LOCUS       NM_013349                916 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens neudesin neurotrophic factor (NENF), transcript
            variant 1, mRNA.
ACCESSION   NM_013349
VERSION     NM_013349.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 916)
  AUTHORS   Karatas,O., Calan,M., Yuksel,A., Chousein,R., Bozkaya,G.,
            Karatas,M., Uslu,A. and Tatar,E.
  TITLE     The level of the neudesin in type-2 diabetic patients and the
            relationship between the metabolic parameters and carotid
            intima-media thickness
  JOURNAL   Minerva Endocrinol (Torino) 48 (3), 288-294 (2023)
   PUBMED   33435641
  REMARK    GeneRIF: The level of the neudesin in type-2 diabetic patients and
            the relationship between the metabolic parameters and carotid
            intima-media thickness.
REFERENCE   2  (bases 1 to 916)
  AUTHORS   Bozkaya,G., Fenercioglu,O., Demir,I., Guler,A., Aslanipour,B. and
            Calan,M.
  TITLE     Neudesin: a neuropeptide hormone decreased in subjects with
            polycystic ovary syndrome
  JOURNAL   Gynecol Endocrinol 36 (10), 849-853 (2020)
   PUBMED   32314607
  REMARK    GeneRIF: Neudesin: a neuropeptide hormone decreased in subjects
            with polycystic ovary syndrome.
REFERENCE   3  (bases 1 to 916)
  AUTHORS   Moutaoufik,M.T., Malty,R., Amin,S., Zhang,Q., Phanse,S.,
            Gagarinova,A., Zilocchi,M., Hoell,L., Minic,Z., Gagarinova,M.,
            Aoki,H., Stockwell,J., Jessulat,M., Goebels,F., Broderick,K.,
            Scott,N.E., Vlasblom,J., Musso,G., Prasad,B., Lamantea,E.,
            Garavaglia,B., Rajput,A., Murayama,K., Okazaki,Y., Foster,L.J.,
            Bader,G.D., Cayabyab,F.S. and Babu,M.
  TITLE     Rewiring of the Human Mitochondrial Interactome during Neuronal
            Reprogramming Reveals Regulators of the Respirasome and
            Neurogenesis
  JOURNAL   iScience 19, 1114-1132 (2019)
   PUBMED   31536960
REFERENCE   4  (bases 1 to 916)
  AUTHORS   Koper-Lenkiewicz,O.M., Kaminska,J., Milewska,A., Sawicki,K.,
            Jadeszko,M., Mariak,Z., Reszec,J., Dymicka-Piekarska,V. and
            Matowicka-Karna,J.
  TITLE     Serum and cerebrospinal fluid Neudesin concentration and Neudesin
            Quotient as potential circulating biomarkers of a primary brain
            tumor
  JOURNAL   BMC Cancer 19 (1), 319 (2019)
   PUBMED   30953468
  REMARK    GeneRIF: In astrocytic brain tumor patients neudesin concentrations
            within the cerebrospinal fluid are higher compared with non-tumoral
            individuals. Serum neudesin concentration strongly correlates with
            its CSF level. In primary brain tumor patients serum neudesin
            concentration is clearly gender-dependent.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 916)
  AUTHORS   Stefanska,B., Cheishvili,D., Suderman,M., Arakelian,A., Huang,J.,
            Hallett,M., Han,Z.G., Al-Mahtab,M., Akbar,S.M., Khan,W.A.,
            Raqib,R., Tanvir,I., Khan,H.A., Rabbani,S.A. and Szyf,M.
  TITLE     Genome-wide study of hypomethylated and induced genes in patients
            with liver cancer unravels novel anticancer targets
  JOURNAL   Clin Cancer Res 20 (12), 3118-3132 (2014)
   PUBMED   24763612
  REMARK    GeneRIF: High NENF expression is associated with liver cancer.
REFERENCE   6  (bases 1 to 916)
  AUTHORS   Kimura,I., Nakayama,Y., Yamauchi,H., Konishi,M., Miyake,A.,
            Mori,M., Ohta,M., Itoh,N. and Fujimoto,M.
  TITLE     Neurotrophic activity of neudesin, a novel extracellular
            heme-binding protein, is dependent on the binding of heme to its
            cytochrome b5-like heme/steroid-binding domain
  JOURNAL   J Biol Chem 283 (7), 4323-4331 (2008)
   PUBMED   18056703
  REMARK    GeneRIF: Describes the predicted heme-binding domains in the human
            neudesin protein sequence.
REFERENCE   7  (bases 1 to 916)
  AUTHORS   Kimura,I., Yoshioka,M., Konishi,M., Miyake,A. and Itoh,N.
  TITLE     Neudesin, a novel secreted protein with a unique primary structure
            and neurotrophic activity
  JOURNAL   J Neurosci Res 79 (3), 287-294 (2005)
   PUBMED   15605373
  REMARK    GeneRIF: Human neudesin of 172 amino acids with high similarity (
            approximately 91% identity) to mouse neudesin was identified; the
            human neudesin gene was mapped to chromosome 1p33.
REFERENCE   8  (bases 1 to 916)
  AUTHORS   Ma,L., Broomfield,S., Lavery,C., Lin,S.L., Xiao,W. and Bacchetti,S.
  TITLE     Up-regulation of CIR1/CROC1 expression upon cell immortalization
            and in tumor-derived human cell lines
  JOURNAL   Oncogene 17 (10), 1321-1326 (1998)
   PUBMED   9771976
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF173937.1, DB574171.1 and
            BC008823.2.
            
            On Nov 22, 2018 this sequence version replaced NM_013349.4.
            
            Summary: This gene encodes a neurotrophic factor that may play a
            role in neuron differentiation and development. A pseudogene of
            this gene is found on chromosome 12. Alternate splicing of this
            gene results in multiple transcript variants. [provided by RefSeq,
            Jan 2009].
            
            Transcript Variant: This variant (1) represents the longer
            transcript.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.296030.1,
                                           SRR1163658.413969.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000366988.5/ ENSP00000355955.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-675               AF173937.1         37-711
            676-697             DB574171.1         219-240
            698-916             BC008823.2         680-898
FEATURES             Location/Qualifiers
     source          1..916
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.3"
     gene            1..916
                     /gene="NENF"
                     /gene_synonym="CIR2; SCIRP10; SPUF"
                     /note="neudesin neurotrophic factor"
                     /db_xref="GeneID:29937"
                     /db_xref="HGNC:HGNC:30384"
                     /db_xref="MIM:611874"
     exon            1..201
                     /gene="NENF"
                     /gene_synonym="CIR2; SCIRP10; SPUF"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..543
                     /gene="NENF"
                     /gene_synonym="CIR2; SCIRP10; SPUF"
                     /note="secreted protein of unknown function; cell
                     growth-inhibiting protein 47; neuron-derived neurotrophic
                     factor; cell immortalization-related protein 2;
                     SCIRP10-related protein; Spinal cord injury related
                     protein 10"
                     /codon_start=1
                     /product="neudesin precursor"
                     /protein_id="NP_037481.1"
                     /db_xref="CCDS:CCDS1505.1"
                     /db_xref="GeneID:29937"
                     /db_xref="HGNC:HGNC:30384"
                     /db_xref="MIM:611874"
                     /translation="MVGPAPRRRLRPLAALALVLALAPGLPTARAGQTPRPAERGPPV
                     RLFTEEELARYGGEEEDQPIYLAVKGVVFDVTSGKEFYGRGAPYNALTGKDSTRGVAK
                     MSLDPADLTHDTTGLTAKELEALDEVFTKVYKAKYPIVGYTARRILNEDGSPNLDFKP
                     EDQPHFDIKDEF"
     exon            202..262
                     /gene="NENF"
                     /gene_synonym="CIR2; SCIRP10; SPUF"
                     /inference="alignment:Splign:2.1.0"
     exon            263..366
                     /gene="NENF"
                     /gene_synonym="CIR2; SCIRP10; SPUF"
                     /inference="alignment:Splign:2.1.0"
     exon            367..916
                     /gene="NENF"
                     /gene_synonym="CIR2; SCIRP10; SPUF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      651..656
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NENF"
                     /gene_synonym="CIR2; SCIRP10; SPUF"
                     /note="hexamer: AATAAA"
     polyA_site      675
                     /gene="NENF"
                     /gene_synonym="CIR2; SCIRP10; SPUF"
                     /note="major polyA site"
     regulatory      890..895
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NENF"
                     /gene_synonym="CIR2; SCIRP10; SPUF"
                     /note="hexamer: AATAAA"
     polyA_site      916
                     /gene="NENF"
                     /gene_synonym="CIR2; SCIRP10; SPUF"
ORIGIN      
        1 cttgccttgc gctgcgcgct caccatggtg ggccccgcgc cgcggcggcg gctgcggccg
       61 ctggcagcgc tggccctggt cctggcgctg gccccggggc tgcccacagc ccgggccggg
      121 cagacaccgc gccctgccga gcgggggccc ccagtgcggc ttttcaccga ggaggagctg
      181 gcccgctatg gcggggagga ggaagatcag cccatctact tggcagtgaa gggagtggtg
      241 tttgatgtca cctccggaaa ggagttttat ggacgaggag ccccctacaa tgccttgacg
      301 gggaaggact ccactagagg ggtagccaag atgtccttgg atcctgcaga cctcacccat
      361 gacactacgg gtctcacggc caaggaactg gaggccctgg atgaggtctt caccaaagtg
      421 tacaaagcca aataccccat cgtcggctac actgcccgga gaattctcaa tgaggatggc
      481 agccctaacc tggacttcaa gcctgaagac cagccccatt ttgacatcaa ggatgagttc
      541 tgatgttccc cctgcaggag caggttcttg ggagcgtgag gcaggaagac actaggtgct
      601 gaatctcctg caaaactggc tgcctggagg ccctgagcca cccagatctg aataaaacag
      661 atgcttaccc tggaagagca aatgcctcct gttgtccttg gtcaggggtt ctgtctacct
      721 ggggacccct gtctgcacac cagggatcaa taagagccaa agtgggacac ctcctagatg
      781 tcagtatcag ctggctgggc agtggaattt tgagcgacct ttactttata cttttctgtg
      841 cttgacagat tttcagccat gaccatgttc actttataat caaaacaaaa ataaaggtcc
      901 catttttaca aaagga
//
