LOCUS       NM_001142645            6172 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens nuclear envelope integral membrane protein 2 (NEMP2),
            transcript variant 1, mRNA.
ACCESSION   NM_001142645 XM_001723469 XM_001723498 XM_001726342
VERSION     NM_001142645.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6172)
  AUTHORS   Shibano,T., Mamada,H., Hakuno,F., Takahashi,S. and Taira,M.
  TITLE     The Inner Nuclear Membrane Protein Nemp1 Is a New Type of
            RanGTP-Binding Protein in Eukaryotes
  JOURNAL   PLoS One 10 (5), e0127271 (2015)
   PUBMED   25946333
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC093388.4.
            
            On Nov 23, 2018 this sequence version replaced NM_001142645.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.5861.1,
                                           SRR5189661.113535.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000409150.8/ ENSP00000386292.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-164               AC093388.4         106765-106928       c
            165-280             AC093388.4         97469-97584         c
            281-512             AC093388.4         91158-91389         c
            513-585             AC093388.4         90942-91014         c
            586-679             AC093388.4         89726-89819         c
            680-794             AC093388.4         88476-88590         c
            795-1020            AC093388.4         86659-86884         c
            1021-1197           AC093388.4         82567-82743         c
            1198-3617           AC093388.4         79099-81518         c
            3618-6172           AC093388.4         76544-79098         c
FEATURES             Location/Qualifiers
     source          1..6172
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q32.2"
     gene            1..6172
                     /gene="NEMP2"
                     /gene_synonym="TMEM194B"
                     /note="nuclear envelope integral membrane protein 2"
                     /db_xref="GeneID:100131211"
                     /db_xref="HGNC:HGNC:33700"
                     /db_xref="MIM:616497"
     exon            1..164
                     /gene="NEMP2"
                     /gene_synonym="TMEM194B"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..1321
                     /gene="NEMP2"
                     /gene_synonym="TMEM194B"
                     /note="UPF0571 transmembrane protein; transmembrane
                     protein 194B"
                     /codon_start=1
                     /product="nuclear envelope integral membrane protein 2
                     precursor"
                     /protein_id="NP_001136117.1"
                     /db_xref="CCDS:CCDS46476.1"
                     /db_xref="GeneID:100131211"
                     /db_xref="HGNC:HGNC:33700"
                     /db_xref="MIM:616497"
                     /translation="MGPRQGRWWLLLWLPPLATLPVRGEAAAAALSVRRCKALKEKDL
                     IRTSESDCYCYNQNSQVEWKYIWSTMQVKITSPGLFRIVYIAERHNCQYPENILSFIK
                     CVIHNFWIPKESNEITIIINPYRETVCFSVEPVKKIFNYMIHVNRNIMDFKLFLVFVA
                     GVFLFFYARTLSQSPTFYYSSGTVLGVLMTLVFVLLLVKRFIPKYSTFWALMVGCWFA
                     SVYIVCQLMEDLKWLWYENRIYVLGYVLIVGFFSFVVCYKHGPLADDRSRSLLMWMLR
                     LLSLVLVYAGVAVPQFAYAAIILLMSSWSLHYPLRACSYMRWKMEQWFTSKELVVKYL
                     TEDEYREQADAETNSALEELRRACRKPDFPSWLVVSRLHTPSKFADFVLGGSHLSPEE
                     ISLHEEQYGLGGAFLEEQLFNPSTA"
     exon            165..280
                     /gene="NEMP2"
                     /gene_synonym="TMEM194B"
                     /inference="alignment:Splign:2.1.0"
     exon            281..512
                     /gene="NEMP2"
                     /gene_synonym="TMEM194B"
                     /inference="alignment:Splign:2.1.0"
     exon            513..585
                     /gene="NEMP2"
                     /gene_synonym="TMEM194B"
                     /inference="alignment:Splign:2.1.0"
     exon            586..679
                     /gene="NEMP2"
                     /gene_synonym="TMEM194B"
                     /inference="alignment:Splign:2.1.0"
     exon            680..794
                     /gene="NEMP2"
                     /gene_synonym="TMEM194B"
                     /inference="alignment:Splign:2.1.0"
     exon            795..1020
                     /gene="NEMP2"
                     /gene_synonym="TMEM194B"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1197
                     /gene="NEMP2"
                     /gene_synonym="TMEM194B"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..6172
                     /gene="NEMP2"
                     /gene_synonym="TMEM194B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1806..1811
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NEMP2"
                     /gene_synonym="TMEM194B"
                     /note="hexamer: AATAAA"
     polyA_site      1831
                     /gene="NEMP2"
                     /gene_synonym="TMEM194B"
     regulatory      3596..3601
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NEMP2"
                     /gene_synonym="TMEM194B"
                     /note="hexamer: AATAAA"
     polyA_site      3617
                     /gene="NEMP2"
                     /gene_synonym="TMEM194B"
                     /note="major polyA site"
     regulatory      4084..4089
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NEMP2"
                     /gene_synonym="TMEM194B"
                     /note="hexamer: AAGAAA"
     polyA_site      4104
                     /gene="NEMP2"
                     /gene_synonym="TMEM194B"
     regulatory      4939..4944
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NEMP2"
                     /gene_synonym="TMEM194B"
                     /note="hexamer: TATAAA"
     polyA_site      4958
                     /gene="NEMP2"
                     /gene_synonym="TMEM194B"
     regulatory      6153..6158
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NEMP2"
                     /gene_synonym="TMEM194B"
                     /note="hexamer: AATAAA"
     polyA_site      6172
                     /gene="NEMP2"
                     /gene_synonym="TMEM194B"
ORIGIN      
        1 acttccgctc ctcgcagcgg agccggtccc ctagggctcg ggtcgcacgg agctgacccc
       61 taacgaaatg gggccgcgcc aagggcggtg gtggctgctg ctctggctgc cgcccctggc
      121 cacactgccc gtgcgcgggg aggcggcggc ggcagcgtta tcagttcgta ggtgtaaagc
      181 tttgaaggaa aaagatttaa ttagaacgtc tgagtcagac tgttactgct acaatcaaaa
      241 ttcccaagtg gagtggaaat acatatggtc aactatgcag gtgaaaatta ccagtccagg
      301 cctgttcaga attgtatata tcgcagaaag acataattgc caatatccag aaaacattct
      361 atcttttatc aaatgtgtga ttcataactt ttggatacca aaggaatcta acgaaataac
      421 cataatcatc aatccataca gggagactgt gtgcttctct gtggagcctg tcaagaagat
      481 atttaactat atgatacatg tgaatcgaaa catcatggat ttcaaactct tccttgtgtt
      541 tgtggcagga gtttttcttt tcttttatgc aaggaccctg agtcaaagcc ctactttcta
      601 ttactcctcg ggaactgtgc taggtgttct aatgacatta gtctttgtct tgctgttggt
      661 gaaaagattc attccgaagt atagcacctt ttgggctcta atggttggtt gttggtttgc
      721 ctcagtttat attgtatgcc agttgatgga agatctgaag tggctgtggt atgaaaacag
      781 gatatatgta ttaggctatg tcttgatagt tggatttttc agctttgttg tttgttacaa
      841 gcatgggccc cttgcagacg acaggagcag aagtcttctg atgtggatgc tgcgactcct
      901 ctccctggtt ctggtctatg ctggtgtggc cgtgcctcag tttgcctatg cagccataat
      961 cctcctcatg tcctcctgga gtctgcacta cccactgaga gcatgcagtt atatgaggtg
     1021 gaaaatggag cagtggttta catcaaaaga gctggtggtg aaatatctta cggaagacga
     1081 gtacagggag caagctgatg ctgaaacgaa cagtgctctg gaggagctac gccgggcctg
     1141 ccgaaaaccc gactttccct catggctggt cgtctccaga ctccacactc ctagcaaatt
     1201 tgcagacttt gttcttggag gaagccactt gtcacctgaa gaaatcagtc tgcatgaaga
     1261 gcagtatggc cttgggggtg ccttcttgga agagcagctc tttaacccga gtactgcctg
     1321 acatgcgacc ttcaagttga cttcattctg gacaaggaag tgggcaaagg gcagggattc
     1381 tattaaagtt aggcagaact gttctagtga acggtggcaa aaacatttgc tgtggagaaa
     1441 aacaagtcag tctggaaagg gaaaccaacc cattttgaag ataacttagc attcttggtg
     1501 acttctgcta cttattgtac tgtaggtgga taccaaaatt ctgtgacagc cactaccact
     1561 taccttgaat gaaggctttc attaggaaca ggggaatggc gttgttctta aggggctagt
     1621 aagcatgaac aggtgctttg tcgacaccag ggcactaaat ctggtcttaa tcccctgaac
     1681 ctgtgtcaga agactctgca atactcttcc tatagttcgt cagtataagt ccttaaagag
     1741 acctgagaca tgctggacca gtgttttcca aagtacagct cacaggctac taccaagtgt
     1801 tggtcaataa aggtattctg aggtcaacta agattgatat aaagttaaac taatgtattt
     1861 cagtatctct cagaggcatt cataatgctc gtgtgcactg tgaatctccc aaaggggaga
     1921 aattgtgtgc tgcagtttct tgcttaattt gaccacagaa ctctttttca tgagattaat
     1981 attccttgga acacgtttgg aaaatgctaa tggtggtgga actgagctca tgagaggtta
     2041 aataacttgt gcaagaccac actgagatgc agcactggta gaaatccagc cctgatgtat
     2101 cctttgactc aggtagacaa gatcttcagg tgcaagctta ggagccatct ccctacagcc
     2161 atgggcctca caatgttggt ggctttactt tttatttttc aataatggcc aacttgctat
     2221 ttaactgtga taaagggaaa tgtttctgaa gacattttaa agttttttat acatacgtaa
     2281 gatttttata tacatacgta aggattagat actatgatta ctttttttgt attttgaaat
     2341 tgaaggcact taagctcttg tgatattttg aattgactga tccatttaaa aaattgttta
     2401 gctataggtg tttgtaacaa tttcttataa aatgattttt tttcttgatt catgatatta
     2461 aactccagat tgaaatgagg ggctatgagc tttgaccctg aggaaagaag gccaaaacat
     2521 agatctgagg aaagatttga acatggcaag acaatctcag ggttaagatg ttgctaagtt
     2581 gattctgaga atcaaaatca ggcttttttt cctgtgatgg gatcataaaa ataatctttt
     2641 tatcaggaca aaggttatgg gcgaaggata gacagaattt tggcactgct gctttcctga
     2701 gccaaattaa gtagtttttc taaatcatga aaaaagagca tgactatcca tctggaactt
     2761 cctagattga ttttcaaatg atagttcctc tttgaagtat ttacaggtct gtttttgcca
     2821 gacatctttt catactggga actttttttt ttgtaatatc cactaaagtt aatctgcctt
     2881 tatatagact tggattttta aaaaaccaaa ggatatattt tccattcaga tttatggtaa
     2941 ctattttatg agtaaataga agtttgaata tttttcttat ggtttaatct gtttttttaa
     3001 attatattta ttggtgatat aaatgtatca gatgtatcag tgcctgtgct caccaagttc
     3061 gtctcctaag aagcagtttg tgtgctacaa cgtatgcgta tgagtaaata acacatgaac
     3121 aatctgctgg ggctgccagg tacatcccag ccaggacagc cgctgggcca gggggaagag
     3181 gtactgctga gggaaggaag cagctcttca tgggcagcta gccaggtgta accatcacag
     3241 taaaaacagc caaagagaga agaacaacag cagtccttga ggatattgtt ttccatgttt
     3301 atttttagag gaaatcatag gtttgtcagt ttctgctttg tgactactgt gagaagctaa
     3361 acaattagaa gcattacttg tgatattttt agtgtattta tgttgttttc atttgatttg
     3421 ggggtgtatt atagtactga tcacaattct aatccccatc aagcaatgta cagataactc
     3481 ttccaagaaa tgtttccctc ctttctttcc tcccttccct tctctttctc cctcacctcc
     3541 tgtctcctct cctcctccct ttttaaaggc ctttgaacag tttaaacgac cactcaataa
     3601 aatggctctg cccttcacag gtggttggaa gttggctttg tgcctcacac accataggtg
     3661 tataattatg gagcctaaca gatccctttg ttattttact gcttatgctt ggtgcctaca
     3721 aaagcttact gttgttagca agttgaactc tttgacacca gatgtgtggg tgagatatag
     3781 tgtaggtggc tatgcttaaa caatcgtatc attcaagtgt tatttttaaa aggttttaaa
     3841 acacatttta catatcacaa aaaatgcttt gtgaattagt tgtatggttt gccagtaata
     3901 cctagggctg aattacaggg gaatgtccat ctgacatgaa ggacaatatt tcaatttatg
     3961 actttttaaa aaaatctgga aatttcatat atttagattt taagagggtt tggaatagat
     4021 gatggattac ataaaaatat ctaaatatgt ggaggaatta agatcctgaa atgatgtcaa
     4081 ctaaagaaat gctctcttac attatgctat gtgtgattgt ttcccagagt gagagatgta
     4141 caattttata aattagcttt tcttgtccaa ctgaaagcaa gatagacaac ataatggatg
     4201 tggaagtttg aagacacctg caggaagaca gagaggtact tttaggtgac aacaggagca
     4261 agctgccttc tgagagagcc tgctgggtgg catgacattg aagagtgaac tatttgggtg
     4321 tgactgttag ccttattgac ttagaaccct gctttttgtt attgcaccat aagacctgtc
     4381 tcttgttagt caattcatat agttggtaca ggtagtgatt cacaaccaaa aatataacta
     4441 gcataaggat aaaaacactt gacttgatat gaccagcaga ttctctctca gaagacagat
     4501 ttacaagggg tcaaattata ataaggtggc tacttggtga actgaaacaa aacaaaggga
     4561 gcttgttata taattcacat ggttaatgtc atgaggccaa agagtttgat gcagatgcca
     4621 ccccccaccc cagtggggct agccttgtta atgggatgag ataccaggtc tgttgacaaa
     4681 gaccacgcct tcctttatgc aggtcctgcc aactttttcc tctctgtgac tgctgttttt
     4741 ctaatcttca ttattgacaa acatcccacc ccctctgatg ggcatatttt tactcagatg
     4801 tgttaaaatc tttagtcttt ctctggccta ggagttggat tatcttttaa aggtaactgt
     4861 attttttttg ttatgatccc tgaatgtgaa accttaatag gtcaccagag atttgaaatg
     4921 aatactatac ttatctaata taaatcttgg aagatacagt tagtgggtag cttctctatt
     4981 atttaaataa tttgaggcat ctgttttttt agatttggtc gtttttccaa aaaagaaaga
     5041 ctgattgaaa agagaaaggg aaagaatacc aacattgact agagatccat caggcactat
     5101 atgaggcacc ttcgatacct cttaatttgc acctcatgac cactctgtga tatgttttgg
     5161 tattttcatt ttacagatga ggaaagaccc agagaaggta ggagaaagtt gctgaaggac
     5221 acatatagct aaagtggtag aatcagaatt caagccccca tatgtctgct tccagggctc
     5281 atattctact tcctttattt attaccatct ttttaagaaa gtgaaggaaa tgaccccatg
     5341 gataaggcat tcaagaggtg actacatctg ctgatgttat acacatacca gtcatttgtg
     5401 ccccgcagca atggacactg tagtctgcgg ctcttgtcag tgcttctcag actgtctggg
     5461 gtgatggacc agtttccctc tagttcatca ctagtaatac ttttgtaaga tacactaaat
     5521 tattagaaaa atgaaataat ctttgaaaga aaagacatac agaatataag cacgatgatc
     5581 atgtcatgac aatgtcaact tgccatacat attttgaaat gtctaatttc tatgttgtca
     5641 cataccagca gtagtttgac agcaccagtc attgagcaca ctttgagtag cactggtcta
     5701 catgttattt ttctaagatg ccagtgatct tttcaggaaa caaaaaaaat ccgacctttt
     5761 ttcaaatgta agtttacaat ttaaaagaat agcatcctac actgactatt ggagagagta
     5821 tggtatataa tttgttaaat gattataaaa ttgtttactt ttgttgacac ctttaagaag
     5881 aaaaagaaaa atgaaaatta tgaaacttat aacctctctc agcagacttt tgcactttat
     5941 ggaattgtca ccatcatcac ttttttccat cctcttcaac ttaagttttg cttaattttg
     6001 tctcttaact aactcatatc cccaaccact taatgtttac aatgcatgtt ggaattgaat
     6061 gccttactgt acagcttact agatataggt aaatatgtat agtatggcac tgtagattgg
     6121 gagaatggaa tatgattata gatttaaatg gcaataaaat aatagaacta ga
//
