagagg
     1681 gcaaagtggt aagcagcttg cagcaggaaa tatgggaaga agaggatcta aacaggaagg
     1741 aaatccagga ctcccaggtt cctttggaaa aagaaaccct gaagtctctg ggagaggaga
     1801 ttcaagagtc actgaagact ctggaaaacc agagccatga gacactagaa agggagaatc
     1861 aagaatgtcc gaggtcttta gaagaagact tagaaacact aaaaagtcta gaaaaggaaa
     1921 ataaagagct attaaaggat gtggaggtag tgagacctct agaaaaagag gctgtaggcc
     1981 aacttaagcc tacaggaaaa gaggacacac agacattgca atccctgcaa aaggagaatc
     2041 aagaactaat gaaatctctt gaaggtaatc tagagacatt tttatttcca ggaacggaaa
     2101 atcaagaatt agtaagttct ctgcaagaga acttagagtc attgacagct ctggaaaagg
     2161 agaatcaaga gccactgaga tctccagaag taggggatga ggaggcactg agacctctga
     2221 caaaggagaa tcaggaaccc ctgaggtctc ttgaagatga gaacaaagag gcctttagat
     2281 ctctagaaaa agagaaccag gagccactga agactctaga agaagaggac cagagtattg
     2341 tgagacctct agaaacagag aatcacaaat cactgaggtc tttagaagaa caggaccaag
     2401 agacattgag aactcttgaa aaagagactc aacagcgacg gaggtctcta ggggaacagg
     2461 atcagatgac attaagaccc ccagaaaaag tggatctaga accactgaag tctcttgacc
     2521 aggagatagc tagacctctt gaaaatgaga atcaagagtt cttaaagtca ctcaaagaag
     2581 agagcgtaga ggcagtaaaa tctttagaaa cagagatcct agaatcactg aagtctgcgg
     2641 gacaagagaa cctggaaaca ctgaaatctc cagaaactca agcaccactg tggactccag
     2701 aagaaataaa tcagggggca atgaatcctc tagaaaagga aattcaagaa ccactggagt
     2761 ctgtggaagt gaaccaagag acattcagac tcctggaaga ggagaatcag gaatcattga
     2821 gatctctggg agcatggaac ctggagaatt tgagatctcc agaggaggta gacaaggaaa
     2881 gtcaaaggaa tctggaagag gaagagaacc tgggaaaggg agagtaccaa gagtcactga
     2941 ggtctctgga ggaggaggga caggagctgc cgcagtctgc agatgtgcag aggtgggaag
     3001 atacggtgga gaaggaccaa gaactggctc aggaaagccc tcctgggatg gctggagtgg
     3061 aaaatgagga tgaggcagag ctgaatctga gggagcagga tggcttcact gggaaggagg
     3121 aggtggtaga gcagggagag ctgaatgcca cagaggaggt ctggatccca ggcgaggggc
     3181 acccagagag ccctgagccc aaagagcaga gaggcctggt tgagggagcc agtgtgaagg
     3241 gaggggctga gggcctccag gaccctgaag ggcaatcaca acaggtgggg gccccaggcc
     3301 tccaggctcc ccaggggctg ccagaggcga tagagcccct ggtggaagat gatgtggccc
     3361 cagggggtga ccaagcctcc ccagaggtca tgttggggtc agagcctgcc atgggtgagt
     3421 ctgctgcggg agctgagcca ggcccggggc agggggtggg agggctgggg gacccaggcc
     3481 atctgaccag ggaagaggtg atggaaccac ccctggaaga ggagagtttg gaggcaaaga
     3541 gggttcaggg cttggaaggg cctagaaagg acctagagga ggcaggtggt ctggggacag
     3601 agttctccga gctgcctggg aagagcagag acccttggga gcctcccagg gagggtaggg
     3661 aggagtcaga ggctgaggcc cccaggggag cagaggaggc gttccctgct gagaccctgg
     3721 gccacactgg aagtgatgcc ccttcacctt ggcctctggg gtcagaggaa gctgaggagg
     3781 atgtaccacc agtgctggtc tcccccagcc caacgtacac cccgatcctg gaagatgccc
     3841 ctgggcctca gcctcaggct gaagggagtc aggaggctag ctggggggtg caggggaggg
     3901 ctgaagccct ggggaaagta gagagcgagc aggaggagtt gggttctggg gagatccccg
     3961 agggccccca ggaggaaggg gaggagagca gagaagagag cgaggaggat gagctcgggg
     4021 agacccttcc agactccact cccctgggct tctacctcag gtcccccacc tcccccaggt
     4081 gggaccccac tggagagcag aggccacccc ctcaagggga gactggaaag gagggctggg
     4141 atcctgctgt cctggcttcc gagggccttg aggccccacc ctcagaaaag gaggaggggg
     4201 aggagggaga agaggagtgt ggccgtgact ctgacctgtc agaagaattt gaggacctgg
     4261 ggactgaggc accttttctt cctggggtcc ctggggaggt ggcagaacct ctgggccagg
     4321 tgccccagct gctactggat cctgcagcct gggatcgaga tggggagtcc gatgggtttg
     4381 cagatgagga agaaagtggg gaggagggag aggaggatca ggaggagggg agggagccag
     4441 gggctgggcg gtgggggcca gggtcttctg ttggcagcct ccaggccctg agtagctccc
     4501 agagagggga attcctggag tctgattctg tgagtgtcag tgtcccctgg gatgacagct
     4561 tgaggggtgc agtggctggt gcccccaaga ctgccctgga aacggagtcc caggacagtg
     4621 ctgagccttc tggctcagag gaagagtctg accctgtttc cttggagagg gaggacaaag
     4681 tccctggccc tctagagatc cccagtggga tggaggatgc aggcccaggg gcagacatca
     4741 ttggtgttaa tggccagggt cccaacttgg aggggaagtc acagcatgtg aatgggggag
     4801 tgatgaacgg gctggagcag tctgaggaag tggggcaagg aatgccgcta gtctctgagg
     4861 gagaccgagg gagccccttt caggaggagg aggggagtgc tctgaagacc tcttgggcag
     4921 gggctcctgt tcacctgggc cagggtcagt tcctgaagtt cactcagagg gaaggagata
     4981 gagagtcctg gtcctcaggg gaggactagg aaaagaccat ctgcccggca ctggggactt
     5041 aggggtgcgg ggaggggaag gacgcctcca agcccgctcc ctgctcagga gcagcactct
     5101 taacttacga tctcttgaca tatggtttct ggctgagagg cctggcccgc taaggtgaaa
     5161 aggggtgtgg caaaggagcc tactccaaga atggaggctg taggaatata acctcccacc
     5221 ctgcaaaggg aatctcttgc ctgctccatc tcataggcta agtcagctga atcccgatag
     5281 tactaggtcc ccttccctcc gcatcccgtc agctggaaaa ggcctgtggc ccagaggctt
     5341 ctccaaaggg agggtgacat gctggctttt gtgcccaagc tcaccagccc tgcgccacct
     5401 cactgcagta gtgcaccatc tcactgcagt agcacgccct cctgggccgt ctggcctgtg
     5461 gctaatggag gtgacggcac tcccatgtgc tgactccccc catccctgcc acgctgtggc
     5521 cctgcctggc tagtccctgc ctgaataaag taatgcctcc gcttcaaa
//
