LOCUS       NM_002499               7108 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens neogenin 1 (NEO1), transcript variant 1, mRNA.
ACCESSION   NM_002499
VERSION     NM_002499.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7108)
  AUTHORS   Vennela,J., Pottakkat,B., Vairappan,B.S., Verma,S.K. and
            Mukherjee,V.
  TITLE     Hepatic Expression of NTN4 and Its Receptors in Patients with
            Hepatocellular Carcinoma
  JOURNAL   Asian Pac J Cancer Prev 24 (12), 4285-4292 (2023)
   PUBMED   38156865
  REMARK    GeneRIF: Hepatic Expression of NTN4 and Its Receptors in Patients
            with Hepatocellular Carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7108)
  AUTHORS   Untiveros,G., Raskind,A., Linares,L., Dotti,A. and Strizzi,L.
  TITLE     Netrin-1 Stimulates Migration of Neogenin Expressing Aggressive
            Melanoma Cells
  JOURNAL   Int J Mol Sci 23 (21), 12751 (2022)
   PUBMED   36361539
  REMARK    GeneRIF: Netrin-1 Stimulates Migration of Neogenin Expressing
            Aggressive Melanoma Cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7108)
  AUTHORS   Sesen,J., Driscoll,J., Shah,N., Moses-Gardner,A., Luiselli,G.,
            Alexandrescu,S., Zurakowski,D., Baxter,P.A., Su,J.M., Pricola
            Fehnel,K. and Smith,E.R.
  TITLE     Neogenin is highly expressed in diffuse intrinsic pontine glioma
            and influences tumor invasion
  JOURNAL   Brain Res 1762, 147348 (2021)
   PUBMED   33571520
  REMARK    GeneRIF: Neogenin is highly expressed in diffuse intrinsic pontine
            glioma and influences tumor invasion.
REFERENCE   4  (bases 1 to 7108)
  AUTHORS   Sun,D., Tan,Z.B., Sun,X.D., Liu,Z.P., Chen,W.B., Milibari,L.,
            Ren,X., Yao,L.L., Lee,D., Shen,C., Pan,J.X., Huang,Z.H., Mei,L. and
            Xiong,W.C.
  TITLE     Hippocampal astrocytic neogenin regulating glutamate uptake, a
            critical pathway for preventing epileptic response
  JOURNAL   Proc Natl Acad Sci U S A 118 (16) (2021)
   PUBMED   33850017
  REMARK    GeneRIF: Hippocampal astrocytic neogenin regulating glutamate
            uptake, a critical pathway for preventing epileptic response.
REFERENCE   5  (bases 1 to 7108)
  AUTHORS   Huyghe,A., Furlan,G., Ozmadenci,D., Galonska,C., Charlton,J.,
            Gaume,X., Combemorel,N., Riemenschneider,C., Allegre,N., Zhang,J.,
            Wajda,P., Rama,N., Vieugue,P., Durand,I., Brevet,M., Gadot,N.,
            Imhof,T., Merrill,B.J., Koch,M., Mehlen,P., Chazaud,C., Meissner,A.
            and Lavial,F.
  TITLE     Netrin-1 promotes naive pluripotency through Neo1 and Unc5b
            co-regulation of Wnt and MAPK signalling
  JOURNAL   Nat Cell Biol 22 (4), 389-400 (2020)
   PUBMED   32231305
  REMARK    GeneRIF: Netrin-1 promotes naive pluripotency through Neo1 and
            Unc5b co-regulation of Wnt and MAPK signaling.
REFERENCE   6  (bases 1 to 7108)
  AUTHORS   Niederkofler,V., Salie,R. and Arber,S.
  TITLE     Hemojuvelin is essential for dietary iron sensing, and its mutation
            leads to severe iron overload
  JOURNAL   J Clin Invest 115 (8), 2180-2186 (2005)
   PUBMED   16075058
REFERENCE   7  (bases 1 to 7108)
  AUTHORS   Krauss,R.S., Cole,F., Gaio,U., Takaesu,G., Zhang,W. and Kang,J.S.
  TITLE     Close encounters: regulation of vertebrate skeletal myogenesis by
            cell-cell contact
  JOURNAL   J Cell Sci 118 (Pt 11), 2355-2362 (2005)
   PUBMED   15923648
  REMARK    Review article
REFERENCE   8  (bases 1 to 7108)
  AUTHORS   Ho,S.M., Lau,K.M., Mok,S.C. and Syed,V.
  TITLE     Profiling follicle stimulating hormone-induced gene expression
            changes in normal and malignant human ovarian surface epithelial
            cells
  JOURNAL   Oncogene 22 (27), 4243-4256 (2003)
   PUBMED   12833147
  REMARK    GeneRIF: neogenin and restin have roles in
            proproliferation/survival action on ovarian cancer cells
REFERENCE   9  (bases 1 to 7108)
  AUTHORS   Vielmetter,J., Chen,X.N., Miskevich,F., Lane,R.P., Yamakawa,K.,
            Korenberg,J.R. and Dreyer,W.J.
  TITLE     Molecular characterization of human neogenin, a DCC-related
            protein, and the mapping of its gene (NEO1) to chromosomal position
            15q22.3-q23
  JOURNAL   Genomics 41 (3), 414-421 (1997)
   PUBMED   9169140
REFERENCE   10 (bases 1 to 7108)
  AUTHORS   Meyerhardt,J.A., Look,A.T., Bigner,S.H. and Fearon,E.R.
  TITLE     Identification and characterization of neogenin, a DCC-related gene
  JOURNAL   Oncogene 14 (10), 1129-1136 (1997)
   PUBMED   9121761
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC129980.6, DB458571.2,
            BC117161.1, AB209412.1 and AL355708.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_002499.3.
            
            Summary: This gene encodes a cell surface protein that is a member
            of the immunoglobulin superfamily. The encoded protein consists of
            four N-terminal immunoglobulin-like domains, six fibronectin type
            III domains, a transmembrane domain and a C-terminal internal
            domain that shares homology with the tumor suppressor candidate
            gene DCC. This protein may be involved in cell growth and
            differentiation and in cell-cell adhesion. Defects in this gene are
            associated with cell proliferation in certain cancers. Alternate
            splicing results in multiple transcript variants. [provided by
            RefSeq, Feb 2010].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U61262.1, U72391.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261908.11/ ENSP00000261908.6
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                AC129980.6         104272-104292       c
            22-147              DB458571.2         256-381
            148-4621            BC117161.1         1-4474
            4622-6384           AB209412.1         3416-5178
            6385-7108           AL355708.1         972-1695
FEATURES             Location/Qualifiers
     source          1..7108
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q24.1"
     gene            1..7108
                     /gene="NEO1"
                     /gene_synonym="IGDCC2; NGN; NTN1R2"
                     /note="neogenin 1"
                     /db_xref="GeneID:4756"
                     /db_xref="HGNC:HGNC:7754"
                     /db_xref="MIM:601907"
     exon            1..343
                     /gene="NEO1"
                     /gene_synonym="IGDCC2; NGN; NTN1R2"
                     /inference="alignment:Splign:2.1.0"
     CDS             214..4599
                     /gene="NEO1"
                     /gene_synonym="IGDCC2; NGN; NTN1R2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; immunoglobulin superfamily DCC subclass member
                     2; neogenin homolog 1"
                     /codon_start=1
                     /product="neogenin isoform 1 precursor"
                     /protein_id="NP_002490.2"
                     /db_xref="CCDS:CCDS10247.1"
                     /db_xref="GeneID:4756"
                     /db_xref="HGNC:HGNC:7754"
                     /db_xref="MIM:601907"
                     /translation="MAAERGARRLLSTPSFWLYCLLLLGRRAPGAAAARSGSAPQSPG
                     ASIRTFTPFYFLVEPVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQ
                     LLPDGSLFISNVVHSKHNKPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEP
                     SSVYAGNNAILNCEVNADLVPFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGL
                     YRCVVESGGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLP
                     TPTIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETIEAQAE
                     LTVQAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKE
                     HNLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPRDVVASLV
                     STRFIKLTWRTPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATV
                     YIFRVMAQNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGN
                     GEIQNYKLYYMEKGTDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDV
                     AVRTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDV
                     TETLVSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPE
                     VPSSLHVRPLVTSIVVSWTPPENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIEN
                     LDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMMP
                     PVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNANATTLS
                     YLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTSPPKDVTVVSKEGKPKT
                     IIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQIQELTLDTPYYF
                     KIQARNSKGMGPMSEAVQFRTPKADSSDKMPNDQASGSGGKGSRLPDLGSDYKPPMSG
                     SNSPHGSPTSPLDSNMLLVIIVSVGVITIVVVVIIAVFCTRRTTSHQKKKRAACKSVN
                     GSHKYKGNSKDVKPPDLWIHHERLELKPIDKSPDPNPIMTDTPIPRNSQDITPVDNSM
                     DSNIHQRRNSYRGHESEDSMSTLAGRRGMRPKMMMPFDSQPPQPVISAHPIHSLDNPH
                     HHFHSSSLASPARSHLYHPGSPWPIGTSMSLSDRANSTESVRNTPSTDTMPASSSQTC
                     CTDHQDPEGATSSSYLASSQEEDSGQSLPTAHVRPSHPLKSFAVPAIPPPGPPTYDPA
                     LPSTPLLSQQALNHHIHSVKTASIGTLGRSRPPMPVVVPSAPEVQETTRMLEDSESSY
                     EPDELTKEMAHLEGLMKDLNAITTA"
     exon            344..661
                     /gene="NEO1"
                     /gene_synonym="IGDCC2; NGN; NTN1R2"
                     /inference="alignment:Splign:2.1.0"
     exon            662..937
                     /gene="NEO1"
                     /gene_synonym="IGDCC2; NGN; NTN1R2"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1091
                     /gene="NEO1"
                     /gene_synonym="IGDCC2; NGN; NTN1R2"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1228
                     /gene="NEO1"
                     /gene_synonym="IGDCC2; NGN; NTN1R2"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1383
                     /gene="NEO1"
                     /gene_synonym="IGDCC2; NGN; NTN1R2"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1504
                     /gene="NEO1"
                     /gene_synonym="IGDCC2; NGN; NTN1R2"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1664
                     /gene="NEO1"
                     /gene_synonym="IGDCC2; NGN; NTN1R2"
                     /inference="alignment:Splign:2.1.0"
     exon            1665..1819
                     /gene="NEO1"
                     /gene_synonym="IGDCC2; NGN; NTN1R2"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..1968
                     /gene="NEO1"
                     /gene_synonym="IGDCC2; NGN; NTN1R2"
                     /inference="alignment:Splign:2.1.0"
     exon            1969..2107
                     /gene="NEO1"
                     /gene_synonym="IGDCC2; NGN; NTN1R2"
                     /inference="alignment:Splign:2.1.0"
     exon            2108..2157
                     /gene="NEO1"
                     /gene_synonym="IGDCC2; NGN; NTN1R2"
                     /inference="alignment:Splign:2.1.0"
     exon            2158..2305
                     /gene="NEO1"
                     /gene_synonym="IGDCC2; NGN; NTN1R2"
                     /inference="alignment:Splign:2.1.0"
     exon            2306..2416
                     /gene="NEO1"
                     /gene_synonym="IGDCC2; NGN; NTN1R2"
                     /inference="alignment:Splign:2.1.0"
     exon            2417..2611
                     /gene="NEO1"
                     /gene_synonym="IGDCC2; NGN; NTN1R2"
                     /inference="alignment:Splign:2.1.0"
     exon            2612..2707
                     /gene="NEO1"
                     /gene_synonym="IGDCC2; NGN; NTN1R2"
                     /inference="alignment:Splign:2.1.0"
     exon            2708..2931
                     /gene="NEO1"
                     /gene_synonym="IGDCC2; NGN; NTN1R2"
                     /inference="alignment:Splign:2.1.0"
     exon            2932..3070
                     /gene="NEO1"
                     /gene_synonym="IGDCC2; NGN; NTN1R2"
                     /inference="alignment:Splign:2.1.0"
     exon            3071..3178
                     /gene="NEO1"
                     /gene_synonym="IGDCC2; NGN; NTN1R2"
                     /inference="alignment:Splign:2.1.0"
     exon            3179..3373
                     /gene="NEO1"
                     /gene_synonym="IGDCC2; NGN; NTN1R2"
                     /inference="alignment:Splign:2.1.0"
     exon            3374..3406
                     /gene="NEO1"
                     /gene_synonym="IGDCC2; NGN; NTN1R2"
                     /inference="alignment:Splign:2.1.0"
     exon            3407..3475
                     /gene="NEO1"
                     /gene_synonym="IGDCC2; NGN; NTN1R2"
                     /inference="alignment:Splign:2.1.0"
     exon            3476..3623
                     /gene="NEO1"
                     /gene_synonym="IGDCC2; NGN; NTN1R2"
                     /inference="alignment:Splign:2.1.0"
     exon            3624..3862
                     /gene="NEO1"
                     /gene_synonym="IGDCC2; NGN; NTN1R2"
                     /inference="alignment:Splign:2.1.0"
     exon            3863..3955
                     /gene="NEO1"
                     /gene_synonym="IGDCC2; NGN; NTN1R2"
                     /inference="alignment:Splign:2.1.0"
     exon            3956..4114
                     /gene="NEO1"
                     /gene_synonym="IGDCC2; NGN; NTN1R2"
                     /inference="alignment:Splign:2.1.0"
     exon            4115..4378
                     /gene="NEO1"
                     /gene_synonym="IGDCC2; NGN; NTN1R2"
                     /inference="alignment:Splign:2.1.0"
     exon            4379..4515
                     /gene="NEO1"
                     /gene_synonym="IGDCC2; NGN; NTN1R2"
                     /inference="alignment:Splign:2.1.0"
     exon            4516..7108
                     /gene="NEO1"
                     /gene_synonym="IGDCC2; NGN; NTN1R2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5271..5276
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NEO1"
                     /gene_synonym="IGDCC2; NGN; NTN1R2"
                     /note="hexamer: ATTAAA"
     polyA_site      5296
                     /gene="NEO1"
                     /gene_synonym="IGDCC2; NGN; NTN1R2"
                     /note="major polyA site"
     regulatory      7084..7089
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NEO1"
                     /gene_synonym="IGDCC2; NGN; NTN1R2"
                     /note="hexamer: AATACA"
     polyA_site      7108
                     /gene="NEO1"
                     /gene_synonym="IGDCC2; NGN; NTN1R2"
                     /note="major polyA site"
ORIGIN      
        1 cccctccccg cccccttgca ggagggaggc gccctggagt ctcccctcca gcgagagggg
       61 ctgcgcgggc cgggccgggc cgggctgggc tggagcagcg gcggccgcgg gagccgagct
      121 tgcagcgagg gaccggctga ggcgcgcggg agggaaggag gcaagggctc cgcggcgctg
      181 tcgccgccgc tgccgctcac tctcggggaa gagatggcgg cggagcgggg agcccggcga
      241 ctcctcagca ccccctcctt ctggctctac tgcctgctgc tgctcgggcg ccgggcgccg
      301 ggcgccgcgg ccgccaggag cggctccgcg ccgcagtccc caggagccag cattcgaacg
      361 ttcactccat tttattttct ggtggagccg gtggatacac tctcagttag aggctcttct
      421 gttatattaa actgttcagc atattctgag ccttctccaa aaattgaatg gaaaaaagat
      481 ggaacttttt taaacttagt atcagatgat cgacgccagc ttctcccgga tggatcttta
      541 tttatcagca atgtggtgca ttccaaacac aataaacctg atgaaggtta ttatcagtgt
      601 gtggccactg ttgagagtct tggaactatt atcagtagaa cagcgaagct catagtagca
      661 ggtcttccaa gatttaccag ccaaccagaa ccttcctcag tttatgctgg gaacaatgca
      721 attctgaatt gtgaagttaa tgcagatttg gtcccatttg tgaggtggga acagaacaga
      781 caaccccttc ttctggatga tagagttatc aaacttccaa gtggaatgct ggttatcagc
      841 aatgcaactg aaggagatgg cgggctttat cgctgcgtag tggaaagtgg tgggccacca
      901 aagtatagtg atgaagttga attgaaggtt cttccagatc ctgaggtgat atcagacttg
      961 gtatttttga aacagccttc tcccttagtc agagtcattg gtcaggatgt agtgttgcca
     1021 tgtgttgctt caggacttcc tactccaacc attaaatgga tgaaaaatga ggaggcactt
     1081 gacacagaaa gctctgaaag attggtattg ctggcaggtg gtagcctgga gatcagtgat
     1141 gttactgagg atgatgctgg gacttatttt tgtatagctg ataatggaaa tgagacaatt
     1201 gaagctcaag cagagcttac agtgcaagct caacctgaat tcctgaagca gcctactaat
     1261 atatatgctc acgaatctat ggatattgta tttgaatgtg aagtgactgg aaaaccaact
     1321 ccaactgtga agtgggtcaa aaatggggat atggttatcc caagtgatta ttttaagatt
     1381 gtaaaggaac ataatcttca agttttgggt ctggtgaaat cagatgaagg gttctatcag
     1441 tgcattgctg aaaatgatgt tggaaatgca caagctggag cccaactgat aatccttgaa
     1501 catgcaccag ccacaacggg accactgcct tcagctcctc gggatgtcgt ggcctccctg
     1561 gtctctaccc gcttcatcaa attgacgtgg cggacacctg catcagatcc tcacggagac
     1621 aaccttacct actctgtgtt ctacaccaag gaagggattg ctagggaacg tgttgagaat
     1681 accagtcacc caggagagat gcaagtaacc attcaaaacc taatgccagc gaccgtgtac
     1741 atctttagag ttatggctca aaataagcat ggctcaggag agagttcagc tccactgcga
     1801 gtagaaacac aacctgaggt tcagctccct ggcccagcac ctaaccttcg tgcatatgca
     1861 gcttcgccta cctccatcac tgttacgtgg gaaacaccag tgtctggcaa tggggaaatt
     1921 cagaattata aattgtacta catggaaaag gggactgata aagaacagga tgttgatgtt
     1981 tcaagtcact cttacaccat taatgggttg aaaaaatata cagagtatag tttccgagtg
     2041 gtggcctaca ataaacatgg tcctggagtt tccacaccag atgttgctgt tcgaacattg
     2101 tcagatgttc ccagtgctgc tcctcagaat ctgtccttgg aagtgagaaa ttcaaagagt
     2161 attatgattc actggcagcc acctgctcca gccacacaaa atgggcagat tactggctac
     2221 aagattcgct accgaaaggc ctcccgaaag agtgatgtca ctgagacctt ggtaagcggg
     2281 acacagctgt ctcagctgat tgaaggtctt gatcggggga ctgagtataa tttccgagtg
     2341 gctgctctaa caatcaatgg tacaggcccg gcaactgact ggctgtctgc tgaaactttt
     2401 gaaagtgacc tagatgaaac tcgtgttcct gaagtgccta gctctcttca cgtacgcccg
     2461 ctcgttacta gcatcgtagt gagctggact cctccagaga atcagaacat tgtggtcaga
     2521 ggttacgcca ttggttatgg cattggcagc cctcatgccc agaccatcaa agtggactat
     2581 aaacagcgct attacaccat tgaaaatctg gatcccagct ctcactatgt gattaccctg
     2641 aaagcattta ataacgtggg tgaaggcatc cccctgtatg agagtgctgt gaccaggcct
     2701 cacacagaca cttctgaagt tgatttattt gttattaatg ctccatacac tccagtgcca
     2761 gatcccactc ccatgatgcc accagtggga gttcaggctt ccattctgag tcatgacacc
     2821 atcaggatta cgtgggcaga caactcgctg cccaagcacc agaagattac agactcccga
     2881 tactacaccg tccgatggaa aaccaacatc ccagcaaaca ccaagtacaa gaatgcaaat
     2941 gcaaccactt tgagttattt ggtgactggt ttaaagccga atacactcta tgaattctct
     3001 gtgatggtga ccaaaggtcg aagatcaagt acatggagta tgacagccca tgggaccacc
     3061 tttgaattag ttccgacttc tccacccaag gatgtgactg ttgtgagtaa agaggggaaa
     3121 cctaagacca taattgtgaa ttggcagcct ccctccgaag ccaatggcaa aattacaggt
     3181 tacatcatat attacagtac agatgtgaat gcagagatac atgactgggt tattgagcct
     3241 gttgtgggaa acagactgac tcaccagata caagagttaa ctcttgacac accatactac
     3301 ttcaaaatcc aggcacggaa ctcaaagggc atgggaccca tgtctgaagc tgtccaattc
     3361 agaacaccta aagcggactc ctctgataaa atgcctaatg atcaagcctc agggtctgga
     3421 gggaaaggaa gccggctgcc agacctagga tccgactaca aacctccaat gagcggcagt
     3481 aacagccctc atgggagccc cacctctcct ctggacagta atatgctgct ggtcataatt
     3541 gtttctgttg gcgtcatcac catcgtggtg gttgtgatta tcgctgtctt ttgtacccgt
     3601 cgtaccacct ctcaccagaa aaagaaacga gctgcctgca aatcagtgaa tggctctcat
     3661 aagtacaaag ggaattccaa agatgtgaaa cctccagatc tctggatcca tcatgagaga
     3721 ctggagctga aacccattga taagtctcca gacccaaacc ccatcatgac tgatactcca
     3781 attcctcgca actctcaaga tatcacacca gttgacaact ccatggacag caatatccat
     3841 caaaggcgaa attcatacag agggcatgag tcagaggaca gcatgtctac actggctgga
     3901 aggcgaggaa tgagaccaaa aatgatgatg ccctttgact cccagccacc ccagcctgtg
     3961 attagtgccc atcccatcca ttccctcgat aaccctcacc atcatttcca ctccagcagc
     4021 ctcgcttctc cagctcgcag tcatctctac cacccgggca gcccatggcc cattggcaca
     4081 tccatgtccc tttcagacag ggccaattcc acagaatccg ttcgaaatac ccccagcact
     4141 gacaccatgc cagcctcttc gtctcaaaca tgctgcactg atcaccagga ccctgaaggt
     4201 gctaccagct cctcttactt ggccagctcc caagaggaag attcaggcca gagtcttccc
     4261 actgcccatg ttcgcccttc ccacccattg aagagcttcg ccgtgccagc aatcccgcct
     4321 ccaggacctc ccacctatga tcctgcattg ccaagcacac cattactgtc ccagcaagct
     4381 ctgaaccatc acattcactc agtgaagaca gcctccatcg ggactctagg aaggagccgg
     4441 cctcctatgc cagtggttgt tcccagtgcc cctgaagtgc aggagaccac aaggatgttg
     4501 gaagactccg agagtagcta tgaaccagat gagctgacca aagagatggc ccacctggaa
     4561 ggactaatga aggacctaaa cgctatcaca acagcatgac gaccttcacc aggacctgac
     4621 ttcaaacctg agtctggaag tcttggaact tacccttgaa aacaaggaat tgtacagagt
     4681 acgagaggac agcacttgag aacacagaat gagccagcag actggccagc gcctctgtgt
     4741 agggctggct ccaggcatgg ccacctgcct tcccctggtc agcctggaag aagcctgtgt
     4801 cgaggcagct tccctttgcc tgctgatatt ctgcaggact gggcaccatg ggccaaaatt
     4861 ttgtgtccag ggaagaggcg agaagtgcaa cctgcatttc actttgtggt caggccgtgt
     4921 ctttgtgctg tgactgcatc acctttatgg agtgtagaca ttggcattta tgtacaattt
     4981 tatttgtgtc ttattttatt ttaccttcaa aaacaaaaac gccatccaaa accaaggaag
     5041 tccttggtgt tctccacaag tggttgacat ttgactgctt gttccaatta tgtatggaaa
     5101 gtctttgaca gtgtgggtcg ttcctggggt tggcttgttt tttggtttca tttttatttt
     5161 ttaattctga gtcattgcat cctctaccag ctgttaatcc atcactctga gggggaggaa
     5221 atgttgcatt gctgtttgta agcttttttt attatttttt tattataatt attaaaggcc
     5281 tgactctttc ctctcatcac tgtgagatta cagatctatt tgaattgaat gaaatgtaac
     5341 attgaaaaga cttgtttgtt gctttctgtg cagtttcagt attggggcgg gtggggggct
     5401 gggggttggt aataggaaat ggaggggctg ctgaggtcct gtgaatgttt ctgtcattgt
     5461 actttcttcc agaagcctgc agagaatgga agcatcttct ttattgtcct ttcctggcat
     5521 gtccatcctt attgtcacta cgttgcaact ggagtttgat ttggatctgg ttttaaaatt
     5581 cttctgtgca atagatgggt ttgaggattt agcggccctg atgtcttggt catagcctgg
     5641 taagaatgtc catgctgagg agccagatgt tgtatttcta actgcctgag tcacacagaa
     5701 tagggtaaga gcctgacccc attctgtaaa tcagaaagca aggatggaga ccctttcctg
     5761 ctgctattat tggctctctt tgaggaagtt ggaggttaag gaaggaactt gtttgtttcc
     5821 gtatacgact ccttcttctc tctagttcag tcttcagcca gtccagcgct ctcttccaca
     5881 cttcagagcc ccttcagaga aagcattagc aggaatgaga caaggcagag ctgcagtgcc
     5941 ccctgaggct tccacacatc tttctgaata ttatttttca agtaacaagg gcagggacag
     6001 cggaaacagc tgcccacccc ccccatccca gcagctcagc taagccctga tgagaatgaa
     6061 gccacaggag ttgtctgagg tgaacccagc cgctcagcca cacatggaag ccattgcctt
     6121 tgcacatagt tcttgggttc tttttcctaa aaaggtaagg agctgaggtg tgtggttttt
     6181 taatattaag aatatataat ggaaaacaca cgactgacgc tcaggcatct tcccctactc
     6241 cccaacagat ccccagaaga cagcgtggaa ggcagtgtag acagtaaatc gggcttcagt
     6301 tctatagcca agaagagatc agctgctgaa accaccagtg ggtaccccag gccacctgcc
     6361 tttgaacttg gggatttgcc atgtttgatc ttgtcacata cttgcttttt tacaagatga
     6421 actctttgta tttatgattt ggggggcaat gaaaggtgca atgcaggaac tgctgctgcc
     6481 gagctcgctg gtcacatggg ggtgccaggc gggattctgg aaaaccagtg cacttaaact
     6541 gatcctgaag agagctgtcc cagcactctg gccaccagga gggccagatt ccccagaaac
     6601 taccttttgc ccaaagaaca tgctcagtat ttggggcatt tcctcccaca aaccctgact
     6661 gcttctgtta cctcagggcc ttggtacctg gatactgcca cagaattggg gcgggtgggg
     6721 gaggggccta tttttaaata aaataactgt tcaaagttgg gggtttttta aaaaattaag
     6781 aaaaaggaaa gctattctgt attgcacctt ttcacaattt aatacatttt cttacatttt
     6841 cctgtgattt tcgaaactaa accattgtgt gtcctgtagt gtcctggttg agctgccgct
     6901 cagcagcttc ctcgggggga tttggaacac ctgtgtctgt cgccgcactg cctgtgggag
     6961 gggcccagag ggctgctggg actggcgtct gtacacactt gtttggcctt ttctgtagtt
     7021 gatgctgtaa actctatggc tttttaaaaa cgatttcatg tttttattta gtattggaaa
     7081 tccaatacac ttttttaatc caatcaaa
//
